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Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum
Open accessAbstract
The dorsal striatum is a large forebrain region involved in action initiation, timing, control, learning and memory. Learning and remembering skilled movement sequences requires the dorsal striatum, and striatal subregions participate in both goal-directed (action-outcome) and habitual (stimulus-response) learning. Modulation of synaptic transmission plays a large part in controlling input to as well as the output from striatal medium spiny projection neurons (MSNs). Synapses in this brain region are subject to short-term modulation, including allosteric alterations in ion channel function and prominent presynaptic inhibition. Two forms of long-term synaptic plasticity have also been observed in striatum, long-term potentiation (LTP) and long-term depression (LTD). LTP at glutamatergic synapses onto MSNs involves activation of NMDA-type glutamate receptors and D1 dopamine or A2A adenosine receptors. Expression of LTP appears to involve postsynaptic mechanisms. LTD at glutamatergic synapses involves retrograde endocannabinoid signaling stimulated by activation of metabotropic glutamate receptors (mGluRs) and D2 dopamine receptors. While postsynaptic mechanisms participate in LTD induction, maintained expression involves presynaptic mechanisms. A similar form of LTD has also been observed at GABAergic synapses onto MSNs. Studies have just begun to examine the roles of synaptic plasticity in striatal-based learning. Findings to date indicate that molecules implicated in induction of plasticity participate in these forms of learning. Neurotransmitter receptors involved in LTP induction are necessary for proper skill and goal-directed instrumental learning. Interestingly, receptors involved in LTP and LTD at glutamatergic synapses onto MSNs of the "indirect pathway" appear to have important roles in habit learning. More work is needed to reveal if and when synaptic plasticity occurs during learning and if so what molecules and cellular processes, both short- and long-term, contribute to this plasticity.
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“It is believed that the interaction between glutamate and striatal activity serves as an important modulator of synaptic plasticity and neural excitability (Surmeier et al., 2007; Kreitzer et al., 2009; Lovinger et al., 2010; Gleich et al., 2015).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Lovinger et al., 2010
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Cites
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068 · cited 1×
“The ratio of responses to paired afferent stimuli delivered at 50 ms intervals is sensitive to the probability of neurotransmitter release (Zucker, 1989), and an increase this paired-pulse ratio generally signals a decrease in release probability.”
D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967 · cited 2×
“These striatonigral neurons strongly express D1Rs and generally do not express A2A or D2Rs (Augood and Emson, 1994; Gerfen et al., 1990; Gong et al., 2003).”
The role of the basal ganglia in habit formation
Yin, H. H., & Knowlton, B. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1919 · Cited by 2,402 · cited 5×
“The striatum is the major input nucleus of the basal ganglia, and as such it plays a crucial role in action control and action learning (Saint-Cyr et al., 1995; Graybiel,1998; Lalonde and Botez-Marquard, 1997; Yin and Knowlton, 2006).”
InfluentialA gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108 · cited 2×
“These striatonigral neurons strongly express D1Rs and generally do not express A2A or D2Rs (Augood and Emson, 1994; Gerfen et al., 1990; Gong et al., 2003).”
Packard, M. G., & McGaugh, J. L. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0007 · Cited by 1,566 · cited 2×
“…injection of a local anesthetic, which should inactivate the structure, just prior to a retention test did not impair the ability of the animal to perform a cross-maze task, but just altered the strategy used by the animal from a response-based to a place-based approach (Packard and McGaugh, 1996).”
The neostriatal mosaic: multiple levels of compartmental organization
Gerfen, C. R. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90355-c · Cited by 1,471
Short-Term Synaptic Plasticity
Zucker, R. S. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.000305 · Cited by 1,450
Integrative activity of the brain
Konorski, J. (1967) · Cited by 1,372
Yin, H. H., Knowlton, B. J., & Balleine, B. W. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03095.x · Cited by 1,226 · cited 1×
“Excitotoxic lesions of dorsolateral striatum disrupted habit learning in this study, as previously reported in rat (Hilario et al., 2007; Yin et al., 2004).”
Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.008 · Cited by 1,203 · cited 2×
“Dopamine can only act via GPCRs, and thus only modulates striatal neuronal function and synaptic transmission (Richfield et al., 1989; Surmeier et al., 2007).”
Cited by
Sorted by citations
Items 201–300 of 488
Johnson, K. A., Niswender, C. M., Conn, P. J., & Xiang, Z. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.09.007 · Cited by 31
“Types of action learning such as memorization of skilled movement sequences, goal-directed learning, and habit learning are known to be dependent on the basal ganglia, particularly involving the dorsal striatum [19].”
BackgroundDifferential association of postsynaptic signaling protein complexes in striatum and hippocampus
Baucum, A. J., Brown, A. M., & Colbran, R. J. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12101 · Cited by 29
Preservation of function in Parkinson's disease: What's learning got to do with it?
Beeler, J. A. (2011) · Brain Research · doi:10.1016/j.brainres.2011.09.040 · Cited by 29
“The focus here is on the role of corticostriatal plasticity in behavior and PD. Excellent reviews of the cellular mechanisms of corticostriatal plasticity can be found elsewhere (Lerner and Kreitzer, 2011; Lovinger, 2010).”
BackgroundCrego, A. C. G., Štoček, F., Marchuk, A. G., Carmichael, J. E., van der Meer, M. A. A., & Smith, K. S. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1313-19.2019 · Cited by 31
“…of a behavioral sequence (Kubota et al., 2009; Smith and Graybiel, 2013a; O’Hare et al., 2016; Vicente et al., 2016) and are involved in habits (Lovinger, 2010; Nelson and Killcross, 2013; Corbit et al., 2014; O’Hare et al., 2018), these studies and others also document dissociations among…”
BackgroundBalleine, B. W., Peak, J. N., Matamales, M., Bertran‐Gonzalez, J., & Hart, G. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.03.004 · Cited by 25
Chen, J., Choi, D., & Cunha, R. A. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109421 · Cited by 29
“…striatal LTD, which is restricted to striatopallidal MSN and requires activation of D 2 R and mGlu5R (Kreitzer and Malenka, 2007; Lovinger, 2010), is the main form of synaptic plasticity in the dorsolateral striatum (DLS) (Di Filippo et al., 2009; Lovinger, 2010; Partridge et al., 2000).”
BackgroundFrontal glutamate and reward processing in adolescence and adulthood
Gleich, T., Lorenz, R. C., Pöhland, L., Raufelder, D., Deserno, L., Beck, A., Heinz, A., Kühn, S., & Gallinat, J. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0844-3 · Cited by 29
“This interaction between striatal activity (especially dopamine related) and glutamate seems to be fundamental to modulate synaptic plasticity and neural excitability in striatal neurons in general (Surmeier et al. 2007; Kreitzer 2009; Di Filippo et al. 2009; Lovinger 2010).”
Nicotinic receptor subtypes differentially modulate glutamate release in the dorsal medial striatum
Howe, W. M., Young, D. A., Bekheet, G., & Kozak, R. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.08.009 · Cited by 28
“Endocannabinoid-mediated negative feedback on glutamatergic inputs, triggered by D2 activation on local projection neurons, has been extensively described in both ventral and lateral striatum (Kreitzer, 2009; Lovinger, 2010).”
Delta Opioid Receptors: Learning and Motivation
Pellissier, L. P., Pujol, C., Becker, J. A. J., & Merrer, J. L. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_89 · Cited by 30
“This result suggests that the control of response learning is facilitated in mutants (Packard 2009; Packard and McGaugh 1996), most likely via the lateral dorsal striatum (Lovinger 2010).”
BackgroundCompensatory Relearning Following Stroke: Cellular and Plasticity Mechanisms in Rodents
Balbinot, G. C., & Schuch, C. P. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.01023 · Cited by 30
“The remaining glutamatergic afferents target intrastriatal interneurons: large cholinergic aspiny neurons (or cholinergic tonically active neurons), GABAergic PV+ or neuropeptide Y+/SOM+ interneurons (Tepper et al., 2004; for reviews and references see Kreitzer, 2009; Lovinger, 2010).”
BackgroundBeeler, J. A., & Burghardt, N. S. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.799548 · Cited by 44
The role of adenosine A2A receptors in Alzheimer's disease and tauopathies
Launay, A., Nebie, O., Shankara, J. V., Lebouvier, T., Buée, L., Faivre, É., & Blum, D. L. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109379 · Cited by 29
Alterations in neurotransmitter co-release in Parkinson's disease
Barcomb, K., & Ford, C. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114562 · Cited by 31
“D 1 Rs and D 2 Rs also influence glutamatergic synaptic plasticity in opposing ways, allowing them to have a greater overall effect on MSN activity (Lovinger, 2010).”
Conditional targeting of medium spiny neurons in the striatal matrix
Reinius, B., Blunder, M., Brett, F. M., Eriksson, A., Patra, K., Jonsson, J., JAZIN, E. E., & Kullander, K. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00071 · Cited by 28
“In addition to its role in regulating locomotor functions, the striatum is known to participate in a variety of cognitive functions, including working memory (Lovinger, 2010; Palmiter, 2011).”
BackgroundTebano, M. T., Martire, A., & Popoli, P. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.051 · Cited by 28
Chassain, C., Melon, C., Salin, P., Vitale, F., Couraud, S., Durif, F., Goff, L. K., & Gubellini, P. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13438 · Cited by 29
Chabbert, D., Caubit, X., Roubertoux, P. L., Carlier, M., Habermann, B. H., Jacq, B., Salin, P., Metwaly, M., Frahm, C., Fatmi, A., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.03.974 · Cited by 27
Takaji, M., Takemoto, A., Yokoyama, C., Watakabe, A., Mizukami, H., Ozawa, K., Onoe, H., Nakamura, K., & Yamamori, T. (2016) · Scientific Reports · doi:10.1038/srep35809 · Cited by 26
“025), with no significant difference in the reductions for the two receptor subtypes in the non-injection sites of the D1R KD marmoset (t(8) = 1.”
InfluentialWang, M., Yoon, G., Song, J., & Jo, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-87809-4 · Cited by 28
Striatal low-threshold spiking interneurons locally gate dopamine
Holly, E. N., Davatolhagh, M. F., España, R. A., & Fuccillo, M. V. (2021) · Current Biology · doi:10.1016/j.cub.2021.06.081 · Cited by 29
Andreska, T., Lüningschrör, P., Wolf, D., McFleder, R. L., Ayon-Olivas, M., Rattka, M., Drechsler, C., Perschin, V., Blum, R., Aufmkolk, S., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112575 · Cited by 27
Functional characterization of G-protein-coupled receptors: A bioinformatics approach
Tovo‐Rodrigues, L., Roux, A., Hutz, M. H., Rohde, L. A., & Woods, A. S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.049 · Cited by 27
“, 2012) as well as the ability of many GPCRs such as A2A adenosine, D1 and D2 dopamine, M1-like mACh, CB1 and mGlus receptors to induce plasticity were reported (Lopez de Maturana and Sanchez-Pernaute, 2010; Lovinger, 2010).”
BackgroundNeurotrophin‐3 restores synaptic plasticity in the striatum of a mouse model of Huntington's disease
Gómez‐Pineda, V. G., Torres-Cruz, F. M., Vivar‐Cortés, I. C., & Hernández, E. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12824 · Cited by 27
Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons
Ruiz-Calvo, A., Bajo‐Grañeras, R., Maroto, I. B., Zian, D., Grabner, G. F., García-Taboada, E., Resel, E., Zechner, R., Zimmermann, R., Ortega‐Gutiérrez, S., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.027 · Cited by 27
Synapse-specific expression of mu opioid receptor long-term depression in the dorsomedial striatum
Muñoz, B., Haggerty, D. L., & Atwood, B. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-64203-0 · Cited by 27
Endocannabinoid contributions to alcohol habits and motivation: Relevance to treatment
Gianessi, C. A., Groman, S. M., Thompson, S. L., Jiang, M., van der Stelt, M., & Taylor, J. R. (2019) · Addiction Biology · doi:10.1111/adb.12768 · Cited by 28
Cdk5 Modulates Long-Term Synaptic Plasticity and Motor Learning in Dorsolateral Striatum
Hernández, A., Tan, C., Mettlach, G., Pozo, K., Plattner, F., & Bibb, J. A. (2016) · Scientific Reports · doi:10.1038/srep29812 · Cited by 27
Yu-Taeger, L., Ott, T., Bonsi, P., Tomczak, C., Wassouf, Z., Martella, G., Sciamanna, G., Imbriani, P., Ponterio, G., Tassone, A., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104634 · Cited by 30
Ren, L., Pour, M. D., Majdi, S., Li, X., Malmberg, P., & Ewing, A. G. (2017) · Angewandte Chemie · doi:10.1002/ange.201700095 · Cited by 26
Tozzi, A., Durante, V., Bastioli, G., Mazzocchetti, P., Novello, S., Mechelli, A., Morari, M., Costa, C., Mancini, A., Filippo, M. D., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.06.008 · Cited by 26
“Regulation of synaptic activity by different signaling systems is at the basis of network functioning in the central nervous system (CNS) and, within the basal ganglia, the glutamatergic and dopaminergic systems are mainly responsible of the modulation of spiny projection neurons (SPNs) and striatal functions (Calabre…”
BackgroundSun, W., Che, H., Li, J., Tang, D., Liu, X., Liu, W., & An, L. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02051-9 · Cited by 24
Mango, D., & Ledonne, A. (2023) · Cells · doi:10.3390/cells12121588 · Cited by 25
To Do or Not to Do: Dopamine, Affordability and the Economics of Opportunity
Beeler, J. A., & Mourra, D. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00006 · Cited by 28
“…learning depends upon complementary corticostriatal plasticity in the two pathways, such that LTP in the direct pathway selectively facilitates cortical activity while LTD in the indirect pathway selectively releases the same activity from inhibition (Lovinger, 2010; Lerner and Kreitzer, 2011).”
BackgroundInfluentialBetolngar, D., Mota, É., Fabritius, A., Nielsen, J., Hougaard, C. Ø., Christoffersen, C. T., Yang, J., Kehler, J., Griesbeck, O., Castro, L. R., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz041 · Cited by 25
“Lovinger DM. 2010.”
Akintunde, J. K., & Irechukwu, C. A. (2016) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098616656812 · Cited by 24
“Acetylcholine (ACh) is the key neurotransmitter of the cholinergic system, playing vital roles such as learning, memory, movement control, and modulation of cerebral blood circulation [Lovinger, 2010].”
BackgroundInfluentialXia, J., Meyers, A. M., & Beeler, J. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.87 · Cited by 24
Alterations in Functional Cortical Hierarchy in Hemiparkinsonian Rats
Jávor-Duray, B., Vinck, M. A., van der Roest, M., Bézard, E., Berendse, H. W., Boraud, T., & Voorn, P. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3257-16.2017 · Cited by 28
“Because functional (synaptic) as well as morphological plasticity is regulated by dopamine (Lovinger, 2010; Villalba and Smith, 2013), dysfunctional dopaminergic neurotransmission may lead to both functional and structural neural circuit changes in striatum as well as in cortex (Friston et al.,…”
BackgroundKoch, E. T., Woodard, C. L., & Raymond, L. A. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00638.2018 · Cited by 24
“HFS-LTD depends on the postsynaptic production of endocannabinoids that then diffuse to the presynaptic terminal to activate CB1 (Lovinger 2010).”
BackgroundInfluentialBasal Ganglia—A Motion Perspective
Grillner, S. E., Robertson, B., & Kotaleski, J. H. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190045 · Cited by 31
Neural underpinnings of fine motor skills under stress and anxiety: A review
Martins, L. A., Schiavo, A., Paz, L. V., Xavier, L. L., & Mestriner, R. G. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114593 · Cited by 30
Wieczerzak, K. B., Patel, S. V., MacNeil, H., Scott, K. E., Schormans, A. L., Hayes, S. H., Herrmann, B., & Allman, B. L. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.019 · Cited by 25
Differential CaMKII regulation by voltage-gated calcium channels in the striatum
Pasek, J. G., Wang, X., & Colbran, R. J. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.08.003 · Cited by 22
“These dopamine receptors couple to distinct biochemical signaling pathways and are generally considered to play opposing roles in coordinating basal ganglia functions (Gerfen & Surmeier 2011, Lovinger 2010, Kreitzer 2009, Calabresi et al. 2014).”
BackgroundLuo, S. X., Martínez, D., Carpenter, K. M., Slifstein, M., & Nunes, E. V. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.04.030 · Cited by 22
Striatal functional connectivity in chronic ketamine users: a pilot study
Hung, C., Zhang, S., Chen, C., Duann, J., Lin, C., Lee, T. S., & Li, C. R. (2019) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2019.1624764 · Cited by 24
“Importantly, the striatum receives glutamatergic inputs from the prefrontal cortex to support learning and goal-directed behavior (54), and dys-”
BackgroundMendes, A., Vignoud, G., Siaume‐Perez, S., Perrin, E., Touboul, J., & Venance, L. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa024 · Cited by 24
Pittenger, C., Brennan, B. P., Koran, L. M., Mathews, C. A., Nestadt, G., Pato, M. T., Phillips, K. A., Rodríguez, C. I., Simpson, H. B., Skapinakis, P., et al. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113853 · Cited by 22
Baca, M., Allan, A. M., Partridge, L., & Wilson, M. C. (2013) · Brain Research · doi:10.1016/j.brainres.2013.08.012 · Cited by 22
Kang, S., Hong, S.-I., Kang, S.-W., Song, M. R., Yang, M., Essa, H., Baker, M., Lee, J., Bruce, R., Lee, S. W., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh9239 · Cited by 22
Creatures of Habit: The Neuroscience of Habit and Purposeful Behavior
Mendelsohn, A. I. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.03.978 · Cited by 21
“This shifting is dependent on the plasticity of corticostriatal connections, a process mediated by multiple neurotransmitter systems, including dopaminergic, glutamatergic, and endocannabinoid signaling (7).”
BackgroundEarly Changes in Striatal Activity and Motor Kinematics in a Huntington's Disease Mouse Model
Koch, E. T., Sepers, M. D., Cheng, J., & Raymond, L. A. (2022) · Movement Disorders · doi:10.1002/mds.29168 · Cited by 21
“eCB signaling in the striatum have been implicated in various forms of learning.(11) YAC128 mice also show changes”
BackgroundRegulation of Corticostriatal Synaptic Plasticity by G Protein-Coupled Receptors
de Maturana, R. L., & Sánchez‐Pernaute, R. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710793361531 · Cited by 21
He, Y., Li, Y., Chen, M., Pu, Z., Zhang, F., Chen, L., Ruan, Y., Pan, X., He, C., Chen, X., et al. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00151 · Cited by 21
“…(LTD) that is restricted to striatopallidal neurons and requires activation of D2Rs and mGluR5 (Kreitzer and Malenka, 2007; Lovinger, 2010) is the main form of plasticity of synaptic transmission in the dorsolateral striatum (DLS; Partridge et al., 2000; Yin and Knowlton, 2006; Lovinger, 2010).”
BackgroundInfluentialD’Amours, G., Bureau, G., Boily, M.-J., & Cyr, M. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.02.030 · Cited by 21
The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling
Likhite, N., Jackson, C. A., Liang, M.-S., Krzyzanowski, M. C., Lei, P., Wood, J. F., Birkaya, B. G., Michaels, K. L., Andreadis, S. T., Clark, S. D., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aad0872 · Cited by 21
Buendia, J. D. J. A., Rueda‐Orozco, P. E., Hernandez-Martinez, R., Galarraga, E., & Bargas, J. (2011) · Learning & Memory · doi:10.1101/lm.023432.111 · Cited by 21
Nylén, J. F., Carannante, I., Grillner, S. E., & Kotaleski, J. H. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14854 · Cited by 20
“The prolonged increase of the activity of the LTS population, due to cortical activity, could cause a prolonged depolarization of the ChINs which in turn would lead to the activation of M1R on both types of SPNs (Galarraga et al., 1999; Lv et al., 2017; Shen, Hamilton, Nathanson, & Surmeier, 2005).”
BackgroundInfluentialBhandari, R., Gyawali, S., Aryal, N., Gaire, D., Paudyal, K., Panta, A., Panth, P., Joshi, D. R., Rokaya, R. K., Aryal, P., et al. (2021) · The Scientific World JOURNAL · doi:10.1155/2021/6649574 · Cited by 20
“An increase in the concentration of AChE in the brain results in the degradation of Ach, eventually reducing the ACh receptors and then inducing undesirable effect on cholinergic neurotransmission, and also results in impairment of cognitive function as well as other neurological disorders [40].”
BackgroundThe effects of intermittent theta burst stimulation (iTBS) on resting-state brain entropy (BEN)
Liu, P., Song, D., Deng, X., Shang, Y., Ge, Q., Wang, Z., & Zhang, H. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00556 · Cited by 19
“At the cellular level, substantial evidence suggests that dopamine (DA) and acetylcholine (ACh) primarily modulate the magnitude of LTP [64,65], while serotonin or 5-hydroxy-tryptamine (5-HT), glutamate (Glu), and gamma-aminobutyric acid (GABA) in fl uence LTD [65 – 67].”
THC inhibits the expression of ethanol-induced locomotor sensitization in mice
Filev, R., Engelke, D. S., da Silveira, D. X., Mello, L. E., & Santos-Junior, J. G. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.06.004 · Cited by 20
Shiadeh, S. M. J., Goretta, F., Svedin, P., Jansson, T., Mallard, C. E., & Ardalan, M. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03030-w · Cited by 20
“The existing body of research on ephrin signaling also suggests that astrocytic ephrin-A3 signaling, mediated by EphA4 receptors, is necessary for controlling the abundance of glial glutamate transporters and glutamatergic synaptic plasticity in the brain [21, 22].”
BackgroundHussein, A., Tielemans, A., Baxter, M. G., Benson, D. L., & Huntley, G. W. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114145 · Cited by 19
High-throughput automated methods for classical and operant conditioning of Drosophila larvae
Croteau-Chonka, E. C., Clayton, M. S., Venkatasubramanian, L., Harris, S. N., Jones, B. M. W., Narayan, L., Winding, M., Masson, J., Zlatic, M., & Klein, K. T. (2022) · eLife · doi:10.7554/elife.70015 · Cited by 19
Pre-Synaptic Release Deficits in a DYT1 Dystonia Mouse Model
Yokoi, F., Cheetham, C. C., Campbell, S. L., Sweatt, J. D., & Li, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072491 · Cited by 19
“Corticostriatal LTD is thought to involve a decrease of presynaptic glutamate release through retrograde endocannabinoid signaling [38].”
BackgroundRole of Phytochemicals in Neurotrophins Mediated Regulation of Alzheimer’s Disease
Sharma, B. (2017) · International Journal of Complementary & Alternative Medicine · doi:10.15406/ijcam.2017.07.00231 · Cited by 19
Ensemble encoding of action speed by striatal fast-spiking interneurons
Roberts, B. M., White, M. G., Patton, M. H., Chen, R., & Mathur, B. N. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01908-7 · Cited by 19
“1999; Luk and Sadikot 2001), which receives primarily somatomotor cortical input (DeLong and Georgopoulos 1981; Lovinger 2010).”
BackgroundKrogsgaard‐Larsen, N., Storgaard, M., Møller, C. T., Demmer, C. S., Hansen, J. K., Han, L., Monrad, R. N., Nielsen, B., Tapken, D., Pickering, D. S., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00750 · Cited by 19
Tahmasebi, L., Komaki, A., Karamian, R., Shahidi, ., Sarihi, A., & Komaki, H. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.058 · Cited by 19
“Neuromodulators regulate most forms of synaptic plasticity both short- and long-term (Lovinger, 2010; Pawlak et al., 2010).”
Akomolafe, S. F. (2017) · Journal of Food Biochemistry · doi:10.1111/jfbc.12401 · Cited by 19
Anadozie, S. O., Akinyemi, J. A., Adewale, O. B., & Isitua, C. C. (2019) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2018-0161 · Cited by 18
Striatal Dopamine D2 Receptors Regulate Cost Sensitivity and Behavioral Thrift
Mourra, D., Gnazzo, F. G., Cobos, S., & Beeler, J. A. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.11.002 · Cited by 19
Bartoll, A., Toledano‐Zaragoza, A., Casas, J., Guzmán, M., Schuchman, E. H., & Ledesma, M. D. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201911776 · Cited by 18
“This eCB activates CB 1 at the presynapses, thereby inhibiting synaptic transmission (Maccarrone et al , 2008; Lovinger, 2010).”
BackgroundAdermark, L. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.039 · Cited by 19
“LTP-formation at excitatory synapses in the striatum is NMDA-dependent and blocked by APV, while LTD-formation at excitatory or inhibitory synapses is not (Lovinger, 2010; Yin et al., 2007; Adermark et al., 2009).”
Demmer, C. S., Møller, C. T., Brown, P. M. G. E., Han, L., Pickering, D. S., Nielsen, B., Bowie, D., Frydenvang, K., Kastrup, J. S., & Bunch, L. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00038 · Cited by 18
The Cdk5 Inhibitor Roscovitine Increases LTP Induction in Corticostriatal Synapses
Miranda-Barrientos, J. A., Nieto-Mendoza, E., & Hernández, E. (2014) · ASN NEURO · doi:10.1042/an20140006 · Cited by 17
“D2 activation has been related to the generation of striatal LTD (Centonze et al., 2001; Lovinger, 2010); nevertheless, the D2 signaling pathway can stimulate PKC in medium spiny cells (Surmeier et al.”
InfluentialAcute and chronic modulation of striatal endocannabinoid‐mediated plasticity by nicotine
Adermark, L., Morud, J., Lotfi, A., Ericson, M., & Söderpalm, B. (2018) · Addiction Biology · doi:10.1111/adb.12598 · Cited by 17
“The net outcome of synaptic plasticity in the striatum is balanced by long-term potentiation (LTP) and LTD at both excitatory and inhibitory synapses (Adermark & Lovinger 2009).”
BackgroundInfluentialLi, Y., Pan, X., He, Y., Ruan, Y., Huang, L., Zhou, Y., Hou, Z., He, C., Wang, Z., Zhang, X., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00393 · Cited by 17
“The striatal control of instrumental behaviors is accomplished through a rich interplay of the numerous neurotransmitters and neuromodulators to modify the input, processing and output functions of the striatum (Lovinger, 2010).”
BackgroundAberrant striatal synaptic plasticity in monogenic parkinsonisms
Madeo, G., Martella, G., Schirinzi, T., Ponterio, G., Shen, J., Bonsi, P., & Pisani, A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.065 · Cited by 17
“The striatum is the major input area of the basal ganglia, subserving a central role in motor function, through a rich interplay among different neurotransmitters (Lovinger, 2010).”
Lü, C., Shi, Z., Sun, X., Pan, R., Chen, S., Li, Y., Qu, L., Sun, L., Dang, H., Bu, L.-L., et al. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.10.002 · Cited by 17
Striatal GluN2B involved in motor skill learning and stimulus-response learning
Duan, Y., Wang, Q., Zeng, Q., Wang, J., Chen, Z., Xu, M., Duan, Y., Zhao, Z. Y., Xue, Q., & Cao, X. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.03.002 · Cited by 16
“The striatum is a subcortical nucleus involved in motor learning and habit formation (Yin et al., 2009; Lovinger, 2010; Wang et al., 2017).”
BackgroundInfluentialImpairment of Synaptic Plasticity by Cannabis, Δ9-THC, and Synthetic CannabinoidsPreprint
Hoffman, A. F., Hwang, E.-K., & Lupica, C. R. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039743 · Cited by 21
A human striatal–midbrain assembloid model of alpha-synuclein propagation
Tran, H., Shin, M., Yeo, X. Y., Jung, S., Junaid, M., Lim, S. B., Kim, J., Woo, H. G., Denman, C. R., Han, R.-R., et al. (2025) · Brain · doi:10.1093/brain/awaf326 · Cited by 16
Morphine Regulated Synaptic Networks Revealed by Integrated Proteomics and Network Analysis
Stockton, S. D., Gomes, I., Liu, T., Chandrakala, M. V., Hipólito, L., Jones, M. R., Ma’ayan, A., Morón, J. A., Li, H., & Devi, L. A. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.047977 · Cited by 16
“Thus morphine exposure reduces transmembrane Ca(2) conductance and neurotransmitter release (9, 10), causes alterations in glutamatergic transmission (11–13), enhances postsynaptic K conductance and membrane hyperpolarization (14), and leads to significant up-regulation of - opiate receptor heteromers in the striatum…”
BackgroundRole of striatal NMDA receptor subunits in a model of paroxysmal dystonia
Avchalumov, Y., Sander, S. E., Richter, F., Porath, K., Hamann, M., Bode, C., Kirschstein, T., Köhling, R., & Richter, A. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.08.012 · Cited by 16
“synapses onto striatal medium spiny neurons (MSN) involves not only activation of GLU receptors, but also of dopamine receptors (Lovinger, 2010).”
BackgroundThe basal ganglia as a substrate for the multiple actions of amphetamines
Natarajan, R., & Yamamoto, B. K. (2011) · Basal Ganglia · doi:10.1016/j.baga.2011.05.003 · Cited by 16
“Goal directed and habitual learning occurs through modulation of the synaptic pathways resulting in the induction of long term potentiation (LTP) or long term depression (LTD) at the GLUergic synapses in the striatum [50].”
BackgroundMadeo, G., Schirinzi, T., Maltese, M., Martella, G., Rapino, C., Fezza, F., Mastrangelo, N., Bonsi, P., Maccarrone, M., & Pisani, A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.021 · Cited by 17
Functional neuroanatomy of the basal ganglia
Fahn, S., Jankovic, J. J., & Hallett, M. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-2369-4.00003-2 · Cited by 16
Blázquez, C., Ruiz-Calvo, A., Bajo‐Grañeras, R., Baufreton, J., Resel, E., Varilh, M., Zottola, A. C. P., Mariani, Y., Cannich, A., Rodríguez‐Navarro, J. A., et al. (2020) · eLife · doi:10.7554/elife.56811 · Cited by 15
Rahimi‐Madiseh, M., Lorigooini, Z., Boroujeni, S. N., Taji, M., & Amini-Khoei, H. (2022) · Behavioural Neurology · doi:10.1155/2022/9015842 · Cited by 15
“As a significant stimulatory neurotransmitter, glutamate participates in several physiological functions such as brain development, synaptic flexibility, memory, and learning [5, 7].”
BackgroundA Review of Glutamate and Its Receptors: Their Roles in Brain Physiology and Pathology
Mutluay, S. U., & Karataş, H. (2022) · Acta Medica · doi:10.32552/2022.actamedica.650 · Cited by 18
“It was observed that NMDAR activity here alters LTP, LTD and striatal learning performance by modulating the dopaminergic system [30,31].”
BackgroundDeng, S., Zhang, E., Tao, J., Zhao, Y., Huo, W., Guo, H., Zheng, B., Mu, X., Yuan, K., Deng, X., et al. (2023) · Toxicology · doi:10.1016/j.tox.2023.153462 · Cited by 15
Tunable Molecular Logic Gates Designed for Imaging Released Neurotransmitters
Klockow, J., Hettie, K. S., Secor, K. E., Barman, D. N., & Glass, T. E. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201501379 · Cited by 15
Pleil, K. E., Glenn, M. J., & Williams, C. L. (2011) · Endocrinology · doi:10.1210/en.2010-0715 · Cited by 15
“Further, estradiol decreases striatal NMDA receptor binding (61) and enhances the impairment in response learning caused by blocking dopamine receptors (7), which are required for several forms of striatal plasticity (62, 63).”
BackgroundChronic methylphenidate exposure during adolescence reduces striatal synaptic responses to ethanol
Crowley, N. A., Cody, P. A., Davis, M. I., Lovinger, D. M., & Mateo, Y. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12426 · Cited by 15
McLeod, M., Kobayashi, N., Sen, A., Baghbaderani, B. A., Sadi, D., Ulalia, R., Behie, L. A., & Mendez, I. M. (2013) · Cell Transplantation · doi:10.3727/096368912x658809 · Cited by 15
Akintunde, J. K., Irondi, A. E., Ajani, E. O., & Olayemi, T. V. (2018) · Journal of Food Biochemistry · doi:10.1111/jfbc.12573 · Cited by 15
Maraone, A., Tarsitani, L., Pinucci, I., & Pasquini, M. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i9.568 · Cited by 19
Estradiol Receptors Inhibit Long-Term Potentiation in the Dorsomedial Striatum
Lewitus, V. J., & Blackwell, K. T. (2023) · eNeuro · doi:10.1523/eneuro.0071-23.2023 · Cited by 15
Wu, D., Ye, L., Li, Y., Sun, Y., Shao, Y., Chen, C., Zhu, Z., Li, Z., Wang, L., Irwin, D. M., et al. (2015) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjv043 · Cited by 14
“…selection and initiation), and motor behaviors including regulation of motor activity, motor skill learning and motor response (Balleine et al., at Institute of Z oology, C A S on D ecem ber 16, 2015 http://jm cb.oxfordjournals.org/ D ow nloaded from 2007; Surmeier et al., 2009; Lovinger, 2010).”
BackgroundMethodEffect of perinatal stress on the biogenic amine neurotransmitter level of the adult rat's brain
Tekes, K., Szegi, P., Laufer, R., Hantos, M., & Csaba, G. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.11.004 · Cited by 14
“Dorsal striatum is involved in learning and memory processes (Lovinger, 2010).”
BackgroundLipatova, O., Byrd, D., Green, J. T., & Toufexis, D. J. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.05.001 · Cited by 14
Metadata
- Authors
- Lovinger, D. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Lovinger, David M.
- ORCID
- Lovinger, David M.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 58
- Issue
- 7
- Pages
- 951-961
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC2849868
- OpenAlex
- W2086614467
- Cited by
- 488
- References
- 150
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 28 · 2023: 21 · 2022: 37 · 2021: 32 · 2020: 27 · 2019: 32 · 2018: 30 · 2017: 39 · 2016: 25 · 2015: 38 · 2014: 30 · 2013: 39 · 2012: 29
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (Z01AA000407)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dorsal striatum, synaptic plasticity, long-term potentiation, long-term depression, medium spiny neurons, glutamatergic synapses, GABAergic synapses, NMDA receptor, dopamine D1 receptor, adenosine A2A receptor, dopamine D2 receptor, metabotropic glutamate receptors, retrograde endocannabinoid signaling, presynaptic inhibition, allosteric modulation, operant conditioning, habit learning, goal-directed learning, indirect pathway, neurotransmitter receptors
- MeSH terms
- Animals, Corpus Striatum, Learning, Neuronal Plasticity, Synapses, Neurotransmitter Agents
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