Cited by 488Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

The DOI matches its Crossref record; 149 of the 150 references it cites were found in a registry or an index.

Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum

Open access

Lovinger, David M.·2010·Neuropharmacology

DOI 10.1016/j.neuropharm.2010.01.008PMC PMC2849868

Open this paper in CoChat — free account

Abstract

The dorsal striatum is a large forebrain region involved in action initiation, timing, control, learning and memory. Learning and remembering skilled movement sequences requires the dorsal striatum, and striatal subregions participate in both goal-directed (action-outcome) and habitual (stimulus-response) learning. Modulation of synaptic transmission plays a large part in controlling input to as well as the output from striatal medium spiny projection neurons (MSNs). Synapses in this brain region are subject to short-term modulation, including allosteric alterations in ion channel function and prominent presynaptic inhibition. Two forms of long-term synaptic plasticity have also been observed in striatum, long-term potentiation (LTP) and long-term depression (LTD). LTP at glutamatergic synapses onto MSNs involves activation of NMDA-type glutamate receptors and D1 dopamine or A2A adenosine receptors. Expression of LTP appears to involve postsynaptic mechanisms. LTD at glutamatergic synapses involves retrograde endocannabinoid signaling stimulated by activation of metabotropic glutamate receptors (mGluRs) and D2 dopamine receptors. While postsynaptic mechanisms participate in LTD induction, maintained expression involves presynaptic mechanisms. A similar form of LTD has also been observed at GABAergic synapses onto MSNs. Studies have just begun to examine the roles of synaptic plasticity in striatal-based learning. Findings to date indicate that molecules implicated in induction of plasticity participate in these forms of learning. Neurotransmitter receptors involved in LTP induction are necessary for proper skill and goal-directed instrumental learning. Interestingly, receptors involved in LTP and LTD at glutamatergic synapses onto MSNs of the "indirect pathway" appear to have important roles in habit learning. More work is needed to reveal if and when synaptic plasticity occurs during learning and if so what molecules and cellular processes, both short- and long-term, contribute to this plasticity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuropharm.2010.01.008

Cites

149 of 149 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068 · cited 1×
“The ratio of responses to paired afferent stimuli delivered at 50 ms intervals is sensitive to the probability of neurotransmitter release (Zucker, 1989), and an increase this paired-pulse ratio generally signals a decrease in release probability.”
D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967 · cited 2×
“These striatonigral neurons strongly express D1Rs and generally do not express A2A or D2Rs (Augood and Emson, 1994; Gerfen et al., 1990; Gong et al., 2003).”
The role of the basal ganglia in habit formation
Yin, H. H., & Knowlton, B. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1919 · Cited by 2,402 · cited 5×
“The striatum is the major input nucleus of the basal ganglia, and as such it plays a crucial role in action control and action learning (Saint-Cyr et al., 1995; Graybiel,1998; Lalonde and Botez-Marquard, 1997; Yin and Knowlton, 2006).”
Influential
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108 · cited 2×
“These striatonigral neurons strongly express D1Rs and generally do not express A2A or D2Rs (Augood and Emson, 1994; Gerfen et al., 1990; Gong et al., 2003).”
Inactivation of Hippocampus or Caudate Nucleus with Lidocaine Differentially Affects Expression of Place and Response Learning
Packard, M. G., & McGaugh, J. L. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0007 · Cited by 1,566 · cited 2×
“…injection of a local anesthetic, which should inactivate the structure, just prior to a retention test did not impair the ability of the animal to perform a cross-maze task, but just altered the strategy used by the animal from a response-based to a place-based approach (Packard and McGaugh, 1996).”
The neostriatal mosaic: multiple levels of compartmental organization
Gerfen, C. R. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90355-c · Cited by 1,471
Short-Term Synaptic Plasticity
Zucker, R. S. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.000305 · Cited by 1,450
Integrative activity of the brain
Konorski, J. (1967) · Cited by 1,372
Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning
Yin, H. H., Knowlton, B. J., & Balleine, B. W. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03095.x · Cited by 1,226 · cited 1×
“Excitotoxic lesions of dorsolateral striatum disrupted habit learning in this study, as previously reported in rat (Hilario et al., 2007; Yin et al., 2004).”
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons
Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.008 · Cited by 1,203 · cited 2×
“Dopamine can only act via GPCRs, and thus only modulates striatal neuronal function and synaptic transmission (Richfield et al., 1989; Surmeier et al., 2007).”

Show all 150 references

Sorted by citations

Items 301–400 of 488

Methyl jasmonate reverses chronic stress-induced memory dysfunctions through modulation of monoaminergic neurotransmission, antioxidant defense system, and Nrf2 expressions
Aluko, O. M., & Umukoro, S. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-01939-6 · Cited by 14
“The cholinergic neuron is responsible for the synthesis of ACh, the neurotransmitter candidate that plays vital roles in learning and memory functions (Schetinger et al. 2007; Lovinger 2010).”
Background
Rapamycin Improves Spatial Learning Deficits, Vulnerability to Alcohol Addiction and Altered Expression of the GluN2B Subunit of the NMDA Receptor in Adult Rats Exposed to Ethanol during the Neonatal Period
Łopatyńska-Mazurek, M., Antolak, A., Grochecki, P., Gibuła‐Tarłowska, E., Bodzoń‐Kułakowska, A., Listos, J., Kędzierska, E., Suder, P., Silberring, J., & Kotlinska, J. H. (2021) · Biomolecules · doi:10.3390/biom11050650 · Cited by 15
“The dorsal striatum is a subcortical brain region important for proper motor function [75], but also plays a key role in instrumental learning, habit formation [76] and drug addiction [77].”
Background
Neuroadaptive changes in metabotropic glutamate mGlu2/3R expression during different phases of cocaine addiction in rats
Pomierny-Chamioło, L., Miszkiel, J., Frankowska, M., Mizera, J., & Filip, M. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.04.016 · Cited by 14
“Both the PFCx and the DST play an important role in the initiating and learning adaptive behaviors and corticostriatal glutamate and/or ventrostriatal dopamine signaling modulates this learning [25].”
Background
Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses
Zhai, S., Otsuka, S., Xu, J., Clarke, V. R. J., Tkatch, T., Wokosin, D. L., Xie, Z., Tanimura, A., Agarwal, H. K., Ellis‐Davies, G. C. R., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114540 · Cited by 13
Rescue of striatal long-term depression by chronic mGlu5 receptor negative allosteric modulation in distinct dystonia models
Martella, G., Bonsi, P., Imbriani, P., Sciamanna, G., Nguyen, H. P., Yu-Taeger, L., Schneider, M., Poli, S. M., Lütjens, R., & Pisani, A. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108608 · Cited by 13
Evaluation of an Aβ1–40-induced cognitive deficit in rat using a reward-directed instrumental learning task
Shi, Z., Sun, X., Liu, X., Chen, S., Chang, Q., Chen, L., Song, G., & Li, H. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.006 · Cited by 13
Simultaneous Mapping of Amino Neurotransmitters and Nucleoside Neuromodulators on Brain Tissue Sections by On-Tissue Chemoselective Derivatization and MALDI-MSI
Liu, D., Liu, X., Huang, S., Shen, X. Y., Zhang, X., Zhang, L., & Zhang, Y. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c02674 · Cited by 12
Spiny projection neurons exhibit transcriptional signatures within subregions of the dorsal striatum
Roman, K. M., Dinasarapu, A. R., VanSchoiack, A., Ross, P. M., Kroeppler, D., Jinnah, H. A., & Hess, E. J. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113435 · Cited by 12
“23 However, LTD in the dorsolateral striatum depends on the activation of type 1 cannabinoid receptors and D2 dopamine receptors, 24,25 consistent with the high expression of type 1 cannabinoid receptors and D2 dopamine receptors in the dorsolateral striatum compared to dorsomedial striatum.”
Cocaine self-administration, extinction training and drug-induced relapse change metabotropic glutamate mGlu5 receptors expression: Evidence from radioligand binding and immunohistochemistry assays
Pomierny-Chamioło, L., Miszkiel, J., Frankowska, M., Bystrowska, B., & Filip, M. (2016) · Brain Research · doi:10.1016/j.brainres.2016.11.014 · Cited by 14
Methylphenidate has long-lasting metaplastic effects in the prefrontal cortex of adolescent rats
Burgos, H., Cofré, C., Hernández, A., Sáez‐Briones, P., Agurto, R., Castillo, A., Morales, B., & Zeise, M. L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.05.009 · Cited by 12
The Gender-Specific Association of DRD2 Polymorphism with Metabolic Syndrome in Patients with Schizophrenia
Paderina, D. Z., Boiko, A. S., Pozhidaev, I. V., Mednova, I. A., Александровна, Г. А., Бочарова, А. В., Fedorenko, O. Y., Kornetova, E. G., Semke, A. V., Bokhan, N. A., et al. (2022) · Genes · doi:10.3390/genes13081312 · Cited by 12
Receptor and Ionic Mechanism of Histamine on Mouse Dorsolateral Striatal Neurons
Peng, J., Shen, K., Fan, X., Qi, Z., Huang, H., Jiang, J., Lu, J.-H., Wang, X., Fang, X.-X., Yuan, W.-R., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03076-y · Cited by 12
Activation of postsynaptic D2 dopamine receptors in the rat dorsolateral striatum prevents the amnestic effect of systemically administered neuroleptics
Boschen, S. L., Andreatini, R., & Cunha, C. D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.12.040 · Cited by 12
Bi‐directional modulation of food habit expression by the endocannabinoid system
Gianessi, C. A., Groman, S. M., & Taylor, J. R. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14330 · Cited by 11
“The sensorimotor striatum has high expression of presynaptic cannabinoid receptor type 1 (CB1) that contributes to forms of short and long term plasticity (Herkenham et al., 1991; Lovinger, 2010).”
Background
Effects of dopamine D1 receptor blockade in the prelimbic prefrontal cortex or lateral dorsal striatum on frontostriatal function in Wistar and Spontaneously Hypertensive Rats
Gauthier, J. M., Tassin, D. H., Dwoskin, L. P., & Kantak, K. M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.018 · Cited by 13
Down-regulation of dorsal striatal αCaMKII causes striatum-related cognitive and synaptic disorders
Wang, Q., Yin, P., Yu, B., Zhao, Z. Y., Richter‐Levin, G., Yu, L., & Cao, X. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.09.004 · Cited by 12
“Especially, the N-methyl-D-aspartic acid receptor (NMDAR) is closely involved in the regulation of C-DMS LTP and certain forms of DMS related cognitive functions (Charpier and Deniau, 1997; Lovinger, 2010; Pisani et al., 2001).”
Background
Chronic and Acute Manipulation of Cortical Glutamate Transmission Induces Structural and Synaptic Changes in Co-cultured Striatal Neurons
Kuhlmann, N., Valladolid, M. W., Quesada-Ramírez, L., Farrer, M. J., & Milnerwood, A. J. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.569031 · Cited by 14
“…propensity to presynaptic plasticity and long-term depression, as well as the importance of neuromodulation by dopamine (Calabresi et al., 1997; Spencer and Murphy, 2000; Wang et al., 2006; Kreitzer and Malenka, 2007; Sergeeva et al., 2007; Li et al., 2009; Lovinger, 2010; Blackwell et al., 2019).”
Background
Morphine Reward Promotes Cue-Sensitive Learning: Implication of Dorsal Striatal CREB Activity
Baudonnat, M., Guillou, J., Husson, M., Bohbot, V. D., Schwabe, L., & David, V. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00087 · Cited by 12
“The l-LTP is clearly involved in long-term memory formation (44), and DA is a potent modulator of these cellular adaptations (45, 46), further suggesting that the reward system modulates interactions between different forms of learning.”
Background
Glutamate – A Forgotten Target for Interval Timing
Hata, T. (2011) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2011.00027 · Cited by 11
“This work was supported by Grants-in-Aid for Young Scientists (B) 23730712 from the Japan Society for the Promotion of Science.”
Method
mGlu5 in GABAergic neurons modulates spontaneous and psychostimulant-induced locomotor activity
Wu, C., Jew, C. P., Sun, H., Ballester‐Rosado, C. J., & Lu, H. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05367-0 · Cited by 11
“Striatopallidal LTD is the main form of synaptic plasticity in the dorsolateral striatum and requires activation of mGlu5 receptors (Kreitzer and Malenka 2007; Lovinger 2010; Partridge et al. 2000; Yin and Knowlton 2006).”
Background
Dopamine Signaling in the Dorsomedial Striatum Promotes Compulsive BehaviorPreprint
Seiler, J. L., Cosme, C. V., Sherathiya, V. N., Bianco, J. M., Bridgemohan, A. S., & Lerner, T. N. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.30.016238 · Cited by 10
“Thus, we could be certain any observed differences between DMS and DLS signals were not due to differences in behavior between groups.”
Influential
The role of the nucleus accumbens in learned approach behavior diminishes with training
Dobrovitsky, V., West, M. O., & Horvitz, J. C. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14523 · Cited by 10
“Like other parts of the ventral and dorsal striatum, the NAc core receives excitatory GLU inputs which drive the activity of spiny projection neurons, and these excitatory input–output connections are under DA's modulatory influence (Horvitz, 2002; Lovinger, 2010; Shiflett & Balleine, 2011).”
Background
Parkinson’s-linked LRRK2-G2019S derails AMPAR trafficking, mobility, and composition in striatum with cell-type and subunit specificity
Gupta, S., Tielemans, A., Guevara, C. A., Huntley, G. W., & Benson, D. L. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2317833121 · Cited by 12
“The drop in sGluA2 - AMPARs may be indicative of a form of postsynaptic LTD that has been described in SPNs (61) and could be consistent with prior work in Lrrk2 G2019S striatum showing that a normally potentiating stimulus yields instead LTD (9).”
Glycyrrhizin treatment ameliorates post‐traumatic stress disorder‐like behaviours and restores circadian oscillation of intracranial serotonin
Lai, S., Shi, L., Jiang, Z., & Lin, Z. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13173 · Cited by 10
Digital design of a spatial-pow-STDP learning block with high accuracy utilizing pow CORDIC for large-scale image classifier spatiotemporal SNN
Bahrami, M. K., & Nazari, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-54043-7 · Cited by 10
Neuroplasticity and impulse control disorders
Muresanu, D. F., Stan, A. D., & Buzoianu, A. D. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.01.016 · Cited by 10
An indirect route to repetitive actions
Lovinger, D. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93918 · Cited by 10
Properties of the corticostriatal long term depression induced by medial prefrontal cortex high frequency stimulation in vivo
Braz, B. Y., Belforte, J. E., Murer, M. G., & Galiñanes, G. L. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.05.001 · Cited by 10
Active Zone Proteins RIM1αβ Are Required for Normal Corticostriatal Transmission and Action Control
Kupferschmidt, D. A., Augustin, S. M., Johnson, K. A., & Lovinger, D. M. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1940-18.2018 · Cited by 10
“…synapses in conditional RIM1 KO mice To assess whether corticostriatal RIM1 was necessary for presynaptic GPCRmediated forms plasticity in the DLS (Lovinger, 2010), we first tested RIM1fl/fl and Emx1::Cre;RIM1 / mice for DSE, an effect mediated by short-term endocannabinoid signaling at CB1Rs on…”
Background
Physiological aging at striatal synapses
Walsh, J. P., & Akopian, G. K. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24484 · Cited by 9
“…and D1 dopamine receptor activation facilitated the expression of NMDA receptor‐dependent long‐term synaptic potentiation (LTP)(Akopian et al., 2008; Calabresi et al., 1992, 1992; Centonze et al., 1999; Kerr & Wickens, 2001; Lovinger, 2010; Villar & Walsh, 1999; Wickens, Begg, & Arbuthnott, 1996).”
Background
Differences in GluN2B-Containing NMDA Receptors Result in Distinct Long-Term Plasticity at Ipsilateral versus Contralateral Cortico-Striatal Synapses
Li, W., & Pozzo‐Miller, L. D. (2019) · eNeuro · doi:10.1523/eneuro.0118-19.2019 · Cited by 9
“Induction of long-term synaptic plasticity in striatal slices has been challenging (Lovinger, 2010).”
Background
Selective Manipulation of G-Protein γ7Subunit in Mice Provides New Insights into Striatal Control of Motor Behavior
Brunori, G., Pelletier, O. B., Stauffer, A. M., & Robishaw, J. D. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1211-21.2021 · Cited by 11
An Integrated Quantitative Proteomics and Systems Biology Approach to Explore Synaptic Protein Profile Changes During Morphine Exposure
Stockton, S. D., & Devi, L. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.227 · Cited by 10
Tong Luo Jiu Nao ameliorates Aβ1–40-induced cognitive impairment on adaptive behavior learning by modulating ERK/CaMKII/CREB signaling in the hippocampus
Shi, Z., Lü, C., Sun, X., Wang, Q., Chen, S., Li, Y., Qu, L., Chen, L., Bu, L.-L., Liao, D., et al. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0584-9 · Cited by 10
“It is evident that the hippocampus is crucial for tasks that involve forming causal relation among cues and consequences [45], whereas Aβ1–40 disrupts this function.”
Background
Corticotropin-releasing factor receptor type-2 is involved in the cocaine-primed reinstatement of cocaine conditioned place preference in rats
Guan, X., Wan, R., Zhu, C., & Li, S. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.019 · Cited by 10
Pathophysiology of Dystonia
Madeo, G., & Pisani, A. (2016) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-802206-1.00047-7 · Cited by 10
The GABAAreceptor agonist muscimol induces an age- and region-dependent form of long-term depression in the mouse striatumPreprint
Zhang, X., Yao, N., & Chergui, K. (2016) · Learning & Memory · doi:10.1101/lm.043190.116 · Cited by 10
Accelerated habitual learning resulting from L-dopa exposure in rats is prevented by N-acetylcysteine
Gibson, A. S., Keefe, K. A., & Furlong, T. M. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.173033 · Cited by 8
Targeted Tshz3 deletion in corticostriatal circuit components segregates core autistic behaviors
Caubit, X., Gubellini, P., Roubertoux, P. L., Carlier, M., Molitor, J., Chabbert, D., Metwaly, M., Salin, P., Fatmi, A., Belaïdouni, Y., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01865-6 · Cited by 10
“For a review about corticostriatal LTD and LTP see [36].”
Facilitation of Corticostriatal Plasticity by the Amygdala Requires Ca2+-Induced Ca2+Release in the Ventral Striatum
Popescu, A. T., Saghyan, A. A., Nagy, F. Z., & Paré, D. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00233.2010 · Cited by 9
“Moreover, N-methyl-D-aspartate (NMDA)–dependent synaptic plasticity in the corticostriatal pathway is believed to underlie motor learning and habit formation (DeLong 2000; Lovinger 2010; Mahon et al. 2004; Pennartz et al. 2009).”
BackgroundResult
Differential Changes of Extracellular Aspartate and Glutamate in the Striatum of Domestic Chicken Evoked by High Potassium or Distress: An In Vivo Microdialysis Study
Zachár, G., Wagner, Z., Tábi, T., Bálint, E., Szökő, É., & Csillag, A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0783-4 · Cited by 9
Neuroplasticity induced by the retention period of a complex motor skill learning in rats
Sampaio, A. S. B., Real, C. C., Gutierrez, R. M. S., Singulani, M. P., Alouche, S. R., Britto, L. R., & Pires, R. S. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113480 · Cited by 10
Plasticity, genetics, and epigenetics in l-dopa-induced dyskinesias
Bove, F., & Calabresi, P. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819410-2.00009-6 · Cited by 9
Back to the Future: The Role of Infections in Psychopathology. Focus on OCD.
Vecchia, A. D., & Marazziti, D. (2022) · PubMed Central · doi:10.36131/cnfioritieditore20220407 · Cited by 10
“Moreover, they play an important role by using complex feedbacks in the recognition of significant behavioral stimuli (and error detection) and in the regulation of targeted responses (Lovinger, 2010).”
Background
Antioxidant evaluation and computational prediction of prospective drug-like compounds from polyphenolic-rich extract of Hibiscus cannabinus L. seed as antidiabetic and neuroprotective targets: assessment through in vitro and in silico studies
Afolabi, O. B., Olasehinde, O. R., Olanipon, D. G., Mabayoje, S. O., Familua, O. M., Jaiyesimi, K. F., Agboola, E. K., Idowu, O. T., Obafemi, T. O., Olaoye, O. A., et al. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04023-7 · Cited by 9
“It could therefore, be suggested that PEHc might possess a neuroprotective potentials that are useful in the management of AD [77], having demonstrated inhibitory effect against these enzymes.”
Background
Gonadal hormones and voluntary exercise interact to improve discrimination ability in a set-shift task.
Eddy, M. C., Rifken, K. M., Toufexis, D. J., & Green, J. T. (2013) · Behavioral Neuroscience · doi:10.1037/a0033728 · Cited by 9
“…reduction in DAT expression in the striatum of mice that exercised for 30 days on a treadmill and were treated with MPTP. Decreases in DAT may slightly bias the DA system towards activation of higher affinity D2 receptors and away from activation of lower affinity D1 receptors (cf. Lovinger (2010).”
Background
High frequency stimulation induces LTD of AMPA receptor-mediated postsynaptic responses and LTP of synaptically-evoked firing in the dorsolateral striatum
Skiteva, O., Yao, N., Nouhi, M., & Chergui, K. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.12.028 · Cited by 9
Molecular Dynamic Simulations to Probe Stereoselectivity of Tiagabine Binding with Human GAT1
Zafar, S., & Jabeen, I. (2020) · Molecules · doi:10.3390/molecules25204745 · Cited by 9
“γ-aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS) that contributes to the regulation of several physiological processes such as plasticity, learning, and memory [1].”
Background
Adenosine A2A receptor blockade improves neuroprosthetic learning by volitional control of population calcium signal in M1 cortical neurons
Zhang, L., Zhou, Y., Liu, C., Zheng, W., Yao, Z., Wang, Q., Jin, Y., Zhang, S., Chen, W., & Chen, J. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108250 · Cited by 8
Odor discrimination learning in the Indian greater short-nosed fruit bat (Cynopterus sphinx): differential expression of Egr-1, C-fos and PP-1 in the olfactory bulb, amygdala and hippocampus
Mukilan, M., Bogdanowicz, W., Marimuthu, G., & Rajan, K. E. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.175364 · Cited by 9
“Depending on the context, the learning experience triggers neurotransmitter release (Lovinger, 2010) and activates a signalling cascade through protein kinase A (PKA), extracellular signal-regulated kinase-1/2 (ERK-1/2) (English and Sweatt, 1997; Yoon and Seger, 2006; García-Pardo et al.”
Background
Endocannabinoid Signaling from 2-Arachidonoylglycerol to CB1 Cannabinoid Receptor Facilitates Reward-based Learning of Motor Sequence
Hayate, T., Yoneda, M., TABATA, Y., Echigo, R., Kikuchi, Y., Yamazaki, M., Kishimoto, Y., Sakimura, K., Kano, M., & Ohno‐Shosaku, T. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.040 · Cited by 8
Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain
Piggott, V. M., Lloyd, S. C., Matchynski, J. I., Perrine, S. A., & Conti, A. C. (2021) · Molecules · doi:10.3390/molecules26072086 · Cited by 8
Aging AdipoR2 ‐deficient mice are hyperactive with enlarged brains excessively rich in saturated fatty acids
Ruiz, M., Devkota, R., Bergh, P., Nik, A. M., Sköldheden, S. B., Mondejar-Duran, J., Tufvesson‐Alm, M., Bohlooly‐Y, M., Sánchez, D., Carlsson, P., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202400293rr · Cited by 7
Efficient hardware design of spiking neurons and unsupervised learning module in large scale pattern classification network
Amiri, M., & Nazari, S. (2024) · Engineering Applications of Artificial Intelligence · doi:10.1016/j.engappai.2024.109255 · Cited by 7
Single-Vesicle Electrochemistry Reveals Polysaccharide from Glochidion eriocarpum Champ. Regulates Vesicular Storage and Exocytotic Release of Dopamine
Cao, L., Zhang, J., Li, M., Zhou, J., Liu, Y., Liu, C., & Li, X. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c02493 · Cited by 7
Electromagnetic radiation and biophoton emission in neuronal communication and neurodegenerative diseases
Erboz, A., Kesekler, E., Gentili, P. L., Uversky, V. N., & Coskuner‐Weber, O. (2024) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2024.12.004 · Cited by 10
Synaptic transistor implementing potentiation or depression via field distribution modulation of dual dielectric layers by single-polarity pulsed voltage stimuli
Kim, J., Lim, J. W., Park, C., Yu, C., & Lee, J. (2025) · Materials Today Advances · doi:10.1016/j.mtadv.2025.100556 · Cited by 7
Effect of traumatic brain injury on nicotine-induced modulation of dopamine release in the striatum and nucleus accumbens shell
Chen, Y.-H., Kuo, T., Huang, E. Y., Chou, Y., Chiang, Y. H., Hoffer, B. J., & Miller, J. (2018) · Oncotarget · doi:10.18632/oncotarget.24245 · Cited by 7
“The striatal dopamine (DA) system is crucial for habit formation [8, 9], and the mesocorticolimbic system is strongly linked to reward behavior [10].”
Background
Effects of methamphetamine-induced neurotoxicity on striatal long-term potentiation
Gibson, A. S., West, P. J., & Keefe, K. A. (2022) · Psychopharmacology · doi:10.1007/s00213-021-06055-8 · Cited by 7
“…abundance (e.g., greater dopamine D2 receptor expression in DLS), as well as differences in glutamate, acetylcholine, and endocannabinoid signaling as extensively reviewed by Lovinger (2010), likely contribute to this welldocumented difference in ability to induce LTP in the DMS versus DLS.”
BackgroundInfluential
A positive allosteric modulator of mGlu4 receptors restores striatal plasticity in an animal model of l-Dopa-induced dyskinesia
Calabrese, V., Picconi, B., Heck, N., Campanelli, F., Natale, G., Marino, G., Sciaccaluga, M., Ghiglieri, V., Tozzi, A., Anceaume, E., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109205 · Cited by 8
Striatonigral direct pathway 2-arachidonoylglycerol contributes to ethanol effects on synaptic transmission and behavior
Augustin, S. M., Gracias, A. L., Luo, G., Anumola, R. C., & Lovinger, D. M. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01671-8 · Cited by 6
“The corticostriatal afferents are an important site of eCB signaling in the striatum [3, 54 – 58], and thus this role for dMSN-derived 2-AG has important implications for striatal function and related behaviors.”
Background
Involvement of metabotropic glutamate receptors in regulation of immune response in the Pacific oyster Crassostrea gigas
Zhang, X., Si, Y., Zhang, L., Wen, X., Yang, C., Wang, L., & Song, L. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.109709 · Cited by 7
Dopaminergic contributions to working memory-related brain activation in postmenopausal women
Dumas, J. A., Filippi, C. G., NEWHOUSE, P. A., & Naylor, M. R. (2016) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000738 · Cited by 7
The Neural Marketplace: I. General Formalism and Linear TheoryPreprint
Lewis, S. N., & Harris, K. D. (2014) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/013185 · Cited by 7
“It is well established that dopamine controls corticostriatal plasticity (Lovinger, 2010), and theoretical models have suggested how dopamine-gated plasticity might enable reinforcement learning to occur (Wickens, 2009; Fee, 2014; Ito and Doya, 2011; Frank, 2011).”
Background
Erasing “bad memories”: reversing aberrant synaptic plasticity as therapy for neurological and psychiatric disorders
Shi, Z., Wen, K., Sammudin, N. H., LoRocco, N. C., & Zhuang, X. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03013-0 · Cited by 7
“This may explain why dopamine signaling plays such a dominant role in the induction and directionality of corticostriatal plasticity [27 – 29 , 51].”
The Neurocognitive and Behavioural Impact of Comorbid Obsessive–Compulsive Syndrome in Schizophrenia
Varlakova, Y., Patel, D. D., Mukhopadhaya, K., Laws, K. R., Eilam, D., Sukwinder, K., & Fineberg, N. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-12952-5_7 · Cited by 6
Molecular and Behavioral Neuroprotective Effects of Clavulanic Acid and Crocin in Haloperidol-Induced Tardive Dyskinesia in Rats
Shoae-Hagh, P., Razavi, B. M., Sadeghnia, H. R., Mehri, S., Karimi, G., & Hosseinzadeh, H. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04566-x · Cited by 6
Memantine‐induced functional rewiring of the glutamate synapse in the striatum of dopamine transporter knockout rats
Caffino, L., Targa, G., Mottarlini, F., Thielens, S., Rizzi, B., Villers, A., Ris, L., Gainetdinov, R. R., Leo, D., & Fumagalli, F. (2024) · British Journal of Pharmacology · doi:10.1111/bph.17403 · Cited by 6
“…because the induction of LTP in medium spiny neurons following high-frequency stimulation (HFS) is more difficult to elicit than LTD and it was shown to require the removal of Mg 2 + ions from the perfusion solution to relieve the voltage-dependent block of NMDA receptors (Lovinger, 2010).”
Influential
Neurobiological insights into twice-exceptionality: Circuits, cells, and molecules
Kelvington, B. A., Nickl‐Jockschat, T., & Abel, T. G. (2022) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2022.107684 · Cited by 10
Involvement of the Cholinergic Parameters and Glial Cells in Learning Delay Induced by Glutaric Acid: Protection by N-Acetylcysteine
Rodrigues, F. S., de Zorzi, V. N., Funghetto, M. P., Haupental, F., Cardoso, A. S., Marchesan, S., Cardoso, A. M., Schinger, M. R. C., Machado, A. K., da Cruz, I. B. M., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1395-z · Cited by 6
Aberrant plasticity and "learned" motor inhibition in Parkinson's disease.
Zhuang, X. (2012) · PubMed · Cited by 6
Acrobatic exercise recovers object recognition memory impairment in hypoxic‐ischemic rats
de Almeida, W., Confortim, H. D., Deniz, B. F., Miguel, P. M., Vieira, M. C., Bronauth, L., dos Santos, A. S., Bertoldi, K., Siqueira, I. R., & Pereira, L. O. (2020) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10075 · Cited by 6
“The motor skill learning associated to acrobatic training leads to an increase in striatal pathways stimulation (Le Merrer et al., 2013; Lovinger, 2010; Yin et al., 2009) and on ability learning (Anaya et al., 2017; González-Tapia et al., 2016; Kida et al., 2016; Salame et al., 2016; Tamakoshi…”
Background
SYNCHRONICITY: THE ROLE OF MIDBRAIN DOPAMINE IN GENERATING WHOLE BRAIN COHERENCE, A HYPOTHESISPreprint
Beeler, J. A., & Dreyer, J. K. (2018) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/8qfp2 · Cited by 6
Organic Small-Molecule Fluorescent Probes for Neurotransmitter Sensing and Bioimaging
Meng, Q., & Zhang, Q. (2025) · 化学学报 · doi:10.6023/a25050200 · Cited by 5
Effects of Probiotics, Prebiotics and Synbiotic Supplementation on Cognitive Impairment: A Review
Mukilan, M. (2022) · Journal of Experimental Biology and Agricultural Sciences · doi:10.18006/2022.10(1).1.11 · Cited by 5
HCN1 channels mediate mu opioid receptor long‐term depression at insular cortex inputs to the dorsal striatum
Muñoz, B., Fritz, B. M., Yin, F., & Atwood, B. K. (2022) · The Journal of Physiology · doi:10.1113/jp283513 · Cited by 5
Striatal mGlu5-mediated synaptic plasticity is independently regulated by location-specific receptor pools and divergent signaling pathways
Jong, Y.-J. I., Izumi, Y., Harmon, S. K., Zorumski, C. F., & O’Malley, K. L. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104949 · Cited by 5
Assessment of sexual behavior and neuromodulation ofCyperus esculentusL. andTetracarpidium conophorumMüll. Arg dietary supplementation regulating the purinergic system in the cerebral cortex of L‐NAME‐challenged rats
Olabiyi, A. A., Afolabi, B. A., Reichert, K. P., Palma, T. V., Morsch, V. M., Oboh, G., & Schetinger, M. R. C. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13862 · Cited by 5
Specialty knowledge and competency standards for pharmacotherapy for pediatric obsessive-compulsive disorder
Weidle, B., Ivarsson, T., Asbahr, F. R., Calvo, R. M., Mataix‐Cols, D., Rynn, M. A., & Storch, E. A. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113858 · Cited by 4
The role of dorsomedial striatum adenosine 2A receptors in the loss of goal-directed behaviour
Emtage, J. A., Shipman, M. L., & Corbit, L. H. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06220-7 · Cited by 5
“2007; Lovinger 2010) including the adenosine A2A receptor (A2AR).”
Background
Loss of the parkinsonism‐associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects
Wang, J., Joseph, S., Vingill, S., Dere, E., Tatenhorst, L., Ronnenberg, A., Lingor, P., Preisinger, C., Ehrenreich, H., Schulz, J. B., et al. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15962 · Cited by 4
“Here, dopamine acts as a critical modulator of the corticostriatal synapse and a regulator of synaptic plasticity as medium spiny neurons harbor both glutamate and dopamine receptors (Calabresi et al., 2007 ; Gerfen & Surmeier, 2011 ; Lovinger, 2010 ).”
Background
GABAA receptor mediated inhibition contributes to corticostriatal frequency filtering
Jelinek, D. A., & Partridge, L. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.09.061 · Cited by 5
GAP43 Located on Corticostriatal Terminals Restrains Novelty-Induced Hyperactivity in Mice
Maroto, I. B., Costas‐Insua, C., Montero-Fernández, C., Hermoso-López, A., Lebouc, M., Bajo‐Grañeras, R., Álvaro-Blázquez, A., Blázquez, C., Cannich, A., Marsicano, G., et al. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.0701-24.2024 · Cited by 4
“As previously reported (Lovinger, 2010), endocannabinoid-mediated LTD of EPSCs was overtly induced by the mGluRI agonist DHPG in corticostriatal synapses of control GAP43 ﬂ / ﬂ mice (Fig.”
Background
Metabotropic Glutamate Receptors and Parkinson’s Disease: Basic and Preclinical Neuroscience
Gubellini, P., Iskhakova, L., Smith, Y., & Amalric, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-56170-7_3 · Cited by 4
Functional neuroanatomy of the basal ganglia
Jankovic, J. J., Hallett, M., Okun, M. S., Comella, C., Fahn, S., & Goldman, J. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-31071-0.00003-2 · Cited by 4
A novel inhibitory corticostriatal circuit that expresses mu opioid receptor-mediated synaptic plasticity
Muñoz, B., & Atwood, B. K. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109696 · Cited by 4
Sustained glial reactivity induced by glutaric acid may be the trigger to learning delay in early and late phases of development: Involvement of p75NTR receptor and protection by N-acetylcysteine
Rodrigues, F. S., França, A. P., Cunha, N. B., Furian, A. F., Oliveira, M. S., Santos, A. R. S., Royes, L. F. F., & Fighera, M. R. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147145 · Cited by 4
Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin volesPreprint
Zhang, L., Qu, Y., Young, L. J., Hou, W., Liu, L., Liu, J., Wang, Y., Li, L., Guo, X., Yin, L., et al. (2024) · eLife · doi:10.7554/elife.100292 · Cited by 5
“DA modulates neurotransmitter release at both GABAergic and glutamatergic striatal synapses ( Lovinger, 2010 ).”
Alcohol effects on associative and sensorimotor cortico-thalamo-basal ganglia circuits alter decision making and alcohol intake
Lovinger, D. M. (2025) · Alcohol · doi:10.1016/j.alcohol.2025.05.005 · Cited by 3
Impairment of Group I Metabotropic Glutamate Receptors in the Dorsal Striatum of the R451C ‐Neuroligin 3 Mouse Model of Autism Spectrum Disorder
Meringolo, M., Montanari, M., D’Antoni, S., Martella, G., Atiallah, I. E., Ponterio, G., Tassone, A., Reverte, I., Caprioli, D., Strimpakos, G., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70253 · Cited by 3
“…activation of NMDA, muscarinic M1, and either D1 or A2A receptors, insertion of AMPA receptors at the synapse, and phosphorylation of DARPP-32 (Lovinger 2010), while LTD involves activation of eCB synthesis and release, and activation of presynaptic CB1 receptors, which produces a…”
Influential
Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles
Zhang, L., Qu, Y., Young, L. J., Hou, W., Liu, L., Liu, J., Wang, Y., Li, L., Guo, X., Yin, L., et al. (2025) · eLife · doi:10.1101/2024.07.24.604911 · Cited by 3
Acute cannabinoids impair association learning via selectively enhancing synaptic transmission in striatonigral neurons
Wu, M., Di, Y., Diao, Z., Yan, C., Cheng, Q., Huang, H. C., Liu, Y., Wei, C., Zheng, Q., Fan, J., et al. (2022) · BMC Biology · doi:10.1186/s12915-022-01307-1 · Cited by 3
“However, activities of dopamine can regulate the emergence of eCB-LTP, which can be elicited in the condition of D1R activation [13].”
BackgroundInfluential
Neurotrophin-3 Rescues Striatal Synaptic Plasticity in Model of Neurodegeneration by PLC Signaling Activation
Gómez‐Pineda, V. G., Nieto-Mendoza, E., Torres-Cruz, F. M., & Hernández, E. (2024) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273298919240531110022 · Cited by 3
Impact and Interrelationships of Striatal Proteins, EPHB2, OPRM1, and PER2 on Mild Cognitive Impairment
Campomayor, N. B., Kim, H. J., Lee, H. J., Sayson, L. V., Ortiz, D. M., Cho, E., Kim, D., Jeon, S. J., Kim, B.-N., Cheong, J. H., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04334-x · Cited by 3
Classic and Modern Approaches to Investigating Interactions Between Dopamine Systems and Metabotropic Glutamate Receptors
Johnson, K. A. (2021) · Neuromethods · doi:10.1007/978-1-0716-1107-4_7 · Cited by 2
Early Dysfunction of Neural Transmission and Cognitive Processing in Huntington’s Disease
Michael, I., Steffes-Lovdahl, S. K., Jayaprakash, N., Wolfram-Aduan, A., & Gary, L. (2012) · InTech eBooks · doi:10.5772/30528 · Cited by 3
“…to a prominent position in striatal synaptic processing, as these compounds tend to be released by MSNs in response to GLU and DA stimulation and provide feedback to CB1 receptors located on GLU-releasing axon terminals (Matyas et al., 2006; Uchigashima et al., 2007; Lovinger, 2010).”
Background
Impaired Replenishment of Cortico-Striatal Synaptic Glutamate in Huntington’s Disease Mouse Model
Buren, C., Tu, G., & Raymond, L. A. (2020) · Journal of Huntington s Disease · doi:10.3233/jhd-200400 · Cited by 3
Synaptic scaling of corticostriatal circuits underlies hyperactivity in GABA Transporter-1 deficient mice
Wu, Y., Yi, X., Gu, X. F., Wang, Q., Jiang, Q., Li, Y., Zhu, M. X., Ding, J., Li, W., & Xu, T. (2023) · iScience · doi:10.1016/j.isci.2023.106322 · Cited by 3
Astrocytes in the external globus pallidus coordinate flexibility of action strategyPreprint
Hong, S., Kang, S., Song, M. R., Yang, M. A., Baker, M. R., Kang, S., Lee, J., Lee, S. W., & Choi, D. (2021) · Research Square · doi:10.21203/rs.3.rs-845991/v1 · Cited by 3
Exploring the role of Cdk5 on striatal synaptic plasticity in a 3-NP-induced model of early stages of Huntington’s disease
Hernández, E., Miranda-Barrientos, J. A., Nieto-Mendoza, E., & Torres-Cruz, F. M. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1362365 · Cited by 2

Authors: Lovinger, D. M.
Affiliations: National Institutes of Health (US)
Corresponding author: Lovinger, David M.
ORCID: Lovinger, David M.
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2010-06
Volume: 58
Issue: 7
Pages: 951-961
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2010.01.008
PMC: PMC2849868
OpenAlex: W2086614467
Cited by: 488
References: 150
Citations by year: 2026: 10 · 2025: 19 · 2024: 28 · 2023: 21 · 2022: 37 · 2021: 32 · 2020: 27 · 2019: 32 · 2018: 30 · 2017: 39 · 2016: 25 · 2015: 38 · 2014: 30 · 2013: 39 · 2012: 29
FWCI: 3.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (Z01AA000407)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: dorsal striatum, synaptic plasticity, long-term potentiation, long-term depression, medium spiny neurons, glutamatergic synapses, GABAergic synapses, NMDA receptor, dopamine D1 receptor, adenosine A2A receptor, dopamine D2 receptor, metabotropic glutamate receptors, retrograde endocannabinoid signaling, presynaptic inhibition, allosteric modulation, operant conditioning, habit learning, goal-directed learning, indirect pathway, neurotransmitter receptors
MeSH terms: Animals, Corpus Striatum, Learning, Neuronal Plasticity, Synapses, Neurotransmitter Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks