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Dynamics of rapid dopamine release in the nucleus accumbens during goal-directed behaviors for cocaine versus natural rewards

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Cameron, Courtney M., Wightman, R. Mark, Carelli, Regina M.·2014·Neuropharmacology

DOI 10.1016/j.neuropharm.2014.08.006PMC PMC4188722

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Abstract

Electrophysiological studies show that distinct subsets of nucleus accumbens (NAc) neurons differentially encode information about goal-directed behaviors for intravenous cocaine versus natural (food/water) rewards. Further, NAc rapid dopamine signaling occurs on a timescale similar to phasic cell firing during cocaine and natural reward-seeking behaviors. However, it is not known whether dopamine signaling is reinforcer specific (i.e., is released during responding for only one type of reinforcer) within discrete NAc locations, similar to neural firing dynamics. Here, fast-scan cyclic voltammetry (FSCV) was used to measure rapid dopamine release during multiple schedules involving sucrose reward and cocaine self-administration (n = 8 rats) and, in a separate group of rats (n = 6), during a sucrose/food multiple schedule. During the sucrose/cocaine multiple schedule, dopamine increased within seconds of operant responding for both reinforcers. Although dopamine release was not reinforcer specific, more subtle differences were observed in peak dopamine concentration [DA] across reinforcer conditions. Specifically, peak [DA] was higher during the first phase of the multiple schedule, regardless of reinforcer type. Further, the time to reach peak [DA] was delayed during cocaine-responding compared to sucrose. During the sucrose/food multiple schedule, increases in dopamine release were also observed relative to operant responding for both natural rewards. However, peak [DA] was higher relative to responding for sucrose than food, regardless of reinforcer order. Overall, the results reveal the dynamics of rapid dopamine signaling in discrete locations in the NAc across reward conditions, and provide novel insight into the functional role of this system in reward-seeking behaviors.

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Authors: Cameron, C. M., Wightman, R. M., & Carelli, R. M.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Carelli, Regina M.
ORCID: Wightman, R. Mark
Carelli, Regina M.
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2014-11
Volume: 86
Pages: 319-328
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2014.08.006
PMC: PMC4188722
OpenAlex: W1996061528
Cited by: 109
References: 45
Citations by year: 2026: 4 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 10 · 2020: 47 · 2019: 8 · 2018: 8 · 2017: 4 · 2016: 8 · 2015: 5
FWCI: 2.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: Catholic Medical Center (DA017318)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: nucleus accumbens, dopamine release, cocaine self-administration, natural reward, sucrose, food reward, goal-directed behavior, multiple schedules, reward seeking, fast-scan cyclic voltammetry
MeSH terms: Animals, Cocaine, Conditioning, Operant, Dopamine, Food, Goals, Male, Nucleus Accumbens, Psychomotor Performance, Reinforcement Schedule, Reward, Self Administration, Behavior, Addictive, Rats, Sprague-Dawley, Dopamine Uptake Inhibitors, Dietary Sucrose, Cocaine-Related Disorders, Drug-Seeking Behavior

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Dynamics of rapid dopamine release in the nucleus accumbens during goal-directed behaviors for cocaine versus natural rewards

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