The role of reward circuitry and food addiction in the obesity epidemic: An update

Leigh, Sarah-Jane; Morris, Margaret J.

doi:10.1016/j.biopsycho.2016.12.013

Cited by 191Eating Disorders and BehaviorsRegulation of Appetite and ObesityNeurotransmitter Receptor Influence on Behavior

The role of reward circuitry and food addiction in the obesity epidemic: An update

Leigh, Sarah-Jane, Morris, Margaret J.·2018·Biological Psychology

DOI 10.1016/j.biopsycho.2016.12.013

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Abstract

The increasing worldwide prevalence of obesity is partially related to the ready availability of highly palatable foods which increases the incidence of hedonic, non-homeostatic feeding. The "food addiction" hypothesis postulates that exposure to these foods alters the brain's reward circuitry, driving an addiction-like behavioural phenotype of compulsive overeating. This review highlights recent evidence that examines changes in the mesolimbic dopaminergic circuit, the primary component of the reward system, associated with exposure to highly palatable foods and obesity. The majority of obesity studies in animals have not measured addictive-like behaviours, but reports of such behaviours have been restricted to experiments using models of binge eating. Where examined, the prevalence of addiction-like behaviour in overweight and obese subjects indicates that 10-25% of the population meets the Yale Food Addiction Score criteria. There is considerable overlap in the behaviours ascribed to food addiction and binge eating disorder, and food addiction scores correlate highly with measures of binge eating. We feel that more research is required in humans to determine whether food addiction is both behaviourally and neurobiologically distinct from binge eating disorder. While the reward circuitry is clearly affected by both highly palatable foods and diet-induced obesity in a similar manner to short and long exposure to drugs of abuse, the challenge for the future is to show that these neurobiological changes are associated with addiction-like behaviour.

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The mesolimbic dopaminergic circuit is clearly affected by both highly palatable foods and diet-induced obesity similar to exposure to drugs of abuse.
“The mesolimbic dopaminergic circuit is clearly affected by both highly palatable foods and diet-induced obesity similar to exposure to drugs of abuse [92].”
From Separating the Signal from the Noise: How Psychiatric Diagnoses Can Help Discern Food Addiction from Dietary Restraint (2020) · cites this paper as [92]

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Figlewicz, D. P., Jay, J. L., Kittleson, S., Sipols, A. J., & Zavosh, A. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00655.2010 · Cited by 38 · see citing works
Neural integration of reward, arousal, and feeding: Recruitment of VTA, lateral hypothalamus, and ventral striatal neurons
Gutiérrez, R., Lobo, M. K., Zhang, F., & de Lecea, L. (2011) · IUBMB Life · doi:10.1002/iub.539 · Cited by 37 · see citing works
Differential expression of CART in feeding and reward circuits in binge eating rat model
Bharne, A. P., Borkar, C. D., Subhedar, N. K., & Kokare, D. M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.05.030 · Cited by 37 · see citing works
Effects of long-term cycling between palatable cafeteria diet and regular chow on intake, eating patterns, and response to saccharin and sucrose
Martire, S. I., Westbrook, R. F., & Morris, M. J. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.11.006 · Cited by 36 · see citing works
Differential effects of chow and purified diet on the consumption of sucrose solution and lard and the development of obesity
Apolzan, J. W., & Harris, R. B. S. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.08.023 · Cited by 35 · see citing works
Sweetened-Fat Intake Sensitizes Gamma-Aminobutyric Acid—Mediated Feeding Responses Elicited from the Nucleus Accumbens Shell
Newman, S. M., Pascal, L., Sadeghian, K., & Baldo, B. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.027 · Cited by 33 · see citing works
Variety and hyperpalatability: are they promoting addictive overeating?
Avena, N. M., & Gold, M. S. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.020164 · Cited by 33 · see citing works
The stability of ‘food addiction’ as assessed by the Yale Food Addiction Scale in a non-clinical population over 18-months
Pursey, K., Collins, C. E., Stanwell, P., & Burrows, T. L. (2015) · Appetite · doi:10.1016/j.appet.2015.10.015 · Cited by 31 · see citing works
Neuroadaptations in the Striatal Proteome of the Rat Following Prolonged Excessive Sucrose Intake
Ahmed, S., Kashem, M. A., Sarker, R., Ahmed, E. U., Hargreaves, G. A., & McGregor, I. S. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1274-6 · Cited by 31 · see citing works
Food addiction associations with psychological distress among people with type 2 diabetes
Raymond, K.-L., & Lovell, G. P. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.01.020 · Cited by 31 · see citing works
Snack food intake in ad libitum fed rats is triggered by the combination of fat and carbohydrates
Hoch, T., Pischetsrieder, M., & Heß, A. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00250 · Cited by 30 · see citing works
Rats Eat a Cafeteria-Style Diet to Excess but Eat Smaller Amounts and Less Frequently when Tested with Chow
South, T., Holmes, N. M., Martire, S. I., Westbrook, R. F., & Morris, M. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093506 · Cited by 30 · see citing works
A new biomarker of hedonic eating? A preliminary investigation of cortisol and nausea responses to acute opioid blockade
Daubenmier, J. J., Lustig, R. H., Hecht, F. M., Kristeller, J. L., Woolley, J. D., Adam, T. C., Dallman, M. F., & Epel, E. S. (2013) · Appetite · doi:10.1016/j.appet.2013.11.014 · Cited by 29 · see citing works
Why is treating obesity so difficult? Justification for the role of bariatric surgery
Proietto, J. (2011) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2011.tb03242.x · Cited by 27 · see citing works
Low Control over Palatable Food Intake in Rats Is Associated with Habitual Behavior and Relapse Vulnerability: Individual Differences
de Jong, J. W., Meijboom, K. E., Vanderschuren, L. J. M. J., & Adan, R. A. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074645 · Cited by 27 · see citing works
Fat/carbohydrate ratio but not energy density determines snack food intake and activates brain reward areas
Hoch, T., Kreitz, S., Gaffling, S., Pischetsrieder, M., & Heß, A. (2015) · Scientific Reports · doi:10.1038/srep10041 · Cited by 25 · see citing works
Correlation between addictive behaviors and mental health in university students
Okasaka, Y., Morita, N., Nakatani, Y., & Fujisawa, K. (2008) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2007.01779.x · Cited by 24 · see citing works
Food dependence in rats selectively bred for low versus high saccharin intake. Implications for “food addiction”
Yakovenko, V., Speidel, E. R., Chapman, C. D., & Dess, N. K. (2011) · Appetite · doi:10.1016/j.appet.2011.06.002 · Cited by 24 · see citing works
Daily Exposure to Sucrose Impairs Subsequent Learning About Food Cues: A Role for Alterations in Ghrelin Signaling and Dopamine D2 Receptors
Sharpe, M. J., Clemens, K. J., Morris, M. J., & Westbrook, R. F. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.287 · Cited by 24 · see citing works
GS 455534 selectively suppresses binge eating of palatable food and attenuates dopamine release in the accumbens of sugar-bingeing rats
Bocarsly, M. E., Hoebel, B. G., Paredes, D., von Loga, I., Murray, S. M., Wang, M., Arolfo, M. P., Yao, L., Diamond, I., & Avena, N. M. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000029 · Cited by 23 · see citing works

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Molecular aspects of fructose metabolism and metabolic disease
Herman, M. A., & Birnbaum, M. J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.09.010 · Cited by 298 · see citing works
The impact of sugar consumption on stress driven, emotional and addictive behaviors
Jacques, A., Chaaya, N., Beecher, K., Ali, S. A., Belmer, A., & Bartlett, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.021 · Cited by 271 · see citing works
The Burden of Carbohydrates in Health and Disease
Clemente‐Suárez, V. J., Mielgo‐Ayuso, J., Martín-Rodríguez, A., Ramos‐Campo, D. J., Redondo-Flórez, L., & Tornero-Aguilera, J. F. (2022) · Nutrients · doi:10.3390/nu14183809 · Cited by 223 · see citing works
Hyper‐Palatable Foods: Development of a Quantitative Definition and Application to the US Food System Database
Fazzino, T. L., Rohde, K., & Sullivan, D. K. (2019) · Obesity · doi:10.1002/oby.22639 · Cited by 179 · see citing works
Western Diet: Implications for Brain Function and Behavior
López-Taboada, I., González‐Pardo, H., & Conejo, N. M. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.564413 · Cited by 141 · see citing works
The cafeteria diet: A standardized protocol and its effects on behavior
Lalanza, J. F., & Snoeren, E. M. S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.11.003 · Cited by 142 · see citing works
Validation of the Spanish Version of the Yale Food Addiction Scale 2.0 (YFAS 2.0) and Clinical Correlates in a Sample of Eating Disorder, Gambling Disorder, and Healthy Control Participants
Granero, R., Jiménez‐Múrcia, S., Gearhardt, A. N., Agüera, Z., Aymamí, N., Gómez‐Peña, M., Lozano‐Madrid, M., Mallorquí‐Bagué, N., Mestre‐Bach, G., Neto-Antao, M. I., et al. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00208 · Cited by 117 · see citing works
Fish as models for understanding the vertebrate endocrine regulation of feeding and weight
Volkoff, H. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.04.017 · Cited by 86 · see citing works
Food Addiction and Lifestyle Habits among University Students
Romero, C., Hernández‐Martínez, A., Parra-Fernández, M. L., Zafra, M. D. O., Prado-Laguna, M. D. C., & Rodríguez‐Almagro, J. (2021) · Nutrients · doi:10.3390/nu13041352 · Cited by 74 · see citing works
Disordered Eating Among Individuals with Excess Weight: a Review of Recent Research
Nightingale, B. A., & Cassin, S. E. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00333-5 · Cited by 68 · see citing works
Overeating and food addiction in Major Depressive Disorder: Links to peripheral dopamine
Mills, J. G., Thomas, S. J., Larkin, T. A., & Deng, C. (2020) · Appetite · doi:10.1016/j.appet.2020.104586 · Cited by 70 · see citing works
Food addiction and impaired executive functions in women with obesity
Steward, T., Mestre‐Bach, G., Vintró‐Alcaraz, C., Lozano‐Madrid, M., Agüera, Z., Fernández‐Formoso, J. A., Granero, R., Jiménez‐Múrcia, S., Vilarrasa, N., de Gordejuela, A. G. R., et al. (2018) · European Eating Disorders Review · doi:10.1002/erv.2636 · Cited by 68 · see citing works
Microbiota and body weight control: Weight watchers within?
Boscaini, S., Leigh, S., Lavelle, A., García‐Cabrerizo, R., Lipuma, T., Clarke, G. A., Schellekens, H., & Cryan, J. F. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101427 · Cited by 66 · see citing works
Separating the Signal from the Noise: How Psychiatric Diagnoses Can Help Discern Food Addiction from Dietary Restraint
Wiss, D., & Brewerton, T. (2020) · Nutrients · doi:10.3390/nu12102937 · Cited by 63 · see citing works
Rainbow trout prefer diets rich in omega-3 long chain polyunsaturated fatty acids DHA and EPA
Roy, J., Mercier, Y., Tonnet, L., Burel, C., Lanuque, A., Surget, A., Larroquet, L., Corraze, G. R., Terrier, F., Panserat, S., et al. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112692 · Cited by 53 · see citing works
Ethical, Stigma, and Policy Implications of Food Addiction: A Scoping Review
Cassin, S. E., Buchman, D. Z., Leung, S. E., Kantarovich, K., Hawa, A., Carter, A., & Sockalingam, S. (2019) · Nutrients · doi:10.3390/nu11040710 · Cited by 52 · see citing works
Decision Making Deficits in Relation to Food Cues Influence Obesity: A Triadic Neural Model of Problematic Eating
Chen, R., Peng-Li, D., Turel, O., Sørensen, T. A., Bechara, A., Li, Y., & He, Q. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00264 · Cited by 50 · see citing works
Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights
Geisler, C. E., & Hayes, M. R. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114236 · Cited by 45 · see citing works
Weight gain in Major Depressive Disorder: Linking appetite and disordered eating to leptin and ghrelin.
Mills, J. G., Larkin, T., Deng, C., & Thomas, S. J. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.03.017 · Cited by 44 · see citing works
Hyperpalatability and the Generation of Obesity: Roles of Environment, Stress Exposure and Individual Difference
Leigh, S.-J., Lee, F., & Morris, M. J. (2018) · Current Obesity Reports · doi:10.1007/s13679-018-0292-0 · Cited by 43 · see citing works
Structural validity, measurement invariance, reliability and diagnostic accuracy of the Italian version of the Yale Food Addiction Scale 2.0 in patients with severe obesity and the general population
Manzoni, G. M., Rossi, A. A., Pietrabissa, G., Mannarini, S., Fabbricatore, M., Imperatori, C., Innamorati, M., Gearhardt, A. N., & Castelnuovo, G. (2020) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-020-00858-y · Cited by 42 · see citing works
Brain regulation of hunger and motivation: The case for integrating homeostatic and hedonic concepts and its implications for obesity and addiction
Morales, I. (2022) · Appetite · doi:10.1016/j.appet.2022.106146 · Cited by 39 · see citing works
Exercise for Weight Loss: Further Evaluating Energy Compensation with Exercise
Flack, K. D., Hays, H. M., MORELAND, J., & Long, D. E. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002376 · Cited by 37 · see citing works
Children, Media and Food. A New Paradigm in Food Advertising, Social Marketing and Happiness Management
Zambrano, R. E., Jiménez-Marín, G., Coronil, A. G., & Ravina-Ripoll, R. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18073588 · Cited by 36 · see citing works
Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway
Yohn, S. E., Galbraith, J., Calipari, E. S., & Conn, P. J. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00601 · Cited by 36 · see citing works
Taste of Fat and Obesity: Different Hypotheses and Our Point of View
Brondel, L., Quilliot, D., Mouillot, T., Khan, N. A., Bastable, P., Boggio, V., Leloup, C., & Pénicaud, L. (2022) · Nutrients · doi:10.3390/nu14030555 · Cited by 36 · see citing works
Effect of exposure to endocrine disrupting chemicals in obesity and neurodevelopment: The genetic and microbiota link
Ramírez, V., González-Palacios, P., Baca, M. Á., González-Domenech, P., Fernández-Cabezas, M., Álvarez-Cubero, M. J., Rodrigo, L. S., & Rivas, A. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158219 · Cited by 36 · see citing works
The dynamic nature of food reward processing in the brain
Roefs, A., Franssen, S., & Jansen, A. T. M. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000504 · Cited by 35 · see citing works
A narrative review of reward sensitivity, rash impulsivity, and food addiction in adolescents
Kidd, C., & Loxton, N. J. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110265 · Cited by 36 · see citing works
Neural mechanisms underlying the role of fructose in overfeeding
Payant, M. A., & Chee, M. J. S. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.034 · Cited by 35 · see citing works
Neuropeptide Y interaction with dopaminergic and serotonergic pathways: interlinked neurocircuits modulating hedonic eating behaviours
Rezitis, J., Herzog, H., & Ip, C. K. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110449 · Cited by 35 · see citing works
Oxytocin reduces the functional connectivity between brain regions involved in eating behavior in men with overweight and obesity
Kerem, L., Hadjikhani, N. K., Holsen, L. M., Lawson, E. A., & Plessow, F. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0489-7 · Cited by 34 · see citing works
Human genes influence the interaction between Streptococcus mutans and host caries susceptibility: a genome-wide association study in children with primary dentition
Meng, Y., Wu, T., Billings, R. J., Kopycka‐Kędzierawski, D. T., & Xiao, J. (2019) · International Journal of Oral Science · doi:10.1038/s41368-019-0051-4 · Cited by 32 · see citing works
Updating gender differences in the control of homeostatic and hedonic food intake: Implications for binge eating disorder
Novelle, M. G., & Diéguez, C. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110508 · Cited by 33 · see citing works
Allostatic Load Is Linked to Cortical Thickness Changes Depending on Body-Weight Status
Ottino‐González, J., Jurado, M. Á., García‐García, I., Segura, B., Marqués‐Iturria, I., Palacios, M. J. S., Tor, E., Prats-Soteras, X., Caldú, X., Junqué, C., et al. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00639 · Cited by 30 · see citing works
Sugars and Sweet Taste: Addictive or Rewarding?
Greenberg, D., & Peter, J. V. S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18189791 · Cited by 30 · see citing works
Further Evidence of a Specific Psychopathology of Addiction. Differentiation from Other Psychiatric Psychopathological Dimensions (Such as Obesity)
Maremmani, A. G. I., Cerniglia, L., Cimino, S., Bacciardi, S., Rovai, L., Pallucchini, A., Spera, V., Perugi, G., & Maremmani, I. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14080943 · Cited by 29 · see citing works
Post-traumatic stress disorder may set the neurobiological stage for eating disorders: A focus on glutamatergic dysfunction
Murray, S. L., & Holton, K. F. (2021) · Appetite · doi:10.1016/j.appet.2021.105599 · Cited by 29 · see citing works
Food Addiction and Emotional Eating Behaviors Co-Occurring with Problematic Smartphone Use in Adolescents?
Park, E. J., Hwang, S. S., Lee, M., & Bhang, S. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19094939 · Cited by 34 · see citing works
Food Addiction
Florio, L., Lassi, D. L. S., Périco, C. D. A.-M., Vignoli, N. G., Torales, J. C., Ventriglio, A., & Castaldelli-Maia, J. M. (2022) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000001555 · Cited by 29 · see citing works
Binge-like intake of sucrose reduces the rewarding value of sucrose in adult rats
Smail-Crevier, R. L., Maracle, A. C., Wash, S. I. J., & Olmstead, M. C. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.06.027 · Cited by 28 · see citing works
Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution?
de Ceglia, M., Decara, J. M., Gaetani, S., & de Fonseca, F. R. (2021) · Pharmaceuticals · doi:10.3390/ph14101002 · Cited by 27 · see citing works
Hippocampal-Dependent Inhibitory Learning and Memory Processes in the Control of Eating and Drug Taking
Clasen, M. M., Riley, A. L., & Davidson, T. L. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200206091447 · Cited by 23 · see citing works
Eating as a motivated behavior: modulatory effect of high fat diets on energy homeostasis, reward processing and neuroinflammation
BUTLER, M. J., & Eckel, L. A. (2018) · Integrative Zoology · doi:10.1111/1749-4877.12340 · Cited by 24 · see citing works
Disentangling the role of NAc D1 and D2 cells in hedonic eating
Guillaumin, M. C. C., Viskaitis, P., Bracey, E. F., Burdakov, D., & Peleg‐Raibstein, D. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02131-x · Cited by 24 · see citing works
Association of the dopamine D2 receptor rs1800497 polymorphism with food addiction, food reinforcement, and eating behavior in Chilean adults
Obregón, A. M., Oyarce, K., García, M. D. L. Á., Valladares, M., Pettinelli, P., & Goldfield, G. S. (2021) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-021-01136-1 · Cited by 23 · see citing works
Mediating effect of self-control in the relationship between psychological distress and food addiction among college students
Luo, Y., Zhang, Y., Sun, X., Dong, J., Wu, J., & Lin, X. (2022) · Appetite · doi:10.1016/j.appet.2022.106278 · Cited by 23 · see citing works
The Role of Brain in Energy Balance
Matafome, P. N., & Seiça, R. M. F. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_2 · Cited by 23 · see citing works
Food Addiction Correlates with Psychosocial Functioning More Than Metabolic Parameters in Patients with Obesity
Kiyici, S., Koca, N., Sigirli, D., Aslan, B. B., Guclu, M., & Kisakol, G. (2020) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2019.0108 · Cited by 22 · see citing works
Increasing Chocolate’s Sugar Content Enhances Its Psychoactive Effects and Intake
Casperson, S. L., Lanza, L., Albajri, E. A., & Nasser, J. A. (2019) · Nutrients · doi:10.3390/nu11030596 · Cited by 22 · see citing works
DEPRESSIVE AND EATING DISORDERS IN PATIENTS POST-BARIATRIC SURGERY WITH WEIGHT REGAIN: A DESCRIPTIVE OBSERVATIONAL STUDY
Furtado, T. D. A., Girundi, M. G., Campolina, C. D. O. C., Mafra, S. C., de Oliveira, A. M. O., dos Santos, M. L. P. D., Lopes, S. F., & Freire, M. A. (2023) · ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) · doi:10.1590/0102-672020230002e1725 · Cited by 22 · see citing works
Assessment of the relationship between food addiction and nutritional status in schizophrenic patients
Küçükerdönmez, Ö., Urhan, M., Altın, M., Hacıraifoğlu, Ö., & Yıldız, B. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1392429 · Cited by 22 · see citing works
Association between food addiction and body dissatisfaction among college students: The mediating role of eating expectancies
Wu, Y., Zimmer, C., Munn‐Chernoff, M. A., & Baker, J. H. (2020) · Eating Behaviors · doi:10.1016/j.eatbeh.2020.101441 · Cited by 22 · see citing works
Neuroendocrinology of Adipose Tissue and Gut–Brain Axis
Matafome, P. N., Eickhoff, H., Letra, L., & Seiça, R. M. F. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_3 · Cited by 21 · see citing works
Distributed amylin receptor signaling and its influence on motivated behavior
Kern, K. A., & Mietlicki‐Baase, E. G. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112958 · Cited by 20 · see citing works
Multiple Dimensions of Sweet Taste Perception Altered after Sleep Curtailment
Szczygiel, E. J., Cho, S., & Tucker, R. M. (2019) · Nutrients · doi:10.3390/nu11092015 · Cited by 20 · see citing works
Brain on food: The neuroepigenetics of nutrition
Vaziri, A., & Dus, M. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105099 · Cited by 19 · see citing works
An evidence review of the association of immune and inflammatory markers with obesity-related eating behaviors
Meng, Y., & Kautz, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.902114 · Cited by 21 · see citing works
The influence of the subcortex and brain stem on overeating: How advances in functional neuroimaging can be applied to expand neurobiological models to beyond the cortex
Kung, P., Soriano‐Mas, C., & Steward, T. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09720-1 · Cited by 18 · see citing works
Power of mind: Attentional focus rather than palatability dominates neural responding to visual food stimuli in females with overweight
Franssen, S., Jansen, A. T. M., van den Hurk, J., Roebroeck, A. F., & Roefs, A. (2020) · Appetite · doi:10.1016/j.appet.2020.104609 · Cited by 18 · see citing works
The accelerator, the brake, and the terrain: associations of reward-related eating, self-regulation, and the home food environment with diet quality during pregnancy and postpartum in the pregnancy eating attributes study (PEAS) cohort
Nansel, T. R., Lipsky, L. M., Faith, M. S., Liu, A., & Siega‐Riz, A. M. (2020) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-020-01047-x · Cited by 17 · see citing works
Sex Dimorphic Responses of the Hypothalamus–Pituitary–Thyroid Axis to Maternal Separation and Palatable Diet
Jaimes-Hoy, L., Romero, F., Charli, J., & Joseph‐Bravo, P. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00445 · Cited by 18 · see citing works
Functional Magnetic Resonance Imaging and Obesity—Novel Ways to Seen the Unseen
Drelich‐Zbroja, A., Matuszek, M., Kaczor, M., & Kuczyńska, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11123561 · Cited by 17 · see citing works
An Exploratory Study on the Influence of Psychopathological Risk and Impulsivity on BMI and Perceived Quality of Life in Obese Patients
Tambelli, R., Cerniglia, L., Cimino, S., Ballarotto, G., Paciello, M., Lubrano, C., Marchitelli, S., Gnessi, L., & Lenzi, A. (2017) · Nutrients · doi:10.3390/nu9050431 · Cited by 17 · see citing works
Hyperpalatable Foods Consumption in a Representative Sample of the General Population in Brazil: Differences of Binge and Non-Binge Eating Meals
de Moraes, C. E. F., Hay, P., Sichieri, R., Fazzino, T. L., Mourilhe, C., & Appolinário, J. C. (2023) · Behavioral Sciences · doi:10.3390/bs13020149 · Cited by 16 · see citing works
Subchronic air pollution exposure increases highly palatable food intake, modulates caloric efficiency and induces lipoperoxidation
da Silveira, C. G., Domenico, M. D., Saldiva, P. H. N., & Rhoden, C. R. (2018) · Inhalation Toxicology · doi:10.1080/08958378.2018.1530317 · Cited by 16 · see citing works
Finding the balance between model complexity and performance: Using ventral striatal oscillations to classify feeding behavior in rats
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Authors: Leigh, S.-J., & Morris, M. J.
Affiliations: UNSW Sydney (AU)
Corresponding author: Morris, Margaret J.
ORCID: Leigh, Sarah-Jane
Morris, Margaret J.
Venue: Biological Psychology
Publisher: Elsevier BV
Published: 2018-01
Volume: 131
Pages: 31-42
ISSN: 0301-0511 (ISSN-L)
DOI: 10.1016/j.biopsycho.2016.12.013
OpenAlex: W2563821226
Cited by: 191
References: 205
Citations by year: 2026: 8 · 2025: 17 · 2024: 10 · 2023: 26 · 2022: 32 · 2021: 28 · 2020: 21 · 2019: 20 · 2018: 17 · 2017: 10 · 2015: 1
FWCI: 2.32
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychology (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council of Australia to MJM
Topics: Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: food addiction, obesity, reward systems, mesolimbic dopamine system, highly palatable food, binge eating, binge eating disorder, compulsive eating, Yale Food Addiction Scale, diet-induced obesity
MeSH terms: Food Addiction, Animals, Feeding Behavior, Female, Humans, Male, Obesity, Reward, Binge-Eating Disorder

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The role of reward circuitry and food addiction in the obesity epidemic: An update

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