The brain’s reward system in health and disease
Open accessAbstract
Rhythmic gene expression is found throughout the central nervous system. This harmonized regulation can be dependent on- and independent of- the master regulator of biological clocks, the suprachiasmatic nucleus (SCN). Substantial oscillatory activity in the brain's reward system is regulated by dopamine. While light serves as a primary time-giver (zeitgeber) of physiological clocks and synchronizes biological rhythms in 24-h cycles, nonphotic stimuli have a profound influence over circadian biology. Indeed, reward-related activities (e.g., feeding, exercise, sex, substance use, and social interactions), which lead to an elevated level of dopamine, alters rhythms in the SCN and the brain's reward system. In this chapter, we will discuss the influence of the dopaminergic reward pathways on circadian system and the implication of this interplay on human health.
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The mesolimbic system controls processing of rewards by associating specific stimuli with positive outcomes, thus influencing behavior.
“The mesolimbic system, also referred to as the brain's reward system, controls the processing of rewards by associating specific stimuli with positive outcomes, thus influencing behavior.”
From Social Media Algorithms and Teen Addiction: Neurophysiological Impact and Ethical Considerations (2025) · cites this paper as [22]
Dopamine determines the reward value of experiences such as food, sex, and social interactions.
“Dopamine is considered to be at the core of this process, determining the reward value of experiences such as food, sex, and social interactions [22].”
From Social Media Algorithms and Teen Addiction: Neurophysiological Impact and Ethical Considerations (2025) · cites this paper as [22]
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Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949 · see citing works
Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395 · see citing works
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900 · see citing works
Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works
Neurobiologic advances from the brain disease model of addiction
Volkow, N. D., Koob, G. F., & McLellan, A. T. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1511480 · Cited by 2,008 · see citing works
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864 · see citing works
The incentive sensitization theory of addiction: some current issues
Robinson, T. E., & Berridge, K. C. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0093 · Cited by 1,717 · see citing works
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
Kalra, S. P., Dube, M. G., Pu, S., Xu, B., Horváth, T. L., & Kalra, P. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.1.0357 · Cited by 1,556 · see citing works
Demirci, K., Akgönül, M., & Akpinar, A. (2015) · Journal of Behavioral Addictions · doi:10.1556/2006.4.2015.010 · Cited by 1,529 · see citing works
Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
Johnson, P. M., & Kenny, P. J. (2010) · Nature Neuroscience · doi:10.1038/nn.2519 · Cited by 1,495 · see citing works
The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review
Klok, M. D., Jakobsdottir, S., & Drent, M. L. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00270.x · Cited by 1,442 · see citing works
The Role of the Dorsal Striatum in Reward and Decision-Making: Figure 1.
Balleine, B. W., Delgado, M. R., & Hikosaka, O. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1554-07.2007 · Cited by 1,390 · see citing works
Neurobehavioural mechanisms of reward and motivation
Robbins, T. W., & Everitt, B. J. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80077-8 · Cited by 1,187 · see citing works
Theory and measurement of generalized problematic internet use : A two-step approach
Caplan, S. E. (2010) · Computers in Human Behavior · doi:10.1016/j.chb.2010.03.012 · Cited by 1,061 · see citing works
Modeling habitual and addictive smartphone behavior
van Deursen, A. J. A. M., Bolle, C. L., Hegner, S. M., & Kommers, P. A. M. (2015) · Computers in Human Behavior · doi:10.1016/j.chb.2014.12.039 · Cited by 1,031 · see citing works
Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29867 · Cited by 984 · see citing works
Lemola, S., Perkinson-Gloor, N., Brand, S., Dewald-Kaufmann, J. F., & Grob, A. (2015) · Journal of Youth and Adolescence · doi:10.1007/s10964-014-0176-x · Cited by 940 · see citing works
Peroxiredoxins are conserved markers of circadian rhythms
Edgar, R. S., Green, E. W., Zhao, Y., Gerben Van Ooijen, A., Olmedo, M., Qin, X., Xu, Y. Q., Pan, M., Valekunja, U. K., Feeney, K. A., et al. (2012) · Nature · doi:10.1038/nature11088 · Cited by 915 · see citing works
Circadian food-anticipatory activity: Formal models and physiological mechanisms
Mistlberger, R. E. (1994) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)90023-x · Cited by 857 · see citing works
Processing of Social and Monetary Rewards in the Human Striatum
Izuma, K., Saito, D. N., & Sadato, N. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.020 · Cited by 855 · see citing works
Neuronal activity in monkey ventral striatum related to the expectation of reward
Schultz, W., Apicella, P., Scarnati, E., & Ljungberg, T. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-12-04595.1992 · Cited by 744 · see citing works
Effects of light on human circadian rhythms, sleep and mood
Blume, C., Garbazza, C., & Spitschan, M. (2019) · Somnologie · doi:10.1007/s11818-019-00215-x · Cited by 695 · cited 1× · see citing works
“Indeed, lights from backlit screens can delay and advance circadian timing causing asynchronization (Blume et al. 2019).”
BackgroundThe structure of the caudate nucleus of the cat: light and electron microscopy
Kemp, J. M., & Powell, T. P. S. (1971) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1971.0102 · Cited by 672 · see citing works
Everitt, B. J. (1990) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80222-2 · Cited by 650 · see citing works
Small, D. M., Jones-Gotman, M., & Dagher, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00253-2 · Cited by 632 · see citing works
Hernandez, L., & Hoebel, B. G. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90036-7 · Cited by 627 · see citing works
Reward deficiency syndrome: genetic aspects of behavioral disorders
Comings, D. E., & Blum, K. (2000) · Progress in Brain Research · doi:10.1016/s0079-6123(00)26022-6 · Cited by 621 · see citing works
Intense Sweetness Surpasses Cocaine Reward
Lenoir, M., Serre, F., Cantin, L., & Ahmed, S. H. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000698 · Cited by 608 · see citing works
Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell
Rada, P. V., Avena, N. M., & Hoebel, B. G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.04.043 · Cited by 542 · see citing works
Volkow, N. D., Wang, G., Fowler, J. S., Tomasi, D., Telang, F., & Baler, R. (2010) · BioEssays · doi:10.1002/bies.201000042 · Cited by 532 · see citing works
Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction
Volkow, N. D., Wang, G. J., Fowler, J. S., Tomasi, D., & Baler, R. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2011_169 · Cited by 525 · see citing works
Regulation of dopaminergic transmission and cocaine reward by the <i>Clock</i> gene
McClung, C. A., Sidiropoulou, K., Vitaterna, M., Takahashi, J. S., White, F. J., Cooper, D. C., & Nestler, E. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503584102 · Cited by 493 · see citing works
Figlewicz, D. P., Evans, S. B., Murphy, J., Hoen, M., & Baskin, D. G. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04087-8 · Cited by 482 · see citing works
Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia.
Weiner, D. M., Levey, A. I., & Brann, M. R. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.18.7050 · Cited by 481 · see citing works
Metabolic Consequences of Sleep and Circadian Disorders
Depner, C. M., Stothard, E. R., & Wright, K. P. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0507-z · Cited by 481 · see citing works
Cocaine sensitization and reward are under the influence of circadian genes and rhythm
Abarca, C., Albrecht, U., & Spanagel, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142039099 · Cited by 472 · see citing works
Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference
Wortley, K. E., Anderson, K. D., García, K., Murray, J. D., Malinova, L., Liu, R., Moncrieffe, M., Thabet, K., Cox, H. J., Yancopoulos, G. D., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402763101 · Cited by 471 · see citing works
Melis, M. R., & Argiolas, A. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)00020-2 · Cited by 428 · see citing works
Regulation of Monoamine Oxidase A by Circadian-Clock Components Implies Clock Influence on Mood
Hampp, G., Ripperger, J. A., Houben, T., Schmutz, I., Blex, C., Perreau‐Lenz, S., Brunk, I., Spanagel, R., Ahnert‐Hilger, G., Meijer, J. H., et al. (2008) · Current Biology · doi:10.1016/j.cub.2008.04.012 · Cited by 419 · see citing works
Kohno, D., Gao, H.-Z., Muroya, S., Kikuyama, S., & Yada, T. (2003) · Diabetes · doi:10.2337/diabetes.52.4.948 · Cited by 390 · see citing works
Neuropharmacological Mechanisms of Drug Reward: Beyond Dopamine in the Nucleus Accumbens
Bardo, M. T. (1998) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v12.i1-2.30 · Cited by 383 · see citing works
Distinct Roles of GABAergic Interneurons in the Regulation of Striatal Output Pathways
Gittis, A. H., Nelson, A., Thwin, M. T., Palop, J. J., & Kreitzer, A. C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4870-09.2010 · Cited by 364 · see citing works
Dopamine Production in the Caudate Putamen Restores Feeding in Dopamine-Deficient Mice
Szczypka, M. S., Kwok, K., Brot, M. D., Marck, B. T., Matsumoto, A. M., Donahue, B. A., & Palmiter, R. D. (2001) · Neuron · doi:10.1016/s0896-6273(01)00319-1 · Cited by 354 · see citing works
Blue light from light-emitting diodes elicits a dose-dependent suppression of melatonin in humans
West, K., Jablonski, M., Warfield, B., Cecil, K. S., James, M. E., Ayers, M. A., Maida, J. C., Bowen, C. K., Sliney, D. H., Rollag, M. D., et al. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01413.2009 · Cited by 344 · see citing works
The Time of Day of Food Intake Influences Overall Intake in Humans
de Castro, J. M. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.1.104 · Cited by 329 · see citing works
Graveland, G. A., & DiFiglia, M. (1985) · Brain Research · doi:10.1016/0006-8993(85)91524-0 · Cited by 323 · see citing works
Fossum, I. N., Nordnes, L. T., Storemark, S. S., Bjorvatn, B., & Pallesen, S. (2013) · Behavioral Sleep Medicine · doi:10.1080/15402002.2013.819468 · Cited by 307 · see citing works
Dopamine D1-like Receptors and Reward-related Incentive Learning
Beninger, R. J. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(97)00019-5 · Cited by 299 · see citing works
Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation
Chung, S., Lee, E. J., Yun, S., Choe, H. K., Park, S., Son, H. J., Kim, K., Dluzen, D. E., Lee, I., Hwang, O., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.039 · Cited by 298 · see citing works
Scheer, F. A. J. L., Morris, C. J., & Shea, S. A. (2013) · Obesity · doi:10.1002/oby.20351 · Cited by 296 · see citing works
Behavioral characterization of neuropeptide Y knockout mice
Bannon, A. W., Seda, J., Carmouché, M., Francis, J. M., Norman, M. H., Karbon, B., & McCaleb, M. L. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02285-x · Cited by 288 · see citing works
Effect of Fasting, Refeeding, and Dietary Fat Restriction on Plasma Leptin Levels
Weigle, D. S. (1997) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.2.561 · Cited by 287 · see citing works
Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight
Meister, B. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.05.021 · Cited by 284 · see citing works
Castañeda, T. R., de Prado, B. M., Prieto, D., & Mora, F. (2004) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00114.x · Cited by 276 · see citing works
Chronotype and psychiatric disorders
Kivelä, L., Papadopoulos, M. R., & Antypa, N. (2018) · Current Sleep Medicine Reports · doi:10.1007/s40675-018-0113-8 · Cited by 273 · see citing works
Pineal Melatonin Rhythm: Reduction in Aging Syrian Hamsters
Reiter, R. J., Richardson, B. A., Johnson, L. Y., Ferguson, B. N., & Dinh, D. T. (1980) · Science · doi:10.1126/science.7434032 · Cited by 251 · see citing works
Hood, S., Cassidy, P., Cossette, M.-P., Weigl, Y., Verwey, M., Robinson, B., Stewart, J., & Amir, S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2128-10.2010 · Cited by 246 · see citing works
From ventral-medial to dorsal-lateral striatum: neural correlates of reward-guided decision-making
Burton, A. C., Nakamura, K., & Roesch, M. R. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.05.003 · Cited by 238 · see citing works
Evening types are prone to depression
Merikanto, I., Lahti, T., Kronholm, E., Peltonen, M., Laatikainen, T., Vartiainen, E., Salomaa, V., & Partonen, T. (2013) · Chronobiology International · doi:10.3109/07420528.2013.784770 · Cited by 237 · see citing works
Daily rhythms of food-anticipatory behavioral activity do not require the known circadian clock
Storch, K.-F., & Weitz, C. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902063106 · Cited by 222 · see citing works
Homeostatic reinforcement learning for integrating reward collection and physiological stability
Keramati, M., & Gutkin, B. (2014) · eLife · doi:10.7554/elife.04811 · Cited by 218 · see citing works
A universal role of the ventral striatum in reward-based learning: Evidence from human studies
Daniel, R., & Pollmann, S. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.05.002 · Cited by 209 · see citing works
The role of dopamine in the nucleus accumbens and striatum during sexual behavior in the female rat
Becker, J. B., Rudick, C. N., & Jenkins, W. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03236.2001 · Cited by 206 · see citing works
Baver, S. B., Hope, K., Guyot, S., Bjørbaek, C., Kaczorowski, C., & O'Connell, K. M. S. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4861-12.2014 · Cited by 203 · see citing works
Dorsal Striatal Circuits for Habits, Compulsions and Addictions
Lipton, D. M., Gonzales, B. J., & Citri, A. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2019.00028 · Cited by 197 · see citing works
Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents
Logan, R. W., Hasler, B. P., Forbes, E. E., Franzen, P. L., Torregrossa, M. M., Huang, Y. H., Buysse, D. J., Clark, D. B., & McClung, C. A. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.035 · Cited by 194 · see citing works
Dopamine transporters govern diurnal variation in extracellular dopamine tone
Ferris, M. J., España, R. A., Locke, J. L., Konstantopoulos, J. K., Rose, J. H., Chen, R., & Jones, S. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407935111 · Cited by 192 · see citing works
Striatal microcircuitry and movement disorders
Gittis, A. H., & Kreitzer, A. C. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.06.008 · Cited by 188 · see citing works
Circadian rhythms of dopamine in mouse retina: The role of melatonin
Doyle, S. E., Grace, M. S., McIvor, W. E., & Menaker, M. (2002) · Visual Neuroscience · doi:10.1017/s0952523802195058 · Cited by 182 · see citing works
Nobis, C. C., Laramée, G. D., Kervezee, L., Sousa, D. M. D., Labrecque, N., & Cermakian, N. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1905080116 · Cited by 180 · see citing works
Sexual Behavior and Sex-Associated Environmental Cues Activate the Mesolimbic System in Male Rats
Balfour, M. E., Yu, L., & Coolen, L. M. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300350 · Cited by 177 · see citing works
Solinas, M., Thiriet, N., Rawas, R. E., Lardeux, V., & Jaber, M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.51 · Cited by 175 · see citing works
The clock gene, brain and muscle Arnt‐like 1, regulates adipogenesis via Wnt signaling pathway
Guo, B., Chatterjee, S., Li, L., Kim, J. M., Lee, J., Yechoor, V. K., Minze, L. J., Hsueh, W. A., & Ma, K. (2012) · The FASEB Journal · doi:10.1096/fj.12-205781 · Cited by 168 · see citing works
Consequences of Circadian Disruption on Cardiometabolic Health
Reutrakul, S., & Knutson, K. L. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.07.005 · Cited by 163 · see citing works
Physiological responses to food intake throughout the day
Johnston, J. D. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000055 · Cited by 158 · see citing works
Luo, A. H., & Aston‐Jones, G. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06606.x · Cited by 154 · see citing works
Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons
Cristino, L., Busetto, G., Imperatore, R., Ferrandino, I., Palomba, L., Silvestri, C., Petrosino, S., Orlando, P., Bentivoglio, M., Mackie, K., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219485110 · Cited by 143 · see citing works
Dopamine receptor-mediated regulation of neuronal “clock” gene expression
Imbesi, M., Yildiz, S., Arslan, A. D., Sharma, R., Manev, H., & Uz, T. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.044 · Cited by 141 · see citing works
Direct Midbrain Dopamine Input to the Suprachiasmatic Nucleus Accelerates Circadian Entrainment
Grippo, R. M., Purohit, A. M., Zhang, Q., Zweifel, L. S., & Güler, A. D. (2017) · Current Biology · doi:10.1016/j.cub.2017.06.084 · Cited by 140 · see citing works
Quantitative microdialysis of dopamine in the striatum: effect of circadian variation
Smith, A. D., Olson, R. J., & Justice, J. B. (1992) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(92)90111-p · Cited by 135 · see citing works
Circadian clock genes: Effects on dopamine, reward and addiction
Parekh, P. K., Ozburn, A. R., & McClung, C. A. (2015) · Alcohol · doi:10.1016/j.alcohol.2014.09.034 · Cited by 132 · see citing works
Webb, I. C., Baltazar, R. M., Wang, X., Pitchers, K. K., Coolen, L. M., & Lehman, M. N. (2009) · Journal of Biological Rhythms · doi:10.1177/0748730409346657 · Cited by 130 · see citing works
Enhanced GABA Transmission Drives Bradykinesia Following Loss of Dopamine D2 Receptor Signaling
Lemos, J. C., Friend, D. M., Kaplan, A. R., Shin, J. H., Rubinstein, M., Kravitz, A. V., & Alvarez, V. A. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.040 · Cited by 130 · see citing works
Circadian insights into dopamine mechanisms
Mendoza, J., & Challet, É. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.081 · Cited by 124 · see citing works
Sen, A., & Hoffmann, H. M. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110655 · Cited by 123 · see citing works
Obesity – A neuropsychological disease? Systematic review and neuropsychological model
Jauch‐Chara, K., & Oltmanns, K. M. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.12.001 · Cited by 121 · see citing works
Uz, T., Akhisaroğlu, M., Ahmed, R., & Manev, H. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300254 · Cited by 117 · see citing works
Kharkwal, G., Brami‐Cherrier, K., Lizardi-Ortiz, J. E., Nelson, A., Ramos, M., Barrio, D. D., Sulzer, D. L., Kreitzer, A. C., & Borrelli, E. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.014 · Cited by 113 · see citing works
Cameron, C. M., Wightman, R. M., & Carelli, R. M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.08.006 · Cited by 109 · see citing works
Prolonged High Fat Diet Reduces Dopamine Reuptake without Altering DAT Gene Expression
Cone, J. J., Chartoff, E. H., Potter, D. N., Ebner, S. R., & Roitman, M. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058251 · Cited by 108 · see citing works
Individual vulnerability to addiction
Swendsen, J. D., & Moal, M. L. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05894.x · Cited by 106 · see citing works
Nikaido, T., Akiyama, M., Moriya, T., & Shibata, S. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.4.894 · Cited by 102 · see citing works
Effect of meal frequency and timing on physical performance
Hawley, J. A., & Burke, L. M. (1997) · British Journal of Nutrition · doi:10.1079/bjn19970107 · Cited by 99 · see citing works
Chronobiological Influence Over Cardiovascular Function
Rana, S., Prabhu, S. D., & Young, M. E. (2020) · Circulation Research · doi:10.1161/circresaha.119.313349 · Cited by 99 · see citing works
Gallardo, C. M., Darvas, M., Oviatt, M., Chang, C. H., Michalik, M. J., Huddy, T. F., Meyer, E. E., Shuster, S. A., Aguayo, A., Hill, E. M., et al. (2014) · eLife · doi:10.7554/elife.03781 · Cited by 98 · see citing works
Weaver, D. R., & Reppert, S. M. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00117-b · Cited by 94 · see citing works
Lincoln, G. A., Andersson, H., & Hazlerigg, D. G. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.00990.x · Cited by 92 · see citing works
Social interactions impact on the dopaminergic system and drive individuality
Torquet, N., Marti, F., Campart, C., Tolu, S., Nguyen, C., Oberto, V. J., Benallaoua, M., Naudé, J., Didienne, S., Debray, N., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05526-5 · Cited by 88 · see citing works
Lynch, W. J., Girgenti, M. J., Breslin, F. J., Newton, S. S., & Taylor, J. R. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.106 · Cited by 87 · see citing works
Cocaine self-administration behaviors in ClockΔ19 mice
Ozburn, A. R., Larson, E. B., Self, D. W., & McClung, C. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2704-2 · Cited by 85 · see citing works
Measuring Television Addiction
Horvath, C. W. (2004) · Journal of Broadcasting & Electronic Media · doi:10.1207/s15506878jobem4803_3 · Cited by 82 · see citing works
Department of Defense influenza and other respiratory disease surveillance during the 2009 pandemic
Burke, R. L., Vest, K. G., Eick, A. A., Sánchez, J. L., Johns, M. C., Pavlin, J. A., Jarman, R. G., Mothershead, J. L., Quintana, M., Palys, T. J., et al. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-s2-s6 · Cited by 81 · see citing works
Effects of cocaine on extracellular dopamine and serotonin levels in the nucleus accumbens
Andrews, C. M., & Lucki, I. (2001) · Psychopharmacology · doi:10.1007/s002130100704 · Cited by 81 · see citing works
Neural basis of reward and craving - a homeostatic point of view
Paulus, M. P. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.4/mpaulus · Cited by 79 · see citing works
Meal Timing in Humans during Isolation without Time Cues
Aschoff, J., von Goetz, C., Wildgruber, C., & Wever, R. A. (1986) · Journal of Biological Rhythms · doi:10.1177/074873048600100206 · Cited by 75 · see citing works
PER1 Phosphorylation Specifies Feeding Rhythm in Mice
Liu, Z., Huang, M., Wu, X., Shi, G., Xing, L., Dong, Z., Qu, Z., Yan, J., Yang, L., Panda, S., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.032 · Cited by 73 · see citing works
The circadian Per1 and Per2 genes influence alcohol intake, reinforcement, and blood alcohol levels
Gamsby, J. J., Templeton, E. L., Bonvini, L., Wang, W., Loros, J., Dunlap, J., Green, A. I., & Gulick, D. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.04.016 · Cited by 72 · see citing works
Impaired light masking in dopamine D2 receptor–null mice
Doi, M., Yujnovsky, I., Hirayama, J., Malerba, M., Tirotta, E., Sassone‐Corsi, P., & Borrelli, E. (2006) · Nature Neuroscience · doi:10.1038/nn1711 · Cited by 71 · see citing works
Paulson, P. E. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00141-y · Cited by 70 · see citing works
Suganuma, N., KIKUCHI, T., YANAGI, K., Yamamura, S., Morishima, H., Adachi, H., Kumano‐go, T., Mikami, A., Sugita, Y., & Takeda, M. (2007) · Sleep and Biological Rhythms · doi:10.1111/j.1479-8425.2007.00276.x · Cited by 70 · see citing works
Molecular Clocks in Pharmacology
Musiek, E. S., & FitzGerald, G. A. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_10 · Cited by 69 · see citing works
Baird, T. J., & Gauvin, D. V. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00207-5 · Cited by 67 · see citing works
Neural basis of reward anticipation and its genetic determinants
Jia, T., Macare, C., Desrivières, S., Gonzalez, D. A., Tao, C., Ji, X., Ruggeri, B., Nees, F., Banaschewski, T., Barker, G. J., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503252113 · Cited by 66 · see citing works
Centrally Administered Ghrelin Acutely Influences Food Choice in Rodents
Schéle, E., Bake, T., Rabasa, C., & Dickson, S. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149456 · Cited by 65 · see citing works
Effects of enriched environment on morphine-induced reward in mice
Xu, Z., Hou, B., Gao, Y., He, F., & Zhang, C. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2006.12.027 · Cited by 63 · see citing works
Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice
Kobayashi, M., Iaccarino, C., Saiardi, A., Heidt, V., Bozzi, Y., Picetti, R., Vitale, C., Westphal, H., Drago, J., & Borrelli, E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402028101 · Cited by 61 · see citing works
Dyck, D. V., Cardon, G., Deforche, B. I., Owen, N. G., Cocker, K. A. D., Wijndaele, K., & Bourdeaudhuij, I. D. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-668 · Cited by 60 · see citing works
Viswanathan, N., & Davis, F. C. (1997) · Journal of Comparative Physiology A · doi:10.1007/s003590050053 · Cited by 59 · see citing works
Webb, I. C. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0764-z · Cited by 57 · see citing works
The Effects of Methamphetamine on Serotonin Transporter Activity
Haughey, H. M., Fleckenstein, A. E., Metzger, R. R., & Hanson, G. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751608.x · Cited by 55 · see citing works
Sanna, F., Bratzu, J., Serra, M. P., Leo, D., Quartu, M., Boi, M., Espinoza, S., Gainetdinov, R. R., Melis, M. R., & Argiolas, A. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00058 · Cited by 52 · see citing works
Common problems in patients recovering from chemical dependency.
Jones, E. M., Knutson, D., & Haines, D. (2003) · PubMed · Cited by 47 · see citing works
Dopamine D2 receptors in striatal output neurons enable the psychomotor effects of cocaine
Kharkwal, G., Radl, D. B., Lewis, R. G., & Borrelli, E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1608362113 · Cited by 45 · see citing works
Biochemistry of Biogenic Amines
(1975) · Springer eBooks · doi:10.1007/978-1-4684-3171-1 · Cited by 44 · see citing works
Periodicity of Presentations of Drugs of Abuse and Overdose in an Emergency Department
Raymond, R. C., Warren, M., Morris, R. W., & Leikin, J. B. (1992) · Journal of Toxicology Clinical Toxicology · doi:10.3109/15563659209021561 · Cited by 44 · see citing works
Dopamine 2 Receptor Activation Entrains Circadian Clocks in Mouse Retinal Pigment Epithelium
Baba, K., DeBruyne, J. P., & Tosini, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-05394-x · Cited by 44 · see citing works
GRANT, C. L., Dorrian, J., Coates, A. M., Pajcin, M., Kennaway, D. J., Wittert, G., Heilbronn, L. K., Vedova, C. B. D., Gupta, C. C., & Banks, S. (2017) · Industrial Health · doi:10.2486/indhealth.2017-0047 · Cited by 43 · see citing works
Rada, P. V., Avena, N. M., Barson, J. R., Hoebel, B. G., & LEIBOWITZ, S. F. (2012) · Brain Sciences · doi:10.3390/brainsci2020242 · Cited by 42 · see citing works
Time for sex: nycthemeral distribution of human sexual behavior
Refinetti, R. (2005) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-3-4 · Cited by 41 · see citing works
Dietary intakes and leptin concentrations.
Izadi, V., Saraf‐Bank, S., & Azadbakht, L. (2014) · PubMed Central · Cited by 39 · see citing works
Marche, K., Martel, A., & Apicella, P. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00052 · Cited by 39 · see citing works
Oorschot, D. E. (2012) · Basal Ganglia · doi:10.1016/j.baga.2012.11.001 · Cited by 34 · see citing works
Lewis, R. G., Serra, M., Radl, D. B., Gori, M., Tran, C., Michalak, S. E., Vanderwal, C. D., & Borrelli, E. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107527 · Cited by 34 · see citing works
Enhanced reward-related responding following cholera toxin infusion into the nucleus accumbens
Kelley, A. E., & Holahan, M. R. (1997) · Synapse · doi:10.1002/(sici)1098-2396(199705)26:1 · Cited by 31 · see citing works
Honma, S., & Honma, K.-I. (1995) · Brain Research · doi:10.1016/0006-8993(95)00027-n · Cited by 30 · see citing works
Circadian Effects of Timed Meals (and Other Rewards)
Davidson, A. J., Tataroğlu, Ö., & Menaker, M. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)93026-7 · Cited by 29 · see citing works
Dopamine Signaling in Circadian Photoentrainment: Consequences of Desynchrony.
Grippo, R. M., & Güler, A. D. (2019) · PubMed Central · Cited by 29 · see citing works
Hotz, M. M., Connolly, M. S., & Lynch, C. B. (1987) · Behavior Genetics · doi:10.1007/bf01066009 · Cited by 24 · see citing works
Active Time-Restricted Feeding Improved Sleep-Wake Cycle in db/db Mice
Hou, T., Wang, C., Joshi, S., O’Hara, B. F., Gong, M. C., & Guo, Z. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00969 · Cited by 24 · see citing works
Decker, A. D., Verbeken, S., Sioen, I., Lippevelde, W. V., Braet, C., Eiben, G., Pala, V. M., Reish, L. A., & Henauw, S. D. (2017) · European Journal of Pediatrics · doi:10.1007/s00431-017-2857-4 · Cited by 22 · see citing works
Scheduled Daily Mating Induces Circadian Anticipatory Activity Rhythms in the Male Rat
Landry, G. J., Opiol, H., Marchant, E. G., Pavlovski, I., Mear, R. J., Hamson, D. K., & Mistlberger, R. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040895 · Cited by 21 · see citing works
Circadian and circannual rhythms of emergency room drug-overdose admissions.
Morris, R. W. (1987) · PubMed · Cited by 18 · see citing works
Perreau‐Lenz, S., Hoelters, L.-S., Leixner, S., Sanchis‐Segura, C., Hansson, A. C., Bilbao, A., & Spanagel, R. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4574-0 · Cited by 17 · see citing works
Brain Imaging in Behavioral Neuroscience
Carter, C., & Dalley, J. (2012) · Current topics in behavioral neurosciences · doi:10.1007/978-3-642-28711-4 · Cited by 13 · see citing works
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Glucagon-like peptide 1 agonist and effects on reward behaviour: A systematic review
Badulescu, S., Tabassum, A., Le, G. H., Wong, S., Phan, L., Gill, H., Llach, C.-D., McIntyre, R. S., Rosenblat, J., & Mansur, R. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114622 · Cited by 90 · see citing works
Social Media Algorithms and Teen Addiction: Neurophysiological Impact and Ethical Considerations
De, D., El Jamal, M., Aydemir, E., & Khera, A. (2025) · Cureus · doi:10.7759/cureus.77145 · Cited by 54 · see citing works
“Dopamine is considered to be at the core of this process, determining the reward value of experiences such as food, sex, and social interactions [22].”
Cell therapy for neurological disorders
Svendsen, S. P., & Svendsen, C. N. (2024) · Nature Medicine · doi:10.1038/s41591-024-03281-3 · Cited by 43 · see citing works
From Reward to Anhedonia-Dopamine Function in the Global Mental Health Context
Dresp, B. (2023) · Biomedicines · doi:10.3390/biomedicines11092469 · Cited by 49 · see citing works
Drug addiction and treatment: An epigenetic perspective
Koijam, A. S., Singh, K. D., Singh, N. B., Haobam, R., & Rajashekar, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115951 · Cited by 43 · see citing works
Stefanaki, K., Karagiannakis, D. S., Peppa, Μ., Vryonidou, A., Kalantaridou, S., Goulis, D. G., Ψαλτοπούλου, Θ., & Paschou, S. Α. (2024) · Nutrients · doi:10.3390/nu16071049 · Cited by 26 · see citing works
Bruno, U., Rana, D., Ausilio, C., Mariano, A., Bettucci, O., Musall, S., Lubrano, C., & Santoro, F. (2024) · Materials Horizons · doi:10.1039/d3mh02202a · Cited by 25 · see citing works
Glucagon-Like Peptide 1: An Introduction and Possible Implications for Neuropsychiatry
López-Ojeda, W., & Hurley, R. A. (2024) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.20230226 · Cited by 24 · see citing works
Kiełbik, P., & Witkowska‐Piłaszewicz, O. (2024) · Animals · doi:10.3390/ani14142048 · Cited by 24 · see citing works
Pharmacological strategies for sexual recovery in men undergoing antipsychotic treatment
Jannini, T. B., Sansone, A., Rossi, R., Lorenzo, G. D., Toscano, M., Siracusano, A., & Jannini, E. A. (2022) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2022.2071124 · Cited by 21 · see citing works
Octary, T., Fajarini, M., Arifin, H., Chen, R., Sung, C., Chang, L., Wang, C., Banda, K. J., & Chou, K. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100091 · Cited by 20 · see citing works
Otsuka, T., Le, H. T., Thein, Z. L., Ihara, H., Sato, F., Nakao, T., & Kohsaka, A. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113960 · Cited by 20 · see citing works
Impaired interhemispheric synchrony in Parkinson's disease patients with apathy
Zhang, H., Shan, A., Gan, C., Zhang, L., Wang, L., Sun, H., Yuan, Y., & Zhang, K. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.006 · Cited by 19 · see citing works
Pagare, P. P., Flammia, R., & Zhang, Y. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.107023 · Cited by 18 · see citing works
Screen use and sleep duration and quality at 15 years old: Cohort study
Echevarria, P., Del‐Ponte, B., Tovo‐Rodrigues, L., Matijasevich, A., Halal, C. S. E., & Santos, I. S. (2023) · Sleep Medicine X · doi:10.1016/j.sleepx.2023.100073 · Cited by 18 · see citing works
Sex differences in glutamate transmission and plasticity in reward related regions
Kniffin, A. R., & Briand, L. A. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1455478 · Cited by 17 · see citing works
Gene expression differences associated with alcohol use disorder in human brain
Willis, C., White, J. D., Minto, M. S., Quach, B. C., Han, S., Tao, R., Shin, J. H., Deep‐Soboslay, A., Hyde, T. M., Mayfield, R. D., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02777-1 · Cited by 15 · see citing works
Albardan, L., & Platat, C. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1645293 · Cited by 12 · see citing works
Mercante, F., Bonaventura, E. M. D., Pucci, M., Botticelli, L., Cifani, C., D’Addario, C., & Bonaventura, M. V. M. D. (2024) · International Journal of Eating Disorders · doi:10.1002/eat.24216 · Cited by 12 · see citing works
Fico, B. G., Maharaj, A., Pena, G. S., & Huang, C. (2023) · Biology · doi:10.3390/biology12060865 · Cited by 14 · see citing works
Exploring the association between melatonin and nicotine dependence (Review)
GEORGAKOPOULOU, V. E., Sklapani, P., Τράκας, Ν., Reiter, R. J., & Spandidos, D. A. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5406 · Cited by 12 · see citing works
Interconnections of screen time with neuroinflammation
Verma, A., Kumar, A., Chauhan, S. S., Sharma, N., Kalani, A., & Gupta, P. C. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05123-9 · Cited by 11 · see citing works
Early Life Stress and Gut Microbiome Dysbiosis: A Narrative Review
Borrego-Ruiz, A., & Borrego, J. J. (2025) · Stresses · doi:10.3390/stresses5020038 · Cited by 11 · see citing works
The role of BDNF on food intake and overweight: Linking neuroplasticity and obesity
Sequeira‐Cordero, A., Brenes, J. C., & Vindas-Smith, R. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111457 · Cited by 13 · see citing works
Matiș, L., Alexandru, B. A., & Ghitea, T. C. (2023) · Biomedicines · doi:10.3390/biomedicines11102600 · Cited by 10 · see citing works
Osuch, B., Misztal, T., Pałatyńska, K., & Tomaszewska-Zaremba, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094845 · Cited by 10 · see citing works
Friuli, M., Eramo, B., Sepe, C., Kiani, M., Casolini, P., & Zuena, A. R. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.114929 · Cited by 11 · see citing works
Moszak, M., Marcickiewicz, J., Pelczyńska, M., & Bogdański, P. (2025) · Nutrients · doi:10.3390/nu17101662 · Cited by 9 · see citing works
Sharma, P., Sawaya, M. F., Dumitrescu, A. M., Kolluru, G. K., Schmoutz, C. D., Salinas, A. G., Cannon, C. E., Kumbhare, D., Korneeva, N. L., Vest, M. F., et al. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00770 · Cited by 11 · see citing works
Framing decision-making: the role of executive functions, cognitive bias and reward
Rovelli, K., & Allegretta, R. A. (2023) · Neuropsychological Trends · doi:10.7358/neur-2023-033-rove · Cited by 9 · see citing works
Boecker, H., Maurer, A., Daamen, M., Bodensohn, L., Werkhausen, J., Lohaus, M., Manunzio, C., Manunzio, U., Radbruch, A., Attenberger, U. I., et al. (2024) · Frontiers in Neuroimaging · doi:10.3389/fnimg.2024.1332384 · Cited by 9 · see citing works
Xu, Y., & Zhang, Y. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16117 · Cited by 8 · see citing works
Nguyen, L. T. H., Nguyen, N. P. K., Tran, K. N., Shin, H., & Yang, I. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117775 · Cited by 8 · see citing works
Zhang, B., Guo, M., Dong, T., Yang, H., Zhang, Q., Yang, Q., Zhou, X., Mao, C., & Zhang, M. (2024) · Journal of Pain Research · doi:10.2147/jpr.s455239 · Cited by 8 · see citing works
Shahani, P., Abolghasemi, H., Abtin, S., Mozafari, R., Barikrow, N., Yekta, B. G., & Haghparast, A. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173911 · Cited by 8 · see citing works
Pathophysiological and therapeutic implications of neuropeptide S system in neurological disorders
Shirasath, K. R., Patil, V. K., Awathale, S. N., Goyal, S. N., & Nakhate, K. T. (2024) · Peptides · doi:10.1016/j.peptides.2024.171167 · Cited by 7 · see citing works
Bertrand, M., Chabardès, S., Fontanier, V., Procyk, E., Bastin, J., & Piallat, B. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1257579 · Cited by 7 · see citing works
Tavakoli, N. S., Malone, S. G., Anderson, T. L., Neeley, R. E., Asadipooya, A., Bardo, M. T., & Ortinski, P. I. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1347491 · Cited by 7 · see citing works
Bonanno, M., Papa, G. F. S., Ruffoni, P., Catalioto, E., Luca, R. D., Maggio, M. G., & Calabrò, R. S. (2024) · Healthcare · doi:10.3390/healthcare12131353 · Cited by 7 · see citing works
Jurek, J. M., & Maruda, A. (2024) · Debates em Psiquiatria · doi:10.25118/2763-9037.2024.v14.1268 · Cited by 10 · see citing works
Calesella, F., Serra, E., Palladini, M., Colombo, F., Bravi, B., Fortaner-Uyà, L., Monopoli, C., Tassi, E., Brambilla, P., Colombo, C., et al. (2025) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2025.05.011 · Cited by 7 · see citing works
Bridging Genetic Insights with Neuroimaging in Autism Spectrum Disorder—A Systematic Review
Vilela, J. E. R., Rasga, C., Santos, J. X., Martiniano, H., Marques, A. R., Oliveira, G., & Vicente, A. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094938 · Cited by 7 · see citing works
Welling, M. S., van Rossum, E. F. C., & van den Akker, E. L. T. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf004 · Cited by 6 · see citing works
Federated Learning: Attacks and Defenses, Rewards, Energy Efficiency: Past, Present and Future
Karydas, D., & Leligou, H. C. (2024) · WSEAS Transactions on Computers archive · doi:10.37394/23205.2024.23.10 · Cited by 6 · see citing works
The Orexin System in Addiction: Neuromodulatory Interactions and Therapeutic Potential
Capó, T., Lillo, J., Rebassa, J. B., Badia, P., Raïch, I., Cubeles-Juberias, E., Reyes‐Resina, I., & Navarro, G. (2025) · Brain Sciences · doi:10.3390/brainsci15101105 · Cited by 5 · see citing works
Pérez, A. D. A., Kautzmann, A. S., & Alvares, L. D. O. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02955-3 · Cited by 5 · see citing works
Wang, W., Cheung, S. H., Cheung, S. F., Sun, R. W., Hui, C.-C. H., Ma, H. Y. D., & Lau, E. Y. Y. (2025) · SLEEP · doi:10.1093/sleep/zsaf021 · Cited by 5 · see citing works
Noruzi, M., Behmadi, H., Sabzevari, O., Foroumadi, A., Ghahremani, M. H., Pourahmad, J., Hassani, S., Baeeri, M., Gholami, M., Ghahremanian, A., et al. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176776 · Cited by 5 · see citing works
Iwama, T., Komatsu, M., Inoue, K. Y., Kubota, K., Ito‐Sasaki, T., & Shiku, H. (2024) · Talanta · doi:10.1016/j.talanta.2024.126509 · Cited by 5 · see citing works
Chern, H., Caruso, G., Desaire, H., & Jarošová, R. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00596 · Cited by 6 · see citing works
Erdemli, A., Audrin, C., & Sander, D. (2024) · doi:10.31234/osf.io/kz2a7 · Cited by 6 · see citing works
Biopsychosocial and Environmental Factors That Impact Brain-Gut-Microbiome Interactions in Obesity
Sood, R., Kilpatrick, L. A., Keefer, L., & Church, A. (2025) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2025.07.045 · Cited by 4 · see citing works
Rodríguez–Serrano, L. M., López-Castillo, A. P., Cabrera-Mejía, M. C., Cedillo-Figueroa, A. S., Zepeda-Ortigosa, N., Carregha-Lozano, C., & Chávez–Hernández, M. E. (2025) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2025.1572374 · Cited by 4 · see citing works
Scislewska, P., Zareba, M., Lengier, J., Schirmer, A. E., Bębas, P., & Szatkowska, I. (2025) · Scientific Reports · doi:10.1038/s41598-025-07049-8 · Cited by 3 · see citing works
Nicolaou, S., Julià, A., Otero, D., Schmidt, C., Pascual, J. C., Soler, J., Marco‐Pallarés, J., & Vega, D. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03536-8 · Cited by 5 · see citing works
Semaglutide for Craving Reduction in a Cocaine Dependent Patient: A Case Report
Sileoni, A. M., Turco, E. T., Semeraro, F., Cavallotto, C., Mosca, A., Chiappini, S., & Martinotti, G. (2025) · Clinical Neuropsychopharmacology and Addiction · doi:10.53941/cna.2025.100003 · Cited by 4 · see citing works
Astrocyte-Neuron Interactions in Substance Use Disorders
Harder, E. V., Franklin, J. P., VanRyzin, J. W., & Reissner, K. J. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-64839-7_7 · Cited by 4 · see citing works
Lagamjis, G., Lu, H., Roeder, N. M., Richardson, B., Marion, M., Quattrin, T., Mastrandrea, L. D., Hadjiargyrou, M., Komatsu, D. E., & Thanos, P. K. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04481-0 · Cited by 4 · see citing works
The neurobiology of love and addiction: Central nervous system signaling and energy metabolism
Esch, T., & Stefano, G. B. (2025) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-025-01333-w · Cited by 3 · see citing works
Hills, C., Hernandez, C. A., Gabbay, V., & Berman, J. W. (2026) · Cells · doi:10.3390/cells15050399 · Cited by 3 · see citing works
Santoni, M., Mastio, A., Concas, L., Mostallino, R., Herres, A., Sagheddu, C., Castelli, M. P., Frau, R., Muntoni, A. L., & Pistis, M. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03926-6 · Cited by 3 · see citing works
Mohammadi, M., Omidiani, S. E., Azizbeigi, R., & Haghparast, A. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04256-z · Cited by 4 · see citing works
González‐González, S., Gutiérrez‐Pérez, M., Guzmán‐Ruiz, M. A., Espítia‐Bautista, E., Pavón, R. M., Estrada‐Rodriguez, K. P., Alejandro Díaz-Infante, R., Gándara, C. G. G., Escobar, C., & Guerrero‐Vargas, N. N. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2024.1520160 · Cited by 3 · see citing works
Masand, P. S., Clayton, A. H., Parikh, M., Laliberté, F., Germain, G., Mahendran, M., Martínez, C., & Nabulsi, N. A. (2025) · Journal of Medical Economics · doi:10.1080/13696998.2025.2457872 · Cited by 3 · see citing works
Stefano, G. B., Büttiker, P., Michaelsen, M. M., & Esch, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125491 · Cited by 6 · see citing works
Enhancement of Electrochemiluminescence by Au Paste Electrode for Bipolar Electroanalysis
Ayane, E. N. D. O., Kubota, K., Ito‐Sasaki, T., Komatsu, M., Iwama, T., Shiku, H., & Inoue, K. Y. (2023) · Electrochemistry · doi:10.5796/electrochemistry.23-68114 · Cited by 3 · see citing works
Çakar, T. E., Son-Turan, S., Girişken, Y., Sayar, A., Ertuğrul, S., Filiz, G., & Tuna, E. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1286918 · Cited by 3 · see citing works
Vartanian, M., Endres, K. J., Lee, Y. T., Friedrich, S., Meemken, M.-T., Schamarek, I., Rohde‐Zimmermann, K., Schürfeld, R., Eisenberg, L., Hilbert, A., et al. (2025) · BMC Nutrition · doi:10.1186/s40795-024-00971-6 · Cited by 4 · see citing works
Disordered Eating Behaviors in Individuals With Physical Disabilities: A Narrative Review
Raffman, E. S., & Jayabalan, P. S. (2025) · American Journal of Lifestyle Medicine · doi:10.1177/15598276251363516 · Cited by 3 · see citing works
Jose, A., Mathew, S., & Arvind, T. (2026) · The British Journal of Psychiatry · doi:10.1192/bjp.2026.10557 · Cited by 2 · see citing works
Big tech, the state, or you? Who is responsible for generative AI addiction?
Stahl, B. C., Ali, R., Hitcham, L., Liebherr, M., Murray, R., Vallejos, E. P., & Yankouskaya, A. (2026) · Behaviour and Information Technology · doi:10.1080/0144929x.2026.2663509 · Cited by 2 · see citing works
Neuroendocrine Control of the Vascular System
Dalmasso, C., & Loria, A. S. (2023) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-39995-4_3 · Cited by 2 · see citing works
Filošević, A., Matić, I. S., Martinović, L. S., & Pavlić, S. D. (2024) · Future Pharmacology · doi:10.3390/futurepharmacol4010009 · Cited by 2 · see citing works
Portillo, R., Synova, T., & Štaud, F. (2025) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2025.112579 · Cited by 2 · see citing works
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Vazifehkhorani, A. K., & Hekmati, I. (2025) · Current Psychology · doi:10.1007/s12144-025-07480-0 · Cited by 2 · see citing works
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Ng, S. H., Lee, Y. Z., Hong, M. Y., Kow, A. S. F., d’Arqom, A., Tham, C. L., Ho, Y., & Lee, M. T. (2025) · Current Clinical Pharmacology · doi:10.2174/0127724328362434250224105609 · Cited by 2 · see citing works
Pirim, D., & Bağcı, F. A. (2025) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2025.2499475 · Cited by 2 · see citing works
Villela, P. N. R., & Johnson, E. C. (2025) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20250003 · Cited by 2 · see citing works
Fronto-striato network function is reduced in major depressive disorder
Kijima, R., Watanabe, K., Okamoto, N., Ikenouchi, A., Tesen, H., Kakeda, S., & Yoshimura, R. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1336370 · Cited by 2 · see citing works
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Gomes, M. D. M. (2024) · Revista brasileira de neurologia · doi:10.46979/rbn.v59i4.63113 · Cited by 2 · see citing works
D’Alessandro, E. M., Karimi, A., Bearss, K. A., Bar, R. J., & DeSouza, J. F. X. (2025) · medRxiv · doi:10.1101/2025.07.19.25331836 · Cited by 2 · see citing works
Reward circuit local field potential modulations precede risk taking
Hughes, N., Qian, H., Doss, D. J., Makhoul, G. S., Zargari, M., Zhao, Z., Singh, B., Wang, Z., Fulton, J. N., Johnson, G. W., et al. (2025) · Brain · doi:10.1093/brain/awaf107 · Cited by 1 · see citing works
Circadian photoreception influences loss aversion
Lander, A. C., Burge, M. T., Thomas, B. G., Phillips, A. J. K., McGlashan, E. M., & Cain, S. W. (2025) · Scientific Reports · doi:10.1038/s41598-025-97370-z · Cited by 1 · see citing works
Underexplored Connections Between Diabetes, Hypomanic States and Insecure Attachment
Bogdanova, D., Maes, M. H. J., & Stoyanov, D. (2025) · Psychology Research and Behavior Management · doi:10.2147/prbm.s524823 · Cited by 1 · see citing works
The gut and heart’s role in reward processing
Arinel, M., & Abdelaal, K. (2025) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2025.1479923 · Cited by 1 · see citing works
Pais, M. L., Crisóstomo, J., Abrunhosa, A., & Castelo-Branco, M. S. (2025) · Communications Medicine · doi:10.1038/s43856-025-01079-z · Cited by 1 · see citing works
Kuehnel, I. M., González‐Irarrázabal, C. E., Pardo, R., Julio‐Pieper, M., & Bravo, J. A. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70224 · Cited by 1 · see citing works
Chua, K., Chong, Y. S., & Sajikumar, S. (2025) · FEBS Journal · doi:10.1111/febs.70266 · Cited by 1 · see citing works
Pedrinelli, V., Rimoldi, B., Conti, L., Bordacchini, A., Parrini, L., Betti, L., Giannaccini, G., Dell’Oste, V., & Carmassi, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262411835 · Cited by 4 · see citing works
Karlócai, Z., Vegelius, J. R., Widegren, E., Kleberg, J. L., Fällmar, D., Kroemer, N. B., Gingnell, M., & Frick, A. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.116008 · Cited by 1 · see citing works
Bai, C., Tian, Q., Chen, J., Li, C., Liu, X., Wei, D., Zhu, X., & Wang, K. (2026) · Scientific Reports · doi:10.1038/s41598-025-34598-9 · Cited by 1 · see citing works
Yue, J., Jones, B., Tran, K. H., Deen, M. C., Holicek, V., Cheng, W. H., Michalik, M. J., Power, S. C., Wellington, C. L., Watson, N. V., et al. (2026) · Journal of Parkinson s Disease · doi:10.1177/1877718x251410291 · Cited by 1 · see citing works
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Marks, A., Berthelot, M., Jones, H., Taylor, A. K., Chang, K. K.-F., Crozier, S., & Cosper, S. M. (2026) · Pediatric Reports · doi:10.3390/pediatric18020043 · Cited by 4 · see citing works
Debnath, R., Lenz, E., Tobelander, J., Schweppe, P. C., Renner, V., & Mulert, C. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03942-6 · Cited by 1 · see citing works
Neurocognitive factors predicting BMI changes from adolescence to young adulthood
Reyes, S., Peirano, P. D., Gahagan, S., Blanco, E., & Algarín, C. R. (2024) · Obesity · doi:10.1002/oby.23978 · Cited by 1 · see citing works
Exploring Decision-Making Processes in Neuroeconomics
Jacob, L., & Reddy, K. J. (2024) · Advances in finance, accounting, and economics book series · doi:10.4018/979-8-3693-6055-2.ch005 · Cited by 1 · see citing works
Neurobiologia do condicionamento pavloviano e condicionamento operante – Revisão narrativa
Silva, W. D. S. (2024) · Research Society and Development · doi:10.33448/rsd-v13i11.47523 · Cited by 1 · see citing works
Oliveira, D. G. D. S. (2024) · Communications in computer and information science · doi:10.1007/978-3-031-74627-7_19 · Cited by 1 · see citing works
Zhao, X., Mueller, J. M., & Mueller, S. M. (2025) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2025.03.005 · Cited by 1 · see citing works
Lee, S., Kim, E., Cha, B., Ferre, C. L., Yücel, M. A., & Kumar, D. (2025) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2025.100615 · Cited by 1 · see citing works
- Authors
- Lewis, R. G., Florio, E., Punzo, D., & Borrelli, E.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Borrelli, Emiliana
- Venue
- Advances in experimental medicine and biology
- Publisher
- Springer International Publishing
- Published
- 2021
- Volume
- 1344
- Pages
- 57-69
- ISSN
- 0065-2598 (ISSN-L)
- 2214-8019
- PMC
- PMC8992377
- OpenAlex
- W3212367742
- Cited by
- 170
- References
- 144
- Citations by year
- 2026: 33 · 2025: 68 · 2024: 53 · 2023: 13 · 2022: 3
- FWCI
- 26.68
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Drug Abuse (T32DA050558)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- brain reward system, circadian rhythm, suprachiasmatic nucleus, dopamine, rhythmic gene expression, circadian clock, feeding behavior, substance use, social interaction, physical activity, sexual behavior
- MeSH terms
- Biological Clocks, Circadian Rhythm, Dopamine, Humans, Reward, Suprachiasmatic Nucleus
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