Cited by 170Circadian rhythm and melatoninNeurotransmitter Receptor Influence on BehaviorSleep and Wakefulness Research

The brain’s reward system in health and disease

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Lewis, Robert G., Florio, Ermanno, Punzo, Daniela, Borrelli, Emiliana·2021·Advances in experimental medicine and biology

Abstract

Rhythmic gene expression is found throughout the central nervous system. This harmonized regulation can be dependent on- and independent of- the master regulator of biological clocks, the suprachiasmatic nucleus (SCN). Substantial oscillatory activity in the brain's reward system is regulated by dopamine. While light serves as a primary time-giver (zeitgeber) of physiological clocks and synchronizes biological rhythms in 24-h cycles, nonphotic stimuli have a profound influence over circadian biology. Indeed, reward-related activities (e.g., feeding, exercise, sex, substance use, and social interactions), which lead to an elevated level of dopamine, alters rhythms in the SCN and the brain's reward system. In this chapter, we will discuss the influence of the dopaminergic reward pathways on circadian system and the implication of this interplay on human health.

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Authors
Lewis, R. G., Florio, E., Punzo, D., & Borrelli, E.
Affiliations
University of California, Irvine (US)
Corresponding author
Borrelli, Emiliana
Venue
Advances in experimental medicine and biology
Published
2021
Volume
1344
Pages
57-69
ISSN
  • 0065-2598 (ISSN-L)
  • 2214-8019
OpenAlex
W3212367742
Cited by
170
References
144
Citations by year
2026: 33 · 2025: 68 · 2024: 53 · 2023: 13 · 2022: 3
FWCI
26.68
Type
book chapter
Language
en
Open access
Locations
  • Advances in experimental medicine and biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
National Institute on Drug Abuse (T32DA050558)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
brain reward system, circadian rhythm, suprachiasmatic nucleus, dopamine, rhythmic gene expression, circadian clock, feeding behavior, substance use, social interaction, physical activity, sexual behavior
MeSH terms
Biological Clocks, Circadian Rhythm, Dopamine, Humans, Reward, Suprachiasmatic Nucleus

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