The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The kynurenine pathway and the brain: Challenges, controversies and promises
Open accessAbstract
Research on the neurobiology of the kynurenine pathway has suffered years of relative obscurity because tryptophan degradation, and its involvement in both physiology and major brain diseases, was viewed almost exclusively through the lens of the well-established metabolite serotonin. With increasing recognition that kynurenine and its metabolites can affect and even control a variety of classic neurotransmitter systems directly and indirectly, interest is expanding rapidly. Moreover, kynurenine pathway metabolism itself is modulated in conditions such as infection and stress, which are known to induce major changes in well-being and behaviour, so that kynurenines may be instrumental in the etiology of psychiatric and neurological disorders. It is therefore likely that the near future will not only witness the discovery of additional physiological and pathological roles for brain kynurenines, but also ever-increasing interest in drug development based on these roles. In particular, targeting the kynurenine pathway with new specific agents may make it possible to prevent disease by appropriate pharmacological or genetic manipulations. The following overview focuses on areas of kynurenine research which are either controversial, of major potential therapeutic interest, or just beginning to receive the degree of attention which will clarify their relevance to neurobiology and medicine. It also highlights technical issues so that investigators entering the field, and new research initiatives, are not misdirected by inappropriate experimental approaches or incorrect interpretations at this time of skyrocketing interest in the subject matter.
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Citations
Cites
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“Specifically, in the absence of anti-KMO antibodies that can be used for unambiguous microscopic localization of the enzyme, evidence for a microglial localization of this pivotal pathway enzyme rests mostly on ex vivo studies (Guillemin et al., 2005; Parrott and O'Connor, 2015).”
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Cited by
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
Platten, M., Nollen, E. A. A., Röhrig, U. F., Fallarino, F., & Opitz, C. A. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0016-5 · Cited by 1,586
Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health
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Neuroinflammation and depression: A review
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Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation
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Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis
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Metadata
- Authors
- Schwarcz, R., & Stone, T. W.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 112
- Issue
- Pt B
- Pages
- 237-247
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2508076655
- Cited by
- 461
- References
- 11
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
