Cited by 102Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

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Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism

Kim, Ji-Woon, Seung, Hana, Kim, Ki Chan, Gonzales, Edson Luck T., Oh, Hyun Ah, Yang, Sung Min, Ko, Mee Jung, Han, Seol-Heui, Banerjee, Sourav, Shin, Chan Young·2017·Neuropharmacology

DOI 10.1016/j.neuropharm.2016.09.014

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Abstract

Autism spectrum disorder (ASD) is an immensely challenging developmental disorder characterized primarily by two core behavioral symptoms of social communication deficits and restricted/repetitive behaviors. Investigating the etiological process and identifying an appropriate therapeutic target remain as formidable challenges to overcome ASD due to numerous risk factors and complex symptoms associated with the disorder. Among the various mechanisms that contribute to ASD, the maintenance of excitation and inhibition balance emerged as a key factor to regulate proper functioning of neuronal circuitry. Interestingly, our previous study involving the valproic acid animal model of autism (VPA animal model) has demonstrated excitatory-inhibitory imbalance (E/I imbalance) due to enhanced differentiation of glutamatergic neurons and reduced GABAergic neurons. Here, we investigated the potential of agmatine, an endogenous NMDA receptor antagonist, as a novel therapeutic candidate in ameliorating ASD symptoms by modulating E/I imbalance using the VPA animal model. We observed that a single treatment of agmatine rescued the impaired social behaviors as well as hyperactive and repetitive behaviors in the VPA animal model. We also observed that agmatine treatment rescued the overly activated ERK1/2 signaling in the prefrontal cortex and hippocampus of VPA animal models, possibly, by modulating over-excitability due to enhanced excitatory neural circuit. Taken together, our results have provided experimental evidence suggesting a possible therapeutic role of agmatine in ameliorating ASD-like symptoms in the VPA animal model of ASD.

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Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768
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Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454
MAPK cascade signalling and synaptic plasticity
Thomas, G. M., & Huganir, R. L. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1346 · Cited by 1,454
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Nelson, S. B., & Valakh, V. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.033 · Cited by 1,001
Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Animal Model of Autism
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Markram, H., & Markram, H. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00224 · Cited by 571
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Ornoy, A. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2009.02.014 · Cited by 526

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El-Ansary, A. K., Al-Dbass, A. M., & Qasem, H. (2018) · InTech eBooks · doi:10.5772/intechopen.69431 · Cited by 2
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Xu, Q., Li, X., Lin, J., Zhang, M.-L., He, T., Huang, W., & Hui-qin, X. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3979570
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(2018) · doi:10.31038/jnnc.2018111
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Bilim, P., Çelik, K., Garip, G., Yardımcı, A. G., Yardımcı, B. Ş., & Baka, M. (2025) · Ege Tıp Dergisi · doi:10.19161/etd.1686034
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Behavioral Effects of Agmatine in a Valproic Acid-Induced Rat Model of Autism Spectrum Disorder
Arıcıoğlu, F., Kabacaoğlu, G., Korkmaz, E., Bahtiyar, B. C., Sümer, E., & Yılmaz, B. (2025) · Clinical and Experimental Health Sciences · doi:10.33808/clinexphealthsci.1812820

Authors: Kim, J.-W., Seung, H., Kim, K. C., Gonzales, E. L. T., Oh, H. A., Yang, S. M., Ko, M. J., Han, S.-H., Banerjee, S., & Shin, C. Y.
Affiliations: Konkuk University (KR)
National Brain Research Centre (IN)
Corresponding author: Shin, Chan Young
ORCID: Kim, Ji-Woon
Kim, Ki Chan
Yang, Sung Min
Ko, Mee Jung
Han, Seol-Heui
Banerjee, Sourav
Shin, Chan Young
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2017-02
Volume: 113
Issue: Pt A
Pages: 71-81
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2016.09.014
OpenAlex: W2519436935
Cited by: 102
References: 65
Citations by year: 2026: 3 · 2025: 13 · 2024: 13 · 2023: 8 · 2022: 14 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 13 · 2017: 6
FWCI: 6.36
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Research Foundation of Korea
Korea government (2014R1A2A2A01003079, 2016R1A5A2012284)
Korea Health industry Development Institute
Ministry of Health & Welfare, Republic of Korea (HI12C0021)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: agmatine, autism spectrum disorder, excitatory-inhibitory imbalance, NMDA receptor antagonists, social behavior deficits, repetitive behavior, hyperactivity, ERK signaling, prefrontal cortex, hippocampus, glutamatergic neurons, GABAergic neurons, autism treatment
MeSH terms: Autism Spectrum Disorder, Agmatine, Animals, Disease Models, Animal, Grooming, Hippocampus, Hyperkinesis, Male, Mice, Transgenic, Neurons, Seizures, Social Behavior, Valproic Acid, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Prefrontal Cortex, MAP Kinase Signaling System, Mice, Rats, Neural Stem Cells, Primary Cell Culture

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Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism

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