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Cited by 1,001Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders

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Nelson, Sacha B., Valakh, Vera·2015·Neuron
DOI 10.1016/j.neuron.2015.07.033PMC PMC4567857
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Abstract

Autism spectrum disorders (ASDs) and related neurological disorders are associated with mutations in many genes affecting the ratio between neuronal excitation and inhibition. However, understanding the impact of these mutations on network activity is complicated by the plasticity of these networks, making it difficult in many cases to separate initial deficits from homeostatic compensation. Here we explore the contrasting evidence for primary defects in inhibition or excitation in ASDs and attempt to integrate the findings in terms of the brain's ability to maintain functional homeostasis.

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  • In humans, a higher excitatory/inhibitory ratio is thought to contribute to the pathophysiology of various neurological and psychiatric disorders, including ASD.

    “In humans, a higher excitatory/inhibitory ratio is thought to contribute to the pathophysiology of various neurological and psychiatric disorders, including ASD (Nelson & Valakh, 2015;Rubenstein & Merzenich, 2003;Robertson et al., 2016).”

    From Vasopressin regulates social play behavior in sex-specific ways through glutamate modulation in the lateral septum (2025) · cites this paper as Nelson & Valakh, 2015

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Cited by

Sorted by citations

Authors
Nelson, S. B., & Valakh, V.
Affiliations
Brandeis University (US)
Corresponding author
Nelson, Sacha B.
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2015-08
Volume
87
Issue
4
Pages
684-698
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2015.07.033
PMC
PMC4567857
OpenAlex
W1613369435
Cited by
1,001
References
30
Citations by year
2026: 94 · 2025: 97 · 2024: 87 · 2023: 94 · 2022: 83 · 2021: 118 · 2020: 112 · 2019: 104 · 2018: 100 · 2017: 71 · 2016: 36 · 2015: 4
FWCI
6.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (P01NS079419, T32NS007292)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
autism spectrum disorder, excitation-inhibition balance, neuronal excitation, neuronal inhibition, homeostatic compensation, network plasticity, genetic mutations, network activity
MeSH terms
Animals, Brain, Child Development Disorders, Pervasive, Homeostasis, Humans, Nerve Net, Neural Inhibition, Synaptic Transmission, Neuronal Plasticity, Excitatory Postsynaptic Potentials

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