MAPK cascade signalling and synaptic plasticity

Thomas, Gareth M.; Huganir, Richard L.

doi:10.1038/nrn1346

Cited by 1,454Neuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase SignalingMemory and Neural Mechanisms

MAPK cascade signalling and synaptic plasticity

Thomas, Gareth M., Huganir, Richard L.·2004·Nature Reviews Neuroscience

DOI 10.1038/nrn1346

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Activity of receptor tyrosine kinases, metabotropic glutamic receptors and NMDA receptors leads to activation of PI3K/AKT and RAS/ERK signaling pathways, and thereby influences synaptic plasticity by mediating expression and trafficking of AMPA receptors in excitatory synapses and controlling LTD and LTP responses.
“Activity of receptor tyrosine kinases, metabotropic glutamic receptors and NMDA receptors lead to the activation of PI3K/AKT and RAS/ERK signaling pathways [185, 189], and thereby influence synaptic plasticity by mediating expression and trafficking of AMPA receptors in excitatory synapses and controlling long-term depression (LTD) and long-term potentiation (LTP) responses [188–190].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [188]
PI3K/AKT, RAS/ERK, WNT and β-catenin pathways control soma size, dendritic arborization, axon generation, spine development and synapse function.
“These pathways control soma size, dendritic arborization, axon generation, spine development and synapse function [184–188].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [188]

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Dopamine: Functions, Signaling, and Association with Neurological Diseases
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TrkB signalling pathways in LTP and learning
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Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum
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Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice
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Negative feedback regulation of the ERK1/2 MAPK pathway
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Epigenetic mechanisms in cognition
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Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking
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Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex
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Molecular mechanisms underlying emotional learning and memory in the lateral amygdala
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Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2
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Dynorphin, stress, and depression
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Nuclear RNA-seq of single neurons reveals molecular signatures of activation
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Different Neuronal Activity Patterns Induce Different Gene Expression Programs
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The ASK1-MAP Kinase Cascades in Mammalian Stress Response
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The ASD Living Biology: from cell proliferation to clinical phenotype
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Regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit
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Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking
Land, B. B., Bruchas, M. R., Schattauer, S., Giardino, W. J., Aita, M., Messinger, D., Hnasko, T. S., Palmiter, R. D., & Chavkin, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910705106 · Cited by 301 · see citing works
Insular Cortex is Critical for the Perception, Modulation, and Chronification of Pain
Lu, C., Yang, T., Zhao, H., Zhang, M., Meng, F., Fu, H., Xie, Y., & Xu, H. (2016) · Neuroscience Bulletin · doi:10.1007/s12264-016-0016-y · Cited by 270 · see citing works
Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP
Araki, Y., Zeng, M., Zhang, M., & Huganir, R. L. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.023 · Cited by 271 · see citing works
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SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons
Rumbaugh, G., Adams, J. P., Kim, J. H., & Huganir, R. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600084103 · Cited by 260 · see citing works
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AMPA receptors are exocytosed in stimulated spines and adjacent dendrites in a Ras-ERK-dependent manner during long-term potentiation
Patterson, M. A., Szatmari, E. M., & Yasuda, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913875107 · Cited by 259 · see citing works
Activity-Dependent Regulation of Synaptic AMPA Receptor Composition and Abundance by β3 Integrins
Cingolani, L. A., Thalhammer, A., Yu, L. M. Y., Catalano, M., Ramos, T., Colicos, M. A., & Goda, Y. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.011 · Cited by 223 · see citing works
Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction
Tong, L., Balazs, R., Soiampornkul, R., Thangnipon, W., & Cotman, C. W. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.02.027 · Cited by 222 · see citing works
Neuroendocrinology of social information processing in rats and mice
Choleris, E., Clipperton-Allen, A. E., Phan, A., & Kavaliers, M. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.003 · Cited by 205 · see citing works
DYRK1A, a dosage-sensitive gene involved in neurodevelopmental disorders, is a target for drug development in down syndrome
Duchon, A., & Herault, Y. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00104 · Cited by 181 · see citing works
ERK2 Contributes to the Control of Social Behaviors in Mice
Satoh, Y., Endo, S., Nakata, T., Kobayashi, Y., Yamada, K., Ikeda, T., Takeuchi, A., Hiramoto, T., Watanabe, Y., & Kazama, T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2349-11.2011 · Cited by 145 · see citing works
Transcriptional regulation in the rat prefrontal cortex and hippocampus after a single administration of psilocybin
Jefsen, O. H., Elfving, B., Wegener, G., & Müller, H. K. (2021) · Journal of Psychopharmacology · doi:10.1177/0269881120959614 · Cited by 127 · see citing works
Egr3, a synaptic activity regulated transcription factor that is essential for learning and memory
Li, L., Yun, S. H., Keblesh, J., Trommer, B. L., Xiong, H., Radulovic, J., & Tourtellotte, W. G. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.02.004 · Cited by 124 · see citing works
Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila
Jacob, P. F., & Waddell, S. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.013 · Cited by 112 · see citing works
The Acquisition of Goal-Directed Actions Generates Opposing Plasticity in Direct and Indirect Pathways in Dorsomedial Striatum
Shan, Q., Ge, M., Christie, M. J., & Balleine, B. W. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0313-14.2014 · Cited by 122 · see citing works
A Circadian Genomic Signature Common to Ketamine and Sleep Deprivation in the Anterior Cingulate Cortex
Orozco-Solis, R., Montellier, E., Aguilar-Arnal, L., Sato, S., Vawter, M. P., Bunney, B. G., Bunney, W. E., & Sassone-Corsi, P. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.1176 · Cited by 119 · see citing works
Supramolecular Nanostructure Activates TrkB Receptor Signaling of Neuronal Cells by Mimicking Brain-Derived Neurotrophic Factor
Edelbrock, A. N., Àlvarez, Z., Simkin, D., Fyrner, T., Chin, S. M., Sato, K., Kiskinis, E., & Stupp, S. I. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b02317 · Cited by 103 · see citing works
Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism
Kim, J.-W., Seung, H., Kim, K. C., Gonzales, E. L. T., Oh, H. A., Yang, S. M., Ko, M. J., Han, S.-H., Banerjee, S., & Shin, C. Y. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.09.014 · Cited by 102 · see citing works
Cognitive profile of disorders associated with dysregulation of the RAS/MAPK signaling cascade
Cesarini, L., Alfieri, P., Pantaleoni, F., Vasta, I., Cerutti, M., Petrangeli, V., Mariotti, P., Leoni, C., Ricci, D., Vicari, S., et al. (2009) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32488 · Cited by 98 · see citing works
Molecular and functional signatures in a novel Alzheimer’s disease mouse model assessed by quantitative proteomics
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Authors: Thomas, G. M., & Huganir, R. L.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Thomas, Gareth M.
Huganir, Richard L.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2004-03
Volume: 5
Issue: 3
Pages: 173-183
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn1346
OpenAlex: W2075361934
Cited by: 1,454
References: 130
Citations by year: 2026: 57 · 2025: 43 · 2024: 42 · 2023: 41 · 2022: 38 · 2021: 58 · 2020: 51 · 2019: 59 · 2018: 75 · 2017: 70 · 2016: 69 · 2015: 75 · 2014: 83 · 2013: 77 · 2012: 80
FWCI: 7.06
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: MAPK signaling, ERK1/ERK2, p38 MAPK, synaptic plasticity, kinase signaling, adult brain, cell proliferation, cell differentiation
MeSH terms: Animals, Cytoskeletal Proteins, Enzyme Activation, Humans, Learning, Memory, Synaptic Transmission, Neuronal Plasticity, Neurons, Cyclic AMP Response Element-Binding Protein, Long-Term Potentiation, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, p38 Mitogen-Activated Protein Kinases

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