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White matter hyperintensities and within-person variability in community-dwelling adults aged 60–64 years
Abstract
Estimates of white matter hyperintensities (WMH) derived from T2-weighted MRI were investigated in relation to cognitive performance in 469 healthy community-dwelling adults aged 60-64 years. Frontal lobe WMH but not WMH from other brain regions (temporal, parietal, and occipital lobes, anterior and posterior horn, periventricular body) were associated with elevated within-person reaction time (RT) variability (trial to trial fluctuations in RT performance) but not performance on several other cognitive tasks including psychomotor speed, memory, and global cognition. The findings are consistent with the view that elevated within-person variability is related to neurobiological disturbance, and that attentional mechanisms supported by the frontal cortex play a key role in this type of variability.
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Reaction time variability is associated with a higher proportion of white matter hyperintensities across frontal regions.
“Finally, RTV has been associated with a higher proportion of white matter hyperintensities (i.e., small regions of high intensity observed on magnetic resonance imaging) across the frontal regions [61].”
From Reaction Time Variability in ADHD: A Review (2012) · cites this paper as [61]
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Reaction Time Variability in ADHD: A Review
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Metadata
- Authors
- BUNCE, D., ANSTEY, K., CHRISTENSEN, H., DEAR, K., WEN, W., & SACHDEV, P.
- Affiliations
- Brunel University of London (GB)
- Australian National University (AU)
- UNSW Sydney (AU)
- Corresponding author
- BUNCE, D
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2007
- Volume
- 45
- Issue
- 9
- Pages
- 2009-2015
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W2011352093
- Cited by
- 126
- References
- 40
- Citations by year
- 2025: 6 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 8 · 2016: 7 · 2015: 12 · 2014: 8 · 2013: 11 · 2012: 9
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Brunel University Research Archive (BURA) (Brunel University London) (submittedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrovascular and genetic disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- white matter hyperintensities, within-person variability, reaction time variability, frontal lobe, cognitive performance, attention, older adults, community-dwelling adults, T2-weighted MRI, psychomotor speed, memory
- MeSH terms
- Attention, Brain Mapping, Cognition, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Psychomotor Performance, Reaction Time, Regression Analysis, Residence Characteristics
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