The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.
Perceived social support moderates the link between threat-related amygdala reactivity and trait anxiety
Open accessAbstract
Several lines of research have illustrated that negative environments can precipitate psychopathology, particularly in the context of relatively increased biological risk, while social resources can buffer the effects of these environments. However, little research has examined how social resources might buffer proximal biological risk for psychopathology or the neurobiological pathways through which such buffering may be mediated. Here we report that the expression of trait anxiety as a function of threat-related amygdala reactivity is moderated by perceived social support, a resource for coping with adversity. A significant positive correlation between amygdala reactivity and trait anxiety was evident in individuals reporting below average levels of support but not in those reporting average or above average levels. These results were consistent across multiple measures of trait anxiety and were specific to anxiety in that they did not extend to measures of broad negative or positive affect. Our findings illuminate a biological pathway, namely moderation of amygdala-related anxiety, through which social support may confer resilience to psychopathology. Moreover, our results indicate that links between neural reactivity and behavior are not static but rather may be contingent on social resources.
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“Fewer studies have demonstrated these relations with anxiety as well, but the observed effects parallel the findings with depression.16–20”
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Citations
Cites
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
Stress, social support, and the buffering hypothesis
Cohen, S., & Wills, T. A. (1985) · Psychological Bulletin · doi:10.1037/0033-2909.98.2.310 · Cited by 18,093 · cited 2×
“…neighbors, community members) that are available in times of need and can provide resources such as emotional support (someone to communicate with), companionship (someone to spend time and share activities with), and instrumental aid (financial and material resources; Cohen & Wills, 1985).”
BackgroundMethodOrdinary magic: Resilience processes in development.
Masten, A. S. (2001) · American Psychologist · doi:10.1037/0003-066x.56.3.227 · Cited by 8,497 · cited 2×
“Partly in response to the work emphasizing the harmful psychological effects of negative environments, resiliency research has explored factors that may buffer against negative environments and biological risk leading to positive outcomes even in unfavorable environments (Cohen & Hoberman, 1983; Masten, 2001; Masten &…”
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · cited 3×
“…of stressful or adverse circumstances in precipitating psychopathology, particularly in relation to individual differences in personality, brain function, and genetic predisposition (Caspi, Hariri, Holmes, Uher, & Moffitt, 2010; Caspi et al., 2003; Costello et al., 2002; Monroe & Simons, 1991).”
BackgroundA psychobiological model of temperament and character
Cloninger, C. R. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820240059008 · Cited by 5,458
Preacher, K. J., Curran, P. J., & Bauer, D. J. (2006) · Journal of Educational and Behavioral Statistics · doi:10.3102/10769986031004437 · Cited by 5,044 · cited 1×
“By using interaction methods described above (Preacher et al., 2006), we were able to determine at what values of social support the relationship between left dorsal amygdala reactivity and the latent construct of anxiety became significant.”
MethodRole of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842 · cited 2×
“, genetic polymorphisms) do not uniformly affect behavior in the form of increased risk for psychopathology (Caspi et al., 2002; Caspi et al., 2003), the current study emphasizes that similarly meaningful interactions may occur at the level of more proximate biology (i.”
BackgroundEkman, P. (1976) · Medical Entomology and Zoology · Cited by 4,345
Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979 · cited 2×
“In general, epidemiological studies have reported increased risk for psychopathology, particularly mood and anxiety disorders, in individuals having encountered a variety of adverse or stressful situations including childhood maltreatment, violent crime, divorce, unemployment, and medical illness (Hammen, 2005; Kendle…”
BackgroundPositive Events and Social Supports as Buffers of Life Change Stress 1
Cohen, S., & Hoberman, H. M. (1983) · Journal of Applied Social Psychology · doi:10.1111/j.1559-1816.1983.tb02325.x · Cited by 2,675
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Pluess, M. (2015) · Child Development Perspectives · doi:10.1111/cdep.12120 · Cited by 556
What is a representative brain? Neuroscience meets population science
Falk, E. B., Hyde, L. W., Mitchell, C., Faul, J., Gonzalez, R., Heitzeg, M. M., Keating, D. P., Langa, K. M., Martz, M. E., Maslowsky, J., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310134110 · Cited by 265
Multilocus Genetic Profile for Dopamine Signaling Predicts Ventral Striatum Reactivity
Nikolova, Y. S., Ferrell, R. E., Manuck, S. B., & Hariri, A. R. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.82 · Cited by 274
Dour, H. J., Wiley, J. F., Roy-Byrne, P., Stein, M. B., Sullivan, G., Sherbourne, C. D., Bystritsky, A., Rose, R. D., & Craske, M. G. (2014) · Depression and Anxiety · doi:10.1002/da.22216 · Cited by 243
Servaas, M. N., van der Velde, J., Costafreda, S. G., Horton, P., Ormel, J., Riese, H., & Aleman, A. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.05.005 · Cited by 208
Metadata
- Authors
- Hyde, L. W., Gorka, A., Manuck, S. B., & Hariri, A. R.
- Affiliations
- University of Pittsburgh (US)
- Duke University (US)
- Corresponding author
- Hyde, Luke W.
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 49
- Issue
- 4
- Pages
- 651-656
- ISSN
- 0028-3932 (ISSN-L)
- PMC
- PMC3026865
- OpenAlex
- W2062947524
- Cited by
- 188
- References
- 49
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 15 · 2020: 42 · 2019: 13 · 2018: 3 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 14 · 2013: 12 · 2012: 13
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (HL040962, HL065137, MH072837)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- perceived social support, amygdala reactivity, trait anxiety, moderation, resilience, psychopathology, biological risk, social buffering, neural reactivity
- MeSH terms
- Adaptation, Psychological, Adult, Aggression, Amygdala, Anxiety, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Social Support, Temperament
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