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Perceived social support moderates the link between threat-related amygdala reactivity and trait anxiety
Open accessAbstract
Several lines of research have illustrated that negative environments can precipitate psychopathology, particularly in the context of relatively increased biological risk, while social resources can buffer the effects of these environments. However, little research has examined how social resources might buffer proximal biological risk for psychopathology or the neurobiological pathways through which such buffering may be mediated. Here we report that the expression of trait anxiety as a function of threat-related amygdala reactivity is moderated by perceived social support, a resource for coping with adversity. A significant positive correlation between amygdala reactivity and trait anxiety was evident in individuals reporting below average levels of support but not in those reporting average or above average levels. These results were consistent across multiple measures of trait anxiety and were specific to anxiety in that they did not extend to measures of broad negative or positive affect. Our findings illuminate a biological pathway, namely moderation of amygdala-related anxiety, through which social support may confer resilience to psychopathology. Moreover, our results indicate that links between neural reactivity and behavior are not static but rather may be contingent on social resources.
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“Fewer studies have demonstrated these relations with anxiety as well, but the observed effects parallel the findings with depression.16–20”
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BackgroundInfluentialHariri, A. R., Gorka, A. X., Hyde, L. W., Kimak, M. A., Halder, I., Ducci, F., Ferrell, R. E., Goldman, D. A., & Manuck, S. B. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.047 · Cited by 264 · cited 2×
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BackgroundMethodManuck, S. B., Marsland, A. L., Flory, J. D., Gorka, A. X., Ferrell, R. E., & Hariri, A. R. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.013 · Cited by 119 · cited 6×
“…paradigm which elicits robust bilateral amygdala reactivity to threat-related cues (Bigos et al., 2008; Brown et al., 2005; Fakra et al., 2009; Fisher et al., 2009; Fisher, Meltzer, Ziolko, Price, & Hariri, 2006; Hariri et al., 2009; Manuck, Brown, Forbes, & Hariri, 2007; Manuck et al., 2010).”
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Metadata
- Authors
- Hyde, L. W., Gorka, A., Manuck, S. B., & Hariri, A. R.
- Affiliations
- University of Pittsburgh (US)
- Duke University (US)
- Corresponding author
- Hyde, Luke W.
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 49
- Issue
- 4
- Pages
- 651-656
- ISSN
- 0028-3932 (ISSN-L)
- PMC
- PMC3026865
- OpenAlex
- W2062947524
- Cited by
- 188
- References
- 49
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 15 · 2020: 42 · 2019: 13 · 2018: 3 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 14 · 2013: 12 · 2012: 13
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (HL040962, HL065137, MH072837)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- perceived social support, amygdala reactivity, trait anxiety, moderation, resilience, psychopathology, biological risk, social buffering, neural reactivity
- MeSH terms
- Adaptation, Psychological, Adult, Aggression, Amygdala, Anxiety, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Social Support, Temperament
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