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Perceived social support moderates the link between threat-related amygdala reactivity and trait anxiety
Open accessAbstract
Several lines of research have illustrated that negative environments can precipitate psychopathology, particularly in the context of relatively increased biological risk, while social resources can buffer the effects of these environments. However, little research has examined how social resources might buffer proximal biological risk for psychopathology or the neurobiological pathways through which such buffering may be mediated. Here we report that the expression of trait anxiety as a function of threat-related amygdala reactivity is moderated by perceived social support, a resource for coping with adversity. A significant positive correlation between amygdala reactivity and trait anxiety was evident in individuals reporting below average levels of support but not in those reporting average or above average levels. These results were consistent across multiple measures of trait anxiety and were specific to anxiety in that they did not extend to measures of broad negative or positive affect. Our findings illuminate a biological pathway, namely moderation of amygdala-related anxiety, through which social support may confer resilience to psychopathology. Moreover, our results indicate that links between neural reactivity and behavior are not static but rather may be contingent on social resources.
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“In terms of social support and anxiety, it appears that social support is a protective factor against the development and expression of anxiety.(71,72) Thus, complete lack of support, as measured by lack of a confidant, is very strongly associated with GAD.”
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Xiao, M., Chen, X., Yi, H., Luo, Y., Yan, Q., Feng, T., He, Q., Lei, X., Qiu, J., & Chen, H. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100418 · Cited by 22
“According to the stress-buffering hypothesis (Cohen and McKay, 2020; Cohen and Wills, 1985), social support moderates the relationship between NA or stress and the physiological reaction (Giesbrecht et al., 2013; Puterman et al., 2014), such as the amygdala action (Hyde et al., 2011).”
Swartz, J. R., Knodt, A. R., Radtke, S. R., & Hariri, A. R. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.12.019 · Cited by 21
Zhong, G., Shu, Y., Zhou, Y., Li, H., Zhou, J., & Yang, L. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06615-8 · Cited by 29
“According to the buffering theory of social support, when individuals face stress or emotional distress, support from social relationships can effectively alleviate negative emotions [42].”
Cultural neuroscience: new directions as the field matures
Hyde, L. W., Tompson, S., Creswell, J. D., & Falk, E. B. (2015) · Culture and Brain · doi:10.1007/s40167-014-0024-6 · Cited by 23
“…and Sasaki 2012, 2014; Kitayama et al. 2014) and the moderating effect of culture on many brain-behavior links (Chiao et al. 2010; Han et al. 2013; Hyde et al. 2011), an emerging emphasis in cultural neuroscience will be merging brain–culture and gene–culture interactions into broader integrative…”
BackgroundInfluentialRabelo, D. F., & Neri, A. L. (2015) · Revista Brasileira de Geriatria e Gerontologia · doi:10.1590/1809-9823.2015.14120 · Cited by 22
Pedersen, W. S., Muftuler, L. T., & Larson, C. L. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.05.009 · Cited by 20
“…study found that the correlation between trait anxiety and amygdala reactivity only exists for participants who are low in perceived social support (Hyde et al., 2011), and a study using an adolescent sample found that amygdala reactivity to facial expressions only correlated with social…”
Pagni, B. A., Hill, E., Walsh, M. J. M., Delaney, S., Ogbeama, D., Monahan, L., Cook, J. R., Guerithault, N., Dixon, M. V., Ballard, L., et al. (2023) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.220159 · Cited by 20
“31,32”
Lewis, G. J., Bates, T. C., Posthuma, D., & Polderman, T. J. C. (2013) · Journal of Personality · doi:10.1111/jopy.12064 · Cited by 23
Neural Effects of the Social Environment
Krabbendam, L., Hooker, C. I., & Aleman, A. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt233 · Cited by 21
Corr, R., Glier, S., Bizzell, J., Pelletier‐Baldelli, A., Campbell, A., Killian-Farrell, C., & Belger, A. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab129 · Cited by 21
Parental control and adolescents’ bullying victimization: the moderating role of teacher support
Ren, P., Yang, L., Chen, C., & Luo, F. (2022) · Current Psychology · doi:10.1007/s12144-022-03864-8 · Cited by 18
“When adolescents are in stressful or unfavorable situations (e.g., under high parental psychological control), teacher support might satisfy adolescents’ security needs to counteract pos - sible negative impacts (Hyde et al., 2011).”
BackgroundA complexidade emocional dos relacionamentos intergeracionais e a saúde mental dos idosos
Rabelo, D. F., & Neri, A. L. (2014) · Pensando familias · Cited by 18
Robinson, M. D., & Sedikides, C. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.031 · Cited by 18
The Five-Factor Model of Personality: Consensus and Controversy
McCrae, R. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.013 · Cited by 20
Grisanzio, K. A., Flournoy, J. C., Mair, P., & Somerville, L. H. (2022) · Emotion · doi:10.1037/emo0001079 · Cited by 16
The association among neighborhood mutual support, well-being, and social work
Yang, H., Zhang, W., Wu, Y., Yao, Y.-D., & Su, M. (2022) · Journal of Social Work · doi:10.1177/14680173221093511 · Cited by 16
“First, regarding the formation of social support, frequent and effective neighborhood mutual support facilitates the formation of supportive social relations, which positively affects mental health (Hyde et al., 2011).”
BackgroundWang, J., Wang, X., Li, P., Zhang, M., Wu, H.-Y., Li, D.-L., Fang, M., & Chi, X. (2022) · Current Psychology · doi:10.1007/s12144-022-03783-8 · Cited by 14
“…effect on both physical and mental health (House et al., 1988); the buffering model of social support suggests that good social support can buffer the negative effects of stressful events (Aneshensel & Stone, 1982), which can improve physical and mental health indi - rectly (Hyde et al., 2011).”
BackgroundZhu, L., Zheng, D., Li, R., Shen, C.-J., Cai, R., Lyu, C., Tang, B., Sun, H. X., Wang, X., Ding, Y., et al. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01081-2 · Cited by 15
“The amygdala is crucial for regulating emotions [1–5] and plays a pivotal role in the pathophysiology of various mental diseases, such as depression [6, 7], social fear [8], and anxiety [9, 10].”
BackgroundAvaliação das Relações Familiares por Idosos com Diferentes Condições Sociodemograficas e de Saúde
Rabelo, D. F., & Neri, A. L. (2016) · Psico-USF · doi:10.1590/1413-82712016210318 · Cited by 14
Wang, B., Zhong, X., Fu, H., Hu, R., He, M., & Zhang, G. (2022) · Scientific Reports · doi:10.1038/s41598-022-25126-0 · Cited by 15
Wang, L., Yu, J., Diao, X., Zhang, Y., Miao, Y., & He, W. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1400267 · Cited by 14
Vidal, C., Silverman, J. R., Petrillo, E. K., & Lilly, F. R. W. (2019) · The Social Science Journal · doi:10.1016/j.soscij.2019.08.008 · Cited by 15
Magal, N., Hendler, T., & Admon, R. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100361 · Cited by 15
“…brain regions, particularly the hippocampus, amygdala, and anterior cingulate cortex (ACC) (Allen and DeYoung, 2016; Brown et al., 2020; Canli, 2008; Chan et al., 2009; Cunningham et al., 2011; Haas et al., 2007; Hyde et al., 2011; Ormel et al., 2013; Schuyler et al., 2014; Servaas et al., 2013).”
BackgroundDeng, K., Jin, W., Jiang, K., Li, Z., Im, H., Chen, S., Du, H., Guan, S., Ge, W. H., Wei, C., et al. (2023) · Behavioral and Brain Functions · doi:10.1186/s12993-023-00223-w · Cited by 13
“The reactivity of the amygdala to negative stimuli has been shown to predict improvements in major depression [11], depressive symptoms 2 years later [48], trait anxiety [32], cannabis use 5 years later [80], psychological vulnerability to future life stress [84], and psychological well-being [90].”
BackgroundThe future of neuroscience in developmental psychopathology
Hyde, L. W., Bezek, J. L., & Michael, C. (2024) · Development and Psychopathology · doi:10.1017/s0954579424000233 · Cited by 14
Qi, Y., Bruch, D., Krop, P., Herrmann, M. J., Latoschik, M. E., Deckert, J., & Hein, G. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01761-5 · Cited by 18
“, stronger social buffering effects [9, 12, 13].”
Prediction Along a Developmental Perspective in Psychiatry: How Far Might We Go?
Nees, F., Deserno, L., Holz, N. E., Romanos, M., & Banaschewski, T. (2021) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2021.670404 · Cited by 13
Social support and fear-inhibition: an examination of underlying neural mechanisms
Hornstein, E. A., Leschak, C. J., Parrish, M. H., Haltom, K. E. B., Fanselow, M. S., Craske, M. G., & Eisenberger, N. I. (2024) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsae002 · Cited by 12
“…a buffering effect of social support on anxiety in the left amygdala; while greater left amygdala activity is related to greater levels of anxiety in those with lower levels of social support, for those with high levels of social support, this relationship is non-significant (Hyde et al. , 2011).”
BackgroundEvolutionary Personality Psychology
Lewis, D. M. G., Al-Shawaf, L., & Buss, D. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.022 · Cited by 11
The School: A Setting for Evidence-Based Prevention Interventions and Policies
Sloboda, Z., & Ringwalt, C. L. (2019) · Advances in prevention science · doi:10.1007/978-3-030-00627-3_9 · Cited by 10
Metadata
- Authors
- Hyde, L. W., Gorka, A., Manuck, S. B., & Hariri, A. R.
- Affiliations
- University of Pittsburgh (US)
- Duke University (US)
- Corresponding author
- Hyde, Luke W.
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 49
- Issue
- 4
- Pages
- 651-656
- ISSN
- 0028-3932 (ISSN-L)
- PMC
- PMC3026865
- OpenAlex
- W2062947524
- Cited by
- 188
- References
- 49
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 15 · 2020: 42 · 2019: 13 · 2018: 3 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 14 · 2013: 12 · 2012: 13
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (HL040962, HL065137, MH072837)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- perceived social support, amygdala reactivity, trait anxiety, moderation, resilience, psychopathology, biological risk, social buffering, neural reactivity
- MeSH terms
- Adaptation, Psychological, Adult, Aggression, Amygdala, Anxiety, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Social Support, Temperament
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