The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Sleep-dependent motor memory plasticity in the human brain
Abstract
Growing evidence indicates a role for sleep in off-line memory processing, specifically in post-training consolidation. In humans, sleep has been shown to trigger overnight learning on a motor-sequence memory task, while equivalent waking periods produce no such improvement. But while the behavioral characteristics of sleep-dependent motor learning become increasingly well characterized, the underlying neural basis remains unknown. Here we present functional magnetic resonance imaging data demonstrating a change in the representation of a motor memory after a night of sleep. Subjects trained on a motor-skill memory and 12 hours later, after either sleep or wake, were retested during functional magnetic resonance imaging. Following sleep relative to wake, regions of increased activation were expressed in the right primary motor cortex, medial prefrontal lobe, hippocampus and left cerebellum; changes that can support faster motor output and more precise mapping of key-press movements. In contrast, signal decreases were identified in parietal cortices, the left insular cortex, temporal pole and fronto-polar region, reflecting a reduced need for conscious spatial monitoring and a decreased emotional task burden. This evidence of an overnight, systems-level change in the representation of a motor memory holds important implications for acquiring real-life skills and in clinical rehabilitation following brain trauma, such as stroke.
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“Finally, sleep-dependent changes in brain activity indicative for a reorganization of memory representations have also been reported for procedural tasks like sequences finger tapping and visual texture discrimination (384, 1292, 1293).”
From About Sleep's Role in Memory (2013) · cites this paper as [1292]
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Statistical parametric maps in functional imaging: A general linear approach
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Functional MRI evidence for adult motor cortex plasticity during motor skill learning
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Practice with Sleep Makes Perfect
Walker, M. P., Brakefield, T., Morgan, A., Hobson, J. A., & Stickgold, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00746-8 · Cited by 1,307
Self-citationSleep-Dependent Learning and Memory Consolidation
Walker, M. P., & Stickgold, R. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.031 · Cited by 1,113 · cited 1×
“A large body of evidence, spanning a wide range of neuroscientific disciplines, now describes evidence of sleepdependent learning in both humans and animals (Walker and Stickgold, 2004), already complemented by cellular and molecular models of sleep-dependent plasticity (Graves et al.”
Self-citationThe role of the anterior prefrontal cortex in human cognition
Koechlin, É., Basso, G., Pietrini, P., Panzer, S., & Grafman, J. H. (1999) · Nature · doi:10.1038/20178 · Cited by 1,046
Dissociable stages of human memory consolidation and reconsolidation
Walker, M. P., Brakefield, T., Allan Hobson, J., & Stickgold, R. (2003) · Nature · doi:10.1038/nature01930 · Cited by 1,025
Self-citationDependence on REM Sleep of Overnight Improvement of a Perceptual Skill
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
Sleep-dependent memory consolidation
Stickgold, R. (2005) · Nature · doi:10.1038/nature04286 · Cited by 1,857
Self-citationAn opportunity cost model of subjective effort and task performance
Kurzban, R., Duckworth, A., Kable, J. W., & Myers, J. (2013) · Behavioral and Brain Sciences · doi:10.1017/s0140525x12003196 · Cited by 1,381
Walker, M. P., & Stickgold, R. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070307 · Cited by 1,075
Self-citationContributions of the basal ganglia and functionally related brain structures to motor learning
Doyon, J., Bellec, P., Amsel, R., Penhune, V., Monchi, O., Carrier, J., Lehéricy, S., & Benali, H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.012 · Cited by 783
Metadata
- Authors
- Walker, M. P., Stickgold, R., Alsop, D., Gaab, N., & Schlaug, G.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Walker, M.P.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 133
- Issue
- 4
- Pages
- 911-917
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2067545381
- Cited by
- 308
- References
- 45
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 9 · 2023: 11 · 2022: 6 · 2021: 9 · 2020: 13 · 2019: 7 · 2018: 7 · 2017: 19 · 2016: 25 · 2015: 8 · 2014: 27 · 2013: 23 · 2012: 13
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R21MH067754, R01MH065292, MH69935, MH-48832, R03MH069935, R01MH048832, MH 65292, MH67754)
- National Institute of Neurological Disorders and Stroke (NS 45049, R01NS045049)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- sleep-dependent memory consolidation, motor memory, motor learning, primary motor cortex, hippocampus, cerebellum, medial prefrontal cortex, motor sequence learning, stroke rehabilitation, traumatic brain injury
- MeSH terms
- Adult, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Motor Skills, Neuronal Plasticity, Oxygen, Sleep, Wakefulness
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