The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.
Density and morphology of dendritic spines in mouse neocortex.
Abstract
Dendritic spines of pyramidal cells are the main postsynaptic targets of cortical excitatory synapses and as such, they are fundamental both in neuronal plasticity and for the integration of excitatory inputs to pyramidal neurons. There is significant variation in the number and density of dendritic spines among pyramidal cells located in different cortical areas and species, especially in primates. This variation is believed to contribute to functional differences reported among cortical areas. In this study, we analyzed the density of dendritic spines in the motor, somatosensory and visuo-temporal regions of the mouse cerebral cortex. Over 17,000 individual spines on the basal dendrites of layer III pyramidal neurons were drawn and their morphologies compared among these cortical regions. In contrast to previous observations in primates, there was no significant difference in the density of spines along the dendrites of neurons in the mouse. However, systematic differences in spine dimensions (spine head size and spine neck length) were detected, whereby the largest spines were found in the motor region, followed by those in the somatosensory region and those in visuo-temporal region.
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“Spine density varies significantly across diverse populations of neurons, likely reflecting the diversity of neuronal morphology and function (Nimchinsky et al., 2002; Ballesteros-Yanez et al., 2006).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Ballesteros-Yanez et al., 2006
In the citing paper
“Spine density varies significantly across diverse populations of neurons, likely reflecting the diversity of neuronal morphology and function (Nimchinsky et al., 2002; Ballesteros-Yanez et al., 2006).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Ballesteros-Yanez et al., 2006
Citations
Cites
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Structural basis of long-term potentiation in single dendritic spines
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Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563
Morphological Changes in Dendritic Spines Associated with Long-Term Synaptic Plasticity
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Structure-stability-function relationships of dendritic spines
Kasai, H., Matsuzaki, M., Noguchi, J., Yasumatsu, N., & Nakahara, H. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00162-0 · Cited by 847
Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus
Nusser, Z., Lujan, R., Laube, G., Roberts, J. D. B., Molnar, E., & Somogyi, P. (1998) · Neuron · doi:10.1016/s0896-6273(00)80565-6 · Cited by 804
The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines
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- Cajal, 1890, Textura de las circunvoluciones cerebrales de los mamíferos inferiores. Nota preventiva, Gac Méd Catalana, 1, 22
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Pyramidal neurons: dendritic structure and synaptic integration
Spruston, N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2286 · Cited by 1,688
Synaptic Islands Defined by the Territory of a Single Astrocyte
Halassa, M. M., Fellin, T., Takano, H., Dong, J.-H., & Haydon, P. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1419-07.2007 · Cited by 767
The Evolution of the Brain, the Human Nature of Cortical Circuits, and Intellectual Creativity
DeFelipe, J. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00029 · Cited by 527
Ultrastructure of dendritic spines: correlation between synaptic and spine morphologies
Arellano, J. I. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.010.2007 · Cited by 529
Principles of Long-Term Dynamics of Dendritic Spines
Yasumatsu, N., Matsuzaki, M., Miyazaki, T., Noguchi, J., & Kasai, H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0603-08.2008 · Cited by 321
Metadata
- Authors
- Ballesteros-Yáñez, I., Benavides-Piccione, R., Elston, G. N., Yuste, R., & DeFelipe, J.
- Affiliations
- The University of Queensland (AU)
- Columbia University (US)
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- DeFelipe, J.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2006
- Volume
- 138
- Issue
- 2
- Pages
- 403-409
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W1972821200
- Cited by
- 143
- References
- 49
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 15 · 2013: 11 · 2012: 8
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- dendritic spines, spine density, dendritic spine morphology, pyramidal neurons, layer III, mouse neocortex, motor cortex, somatosensory cortex, cortical regions, excitatory synapses, neuroplasticity
- MeSH terms
- Animals, Male, Mice, Inbred C57BL, Neuronal Plasticity, Pyramidal Cells, Neocortex, Dendritic Spines, Mice
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