Cited by 143Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersNeural dynamics and brain function

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Density and morphology of dendritic spines in mouse neocortex.

Ballesteros-Yáñez, I., Benavides-Piccione, R., Elston, G.N., Yuste, R., DeFelipe, J.·2006·Neuroscience

DOI 10.1016/j.neuroscience.2005.11.038

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Abstract

Dendritic spines of pyramidal cells are the main postsynaptic targets of cortical excitatory synapses and as such, they are fundamental both in neuronal plasticity and for the integration of excitatory inputs to pyramidal neurons. There is significant variation in the number and density of dendritic spines among pyramidal cells located in different cortical areas and species, especially in primates. This variation is believed to contribute to functional differences reported among cortical areas. In this study, we analyzed the density of dendritic spines in the motor, somatosensory and visuo-temporal regions of the mouse cerebral cortex. Over 17,000 individual spines on the basal dendrites of layer III pyramidal neurons were drawn and their morphologies compared among these cortical regions. In contrast to previous observations in primates, there was no significant difference in the density of spines along the dendrites of neurons in the mouse. However, systematic differences in spine dimensions (spine head size and spine neck length) were detected, whereby the largest spines were found in the motor region, followed by those in the somatosensory region and those in visuo-temporal region.

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Authors: Ballesteros-Yáñez, I., Benavides-Piccione, R., Elston, G. N., Yuste, R., & DeFelipe, J.
Affiliations: The University of Queensland (AU)
Columbia University (US)
Consejo Superior de Investigaciones Científicas (ES)
Corresponding author: DeFelipe, J.
ORCID: Yuste, R.
DeFelipe, J.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2006
Volume: 138
Issue: 2
Pages: 403-409
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2005.11.038
OpenAlex: W1972821200
Cited by: 143
References: 49
Citations by year: 2026: 3 · 2025: 8 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 15 · 2013: 11 · 2012: 8
FWCI: 2.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: dendritic spines, spine density, dendritic spine morphology, pyramidal neurons, layer III, mouse neocortex, motor cortex, somatosensory cortex, cortical regions, excitatory synapses, neuroplasticity
MeSH terms: Animals, Male, Mice, Inbred C57BL, Neuronal Plasticity, Pyramidal Cells, Neocortex, Dendritic Spines, Mice

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Density and morphology of dendritic spines in mouse neocortex.

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