The DOI matches its Crossref record; 116 of the 119 references it cites were found in a registry or an index.
Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development
Open accessAbstract
There has been a dramatic rise in gene x environment studies of human behavior over the past decade that have moved the field beyond simple nature versus nurture debates. These studies offer promise in accounting for more variability in behavioral and biological phenotypes than studies that focus on genetic or experiential factors alone. They also provide clues into mechanisms of modifying genetic risk or resilience in neurodevelopmental disorders. Yet, it is rare that these studies consider how these interactions change over the course of development. In this paper, we describe research that focuses on the impact of a polymorphism in a brain-derived neurotrophic factor (BDNF) gene, known to be involved in learning and development. Specifically we present findings that assess the effects of genotypic and environmental loadings on neuroanatomic and behavioral phenotypes across development. The findings illustrate the use of a genetic mouse model that mimics the human polymorphism, to constrain the interpretation of gene-environment interactions across development in humans.
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“These regulation difficulties have additionally been evidenced by increased internalizing (Casey, et al., 2009) and externalizing behaviors in some samples of children with a history of institutional care (see meta-analysis in Juffer & van Ijzendoorn, 2005) (although PI children show fewer internalizing and externalizing behavior problems than children adopted domestically).”
From Risk and developmental heterogeneity in previously institutionalized children (2012) · cites this paper as Casey, et al., 2009
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Yu, J., Pressoir, G., Briggs, W. H., Bi, I. V., Yamasaki, M., Doebley, J., McMullen, M. D., Gaut, B. S., Nielsen, D. M., Holland, J. B., et al. (2005) · Nature Genetics · doi:10.1038/ng1702 · Cited by 4,155
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00035-7 · Cited by 3,888
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,588
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217
Synaptic Activity and the Construction of Cortical Circuits
Katz, L. C., & Shatz, C. J. (1996) · Science · doi:10.1126/science.274.5290.1133 · Cited by 3,048
BIRMAHER, B., KHETARPAL, S., BRENT, D., CULLY, M., BALACH, L., KAUFMAN, J., & NEER, S. M. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199704000-00018 · Cited by 2,846
BIRMAHER, B., BRENT, D. A., CHIAPPETTA, L., BRIDGE, J., MONGA, S., & BAUGHER, M. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199910000-00011 · Cited by 2,252
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Research works printed but not linked: 2
- Magarinos AM, McEwen BS. Decreased hippocampal spine density as a morphological marker of chronically stressed adult male mice with intact neurotrophic support. Proceedings of the Society for Neuroscience 282.17/OO24, in press.
- Tottenham N Hare T, Quinn B, Nurse M, McCarry T, Galvan A, Davidson M, Thomas KM, McEwen B, Gunna M, Casey BJ. The effects of institutionalization on amygdala and hippocampal volumes. Dev Sci, in press.
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Jenks, B. G., Kuribara, M., Kidane, A. H., Kramer, B. M. R., Roubos, E. W., & Scheenen, W. J. J. M. (2012) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2012.01.001 · Cited by 4
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Escolano-Pérez, E., & Blanco-Villaseñor, Á. (2015) · Anales de Psicología · doi:10.6018/analesps.31.2.166361 · Cited by 4
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Cohen‐Gilbert, J. E., Stein, E., Gunnar, M. R., & Thomas, K. M. (2016) · The Journal of Early Adolescence · doi:10.1177/0272431616675975 · Cited by 3
Self-citationde Araújo, C. M., Swardfager, W., Zugman, A., Cogo‐Moreira, H., Belangero, S. I., Ota, V., Spíndola, L., Hakonarson, H. H., Pellegrino, R., Gadelha, A., et al. (2019) · CNS Spectrums · doi:10.1017/s1092852919001688 · Cited by 1
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Alonso, D. L. (2017) · Psychology and Behavioral Science International Journal · doi:10.19080/pbsij.2017.07.555712
Adkins, D. E. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/px1e-4x30
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Metadata
- Authors
- Casey, B. J., Glatt, C. E., Tottenham, N., Soliman, F., Bath, K., Amso, D., Altemus, M., Pattwell, S., Jones, R., Levita, L., McEwen, B., Magariños, A. M., Gunnar, M., Thomas, K. M., Mezey, J., Clark, A. G., Hempstead, B. L., & Lee, F. S.
- Affiliations
- Cornell University (US)
- Weill Cornell Medicine (US)
- Rockefeller University (US)
- University of Minnesota (US)
- Corresponding author
- Casey, B.J.
- ORCID
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 164
- Issue
- 1
- Pages
- 108-120
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC2760671
- OpenAlex
- W2000196263
- Cited by
- 129
- References
- 119
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 11 · 2016: 6 · 2015: 13 · 2014: 13 · 2013: 12 · 2012: 12
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH079513, R01MH073175, R01MH091864, R01 MH73175)
- National Institute of General Medical Sciences (T32GM007739)
- National Institute of Neurological Disorders and Stroke (R01NS052819)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- brain-derived neurotrophic factor, BDNF gene polymorphism, gene-environment interaction, developmental trajectories, genetic mouse models, behavioral phenotypes, neurodevelopmental disorders, learning and development
- MeSH terms
- Aging, Animals, Brain, Environment, Humans, Human Development, Models, Genetic, Phenotype, Polymorphism, Genetic, Brain-Derived Neurotrophic Factor, Mice
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