Cited by 129Neurotransmitter Receptor Influence on BehaviorGenetics and Neurodevelopmental DisordersGenetic Associations and Epidemiology

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Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development

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Casey, B.J., Glatt, C.E., Tottenham, N., Soliman, F., Bath, K., Amso, D., Altemus, M., Pattwell, S., Jones, R., Levita, L., McEwen, B., Magariños, A.M., Gunnar, M., Thomas, K.M., Mezey, J., Clark, A.G., Hempstead, B.L., Lee, F.S.·2009·Neuroscience

DOI 10.1016/j.neuroscience.2009.03.081PMC PMC2760671

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Abstract

There has been a dramatic rise in gene x environment studies of human behavior over the past decade that have moved the field beyond simple nature versus nurture debates. These studies offer promise in accounting for more variability in behavioral and biological phenotypes than studies that focus on genetic or experiential factors alone. They also provide clues into mechanisms of modifying genetic risk or resilience in neurodevelopmental disorders. Yet, it is rare that these studies consider how these interactions change over the course of development. In this paper, we describe research that focuses on the impact of a polymorphism in a brain-derived neurotrophic factor (BDNF) gene, known to be involved in learning and development. Specifically we present findings that assess the effects of genotypic and environmental loadings on neuroanatomic and behavioral phenotypes across development. The findings illustrate the use of a genetic mouse model that mimics the human polymorphism, to constrain the interpretation of gene-environment interactions across development in humans.

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Research works printed but not linked: 2

Magarinos AM, McEwen BS. Decreased hippocampal spine density as a morphological marker of chronically stressed adult male mice with intact neurotrophic support. Proceedings of the Society for Neuroscience 282.17/OO24, in press.
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Authors: Casey, B. J., Glatt, C. E., Tottenham, N., Soliman, F., Bath, K., Amso, D., Altemus, M., Pattwell, S., Jones, R., Levita, L., McEwen, B., Magariños, A. M., Gunnar, M., Thomas, K. M., Mezey, J., Clark, A. G., Hempstead, B. L., & Lee, F. S.
Affiliations: Cornell University (US)
Weill Cornell Medicine (US)
Rockefeller University (US)
University of Minnesota (US)
Corresponding author: Casey, B.J.
ORCID: Casey, B.J.
Tottenham, N.
Bath, K.
Amso, D.
Altemus, M.
Pattwell, S.
Jones, R.
Levita, L.
McEwen, B.
Magariños, A.M.
Gunnar, M.
Mezey, J.
Clark, A.G.
Hempstead, B.L.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2009-11
Volume: 164
Issue: 1
Pages: 108-120
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2009.03.081
PMC: PMC2760671
OpenAlex: W2000196263
Cited by: 129
References: 119
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 11 · 2016: 6 · 2015: 13 · 2014: 13 · 2013: 12 · 2012: 12
FWCI: 1.21
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (P50MH079513, R01MH073175, R01MH091864, R01 MH73175)
National Institute of General Medical Sciences (T32GM007739)
National Institute of Neurological Disorders and Stroke (R01NS052819)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: brain-derived neurotrophic factor, BDNF gene polymorphism, gene-environment interaction, developmental trajectories, genetic mouse models, behavioral phenotypes, neurodevelopmental disorders, learning and development
MeSH terms: Aging, Animals, Brain, Environment, Humans, Human Development, Models, Genetic, Phenotype, Polymorphism, Genetic, Brain-Derived Neurotrophic Factor, Mice

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Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development

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