The DOI matches its Crossref record; 116 of the 119 references it cites were found in a registry or an index.
Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development
Open accessAbstract
There has been a dramatic rise in gene x environment studies of human behavior over the past decade that have moved the field beyond simple nature versus nurture debates. These studies offer promise in accounting for more variability in behavioral and biological phenotypes than studies that focus on genetic or experiential factors alone. They also provide clues into mechanisms of modifying genetic risk or resilience in neurodevelopmental disorders. Yet, it is rare that these studies consider how these interactions change over the course of development. In this paper, we describe research that focuses on the impact of a polymorphism in a brain-derived neurotrophic factor (BDNF) gene, known to be involved in learning and development. Specifically we present findings that assess the effects of genotypic and environmental loadings on neuroanatomic and behavioral phenotypes across development. The findings illustrate the use of a genetic mouse model that mimics the human polymorphism, to constrain the interpretation of gene-environment interactions across development in humans.
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“These regulation difficulties have additionally been evidenced by increased internalizing (Casey, et al., 2009) and externalizing behaviors in some samples of children with a history of institutional care (see meta-analysis in Juffer & van Ijzendoorn, 2005) (although PI children show fewer internalizing and externalizing behavior problems than children adopted domestically).”
From Risk and developmental heterogeneity in previously institutionalized children (2012) · cites this paper as Casey, et al., 2009
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Research works printed but not linked: 2
- Magarinos AM, McEwen BS. Decreased hippocampal spine density as a morphological marker of chronically stressed adult male mice with intact neurotrophic support. Proceedings of the Society for Neuroscience 282.17/OO24, in press.
- Tottenham N Hare T, Quinn B, Nurse M, McCarry T, Galvan A, Davidson M, Thomas KM, McEwen B, Gunna M, Casey BJ. The effects of institutionalization on amygdala and hippocampal volumes. Dev Sci, in press.
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Knaepen, K., Goekint, M., Heyman, E. M., & Meeusen, R. (2010) · Sports Medicine · doi:10.2165/11534530-000000000-00000 · Cited by 882
Duman, R. S., & Voleti, B. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.004 · Cited by 714
A review of adversity, the amygdala and the hippocampus: a consideration of developmental timing
Tottenham, N. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.068.2009 · Cited by 651
Self-citationSignaling pathways underlying the rapid antidepressant actions of ketamine
Duman, R. S., Li, N., Liu, R.-J., Duric, V., & Aghajanian, G. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.044 · Cited by 537
Elevated amygdala response to faces following early deprivation
Tottenham, N., Hare, T. A., Millner, A., Gilhooly, T., Zevin, J. D., & Casey, B. J. (2011) · Developmental Science · doi:10.1111/j.1467-7687.2010.00971.x · Cited by 468
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Metadata
- Authors
- Casey, B. J., Glatt, C. E., Tottenham, N., Soliman, F., Bath, K., Amso, D., Altemus, M., Pattwell, S., Jones, R., Levita, L., McEwen, B., Magariños, A. M., Gunnar, M., Thomas, K. M., Mezey, J., Clark, A. G., Hempstead, B. L., & Lee, F. S.
- Affiliations
- Cornell University (US)
- Weill Cornell Medicine (US)
- Rockefeller University (US)
- University of Minnesota (US)
- Corresponding author
- Casey, B.J.
- ORCID
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 164
- Issue
- 1
- Pages
- 108-120
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC2760671
- OpenAlex
- W2000196263
- Cited by
- 129
- References
- 119
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 11 · 2016: 6 · 2015: 13 · 2014: 13 · 2013: 12 · 2012: 12
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH079513, R01MH073175, R01MH091864, R01 MH73175)
- National Institute of General Medical Sciences (T32GM007739)
- National Institute of Neurological Disorders and Stroke (R01NS052819)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- brain-derived neurotrophic factor, BDNF gene polymorphism, gene-environment interaction, developmental trajectories, genetic mouse models, behavioral phenotypes, neurodevelopmental disorders, learning and development
- MeSH terms
- Aging, Animals, Brain, Environment, Humans, Human Development, Models, Genetic, Phenotype, Polymorphism, Genetic, Brain-Derived Neurotrophic Factor, Mice
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