The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Behavioral control over shock blocks behavioral and neurochemical effects of later social defeat
Open accessAbstract
Experience with behavioral control over tailshock (escapable shock, ES) has been shown to block the behavioral and neurochemical changes produced by later uncontrollable tail shock (inescapable shock, IS). The present experiments tested, in rats, whether the protective effect of control over tailshock extends beyond reducing the behavioral and neurochemical impact of a subsequent tailshock experience to stressors that are quite different. Social defeat (SD) was chosen as the second stress experience because it has few if any cues in common with tailshock. SD produced shuttlebox escape learning deficits ("learned helplessness") and reduced juvenile social investigation 24 h later, as does IS. IS is notable for inducing a large increase in dorsal raphe nucleus (DRN) serotonergic (5-HT) activity as measured by extracellular levels of 5-HT within the DRN, and SD did so as well. ES occurring 7 days before SD blocked this SD-induced DRN activation, as well as the SD-induced interference with shuttlebox escape and reduction in social investigation. Prior exposure to yoked IS did not reduce the DRN 5-HT activation or later behavioral effects produced by SD, and thus the proactive stress-blunting effects of ES can be attributed to it's controllability. Thus, ES confers a very general protection to the impact of a subsequent stress experience.
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“Second, it is trans-situational and so inescapable shock in one situation blocks the passivity/anxiety caused by even stressors that do not involve shock in different situations.”
From Learned helplessness at fifty: Insights from neuroscience. (2016) · cites this paper as Amat et al. (2010)
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“For example, Amat et al. (2010) reported that experience with escapable shock blocked the passivity in shuttle escape and also blocked the reduced social investigation (anxiety) produced by social defeat occurring seven days later.”
From Learned helplessness at fifty: Insights from neuroscience. (2016) · cites this paper as Amat et al. (2010)
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“As would be expected, social defeat also increased dorsal raphe nucleus 5-HT activity, and this increase was prevented by the prior escapable shock (Amat et al., 2010).”
From Learned helplessness at fifty: Insights from neuroscience. (2016) · cites this paper as Amat et al., 2010
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Learned helplessness: Theory and evidence
Maier, S. F., & Seligman, M. E. (1976) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.105.1.3 · Cited by 2,494
Self-citationFailure to escape traumatic shock.
Seligman, M. E., & Maier, S. F. (1967) · Journal of Experimental Psychology · doi:10.1037/h0024514 · Cited by 1,981 · cited 1×
“As noted above, it has been known for some years that an initial experience with ES blocks the typical behavioral and neurochemical effects of later exposure to IS (Seligman & Maier, 1967; Williams & Maier, 1977).”
BackgroundSelf-citationDifferential projections of the infralimbic and prelimbic cortex in the rat
Vertes, R. P. (2004) · Synapse · doi:10.1002/syn.10279 · Cited by 1,550
The Psychobiology of Depression and Resilience to Stress: Implications for Prevention and Treatment
Southwick, S. M., Vythilingam, M., & Charney, D. S. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143948 · Cited by 1,160
Amat, J., Baratta, M. V., Paul, E., Bland, S. T., Watkins, L. R., & Maier, S. F. (2005) · Nature Neuroscience · doi:10.1038/nn1399 · Cited by 931
Self-citationGrahn, R. E., Will, M. J., Hammack, S. E., Maswood, S., McQueen, M. B., Watkins, L. R., & Maier, S. F. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01208-1 · Cited by 307
Self-citationAmat, J., Paul, E., Zarza, C., Watkins, L. R., & Maier, S. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3630-06.2006 · Cited by 249
Self-citationAmat, J., Sparks, P., Matus-Amat, P., Griggs, J., Watkins, L. R., & Maier, S. F. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02934-1 · Cited by 187
Self-citationJankowski, M. P., & Sesack, S. R. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.10976 · Cited by 186
Rueter, L. E., & Jacobs, B. L. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00809-8 · Cited by 183
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Sorted by citations
Learned helplessness at fifty: Insights from neuroscience.
Maier, S. F., & Seligman, M. E. P. (2016) · Psychological Review · doi:10.1037/rev0000033 · Cited by 1,031
“As would be expected, social defeat also increased dorsal raphe nucleus 5-HT activity, and this increase was prevented by the prior escapable shock (Amat et al., 2010).”
BackgroundSelf-citationStress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects
Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519
Stress, social behavior, and resilience: Insights from rodents
Beery, A. K., & Kaufer, D. (2014) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.004 · Cited by 394
Role of the medial prefrontal cortex in coping and resilience
Maier, S. F., & Watkins, L. R. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.039 · Cited by 292
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Metadata
- Authors
- Amat, J., Aleksejev, R. M., Paul, E., Watkins, L. R., & Maier, S. F.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Amat, J.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 165
- Issue
- 4
- Pages
- 1031-1038
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC2847505
- OpenAlex
- W1993727909
- Cited by
- 101
- References
- 30
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 5 · 2020: 9 · 2019: 9 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 4 · 2014: 8 · 2013: 7 · 2012: 7
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (MH 50479)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- escapable shock, inescapable shock, social defeat, stress resilience, learned helplessness, dorsal raphe nucleus, serotonin, social investigation, yoked control
- MeSH terms
- Animals, Behavior, Animal, Dominance-Subordination, Electroshock, Escape Reaction, Exploratory Behavior, Extracellular Space, Helplessness, Learned, Learning, Male, Raphe Nuclei, Serotonin, Stress, Psychological, Time Factors, Rats, Sprague-Dawley, Rats
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