Role of the medial prefrontal cortex in coping and resilience
Open accessAbstract
The degree of behavioral control that an organism has over an aversive event is well known to modulate the behavioral and neurochemical consequences of exposure to the event. Here we review recent research that suggests that the experience of control over a potent stressor alters how the organism responds to future aversive events as well as to the stressor being controlled. More specifically, subjects that have experienced control show blunted behavioral and neurochemical responses to subsequent stressors occurring days to months later. Indeed, these subjects respond as if a later uncontrollable stressor is actually controllable. Further, we review research indicating that the stress resistance induced by control depends on control-induced activation of ventral medial prefrontal cortical (vmPFC) inhibitory control over brainstem and limbic structures. Furthermore, there appears to be plasticity in these circuits such that the experience of control alters the vmPFC in such a way that later uncontrollable stressors now activate the vmPFC circuitry, leading to inhibition of stress-responsive limbic and brainstem structures, i.e., stressor resistance. This controllability-induced proactive stressor resistance generalizes across very different stressors and may be involved in determining individual difference in reactions to traumatic events.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
vmPFC inactivation abolishes all these benefits of control without affecting the learning of escape responses per se.
“vmPFC inactivation abolishes all these benefits of control without affecting the learning of escape responses per se.”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [42]
Control over shock speeds subsequent escape learning, slows subsequent fear conditioning, reduces threat-related serotonin responses in the dorsal raphe to novel contexts, and buffers animals against later adverse effects of inescapable shock.
“Control speeds subsequent escape learning [40] and slows subsequent fear conditioning [41], reduces threat-related serotonin responses in the dorsal raphe to novel contexts [40], and buffers the animals against later adverse effects of inescapable shock [42].”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [42]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803 · see citing works
Coping styles in animals: current status in behavior and stress-physiology
Koolhaas, J. M., Korte, S. M., De Boer, S. F., Van Der Vegt, B. J., Van Reenen, C. G., Hopster, H., De Jong, I. C., Ruis, M. A. W., & Blokhuis, H. J. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00026-3 · Cited by 2,875 · cited 1× · see citing works
“At the animal level investigators have generally distinguished between active and passive coping styles (Koolhaas et al., 1999).”
Learned helplessness: Theory and evidence
Maier, S. F., & Seligman, M. E. (1976) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.105.1.3 · Cited by 2,494 · see citing works
Self-citationFailure to escape traumatic shock.
Seligman, M. E., & Maier, S. F. (1967) · Journal of Experimental Psychology · doi:10.1037/h0024514 · Cited by 1,981 · cited 1× · see citing works
“…our laboratory directed at these questions derives from older reports indicating that a session of ES prevented a later exposure to IS from producing shuttle box escape deficits (Seligman and Maier, 1967), even if the two experiences occurred in different environments (Williams and Maier, 1977).”
Self-citationDifferential projections of the infralimbic and prelimbic cortex in the rat
Vertes, R. P. (2004) · Synapse · doi:10.1002/syn.10279 · Cited by 1,550 · see citing works
Goal-directed instrumental action: contingency and incentive learning and their cortical substrates
Balleine, B. W., & Dickinson, A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00033-1 · Cited by 1,541 · see citing works
LeDoux, J. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.005 · Cited by 1,281 · see citing works
The Psychobiology of Depression and Resilience to Stress: Implications for Prevention and Treatment
Southwick, S. M., Vythilingam, M., & Charney, D. S. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143948 · Cited by 1,160 · see citing works
Urry, H. L., van Reekum, C. M., Johnstone, T., Kalin, N. H., Thurow, M. E., Schaefer, H. S., Jackson, C. A., Frye, C. J., Greischar, L. L., Alexander, A. L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3215-05.2006 · Cited by 1,056 · see citing works
Shin, L. M., Wright, C. I., Cannistraro, P. A., Wedig, M. M., McMullin, K., Martis, B., Macklin, M. L., Lasko, N. B., Cavanagh, S. R., Krangel, T. S., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.3.273 · Cited by 960 · see citing works
Amat, J., Baratta, M. V., Paul, E., Bland, S. T., Watkins, L. R., & Maier, S. F. (2005) · Nature Neuroscience · doi:10.1038/nn1399 · Cited by 931 · see citing works
Self-citationVertes, R. P. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.027 · Cited by 811 · see citing works
Bremner, J., Staib, L., Kaloupek, D., Southwick, S., Soufer, R., & Charney, D. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00297-2 · Cited by 730 · see citing works
Peyron, C., Petit, J.-M., Rampon, C., Jouvet, M., & Luppi, P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00268-6 · Cited by 509 · see citing works
Stress-induced enhancement of fear learning: An animal model of posttraumatic stress disorder
Rau, V., DeCola, J. P., & Fanselow, M. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.010 · Cited by 428 · see citing works
Hajós, M., Richards, C. D., Székely, A. D., & Sharp, T. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00157-2 · Cited by 299 · see citing works
Grahn, R. E., Will, M. J., Hammack, S. E., Maswood, S., McQueen, M. B., Watkins, L. R., & Maier, S. F. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01208-1 · Cited by 298 · see citing works
Self-citationAmat, J., Paul, E., Zarza, C., Watkins, L. R., & Maier, S. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3630-06.2006 · Cited by 249 · see citing works
Self-citationInfralimbic cortex activation increases c-fos expression in intercalated neurons of the amygdala
Berretta, S., Pantazopoulos, H., Caldera, M., Pantazopoulos, P., & Paré, D. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.020 · Cited by 223 · see citing works
Amat, J., Matus-Amat, P., Watkins, L. R., & Maier, S. F. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00960-3 · Cited by 222 · see citing works
Self-citationDual role of 5-HT in defense and anxiety
Graeff, F. G., Viana, M. D. B., & Mora, P. O. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00059-0 · Cited by 195 · see citing works
Amat, J., Sparks, P., Matus-Amat, P., Griggs, J., Watkins, L. R., & Maier, S. F. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02934-1 · Cited by 187 · see citing works
Self-citationJankowski, M. P., & Sesack, S. R. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.10976 · Cited by 186 · see citing works
Maier, S. F., Grahn, R. E., Kalman, B. A., Sutton, L. C., Wiertelak, E. P., & Watkins, L. R. (1993) · Behavioral Neuroscience · doi:10.1037//0735-7044.107.2.377 · Cited by 177 · see citing works
Self-citationMaswood, S., Barter, J. E., Watkins, L. R., & Maier, S. F. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01313-9 · Cited by 173 · see citing works
Self-citationEarly life experience alters behavior during social defeat: Focus on serotonergic systems
Gardner, K. L., Thrivikraman, K. V., Lightman, S. L., Plotsky, P. M., & Lowry, C. A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.042 · Cited by 169 · see citing works
Maier, S. F., Grahn, R. E., & Watkins, L. R. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.3.404 · Cited by 167 · see citing works
Self-citationCorticolimbic Blood Flow During Nontraumatic Emotional Processing in Posttraumatic Stress Disorder
Phan, K. L., Britton, J. C., Taylor, S. F., Fig, L. M., & Liberzon, I. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.184 · Cited by 161 · see citing works
Baratta, M. V., Christianson, J. P., Gomez, D. M., Zarza, C. M., Amat, J., Masini, C. V., Watkins, L. R., & Maier, S. F. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.042 · Cited by 156 · see citing works
Self-citationAmat, J., Paul, E., Watkins, L. R., & Maier, S. F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.005 · Cited by 153 · see citing works
Self-citationStressor controllability and the pituitary-adrenal system.
Maier, S. F., Ryan, S. M., Barksdale, C. M., & Kalin, N. H. (1986) · Behavioral Neuroscience · doi:10.1037//0735-7044.100.5.669 · Cited by 150 · see citing works
Self-citationFrom arousal to cognition: the integrative position of the prefrontal cortex
Robbins, T. W. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)26030-5 · Cited by 145 · see citing works
Maier, S. F., Grahn, R. E., & Watkins, L. R. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.3.404 · Cited by 136 · see citing works
Self-citationMaier, S. F., Grahn, R. E., Kalman, B. A., et al. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.2.377 · Cited by 134 · see citing works
Self-citationStressor controllability and the pituitary-adrenal system.
Maier, S. F., Ryan, S. M., Barksdale, C. M., et al. (1986) · Behavioral Neuroscience · doi:10.1037/0735-7044.100.5.669 · Cited by 127 · see citing works
Self-citationStressor Controllability, Anxiety, and Serotonin
Maier, S. F., & Watkins, L. R. (1998) · Cognitive Therapy and Research · doi:10.1023/a:1018794104325 · Cited by 123 · see citing works
Self-citationBaratta, M. V., Zarza, C. M., Gomez, D. M., Campeau, S., Watkins, L. R., & Maier, S. F. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06867.x · Cited by 106 · see citing works
Self-citationTransituational immunization and therapy of learned helplessness in the rat.
Williams, J. L., & Maier, S. F. (1977) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.3.3.240 · Cited by 101 · see citing works
Self-citationBehavioral control over shock blocks behavioral and neurochemical effects of later social defeat
Amat, J., Aleksejev, R. M., Paul, E., Watkins, L. R., & Maier, S. F. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.005 · Cited by 101 · see citing works
Self-citationChristianson, J. P., Benison, A. M., Jennings, J., Sandsmark, E. K., Amat, J., Kaufman, R. D., Baratta, M. V., Paul, E. D., Campeau, S., Watkins, L. R., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4270-08.2008 · Cited by 97 · see citing works
Self-citationTao, R., Ma, Z., & Auerbach, S. B. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39108-6 · Cited by 89 · see citing works
Christianson, J. P., Thompson, B. M., Watkins, L. R., & Maier, S. F. (2008) · Stress · doi:10.1080/10253890802510302 · Cited by 87 · see citing works
Self-citationHelmreich, Watkins, Deak, Maier, Akil, & Watson (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00300.x · Cited by 73 · see citing works
Anxiety-control strategies: Is there room for neutralization in successful exposure treatment?
Parrish, C. L., Radomsky, A. S., & Dugas, M. J. (2008) · Clinical Psychology Review · doi:10.1016/j.cpr.2008.07.007 · Cited by 73 · see citing works
Maier, S. F., Busch, C. R., Maswood, S., Grahn, R. E., & al, E. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.4.759 · Cited by 73 · see citing works
Self-citationHemispheric Mapping of Secondary Somatosensory Cortex in the Rat
Benison, A. M., Rector, D. M., & Barth, D. S. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00673.2006 · Cited by 70 · see citing works
Baratta, M. V., Lucero, T. R., Amat, J., Watkins, L. R., & Maier, S. F. (2008) · Learning & Memory · doi:10.1101/lm.800308 · Cited by 58 · see citing works
Self-citationMaier, S. F., Busch, C. R., Maswood, S., Grahn, R. E., & Watkins, L. R. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.759 · Cited by 53 · see citing works
Self-citationJackson, R. L., & Minor, T. R. (1988) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.14.4.390 · Cited by 47 · see citing works
Rozeske, R. R., Der‐Avakian, A., Bland, S. T., Beckley, J. T., Watkins, L. R., & Maier, S. F. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.34 · Cited by 41 · see citing works
Self-citationMinor, T. R., Trauner, M. A., Lee, C.-Y., & Dess, N. K. (1990) · Journal of Experimental Psychology: Animal Behavior Processes · doi:10.1037/0097-7403.16.2.123 · Cited by 37 · see citing works
Maier, S. F., & Warren, D. A. (1988) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.14.1.18 · Cited by 25 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Sense of agency in the human brain
Haggard, P. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.14 · Cited by 1,107 · see citing works
Ventromedial prefrontal–subcortical systems and the generation of affective meaning
Roy, M., Shohamy, D., & Wager, T. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.01.005 · Cited by 856 · see citing works
A unified framework for inhibitory control
Munakata, Y., Herd, S. A., Chatham, C. H., Depue, B. E., Banich, M. T., & O’Reilly, R. C. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.07.011 · Cited by 699 · see citing works
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works
Emotion and Decision Making: Multiple Modulatory Neural Circuits
Phelps, E. A., Lempert, K. M., & Sokol‐Hessner, P. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014119 · Cited by 437 · see citing works
Neural control of chronic stress adaptation
Herman, J. P. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00061 · Cited by 384 · see citing works
The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm
LeDoux, J. E., Moscarello, J., Sears, R., & Campese, V (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.166 · Cited by 348 · see citing works
Radley, J., Morilak, D., Viau, V., & Campeau, S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.018 · Cited by 339 · see citing works
Treadway, M. T., Waskom, M. L., Dillon, D. G., Holmes, A. J., Park, M. T. M., Chakravarty, M. M., Dutra, S. J., Polli, F. E., Iosifescu, D. V., Fava, M., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.018 · Cited by 331 · see citing works
Dunsmoor, J. E., Niv, Y., Daw, N., & Phelps, E. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.028 · Cited by 329 · see citing works
The mesoaccumbens dopamine in coping with stress
Cabib, S., & Puglisi-Allegra, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.012 · Cited by 329 · see citing works
Neuronal Dynamics Regulating Brain and Behavioral State Transitions
Andalman, A. S., Burns, V. M., Lovett-Barron, M., Broxton, M. J., Poole, B., Yang, S., Grosenick, L., Lerner, T. N., Chen, R., Benster, T., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.037 · Cited by 246 · see citing works
Alcohol, stress, and glucocorticoids: From risk to dependence and relapse in alcohol use disorders
Blaine, S. K., & Sinha, R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.037 · Cited by 257 · see citing works
“appraising emotion and stress states and also exercising selfcontrol over emotions, desires, and impulses (Maier and Watkins, 2010; Roberts et al., 1998).”
Dynamic neural activity during stress signals resilient coping
Sinha, R., Lacadie, C., Constable, R. T., & Seo, D. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600965113 · Cited by 246 · see citing works
Coping with the forced swim stressor: Current state-of-the-art
Molendijk, M. L., & de Kloet, E. R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.005 · Cited by 231 · see citing works
Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
Douma, E. H., & de Kloet, E. R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.015 · Cited by 226 · see citing works
Bolwerk, A., Mack-Andrick, J., Lang, F. R., Dörfler, A., & Maihöfner, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101035 · Cited by 224 · see citing works
Puglisi‐Allegra, S., & Andolina, D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.052 · Cited by 203 · see citing works
Theories and computational models of affordance and mirror systems: An integrative review
Thill, S., Caligiore, D., Borghi, A. M., Ziemke, T., & Baldassarre, G. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.012 · Cited by 189 · see citing works
Exercise, Stress Resistance, and Central Serotonergic Systems
Greenwood, B. N., & Fleshner, M. (2011) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31821f7e45 · Cited by 183 · see citing works
Viewpoints: Dialogues on the functional role of the ventromedial prefrontal cortex
Delgado, M. R., Beer, J. S., Fellows, L. K., Huettel, S. A., Platt, M. L., Quirk, G. J., & Schiller, D. (2016) · Nature Neuroscience · doi:10.1038/nn.4438 · Cited by 163 · see citing works
Goldfarb, E. V., Seo, D., & Sinha, R. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100177 · Cited by 156 · see citing works
Fogaça, M. V., Reis, F. M. C. V., Campos, A. C., & Guimarães, F. S. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.10.012 · Cited by 153 · see citing works
Cortico–Basal Ganglia Circuit Function in Psychiatric Disease
Gunaydin, L. A., & Kreitzer, A. C. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105355 · Cited by 147 · see citing works
Exercise, Energy Intake, Glucose Homeostasis, and the Brain
van Praag, H., Fleshner, M., Schwartz, M. W., & Mattson, M. P. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2814-14.2014 · Cited by 145 · see citing works
Maier, S. F. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.003 · Cited by 143 · see citing works
Self-citationTreatment-resistant depression: are animal models of depression fit for purpose?
Willner, P., & Belzung, C. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4034-7 · Cited by 140 · see citing works
Henderson, R. K., Snyder, H. R., Gupta, T., & Banich, M. (2012) · Front. Psychology · doi:10.3389/fpsyg.2012.00179 · Cited by 129 · see citing works
Cohodes, E. M., Kitt, E. R., Baskin-sommers, A. R., & Gee, D. G. (2020) · Developmental Psychobiology · doi:10.1002/dev.21969 · Cited by 125 · see citing works
Resilience: A psychobiological construct for psychiatric disorders
Shrivastava, A., & Desousa, A. (2016) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.174365 · Cited by 127 · see citing works
Neurocognitive effects of stress: a metaparadigm perspective
Kim, E. J., & Kim, J. J. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01986-4 · Cited by 136 · see citing works
Top‐down and bottom‐up control of stress‐coping
de Kloet, E. R., de Kloet, S. F., de Kloet, C. S., & de Kloet, A. D. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12675 · Cited by 120 · see citing works
Griffiths, K. R., Morris, R. W., & Balleine, B. W. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00101 · Cited by 118 · see citing works
Griffiths, B. B., & Hunter, R. G. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.041 · Cited by 111 · see citing works
Stressor controllability modulates fear extinction in humans
Hartley, C. A., Gorun, A., Reddan, M. C., Ramirez, F., & Phelps, E. A. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.12.003 · Cited by 110 · see citing works
The role of frontal EEG asymmetry in post-traumatic stress disorder
Meyer, T., Smeets, T., Giesbrecht, T., Quaedflieg, C. W. E. M., Smulders, F. T. Y., Meijer, E. H., & Merckelbach, H. L. G. J. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.03.018 · Cited by 98 · see citing works
Chen, P., Lou, S., Huang, Z., Wang, Z., Shan, Q., Wang, Y., Yang, Y., Li, X., Gong, H., Jin, Y., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.01.033 · Cited by 97 · see citing works
The neurobiology of the stress-resistant brain
Fleshner, M., Maier, S. F., Lyons, D. M., & Raskind, M. A. (2011) · Stress · doi:10.3109/10253890.2011.596865 · Cited by 98 · see citing works
Self-citationSerotonin transporter gene, stress and raphe–raphe interactions: a molecular mechanism of depression
Jasinska, A. J., Lowry, C. A., & Burmeister, M. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.01.001 · Cited by 92 · see citing works
Recover from the adversity: functional connectivity basis of psychological resilience
Shi, L., Sun, J., Wei, D., & Qiu, J. (2018) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2018.12.002 · Cited by 89 · see citing works
Reduced Cardiac Vagal Modulation Impacts on Cognitive Performance in Chronic Fatigue Syndrome
Beaumont, A., Burton, A. R., Lemon, J., Bennett, B. K., Lloyd, A. R., & Vollmer-Conna, U. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049518 · Cited by 88 · see citing works
Goode, T. D., & Maren, S. (2014) · ILAR Journal · doi:10.1093/ilar/ilu008 · Cited by 87 · see citing works
Mirrione, M. M., Schulz, D., Lapidus, K. A. B., Zhang, S., Goodman, W. K., & Henn, F. A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00029 · Cited by 86 · see citing works
Behavioral and neural mechanisms underlying habitual and compulsive drug seeking
Smith, R. J., & Laiks, L. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.003 · Cited by 87 · see citing works
Himmler, B. T., Pellis, S. M., & Kolb, B. E. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.09.061 · Cited by 79 · see citing works
The resilient brain and the guardians of sleep: New perspectives on old assumptions
Parrino, L., & Vaudano, A. E. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.08.003 · Cited by 79 · see citing works
When the brain does not adequately feel the body: Links between low resilience and interoception
Haase, L., Stewart, J. L., Youssef, B., May, A. C., Isakovic, S., Simmons, A. N., Johnson, D. C., Potterat, E. G., & Paulus, M. P. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.11.004 · Cited by 79 · see citing works
Lara, D. R., Bisol, L. W., Brunstein, M. G., Reppold, C. T., de Carvalho, H. W., & Ottoni, G. L. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.036 · Cited by 76 · see citing works
Chen, C., Nakagawa, S., Kitaichi, Y., An, Y., Omiya, Y., Song, N., Koga, M., Kato, A., Inoue, T., & Kusumi, I. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.03.008 · Cited by 78 · see citing works
Sleep and homeostatic control of plasticity
Lanza, G., DelRosso, L. M., & Ferri, R. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819410-2.00004-7 · Cited by 77 · see citing works
Cortical-Subcortical Interactions in Depression: From Animal Models to Human Psychopathology
Heller, A. S. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00020 · Cited by 76 · see citing works
Krichmar, J. L. (2013) · Frontiers in Neurorobotics · doi:10.3389/fnbot.2013.00001 · Cited by 75 · see citing works
Exploring the bi-directional relationship between sleep and resilience in adolescence
Wang, J., Zhang, X., Simons, S., Sun, J., Shao, D., & Cao, F. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.04.018 · Cited by 70 · see citing works
Prefrontal/Amygdalar System Determines Stress Coping Behavior Through 5-HT/GABA Connection
Andolina, D., Maran, D., Valzania, A., Conversi, D., & Puglisi‐Allegra, S. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.107 · Cited by 69 · see citing works
Greenwood, B. N., Spence, K. G., Crevling, D. M., Clark, P., Craig, W. C., & Fleshner, M. (2012) · European Journal of Neuroscience · doi:10.1111/ejn.12044 · Cited by 69 · see citing works
Burleson, C. A., Pedersen, R. W., Seddighi, S., DeBusk, L. E., Burghardt, G. M., & Cooper, M. A. (2016) · Behavioral Neuroscience · doi:10.1037/bne0000148 · Cited by 69 · see citing works
Marinho, A. L. Z., Vila-Verde, C., Fogaça, M. V., & Guimarães, F. S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.023 · Cited by 68 · see citing works
Perceived stress predicts altered reward and loss feedback processing in medial prefrontal cortex
Treadway, M. T., Buckholtz, J. W., & Zald, D. H. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00180 · Cited by 68 · see citing works
Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation
Etiévant, A., Oosterhof, C., Bétry, C., Abrial, E., Novo-Perez, M., Rovera, R., Scarna, H., Devader, C., Mazella, J., Wegener, G., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.06.023 · Cited by 65 · see citing works
Rimmerman, N., Schottlender, N., Reshef, R., Dan-Goor, N., & Yirmiya, R. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.023 · Cited by 65 · see citing works
Logan, T., & Walker, R. (2017) · Journal of Interpersonal Violence · doi:10.1177/0886260517729405 · Cited by 64 · see citing works
Blaine, S. K., Wemm, S., Fogelman, N., Lacadie, C., Seo, D., Scheinost, D., & Sinha, R. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.19070703 · Cited by 63 · see citing works
Controllability Modulates the Anticipatory Response in the Human Ventromedial Prefrontal Cortex
Kerr, D. L., McLaren, D. G., Mathy, R. M., & Nitschke, J. B. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00557 · Cited by 61 · see citing works
Functions of the ventromedial prefrontal cortex in emotion regulation under stress
Suzuki, Y., & Tanaka, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-97751-0 · Cited by 60 · see citing works
A Decision Architecture for Safety Computations
Tashjian, S. M., Zbozinek, T. D., & Mobbs, D. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2021.01.013 · Cited by 60 · see citing works
Galanin mediates features of neural and behavioral stress resilience afforded by exercise
Sciolino, N. R., Smith, J. M., Stranahan, A. M., Freeman, K. G., Edwards, G. L., Weinshenker, D., & Holmes, P. V. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.09.029 · Cited by 59 · see citing works
A trip down memory lane about sex differences in the brain
Shors, T. J. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0124 · Cited by 58 · see citing works
Interleukin-1 beta: a potential link between stress and the development of visceral obesity
Speaker, K. J., & Fleshner, M. (2012) · BMC Physiology · doi:10.1186/1472-6793-12-8 · Cited by 55 · see citing works
Controllability modulates the neural response to predictable but not unpredictable threat in humans
Wood, K. H., Wheelock, M. D., Shumen, J. R., Bowen, K. H., Hoef, L. V., & Knight, D. C. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.06.086 · Cited by 57 · see citing works
Varela, J. A., Wang, J., Christianson, J. P., Maier, S. F., & Cooper, D. C. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2669-12.2012 · Cited by 56 · see citing works
Self-citationPrinsloo, G. E., Derman, W. E., Lambert, M., & Rauch, L. (2013) · International Journal of Stress Management · doi:10.1037/a0034777 · Cited by 58 · see citing works
Prefrontal–Bed Nucleus Circuit Modulation of a Passive Coping Response Set
Johnson, S. B., Emmons, E. B., Lingg, R. T., Anderson, R. M., Romig‐Martin, S. A., LaLumiere, R. T., Narayanan, N. S., Viau, V., & Radley, J. J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1421-18.2018 · Cited by 54 · see citing works
Optogenetic reactivation of prefrontal social neural ensembles mimics social buffering of fear
Gutzeit, V. A., Ahuna, K., Santos, T. L., Cunningham, A. M., Rooney, M. S., Zamora, A., Denny, C. A., & Donaldson, Z. R. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0631-1 · Cited by 52 · see citing works
Radley, J. J., & Johnson, S. B. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.12.005 · Cited by 52 · see citing works
A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice
Dai, W.-P., Yang, M., Xia, P., Xiao, C., Huang, S., Zhang, Z., Cheng, X. R., Li, W., Jin, J., Zhang, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32556-x · Cited by 49 · see citing works
Control over a stressor involves the posterior dorsal striatum and the act/outcome circuit
Amat, J., Christianson, J. P., Aleksejev, R. M., Kim, J., Richeson, K. R., Watkins, L. R., & Maier, S. F. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12609 · Cited by 50 · see citing works
Self-citationInhibition of a Descending Prefrontal Circuit Prevents Ketamine-Induced Stress Resilience in Females
Dolzani, S. D., Baratta, M. V., Moss, J. R., Leslie, N. L., Tilden, S. G., Sørensen, A. T., Watkins, L. R., Lin, Y., & Maier, S. F. (2018) · eNeuro · doi:10.1523/eneuro.0025-18.2018 · Cited by 51 · see citing works
Self-citationCerqueira, M. A. C., Millot, S., Félix, A. S., Silva, T. S., Oliveira, G. A., Oliveira, C. C. V., Rey, S., MacKenzie, S. A., & Oliveira, R. F. (2020) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.2922 · Cited by 49 · see citing works
Neuroeconomics of Emotion and Decision Making
Lempert, K. M., & Phelps, E. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-416008-8.00012-7 · Cited by 47 · see citing works
Neuro-Epigenetic Indications of Acute Stress Response in Humans: The Case of MicroRNA-29c
Vaisvaser, S., Modai, S., Farberov, L., Lin, T., Sharon, H., Gilam, A., Volk, N., Admon, R., Edry, L., Fruchter, E., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146236 · Cited by 47 · see citing works
Prefrontal endocannabinoids, stress controllability and resilience: A hypothesis
Worley, N. B., Hill, M. N., & Christianson, J. P. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.004 · Cited by 47 · see citing works
How perception of control shapes decision making
Wang, K. S., Yang, Y.-Y., & Delgado, M. R. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.04.003 · Cited by 46 · see citing works
Suicide Attempters and Repeaters
Nrugham, L., Holen, A., & Sund, A. M. (2012) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e318247c914 · Cited by 46 · see citing works
The stress-coping (mis)match hypothesis for nature×nurture interactions
Homberg, J. R. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.037 · Cited by 45 · see citing works
The Impact of Stalking-Related Fear and Gender on Personal Safety Outcomes
Logan, T., & Walker, R. (2019) · Journal of Interpersonal Violence · doi:10.1177/0886260519829280 · Cited by 47 · see citing works
Improving Sleep to Improve Stress Resilience
Martire, V. L., Berteotti, C., Zoccoli, G., & Bastianini, S. (2024) · Current Sleep Medicine Reports · doi:10.1007/s40675-024-00274-z · Cited by 52 · see citing works
Social status alters defeat-induced neural activation in Syrian hamsters
Morrison, K. E., Curry, D. W., & Cooper, M. A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.002 · Cited by 44 · see citing works
Learning to cope with stress: psychobiological mechanisms of stress resilience
Cabib, S., Campus, P., & Colelli, V. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2012-0080 · Cited by 45 · see citing works
Stress-protective neural circuits: not all roads lead through the prefrontal cortex
Christianson, J. P., & Greenwood, B. N. (2013) · Stress · doi:10.3109/10253890.2013.794450 · Cited by 42 · see citing works
Corticostriatal Circuits Encode the Subjective Value of Perceived Control
Wang, K. S., & Delgado, M. R. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz045 · Cited by 42 · see citing works
Morrison, K. E., Bader, L. R., Clinard, C. T., Gerhard, D. M., Gross, S. E., & Cooper, M. A. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.041 · Cited by 41 · see citing works
Salehinejad, M. A., Nejati, V., & Derakhshan, M. (2016) · Personality and Individual Differences · doi:10.1016/j.paid.2016.11.005 · Cited by 41 · see citing works
Chronic pain, chronic stress and substance use: overlapping mechanisms and implications
Schaffer, J., Fogelman, N., Seo, D., & Sinha, R. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1145934 · Cited by 40 · see citing works
Learned stressor resistance requires extracellular signal-regulated kinase in the prefrontal cortex
Christianson, J. P., Flyer-Adams, J. G., Drugan, R. C., Amat, J., Daut, R. A., Foilb, A. R., Watkins, L. R., & Maier, S. F. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00348 · Cited by 39 · see citing works
Self-citationCory‐Slechta, D. A., Merchant‐Borna, K., Allen, J. L., Liu, S. M., Weston, D., & Conrad, K. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs260 · Cited by 39 · see citing works
Measuring behaviour in rodents: Towards translational neuropsychiatric research
Homberg, J. R. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.09.005 · Cited by 39 · see citing works
Neurobiological mechanisms supporting experience-dependent resistance to social stress
Cooper, M. A., Clinard, C. T., & Morrison, K. E. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.072 · Cited by 38 · see citing works
Functional and Dysfunctional Neuroplasticity in Learning to Cope with Stress
Cabib, S., Campus, P., Conversi, D., Orsini, C., & Puglisi‐Allegra, S. (2020) · Brain Sciences · doi:10.3390/brainsci10020127 · Cited by 38 · see citing works
Gender- and anxiety level-dependent effects of perinatal stress exposure on medial prefrontal cortex
Söztutar, E., Çolak, E., & Ulupınar, E. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.06.005 · Cited by 38 · see citing works
Astrocyte-Derived Lactate Modulates the Passive Coping Response to Behavioral Challenge in Male Mice
Yin, Y., Hu, J., Wei, Y., Li, Z., Luo, Z.-C., Wang, R., Yang, K.-X., Li, S.-J., Li, X., Yang, J., et al. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00553-z · Cited by 37 · see citing works
- Authors
- Maier, S. F., & Watkins, L. R.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Maier, Steven F.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 1355
- Pages
- 52-60
- ISSN
- 0006-8993 (ISSN-L)
- PMC
- PMC2967290
- OpenAlex
- W1999655743
- Cited by
- 292
- References
- 49
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 15 · 2023: 20 · 2022: 21 · 2021: 15 · 2020: 23 · 2019: 20 · 2018: 7 · 2017: 19 · 2016: 23 · 2015: 22 · 2014: 23 · 2013: 24 · 2012: 22
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (MH50479)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- medial prefrontal cortex, stress resilience, perceived control, coping, ventromedial prefrontal cortex, inhibitory control, brainstem, limbic system, neuroplasticity, individual differences, trauma, aversive events
- MeSH terms
- Adaptation, Psychological, Animals, Brain Stem, Humans, Limbic System, Neural Inhibition, Neural Pathways, Neuronal Plasticity, Stress, Psychological, Prefrontal Cortex, Resilience, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
