Met158 variant of the catechol-O-methyltransferase genotype is associated with thicker cortex in adult brain
Abstract
Cortical thickness has been proposed as a new promising brain imaging endophenotype in elucidating the nature of gene-brain relationships. Here, we define the morphological impact of the Val(158)Met polymorphism in the catechol-O-methyltransferase (COMT) gene on human brain anatomy. One hundred and forty-nine adult healthy subjects (mean age: 40.7+/-16.1; ranging from 19 to 76 years) were genotyped (38 in the homozygous Val(158) group; 80 in the Val(158)Met group; 31 in the homozygous Met(158) group) for the COMT polymorphism and underwent morphological examination. Surface-based analysis of the cortical mantle showed that the COMT genotype was associated with structural differences in the right superior temporal sulcus and inferior prefrontal sulcus, where the individuals carrying the Met(158) allele had a thicker cortex with respect to their Val(158) counterparts. Our study extends the previous evidence found on pediatric population to the adult population, demonstrating that the higher synaptic dopamine levels associated with the presence of the Met(158) allele may influence neuronal architecture in brain structures important for executive and emotional processing.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Structural imaging studies report less consistent results on COMT genotype effects.
“Structural imaging studies report less consistent results (14-16).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [15]
Our findings of rs4680 effects on GM volumes are consistent with previous evidence for an effect of this polymorphism on both adolescent and adult GM volumes and cortical thickness.
“Our findings of rs4680 effects on GM volumes are consistent with previous evidence for an effect of this polymorphism on both adolescent and adult GM volumes (14,16) and cortical thickness (15,18).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [15]
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Cortical Surface-Based Analysis
Dale, A. M., Fischl, B., & Sereno, M. I. (1999) · NeuroImage · doi:10.1006/nimg.1998.0395 · Cited by 10,910 · see citing works
Cortical Surface-Based Analysis
Fischl, B., Sereno, M. I., & Dale, A. M. (1999) · NeuroImage · doi:10.1006/nimg.1998.0396 · Cited by 6,147 · see citing works
Measuring the thickness of the human cerebral cortex from magnetic resonance images
Fischl, B. R., & Dale, A. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200033797 · Cited by 5,789 · see citing works
The distributed human neural system for face perception
Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01482-0 · Cited by 4,891 · see citing works
Automatically Parcellating the Human Cerebral Cortex
Fischl, B. R. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg087 · Cited by 4,208 · see citing works
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,374 · see citing works
Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T. M., Herman, M. M., Apud, J., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/425589 · Cited by 1,675 · see citing works
(1997) · American Psychiatric Press eBooks · Cited by 1,436 · see citing works
Distinct Genetic Influences on Cortical Surface Area and Cortical Thickness
Panizzon, M. S., Fennema-Notestine, C., Eyler, L. T., Jernigan, T. L., Prom-Wormley, E., Neale, M., Jacobson, K., Lyons, M. J., Grant, M. D., Franz, C. E., et al. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp026 · Cited by 1,304 · see citing works
Winkler, A. M., Kochunov, P., Blangero, J., Almasy, L., Zilles, K., Fox, P. T., Duggirala, R., & Glahn, D. C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.028 · Cited by 1,172 · see citing works
Lotta, T. I., Vidgren, J., Tilgmann, C., Ulmanen, I., Melén, K., Julkunen, I., & Taskinen, J. (1995) · Biochemistry · doi:10.1021/bi00013a008 · Cited by 1,167 · see citing works
Männistö, P. T., & Kaakkola, S. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01423-6 · Cited by 1,068 · see citing works
Mattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., Egan, M. F., Kolachana, B., Callicott, J. H., & Weinberger, D. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931309100 · Cited by 893 · see citing works
Pezawas, L., Verchinski, B. A., Mattay, V. S., Callicott, J. H., Kolachana, B. S., Straub, R. E., Egan, M. F., Meyer-Lindenberg, A., & Weinberger, D. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2680-04.2004 · Cited by 890 · see citing works
Prefrontal neurons and the genetics of schizophrenia
Weinberger, D. R., Egan, M. F., Bertolino, A., Callicott, J. H., Mattay, V. S., Lipska, B. K., Berman, K. F., & Goldberg, T. E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01252-5 · Cited by 744 · see citing works
Executive Subprocesses in Working Memory
Goldberg, T. E., Egan, M. F., Gscheidle, T., Coppola, R., Weickert, T. W., Kolachana, B. S., Goldman, D. A., & Weinberger, D. R. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.889 · Cited by 580 · see citing works
Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis
Mier, D., Kirsch, P., & Meyer-Lindenberg, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.36 · Cited by 464 · see citing works
Sander, D., Grandjean, D., Pourtois, G., Schwartz, S., Seghier, M. L., Scherer, K. R., & Vuilleumier, P. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.023 · Cited by 392 · see citing works
Deichmann, R., Schwarzbauer, C., & Turner, R. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.09.062 · Cited by 391 · see citing works
Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles.
Palmatier, M., Kang, M. A., & Kidd, K. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00098-0 · Cited by 385 · see citing works
Matsumoto, M., Weickert, C. S., Akil, M., Lipska, B. K., Hyde, T. M., Herman, M. M., Kleinman, J. E., & Weinberger, D. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00556-0 · Cited by 365 · see citing works
Neural Processing of Fearful Faces: Effects of Anxiety are Gated by Perceptual Capacity Limitations
Bishop, S. J., Jenkins, R., & Lawrence, A. D. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl070 · Cited by 343 · see citing works
Bruder, G. E., Keilp, J. G., Xu, H., Shikhman, M., Schori, E., Gorman, J. M., & Gilliam, T. C. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.010 · Cited by 260 · see citing works
Functional neuroanatomy of spatial working memory in children.
Nelson, C. A., Monk, C. S., Lin, J., Carver, L. J., Thomas, K. M., & Truwit, C. L. (2000) · Developmental Psychology · doi:10.1037//0012-1649.36.1.109 · Cited by 243 · see citing works
Functional neuroanatomy of spatial working memory in children.
Nelson, C. A., Monk, C. S., Lin, J., et al. (2000) · Developmental Psychology · doi:10.1037/0012-1649.36.1.109 · Cited by 197 · see citing works
Ohnishi, T., Hashimoto, R., Mori, T., Nemoto, K., Moriguchi, Y., Iida, H., Noguchi, H., Nakabayashi, T., Hori, H., Ohmori, M., et al. (2005) · Brain · doi:10.1093/brain/awh702 · Cited by 151 · see citing works
Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder
Nakata, K., Ujike, H., Sakai, A., Uchida, N., Nomura, A., Imamura, T., Katsu, T., Tanaka, Y., Hamamura, T., & Kuroda, S. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01292-2 · Cited by 138 · see citing works
Impact of interacting functional variants in COMT on regional gray matter volume in human brain
Honea, R., Verchinski, B. A., Pezawas, L., Kolachana, B. S., Callicott, J. H., Mattay, V. S., Weinberger, D. R., & Meyer-Lindenberg, A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.10.064 · Cited by 128 · see citing works
Imaging genetics of anxiety disorders
Domschke, K., & Dannlowski, U. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.042 · Cited by 122 · see citing works
Relationship between the Val158Met polymorphism of catechol O-methyl transferase and breast cancer
Yim, D., Park, S. K., Yoo, K.-Y., et al. (2001) · Pharmacogenetics · doi:10.1097/00008571-200106000-00001 · Cited by 100 · see citing works
Kempton, M. J., Haldane, M., Jogia, J., Christodoulou, T., Powell, J. F., Collier, D. A., Williams, S., & Frangou, S. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009395 · Cited by 93 · see citing works
Cerasa, A., Gioia, M. C., Labate, A., Liguori, M., Lanza, P., & Quattrone, A. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3282f5f784 · Cited by 70 · see citing works
Self-citationThe COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults
Taylor, W. D., Zuchner, S. L., Payne, M. E., Messer, D. F., Doty, T. J., MacFall, J. R., Beyer, J. L., & Krishnan, K. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.01.005 · Cited by 59 · see citing works
Cerasa, A., Tongiorgi, E., Fera, F. S., Gioia, M. C., Valentino, P., Liguori, M., Manna, I., Zito, G., Passamonti, L., Nisticò, R., et al. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.10.022 · Cited by 51 · see citing works
Self-citationLiguori, M., Fera, F. S., Gioia, M. C., Valentino, P., Manna, I., Condino, F., Cerasa, A., Russa, A. L., Clodomiro, A., Paolillo, A., et al. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00245.x · Cited by 45 · see citing works
Self-citationShaw, P., Wallace, G. L., Addington, A., Evans, A., Rapoport, J., & Giedd, J. N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.121 · Cited by 38 · see citing works
Mechelli, A., Tognin, S., McGuire, P. K., Prata, D. P., Sartori, G., Fusar‐Poli, P., Brito, S. A. D., Hariri, A. R., & Viding, E. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.033 · Cited by 31 · see citing works
Eisenberg, D. P., Sarpal, D. K., Kohn, P. D., Meyer‐Lindenberg, A., Wint, D. P., Kolachana, B. S., Apud, J. A., Weinberger, D. R., & Berman, K. F. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.039 · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Influence of the COMT genotype on working memory and brain activity changes during development
Dumontheil, I., Roggeman, C., Ziermans, T., Peyrard-Janvid, M., Matsson, H., Kere, J., & Klingberg, T. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.027 · Cited by 165 · see citing works
- Authors
- Cerasa, A., Cherubini, A., Quattrone, A., Gioia, M. C., Tarantino, P., Annesi, G., Assogna, F., Caltagirone, C., & Spalletta, G.
- Affiliations
- Institute of Neurological Sciences (IT)
- Fondazione Santa Lucia (IT)
- Magna Graecia University (IT)
- University of Rome Tor Vergata (IT)
- Corresponding author
- Cerasa, A.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 167
- Issue
- 3
- Pages
- 809-814
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W1969293835
- Cited by
- 34
- References
- 39
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 3
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- catechol-O-methyltransferase, COMT Val158Met polymorphism, cortical thickness, superior temporal sulcus, dopamine
- MeSH terms
- Adult, Aged, Catechol O-Methyltransferase, Cerebral Cortex, DNA Mutational Analysis, Dopamine, Female, Genetic Testing, Genotype, Humans, Male, Methionine, Middle Aged, Phenotype, Polymorphism, Genetic, Temporal Lobe, Genetic Variation, Point Mutation, Prefrontal Cortex, Body Patterning, Amino Acid Substitution, Organogenesis, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
