Impact of catechol-O-methyltransferase Val108/158 Met genotype on hippocampal and prefrontal gray matter volume
Abstract
A variation in catechol-O-methyltransferase (COMT) gene (Val(108/158)Met) affects the physiological response of hippocampal-prefrontal circuits, predicts variation in human memory and is associated with increased risk for psychiatric disorders. Using optimized voxel-based morphometry we studied the effect of this functional polymorphism on the anatomy of the hippocampus, and the prefrontal cortex. Fifty-seven healthy participants were investigated (nine had Met/Met, 30 Val/Met, and 14 Val/Val). Voxel-based morphometry showed that individuals who are homozygous for the Val-COMT allele had greater gray matter volume of the prefrontal cortex bilaterally, whereas Met-COMT carriers were associated with increased tissue volume of the hippocampus bilaterally. This study provides evidence that the Val(108/158)Met polymorphism of the COMT gene might be responsible for individual variation in the human brain morphology.
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Structural imaging studies report less consistent results on COMT genotype effects.
“Structural imaging studies report less consistent results (14-16).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [14]
Our findings of rs4680 effects on GM volumes are consistent with previous evidence for an effect of this polymorphism on both adolescent and adult GM volumes and cortical thickness.
“Our findings of rs4680 effects on GM volumes are consistent with previous evidence for an effect of this polymorphism on both adolescent and adult GM volumes (14,16) and cortical thickness (15,18).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [14]
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Self-citation
- Authors
- Cerasa, A., Gioia, M. C., Labate, A., Liguori, M., Lanza, P., & Quattrone, A.
- Affiliations
- University of Messina (IT)
- National Academies of Sciences, Engineering, and Medicine (US)
- Corresponding author
- Cerasa, Antonio
- Venue
- Neuroreport
- Published
- 2008-03-05
- Volume
- 19
- Issue
- 4
- Pages
- 405-408
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2083167045
- Cited by
- 70
- References
- 23
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 7 · 2015: 7 · 2014: 3 · 2013: 6 · 2012: 2
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- catechol-O-methyltransferase, COMT Val158Met polymorphism, gray matter volume, hippocampus, prefrontal cortex, brain structure, genetic variation, individual differences
- MeSH terms
- Adult, Brain Mapping, Catechol O-Methyltransferase, DNA Mutational Analysis, Dopamine, Female, Gene Frequency, Genetic Testing, Genotype, Hippocampus, Homozygote, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Methionine, Middle Aged, Polymorphism, Genetic, Valine, Prefrontal Cortex, Amino Acid Substitution
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