Corticosterone-regulated actions in the rat brain are affected by perinatal exposure to low dose of bisphenol A
Abstract
The estrogen-mimicking endocrine disrupter bisphenol A (BPA) which is used in the manufacture of plastic and epoxy resins, is one of the world's most heavily produced synthetic chemicals. BPA is detected in animal tissues, and its bio-accumulation has shown to be higher in the fetus than the mother. Exposure to doses below the daily safe limit has been reported to affect the sexual differentiation of the brain and modify the behavior of the exposed rodent offspring. The aim of the present study was to investigate in the rat the possible organizational effects of low BPA exposure on glucocorticoid-regulated responses. Female breeders were exposed to 40 microg/kg b.w. BPA daily throughout pregnancy and lactation. Plasma corticosterone levels and the two types of hippocampal corticosteroid receptors (GR and MR) were determined in mid-adolescent offspring under basal conditions and following a Y-maze task. BPA treated females had higher corticosterone levels than control females and BPA males and lower GR levels than BPA males, under basal conditions. Following the mildly stressful experience of Y-maze, corticosterone levels were increased in BPA-treated animals of both sexes, compared to the controls. GR levels were also increased in BPA-treated females compared to males. No effect of BPA was observed on MR levels, whereas the Y-maze experience significantly decreased receptors' levels in both female groups. The animals' performance in the task was also evaluated. BPA exposure s…
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Pre- and/or peri-natal exposure to BPA in rodents is associated with cognitive impairments and decreased exploration in a novel environment.
“Pre- and/or peri-natal exposure to BPA in rodents is associated with cognitive impairments and decreased exploration in a novel environment [12], [13], [14].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [14]
Induction of LTP at Sch-CA1 synapses is dependent on glutamate receptors, especially NR2A, NR2B, GluR1, and GluR2.
“Induction of LTP at Sch‐CA1 synapses is dependent on glutamate receptors, especially NR2A, NR2B, GluR1, and GluR2.15”
From Bisphenol A Impairs Synaptic Plasticity by Both Pre‐ and Postsynaptic Mechanisms (2017) · cites this paper as [15]
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“Pre- and/or peri-natal exposure to BPA in rodents is associated with cognitive impairments and decreased exploration in a novel environment [12,13,14].”
BackgroundBisphenol A Impairs Synaptic Plasticity by Both Pre‐ and Postsynaptic Mechanisms
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Perinatal Exposure to Low-Dose Bisphenol A Impairs Spatial Learning and Memory in Male Rats
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Effects of maternal or paternal bisphenol A exposure on offspring behavior
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- Authors
- Poimenova, A., Markaki, E., Rahiotis, C., & Kitraki, E.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 167
- Issue
- 3
- Pages
- 741-749
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W1984573399
- Cited by
- 174
- References
- 2
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 11 · 2021: 10 · 2020: 9 · 2019: 8 · 2018: 14 · 2017: 14 · 2016: 12 · 2015: 19 · 2014: 12 · 2013: 19 · 2012: 8
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- bisphenol A, endocrine disruptors, corticosterone, glucocorticoid receptor, mineralocorticoid receptor, hippocampus, perinatal exposure, developmental programming, sex differences, spatial recognition memory, anxiety-like behavior, stress response, Y-maze, offspring behavior
- MeSH terms
- Bisphenol A Compounds, Adaptation, Psychological, Animals, Anxiety, Benzhydryl Compounds, Brain, Corticosterone, Dose-Response Relationship, Drug, Environmental Exposure, Estrogens, Non-Steroidal, Exploratory Behavior, Female, Hippocampus, Hypothalamo-Hypophyseal System, Male, Memory Disorders, Neurosecretory Systems, Phenols, Pituitary-Adrenal System, Pregnancy, Prenatal Exposure Delayed Effects, Receptors, Steroid, Sex Characteristics, Rats, Wistar, Maze Learning, Rats, Endocrine Disruptors
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