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Cited by 101Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchMemory and Neural Mechanisms

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Elevated response of human amygdala to neutral stimuli in mild post traumatic stress disorder: neural correlates of generalized emotional response

Brunetti, M., Sepede, G., Mingoia, G., Catani, C., Ferretti, A., Merla, A., Del Gratta, C., Romani, G.L., Babiloni, C.·2010·Neuroscience
DOI 10.1016/j.neuroscience.2010.04.024
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Abstract

Previous evidence from functional magnetic resonance imaging (fMRI) studies has shown that amygdala responses to emotionally neutral pictures are exaggerated at a group level in patients with severe post-traumatic stress disorder (PTSD) [Hendler T, Rotshtein P, Yeshurun Y, Weizmann T, Kahn I, Ben-Bashat D, Malach R, Bleich A (2003) Neuroimage 19(3):587-600]. The present fMRI study tested the hypothesis that amygdala responses are elevated not only in response to negative pictures but also to neutral pictures as a function of disease severity in patients with mild symptoms and in subjects who did not develop symptoms. To this end, fMRI scans were performed in 10 patients with mild PTSD and 10 healthy controls (both victims of a bank robbery), during the execution of a visuo-attentional task in which they were asked to observe emotionally negative or neutral pictures. Control subjects showed enhanced amygdala responses to emotionally negative stimuli compared to neutral stimuli. On the contrary, PTSD patients were characterized by high amygdala responses to both neutral and emotional pictures, with no statistically significant difference between the two classes of stimuli. In the entire group, we found correlations among the severity of the PTSD symptoms, task performance, and amygdala activation during the processing of neutral stimuli. Results of this study suggest that amygdala responses and the selectivity of the emotional response to neutral stimuli are elevated as a function of disease severity in PTSD patients with mild symptoms.

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Metadata

Authors
Brunetti, M., Sepede, G., Mingoia, G., Catani, C., Ferretti, A., Merla, A., Del Gratta, C., Romani, G. L., & Babiloni, C.
Affiliations
  • University of Chieti-Pescara (IT)
  • Bielefeld University (DE)
  • University of Foggia (IT)
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2010-07
Volume
168
Issue
3
Pages
670-679
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2010.04.024
OpenAlex
W2088502524
Semantic Scholar
310cee15d6a617a0ed5e079eb8b85cad5f3cf016
Cited by
101
References
38
Citations by year
2026: 5 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 3 · 2015: 6 · 2014: 8 · 2013: 13 · 2012: 6
FWCI
9.15
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
  • PUB – Publications at Bielefeld University (Bielefeld University) (submittedVersion)
  • Publikationen an der Universität Bielefeld (Universität Bielefeld) (submittedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
post-traumatic stress disorder, amygdala, neutral stimuli, disease severity, emotional face processing
MeSH terms
Adult, Amygdala, Emotions, Fear, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Photic Stimulation, Severity of Illness Index, Stress Disorders, Post-Traumatic

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