Cannabinoid receptor type 1 antagonism significantly modulates basal and loud noise induced neural and hypothalamic–pituitary–adrenal axis responses in male Sprague–Dawley rats
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Altered regulation of the hypothalamic-pituitary-adrenal (HPA) axis is associated with stress-induced changes in cognitive, emotional, and physical health. Recent evidence indicates that the endogenous cannabinoid (eCB) system may modulate HPA-axis function both directly and more centrally, via regulation of limbic brain systems that control HPA-axis activity. The current study examines the contribution of cannabinoid type 1 (CB1) receptor modulation throughout the neuraxis on control and stress-induced HPA-axis activity. Adult male Sprague-Dawley rats were given intraperitoneal injections of either CB1 receptor antagonist (AM251, 2 mg/kg) or vehicle 30 min prior to a session of loud white noise stress (95 dBA for 30 min) or placement in a familiar sound-proof chamber. Immediately following stress and control treatments, rats were killed, the brains and pituitary glands were excised for subsequent immediate early gene (c-fos mRNA) measurement, and trunk blood was collected for subsequent determination of corticosterone (CORT) and adrenocorticotropic (ACTH) hormone levels. AM251 treatment resulted in a potentiated plasma ACTH response to loud noise stress. AM251 treatment also increased stress-induced plasma CORT levels, but that increase may be due to an increase in basal plasma CORT levels, as was evident in control rats. AM251 treatment produced three distinctive c-fos mRNA response patterns across the various brain regions examined. In cortical (prelimbic, infralimbic, somatosensory, and auditory) and some subcortical structures (basolateral amygdala and paraventricular nucleus of the hypothalamus), AM251 treatment produced a substantial increase in c-fos mRNA that was comparable with the elevated c-fos mRNA levels present in those brain regions of both vehicle and AM251-treated stressed rats. In some other subcortical structures (bed nucleus of the stria terminalis and medial preoptic area) and the anterior pituitary, AM251 treatment produced a c-fos mRNA response pattern that was similar to the response pattern of ACTH hormone levels, that is, no effect on no noise control levels, but an augmentation of stress-induced levels. Conversely, in the medial geniculate and ventral posterior thalamus, AM251 treatment inhibited stress-induced c-fos mRNA induction. These data indicate that disruption of eCB signaling through CB1 receptors results in potentiated neural and endocrine responses to loud noise stress, but also substantial increases in activity in various brain regions and the adrenal gland.
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CB1R antagonism increases BLA excitability, activates the HPA axis, and increases anxiety-like behavior.
“First, presumably by removing AEA-mediated tonic inhibitory activity, CB1R antagonism increases BLA excitability [61–63], activates the hypothalamic–pituitary–adrenal (HPA) axis and increases anxiety-like behavior [58,64,65].”
From Amygdala FAAH and anandamide: mediating protection and recovery from stress (2013) · cites this paper as [63]
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Liu, M., & Hu, X. (2025) · Noise and Health · doi:10.4103/nah.nah_88_25
Roukens, J.-J., Meier, P., Simão, A. C., Chicca, A., Bregy, R., Altmann, K., & Gertsch, J. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.117827
- Authors
- Newsom, R. J., Osterlund, C., Masini, C. V., Day, H. E., Spencer, R. L., & Campeau, S.
- Affiliations
- University of Colorado Boulder (US)
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 204
- Pages
- 64-73
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC3288505
- OpenAlex
- W1998894486
- Cited by
- 54
- References
- 47
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH077152, R01MH075968)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- cannabinoid receptor type 1, CB1 receptor antagonism, AM251, endocannabinoid system, hypothalamic-pituitary-adrenal axis, noise stress, corticosterone, ACTH, c-fos mRNA, stress response, thalamus, amygdala, bed nucleus of the stria terminalis, medial preoptic area, limbic system
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Corticosterone, Hypothalamo-Hypophyseal System, Male, Neurons, Noise, Piperidines, Pituitary-Adrenal System, Pyrazoles, Stress, Physiological, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB1, Rats
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