Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress
Open accessAbstract
Central endocannabinoid signaling is known to be responsive to stressful stimuli; however, there is no research to date characterizing the effects of stress on peripheral endocannabinoid content. The current study examined serum content of the endocannabinoid ligands N-arachidonylethanolamide (anandamide; AEA) and 2-arachidonoylglycerol (2-AG), and the non-cannabinoid N-acyl ethanolamine (NAE) molecules palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) under basal conditions, immediately following the Trier Social Stress Test (TSST), and 30 min thereafter, in 15 medication-free women diagnosed with major depression, and 15 healthy matched controls. Basal serum concentrations of AEA and 2-AG, but not PEA or OEA, were significantly reduced in women with major depression relative to matched controls, indicating a deficit in peripheral endocannabinoid activity. Immediately following the TSST, serum 2-AG concentrations were increased compared to baseline; serum AEA concentration was unchanged at this time point. Serum concentrations of PEA and OEA were significantly lower than baseline 30 min following the cessation of the TSST. The magnitude of these responses did not differ between depressed and control subjects. These are the first data to demonstrate that the peripheral endocannabinoid/NAE system is responsive to exposure to stress.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Endocannabinoids AEA and 2AG are endogenously produced lipids that are elevated in blood in response to psychological stress.
“The endocannabinoids anandamide (AEA) and 2arachidonoylglycerol (2AG) are endogenously produced lipids that have been found, for instance, to be elevated in blood in response to psychological stress (Hill et al., 2009;Dlugos et al., 2012).”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Hill et al., 2009
Similar effects (a rise in 2AG) have been found after acute psychological stress.
“Similar effects have been found after acute psychological stress (Hill et al., 2009).”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Hill et al., 2009
AEA levels are reduced in patients with major depression and PTSD.
“a number of studies have detected reduced levels of AEA in patients suffering from stress-related psychiatric illnesses, including major depression (Hill et al., 2009) and PTSD (Neumeister et al., 2013).”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Hill et al., 2009
2-AG levels are reduced in individuals with major depression.
“two independent studies have now both reported that 2-AG levels are reduced in individuals with major depression (Hill et al., 2008; Hill et al., 2009)”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Hill et al., 2009
EC plasma concentrations are modified by the presence of affective disorders and severe mental illness.
“EC plasma concentrations are also modified by the presence of affective disorders and severe mental illness [7], [8].”
From Plasma concentrations of endocannabinoids and related primary fatty acid amides in patients with post-traumatic stress disorder (2013) · cites this paper as [7]
EC and NAE blood concentrations increase in response to acute stress.
“there are a number of recent studies which demonstrated that EC and NAE blood concentrations increase in response to acute stress [7], [10] and that they are higher in individuals who show stress tolerance [10] and lower in patients with depression [18].”
From Plasma concentrations of endocannabinoids and related primary fatty acid amides in patients with post-traumatic stress disorder (2013) · cites this paper as [7]
Patients with major depression show reduced serum ANA and 2-AG concentrations.
“The possible protective effects of an activated EC system are illustrated by the fact that patients with major depression show reduced serum ANA and 2-AG concentrations [7]”
From Plasma concentrations of endocannabinoids and related primary fatty acid amides in patients with post-traumatic stress disorder (2013) · cites this paper as [7]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267 · see citing works
Robins, L. N. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780290015001 · Cited by 5,219 · see citing works
Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study
Spitzer, R. L. (1994) · JAMA · doi:10.1001/jama.272.22.1749 · Cited by 2,648 · see citing works
Utility of a New Procedure for Diagnosing Mental Disorders in Primary Care: The PRIME-MD 1000 Study
Spitzer, R. L. (1994) · JAMA · doi:10.1001/jama.1994.03520220043029 · Cited by 1,873 · see citing works
Endocrinology of the stress response
Charmandari, E., Tsigos, C., & Chrousos, G. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.120816 · Cited by 1,799 · see citing works
Fu, J., Gaetani, S., Oveisi, F., Verme, J., Serrano, A., de Fonseca, F. D., Rosengarth, A., Luecke, H., Giacomo, B. D., Tarzia, G., et al. (2003) · Nature · doi:10.1038/nature01921 · Cited by 1,113 · see citing works
Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials
Christensen, R., Kristensen, P. K., Bartels, E. M., Bliddal, H., & Astrup, A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61721-8 · Cited by 1,097 · see citing works
Lo Verme, J., Fu, J., Astarita, G., La Rana, G., Russo, R., Calignano, A., & Piomelli, D. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.006353 · Cited by 882 · see citing works
Pace, T. W. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., & Heim, C. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1630 · Cited by 810 · see citing works
Kirschbaum, C., Prussner, J. C., Stone, A. A., Federenko, I., Gaab, J., Lintz, D., Schommer, N., & Hellhammer, D. H. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199509000-00009 · Cited by 666 · see citing works
Pace, T. W. W., Hu, F., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.08.009 · Cited by 621 · see citing works
Howlett, A. C. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00060-6 · Cited by 536 · see citing works
Ishac, E. J. N., Jiang, L., Lake, K. D., Varga, K., Abood, M. E., & Kunos, G. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15639.x · Cited by 345 · see citing works
Serum Endocannabinoid Content is Altered in Females with Depressive Disorders: A Preliminary Report
Hill, M., Miller, G., Ho, W.-S., Gorzalka, B., & Hillard, C. (2008) · Pharmacopsychiatry · doi:10.1055/s-2007-993211 · Cited by 292 · see citing works
Cannabinoid receptors and endocannabinoids: Evidence for new players
Mackie, K., & Stella, N. (2006) · The AAPS Journal · doi:10.1007/bf02854900 · Cited by 275 · see citing works
Clinical depression and regulation of the inflammatory response during acute stress
Miller, G. E., Rohleder, N., Stetler, C., & Kirschbaum, C. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000174172.82428.ce · Cited by 253 · see citing works
Simon, G. M., & Cravatt, B. F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707807200 · Cited by 228 · see citing works
Gorzalka, B. B., Hill, M. N., & Hillard, C. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.004 · Cited by 211 · see citing works
Hill, M. N., & Gorzalka, B. B. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00006 · Cited by 193 · see citing works
Role of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis
Steiner, M. S., & Wotjak, C. T. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00433-0 · Cited by 167 · see citing works
Berdyshev, E. V., Boichot, E., Germain, N., Allain, N., Anger, J.-P., & Lagente, V. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01007-8 · Cited by 167 · see citing works
Endogenous Cannabinoids: Structure and Metabolism
Bisogno, T. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01676.x · Cited by 165 · see citing works
Freedland, K. E., Skala, J. A., Carney, R. M., Raczynski, J. M., Taylor, C. B., de Leon, C. F. M., Ironson, G. H., Youngblood, M., Krishnan, K., & Veith, R. C. (2002) · Psychosomatic Medicine · doi:10.1097/01.psy.0000028826.64279.29 · Cited by 155 · see citing works
Matias, I., Bisogno, T., & Marzo, V. D. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803271 · Cited by 149 · see citing works
Cannabinoid Receptors and Endocannabinoids: Evidence for New Players
Mackie, K., & Stella, N. (2006) · The AAPS Journal · doi:10.1208/aapsj080234 · Cited by 149 · see citing works
Role and regulation of acylethanolamides in energy balance: focus on adipocytes and β‐cells
Matias, I., Gonthier, M., Petrosino, S., Docimo, L., Capasso, R., Hoareau, L., Monteleone, P., Roche, R., Izzo, A. A., & Marzo, V. D. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707424 · Cited by 104 · see citing works
Impairments in Endocannabinoid Signaling and Depressive Illness
Hill, M. N. (2009) · JAMA · doi:10.1001/jama.2009.369 · Cited by 69 · see citing works
Endocannabinoids and the haematological system
Randall, M. D. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707420 · Cited by 50 · see citing works
Flagged first, then by citations
1 of the 30 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Psychogios, N., Hau, D., Peng, J., Guo, A. C., Mandal, R., Bouatra, S., Sinelnikov, I. V., Krishnamurthy, R., Eisner, R., Gautam, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016957 · Cited by 1,718 · see citing works
Neurobiological Interactions Between Stress and the Endocannabinoid System
Morena, M., Patel, S., Bains, J. S., & Hill, M. N. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.166 · Cited by 663 · see citing works
Multiple Functions of Endocannabinoid Signaling in the Brain
Katona, I., & Freund, T. F. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150420 · Cited by 630 · see citing works
Ligresti, A., PETROCELLIS, L. D., & Marzo, V. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00002.2016 · Cited by 484 · see citing works
Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?
Hillard, C. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.130 · Cited by 449 · see citing works
Hill, M. N., & Tasker, J. G. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.030 · Cited by 341 · see citing works
Hill, M. N., Bierer, L. M., Makotkine, I., Golier, J. A., Galea, S., McEwen, B. S., Hillard, C. J., & Yehuda, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.08.004 · Cited by 256 · see citing works
Self-citationAcute stress increases circulating anandamide and other N-acylethanolamines in healthy humans
Dlugos, A., Childs, E., Stuhr, K. L., Hillard, C. J., & de Wit, H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.100 · Cited by 248 · see citing works
Hill, M. N., Campolongo, P., Yehuda, R., & Patel, S. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.162 · Cited by 239 · see citing works
Sartori, S. B., & Singewald, N. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107402 · Cited by 236 · see citing works
Hill, M. N., & McEwen, B. S. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.11.001 · Cited by 235 · see citing works
The endocannabinoid system as a target for novel anxiolytic drugs
Patel, S., Hill, M. N., Cheer, J. F., Wotjak, C. T., & Holmes, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.033 · Cited by 233 · see citing works
The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development
Meyer, H. C., Lee, F. S., & Gee, D. G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.143 · Cited by 222 · see citing works
Hauer, D., Schelling, G., Gola, H., Campolongo, P., Morath, J., Roozendaal, B., Hamuni, G., Karabatsiakis, A., Atsak, P., Vogeser, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062741 · Cited by 200 · see citing works
Hillard, C. J., Weinlander, K. M., & Stuhr, K. L. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.020 · Cited by 186 · see citing works
Endocannabinoid signalling: has it got rhythm?
Vaughn, L. K., Denning, G., Stuhr, K. L., de Wit, H., Hill, M. N., & Hillard, C. J. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00790.x · Cited by 176 · see citing works
Sciolino, N. R., Zhou, W., & Hohmann, A. G. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.04.010 · Cited by 179 · see citing works
Lipids in Psychiatric Disorders and Preventive Medicine
Schneider, M., Levant, B., Reichel, M., Gulbins, E., Kornhuber, J., & Müller, C. P. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.002 · Cited by 175 · see citing works
Hill, M. N., Hillard, C. J., Bambico, F. R., Patel, S., Gorzalka, B. B., & Gobbi, G. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.06.006 · Cited by 172 · see citing works
Anxiety, stress, and fear response in mice with reduced endocannabinoid levels
Jenniches, I., Ternes, S., Albayram, O., Otte, D. M., Bach, K., Bindila, L., Michel, K., Lutz, B., Bilkei-Gorzo, A., & Zimmer, A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.033 · Cited by 169 · see citing works
The endocannabinoid system and psychiatric disorders
Parolaro, D., Realini, N., Viganò, D., Guidali, C., & Rubino, T. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.03.018 · Cited by 150 · see citing works
The endocannabinoid system: An emotional buffer in the modulation of memory function
Morena, M., & Campolongo, P. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.12.010 · Cited by 143 · see citing works
Palmitoylethanolamide: A Natural Compound for Health Management
Clayton, P., Hill, M., Bogoda, N. O., Subah, S., & Venkatesh, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105305 · Cited by 145 · see citing works
Motion Sickness, Stress and the Endocannabinoid System
Choukèr, A., Kaufmann, I., Kreth, S., Hauer, D., Feuerecker, M., Thieme, D., Vogeser, M., Thiel, M., & Schelling, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010752 · Cited by 140 · see citing works
Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways
Welcome, M. O., & Mastorakis, N. E. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104769 · Cited by 139 · see citing works
Marco, E. M. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00063 · Cited by 136 · see citing works
Endocannabinoid signalling modulates susceptibility to traumatic stress exposure
Bluett, R. J., Báldi, R., Haymer, A., Gaulden, A. D., Hartley, N. D., Parrish, W. P., Baechle, J. J., Marcus, D. J., Bey, R. M., Shonesy, B. C., et al. (2017) · Nature Communications · doi:10.1038/ncomms14782 · Cited by 136 · see citing works
Endocannabinoid System Components as Potential Biomarkers in Psychiatry
Navarrete, F., García‐Gutiérrez, M. S., Barba, R. J., Rubio, G., Gasparyan, A., Austrich-Olivares, A., & Manzanares, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00315 · Cited by 134 · see citing works
Hill, M. N., Hillard, C. J., & McEwen, B. S. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq280 · Cited by 127 · see citing works
Oleic acid-derived oleoylethanolamide: A nutritional science perspective
Bowen, K. J., Kris‐Etherton, P. M., Shearer, G. C., West, S. G., Reddivari, L., & Jones, P. J. H. (2017) · Progress in Lipid Research · doi:10.1016/j.plipres.2017.04.001 · Cited by 120 · see citing works
Gorzalka, B. B., & Hill, M. N. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.021 · Cited by 118 · see citing works
Endocannabinoid concentrations in hair are associated with PTSD symptom severity
Wilker, S., Pfeiffer, A., Elbert, T. R., Ovuga, E., Karabatsiakis, A., Krumbholz, A., Thieme, D., Schelling, G., & Kolassa, I. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.02.010 · Cited by 116 · see citing works
Hill, M. N., & Patel, S. (2013) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-3-19 · Cited by 117 · see citing works
Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing
Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106 · see citing works
Endocannabinoid Signaling in the Control of Social Behavior
Don, W., Allsop, S. A., Tye, K. M., & Piomelli, D. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.04.005 · Cited by 111 · see citing works
Bedse, G., Hartley, N. D., Neale, E., Gaulden, A. D., Patrick, T. A., Kingsley, P. J., Uddin, M. J., Plath, N., Marnett, L. J., & Patel, S. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.03.002 · Cited by 104 · see citing works
Bosch-Bouju, C., Larrieu, T., Linders, L., Manzoni, O. J., & Layé, S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.082 · Cited by 100 · see citing works
Sayd, A., Antón, M., Alén, F., Caso, J. R., Pavon, J., Leza, J. C., de Fonseca, F. R., García‐Bueno, B., & Orío, L. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu111 · Cited by 99 · see citing works
Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder
Pinna, G., & Rasmusson, A. M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00256 · Cited by 94 · see citing works
Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain
Porta, C. L., Bura, S. A., Llorente‐Onaindia, J., Pastor, A., Navarrete, F., García‐Gutiérrez, M. S., de la Torre, R., Manzanares, J., Monfort, J., & Maldonado, R. J. (2015) · Pain · doi:10.1097/j.pain.0000000000000260 · Cited by 94 · see citing works
Olango, W., Roche, M., Ford, G., Harhen, B., & Finn, D. P. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01478.x · Cited by 91 · see citing works
Fernandes, M. F., Mutch, D. M., & Leri, F. (2017) · Nutrients · doi:10.3390/nu9030298 · Cited by 90 · see citing works
Serum Endocannabinoid and Mood Changes after Exercise in Major Depressive Disorder
Meyer, J. D., Crombie, K. M., Cook, D. B., Hillard, C. J., & Koltyn, K. F. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002006 · Cited by 90 · see citing works
Locci, A., & Pinna, G. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.006 · Cited by 90 · see citing works
Bailey, C. R., Cordell, E., Sobin, S. M., & Neumeister, A. (2013) · CNS Drugs · doi:10.1007/s40263-013-0051-4 · Cited by 89 · see citing works
Finn, D. P. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.05.011 · Cited by 88 · see citing works
Oleoylethanolamide, Neuroinflammation, and Alcohol Abuse
Orío, L., Alén, F., Pavón, F. J., Serrano, A., & García‐Bueno, B. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00490 · Cited by 90 · see citing works
Endocannabinoids, cannabinoids and the regulation of anxiety
Petrie, G. N., Nastase, A. S., Aukema, R. J., & Hill, M. N. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108626 · Cited by 85 · see citing works
Brain CB2 Receptors: Implications for Neuropsychiatric Disorders
Roche, M., & Finn, D. P. (2010) · Pharmaceuticals · doi:10.3390/ph3082517 · Cited by 87 · see citing works
Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity
Segev, A., Korem, N., Zer‐Aviv, T. M., Abush, H., Lange, R., Sauber, G., Hillard, C. J., & Akirav, I. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0135-4 · Cited by 77 · see citing works
Endocannabinoid Signaling in the Etiology and Treatment of Major Depressive Illness
Hillard, C. J., & Liu, Q.-S. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660735 · Cited by 79 · see citing works
The endocannabinoid system in mental disorders: Evidence from human brain studies
Ibarra‐Lecue, I., Pilar-Cuéllar, F., Muguruza, C., Florensa-Zanuy, E., Díaz, Á., Urigüen, L., Castro, E., Pazos, Á., & Callado, L. F. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.009 · Cited by 80 · see citing works
Endocannabinoid system in psychotic and mood disorders, a review of human studies
Ramesh, R. G., Watts, J. J., & Mizrahi, R. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110096 · Cited by 79 · see citing works
Endocannabinoids: Effectors of glucocorticoid signaling
Balsevich, G., Petrie, G. N., & Hill, M. N. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.005 · Cited by 78 · see citing works
Neumeister, A., Seidel, J., Ragen, B., & Pietrzak, R. H. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.012 · Cited by 76 · see citing works
Bedse, G., Hill, M. N., & Patel, S. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.01.015 · Cited by 75 · see citing works
Griebel, G., Stemmelin, J., Lopez‐Grancha, M., Fauchey, V., Slowinski, F., Pichat, P., Dargazanli, G., Abouabdellah, A., Cohen, C., & Bergis, O. E. (2018) · Scientific Reports · doi:10.1038/s41598-018-20895-z · Cited by 76 · see citing works
A Systematic Review and Meta-Analysis on the Effects of Exercise on the Endocannabinoid System
Desai, S., Borg, B. A., Cuttler, C., Crombie, K. M., Rabinak, C. A., Hill, M. N., & Marusak, H. A. (2021) · Cannabis and Cannabinoid Research · doi:10.1089/can.2021.0113 · Cited by 73 · see citing works
Rahimian, R., Belliveau, C., Chen, R., & Mechawar, N. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.871997 · Cited by 73 · see citing works
Lipidomics applications in health, disease and nutrition research
MURPHY, S. A., & Nicolaou, A. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200863 · Cited by 69 · see citing works
Endocannabinoids and Mental Disorders
Rubino, T., Zamberletti, E., & Parolaro, D. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-20825-1_9 · Cited by 71 · see citing works
Developmental regulation of fear learning and anxiety behavior by endocannabinoids
Lee, T. T.-Y., Hill, M. N., & Lee, F. S. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12253 · Cited by 67 · see citing works
Ney, L. J., Matthews, A. J., Bruno, R., & Felmingham, K. L. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.006 · Cited by 66 · see citing works
Effects of parabolic flight and spaceflight on the endocannabinoid system in humans
Strewe, C., Feuerecker, M., Nichiporuk, I., Kaufmann, I., Hauer, D., Morukov, B., Schelling, G., & Choukèr, A. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2012-0057 · Cited by 63 · see citing works
Consideration of sex and gender differences in addiction medication response
McKee, S. A., & McRae‐Clark, A. L. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00441-3 · Cited by 64 · see citing works
Psychobiological Responses to Aerobic Exercise in Individuals With Posttraumatic Stress Disorder
Crombie, K. M., Brellenthin, A. G., Hillard, C. J., & Koltyn, K. F. (2018) · Journal of Traumatic Stress · doi:10.1002/jts.22253 · Cited by 65 · see citing works
Hindocha, C., Cousijn, J., Rall, M., & Bloomfield, M. (2019) · Journal of Dual Diagnosis · doi:10.1080/15504263.2019.1652380 · Cited by 64 · see citing works
Wieck, A., Grassi-Oliveira, R., do Prado, C. H., Rizzo, L. B., de Oliveira, A. S., Kommers-Molina, J., Viola, T. W., Teixeira, A. L., & Bauer, M. E. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.07.005 · Cited by 63 · see citing works
Oleoylethanolamide: A novel pharmaceutical agent in the management of obesity‐an updated review
Payahoo, L., Khajebishak, Y., & Ostadrahimi, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27913 · Cited by 64 · see citing works
Crombie, K. M., Leitzelar, B. N., Brellenthin, A. G., Hillard, C. J., & Koltyn, K. F. (2019) · Biological Psychology · doi:10.1016/j.biopsycho.2019.04.002 · Cited by 63 · see citing works
Antidepressant and Anxiolytic Effects of Medicinal Cannabis Use in an Observational Trial
Martin, E. L., Strickland, J. C., Schlienz, N. J., Munson, J., Jackson, H., Bonn‐Miller, M. O., & Vandrey, R. G. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.729800 · Cited by 62 · see citing works
Cedernaes, J., Fanelli, F., Fazzini, A., Pagotto, U., Broman, J.-E., Vogel, H., Dickson, S. L., Schiöth, H. B., & Benedict, C. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.014 · Cited by 59 · see citing works
Endocannabinoids, exercise, pain, and a path to health with aging
Watkins, B. A. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.10.001 · Cited by 59 · see citing works
Endocannabinoid‐related lipids are increased during an episode of cyclic vomiting syndrome
Venkatesan, T., Zadvornova, Y., Raff, H., & Hillard, C. J. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12843 · Cited by 58 · see citing works
High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity
Fitzgibbon, M., Finn, D. P., & Roche, M. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv095 · Cited by 57 · see citing works
Gao, W., Walther, A., Wekenborg, M., Penz, M. S., & Kirschbaum, C. (2020) · Talanta · doi:10.1016/j.talanta.2020.121006 · Cited by 56 · see citing works
Newsom, R. J., Osterlund, C., Masini, C. V., Day, H. E., Spencer, R. L., & Campeau, S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.043 · Cited by 54 · see citing works
Metabolite profiling in posttraumatic stress disorder
Karabatsiakis, A., Hamuni, G., Wilker, S., Kolassa, S., Renu, D., Kadereit, S., Schauer, M., Hennessy, T., & Kolassa, I. (2015) · Journal of Molecular Psychiatry · doi:10.1186/s40303-015-0007-3 · Cited by 52 · see citing works
Mitjans, M., Serretti, A., Fabbri, C., Gastó, C., Catalán, R., Fañanás, L., & Arias, B. (2013) · Psychopharmacology · doi:10.1007/s00213-013-2995-y · Cited by 52 · see citing works
Yi, B., Ничипорук, И. А., Nicolas, M., Schneider, S., Feuerecker, M., Vassilieva, G. Y., Thieme, D., Schelling, G., & Choukèr, A. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.01.004 · Cited by 51 · see citing works
Romero‐Sanchiz, P., Nogueira‐Arjona, R., Pastor, A., Araos, P. F., Serrano, A., Boronat, A., García‐Marchena, N., Mayoral, F., Bordallo-Aragón, A., Alén, F., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.026 · Cited by 52 · see citing works
Characterization of serotonin neurotransmission in knockout mice: implications for major depression
Domínguez-López, S., Howell, R. D., & Gobbi, G. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2012-0044 · Cited by 51 · see citing works
Schizophrenia and depression, two poles of endocannabinoid system deregulation
Rodríguez-Muñoz, M., Sánchez‐Blázquez, P., Callado, L. F., Meana, J. J., & Garzón-Niño, J. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0029-y · Cited by 52 · see citing works
Payahoo, L., Khajebishak, Y., Jafarabadi, M. A., & Ostadrahimi, A. (2018) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2018.056 · Cited by 51 · see citing works
Thieme, U., Schelling, G., Hauer, D., Greif, R. T., Dame, T., Laubender, R. P., Bernhard, W. R., Thieme, D., Campolongo, P., & Theiler, L. G. (2013) · Drug Testing and Analysis · doi:10.1002/dta.1561 · Cited by 50 · see citing works
Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder
Ogawa, S., Hattori, K., Sasayama, D., Yokota, Y., Matsumura, R., Matsuo, J., Ota, M., Hori, H., Teraishi, T., Yoshida, S., et al. (2015) · Scientific Reports · doi:10.1038/srep07796 · Cited by 48 · see citing works
Bassi, M. S., Gilio, L., Maffei, P., Dolcetti, E., Bruno, A., Buttari, F., Centonze, D., & Iezzi, E. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00424 · Cited by 49 · see citing works
Suárez, J., Rivera, P., Llorente, R., Romero‐Zerbo, S., Bermúdez‐Silva, F. J., de Fonseca, F. R., & Viveros, M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.06.042 · Cited by 48 · see citing works
Ogawa, S., & Kunugi, H. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150612225212 · Cited by 48 · see citing works
Neumeister, A. (2013) · Depression and Anxiety · doi:10.1002/da.22031 · Cited by 47 · see citing works
Role of the Endocannabinoid System in Depression: from Preclinical to Clinical Evidence
Micale, V., Tabiová, K., Kučerová, J., & Drago, F. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_5 · Cited by 47 · see citing works
Zamberletti, E., Piscitelli, F., Castro, V. D., Murru, E., Gabaglio, M., Colucci, P., Fanali, C., Prini, P., Bisogno, T., Maccarrone, M., et al. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m068387 · Cited by 47 · see citing works
Serum contents of endocannabinoids are correlated with blood pressure in depressed women
Ho, W. ‐. V., Hill, M. N., Miller, G. E., Gorzalka, B. B., & Hillard, C. J. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-32 · Cited by 46 · see citing works
Abnormalities in neuroendocrine stress response in psychosis: the role of endocannabinoids
Appiah‐Kusi, E., Leyden, E., Parmar, S. R., Mondelli, V., McGuire, P. K., & Bhattacharyya, S. (2015) · Psychological Medicine · doi:10.1017/s0033291715001786 · Cited by 45 · see citing works
Endocannabinoid signaling in psychiatric disorders: a review of positron emission tomography studies
Sloan, M. E., Grant, C. W., Gowin, J. L., Ramchandani, V. A., & Foll, B. L. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0081-z · Cited by 47 · see citing works
Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology
Rodrigues, R. S., Lourenço, D. M., Paulo, S. L., Mateus, J. M., Ferreira, M. F., Mouro, F. M., Moreira, J. B., Ribeiro, F. F., Sebastião, A. M., & Xapelli, S. (2019) · Molecules · doi:10.3390/molecules24071350 · Cited by 45 · see citing works
Locci, A., & Pinna, G. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.12.014 · Cited by 42 · see citing works
Molecular Alterations of the Endocannabinoid System in Psychiatric Disorders
Navarro, D., Gasparyan, A., Navarrete, F., Torregrosa, A. B., Rubio, G., Marín, M., Acosta, G. B., García‐Gutiérrez, M. S., & Manzanares, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094764 · Cited by 45 · see citing works
Modulation of Endocannabinoid System Components in Depression: Pre-Clinical and Clinical Evidence
Bright, U., & Akirav, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105526 · Cited by 47 · see citing works
Inserra, A., Giorgini, G., Lacroix, S., Bertazzo, A., Choo, J. M., Markopolous, A., Grant, E., Abolghasemi, A., Gregorio, D. D., Flamand, N., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15977 · Cited by 40 · see citing works
- Authors
- Hill, M. N., Miller, G. E., Carrier, E. J., Gorzalka, B. B., & Hillard, C. J.
- Affiliations
- University of British Columbia (CA)
- Medical College of Wisconsin (US)
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 34
- Issue
- 8
- Pages
- 1257-1262
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC2716432
- OpenAlex
- W2097199164
- Cited by
- 328
- References
- 30
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 29 · 2023: 19 · 2022: 25 · 2021: 37 · 2020: 23 · 2019: 22 · 2018: 22 · 2017: 17 · 2016: 15 · 2015: 18 · 2014: 8 · 2013: 20 · 2012: 12
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01DA009155)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- endocannabinoids, N-acylethanolamines, major depressive disorder, social stress, anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, oleoylethanolamide, serum biomarkers, Trier Social Stress Test, women, stress response
- MeSH terms
- Adult, Amides, Arachidonic Acids, Major Depressive Disorder, Ethanolamines, Female, Glycerides, Humans, Oleic Acids, Palmitic Acids, Stress, Psychological, Case-Control Studies, Polyunsaturated Alkamides, Cannabinoid Receptor Modulators, Endocannabinoids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
