Cited by 296Probiotics and Fermented FoodsNeuroscience and Neuropharmacology ResearchGut microbiota and health

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Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: Behavioral and electrophysiological proofs for microbiome–gut–brain axis

Davari, S., Talaei, S.A., Alaei, H., salami, M.·2013·Neuroscience

DOI 10.1016/j.neuroscience.2013.02.055

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Abstract

Diabetes mellitus-induced metabolic disturbances underlie the action of many systems including some higher functions of the brain such as learning and memory. Plenty of evidence supports the effects of probiotics on the function of many systems including the nervous system. Here we report the effect of probiotics treatment on the behavioral and electrophysiological aspects of learning and memory disorders. Diabetic rats were made through intraperitoneal injection of streptozocin. The control and diabetic rats were fed with either normal regimen (control rats recieving normal regimen (CO) and diabetics rats receiving normal regimen (DC), respectively) or normal regimen plus probiotic supplementation for 2months (control rats receiving probiotic supplementation (CP) and diabetics rats recieving probiotic supplementation (DP), respectively). The animals were first introduced to spatial learning task in the Morris water maze. Then, in electrophysiological experiments, stimulating the Schaffer collaterals the basic and potentiated excitatory postsynaptic potential (EPSPs) were recorded in the CA1 area of the hippocampus. Finally, the serum levels of glucose, insulin, superoxide dismutase and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured. We found that probiotics administration considerably improved the impaired spatial memory in the diabetic animals. The probiotics supplementation in the diabetic rats recovered the declined basic synaptic transmission and further restored the hippocampal long-term potentiation (LTP). While the probiotics administration enhanced the activation of superoxide dismutase and increased the insulin level of serum it decreased both the glucose level of serum and the 8-OHdG factor. From the present results we concluded that probiotics efficiently reverse deteriorated brain functions in the levels of cognitive performances and their proposed synaptic mechanisms in diabetes mellitus. These considerations imply on the necessity of an optimal function of the microbiome-gut-brain axis in the behavioral as well as electrophysiological aspects of brain action.

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Additional file 14 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688688
Additional file 18 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688700
Additional file 17 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688697
Additional file 20 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688706
Additional file 15 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688691
Additional file 13 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688685
Additional file 19 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688703
Additional file 16 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688694
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“Fundamentally, SOD functions as the primary defense mechanism against harm inflicted by free radicals, facilitating the conversion of oxide radicals into oxygen and water (Davari et al ., 2013).”
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Self-citation
Additional file 9 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688664
Additional file 11 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688673
Additional file 6 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688646
Additional file 7 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688649
Additional file 2 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688631
Additional file 3 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688634
Additional file 12 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688679
Additional file 1 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688628
Additional file 4 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688640
Additional file 5 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688643
Additional file 8 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688655
Additional file 10 of Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
Hao, Z., Meng, C., Li, L., Feng, S., Zhu, Y., Yang, J., Han, L., Sun, L., Lv, W., Figeys, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22688667
Administration of Lactobacillus helveticus decreases the mortality caused by audiogenic seizures in DBA/1 mice
Jiang, C., Yue, Q., Cai, M., Zeng, C., & Zhan, Q. (2024) · Neurophysiology · doi:10.1007/s11062-025-09988-4
The effect of various types of autoprobiotics on the microbiota and behavior in correction of experimental intestinal dysbiosis
Ермоленко, Е. И., Novikova, N. S., Котылева, М. П., Matsulevich, A. V., Karaseva, A. B., Zabelnikova, A. M., & Abdurasulova, I. N. (2026) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-239-7-147-161
Neuroendocrine regulation of metabolism in the brain of type 2 diabetes
Yadav, H., Soni, S. K., Kumari, S., & Maurya, S. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-32848-0.00017-0
Therapeutic Role of Oxidative Stress in Diabetes
Saha, S., Karande, A. V., Nair, G. G., & Srivastava, N. (2026) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-032-19837-2_7
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Jiang, Y., Liu, S., Liu, X., Tang, W., Sun, B., Wang, Y., Li, X. Q., & Zhao, H. (2026) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2026.103086
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Kuba, E. E. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Effect of probiotic fermented milk (kefir) on glycemic control and lipid profile in type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial.
(2015) · PubMed Central · Cited by 242

Authors: Davari, S., Talaei, S. A., Alaei, H., & salami, M.
Affiliations: Isfahan University of Medical Sciences (IR)
Kashan University of Medical Sciences (IR)
Corresponding author: salami, M.
ORCID: Davari, S.
Talaei, S.A.
Alaei, H.
salami, M.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2013-06
Volume: 240
Pages: 287-296
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2013.02.055
OpenAlex: W2082281485
Cited by: 290
References: 53
Citations by year: 2026: 6 · 2025: 17 · 2024: 19 · 2023: 31 · 2022: 24 · 2021: 25 · 2020: 32 · 2019: 31 · 2018: 18 · 2017: 19 · 2016: 31 · 2015: 17 · 2014: 11 · 2013: 9
FWCI: 33.73
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Deputy of Research, Isfahan University of Medical Sciences (390491)
Deputy of Research, Kashan University of Medical Sciences (9020)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: probiotics, diabetes mellitus, microbiome-gut-brain axis, spatial memory, learning disabilities, hippocampus, synaptic transmission, long-term potentiation, excitatory postsynaptic potentials, Schaffer collaterals, oxidative stress, superoxide dismutase, 8-hydroxy-2'-deoxyguanosine, insulin, streptozotocin-induced diabetes, cognitive function
MeSH terms: 8-Hydroxy-2'-Deoxyguanosine, Analysis of Variance, Animals, Biophysics, Blood Glucose, Brain, Cognition Disorders, Deoxyguanosine, Diabetes Mellitus, Experimental, Disease Models, Animal, Drug Administration Schedule, Electric Stimulation, Hippocampus, Insulin, Male, Streptozocin, Superoxide Dismutase, Rats, Wistar, Long-Term Potentiation, Maze Learning, Probiotics, Rats, Metagenome, In Vitro Techniques

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Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: Behavioral and electrophysiological proofs for microbiome–gut–brain axis

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