Cited by 296Probiotics and Fermented FoodsNeuroscience and Neuropharmacology ResearchGut microbiota and health

The DOI matches its Crossref record; 51 of the 53 references it cites were found in a registry or an index.

Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: Behavioral and electrophysiological proofs for microbiome–gut–brain axis

Davari, S., Talaei, S.A., Alaei, H., salami, M.·2013·Neuroscience

DOI 10.1016/j.neuroscience.2013.02.055

Open this paper in CoChat — free account

Abstract

Diabetes mellitus-induced metabolic disturbances underlie the action of many systems including some higher functions of the brain such as learning and memory. Plenty of evidence supports the effects of probiotics on the function of many systems including the nervous system. Here we report the effect of probiotics treatment on the behavioral and electrophysiological aspects of learning and memory disorders. Diabetic rats were made through intraperitoneal injection of streptozocin. The control and diabetic rats were fed with either normal regimen (control rats recieving normal regimen (CO) and diabetics rats receiving normal regimen (DC), respectively) or normal regimen plus probiotic supplementation for 2months (control rats receiving probiotic supplementation (CP) and diabetics rats recieving probiotic supplementation (DP), respectively). The animals were first introduced to spatial learning task in the Morris water maze. Then, in electrophysiological experiments, stimulating the Schaffer collaterals the basic and potentiated excitatory postsynaptic potential (EPSPs) were recorded in the CA1 area of the hippocampus. Finally, the serum levels of glucose, insulin, superoxide dismutase and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured. We found that probiotics administration considerably improved the impaired spatial memory in the diabetic animals. The probiotics supplementation in the diabetic rats recovered the declined basic synaptic transmission and further restored the hippocampal long-term potentiation (LTP). While the probiotics administration enhanced the activation of superoxide dismutase and increased the insulin level of serum it decreased both the glucose level of serum and the 8-OHdG factor. From the present results we concluded that probiotics efficiently reverse deteriorated brain functions in the levels of cognitive performances and their proposed synaptic mechanisms in diabetes mellitus. These considerations imply on the necessity of an optimal function of the microbiome-gut-brain axis in the behavioral as well as electrophysiological aspects of brain action.

Integrity signals

Registry

Crossref · 10.1016/j.neuroscience.2013.02.055

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Oxidative stress: oxidants and antioxidants
Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Diabetes, oxidative stress, and antioxidants: A review
Maritim, A. C., Sanders, R. A., & Watkins, J. B. (2003) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.10058 · Cited by 3,167
Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
Baynes, J. W., & Thorpe, S. R. (1999) · Diabetes · doi:10.2337/diabetes.48.1.1 · Cited by 2,441
Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction?
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.1 · Cited by 1,482
Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells
Tiedge, M., Lortz, S., Drinkgern, J., & Lenzen, S. (1997) · Diabetes · doi:10.2337/diab.46.11.1733 · Cited by 1,211
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD).
Luscher, C., & Malenka, R. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005710 · Cited by 1,110 · cited 1×
“Long-term potentiation (LTP) and long-term depression (LTD) are activity-dependent changes in synaptic efficacy which have been considered for cellular mechanisms of learning and memory (Luscher and Malenka, 2012).”
Background
Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
Ungless, M. A., Whistler, J. L., Malenka, R. C., & Bonci, A. (2001) · Nature · doi:10.1038/35079077 · Cited by 1,106
The microbiome-gut-brain axis: from bowel to behavior
Cryan, J. F., & O’Mahony, S. M. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01664.x · Cited by 990

Show all 53 references

Sorted by citations

Items 101–200 of 296

Human Oral Buccal Microbiomes Are Associated with Farmworker Status and Azinphos-Methyl Agricultural Pesticide Exposure
Stanaway, I. B., Wallace, J. C., Shojaie, A., Griffith, W. C., Hong, S., Wilder, C. S., Green, F. H., Tsai, J. M., Knight, M., Workman, T. W., et al. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.02149-16 · Cited by 48
Early nutrition and gut microbiome: interrelationship between bacterial metabolism, immune system, brain structure, and neurodevelopment
Cerdó, T., Diéguez, E., & Campoy, C. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00188.2019 · Cited by 48
Microbial memories: Sex‐dependent impact of the gut microbiome on hippocampal plasticity
Darch, H. T., Collins, M., O’Riordan, K. J., & Cryan, J. F. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15119 · Cited by 51
Psychoactive Effects of Lactobacillus johnsonii Against Restraint Stress-Induced Memory Dysfunction in Mice Through Modulating Intestinal Inflammation and permeability—a Study Based on the Gut–Brain Axis Hypothesis
Wang, H., He, S., Xin, J., Zhang, T., Sun, N., Li, L., Ni, X., Zeng, D., Ma, H., & Bai, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.662148 · Cited by 47
“Many probiotics have psychobiotic potential of restoring or preventing hippocampal-dependent memory deficits in rodents induced by many different factors such as aging (Jeong et al., 2015) and diabetes (Davari et al., 2013).”
Background
Probiotic supplementation improves the cognitive function and the anxiety-like behaviors in the stressed rats.
Hadizadeh, M., Hamidi, G. A., & Salami, M. (2019) · PubMed Central · doi:10.22038/ijbms.2019.33956.8078 · Cited by 48
“The present results are consistent to reports indicating favorable effect of probiotics on the cognitive trends (37, 56).”
ResultSelf-citation
Microbes, metabolites and (synaptic) malleability, oh my! T he effect of the microbiome on synaptic plasticity
Glinert, A., Turjeman, S., Elliott, E., & Koren, O. (2021) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12812 · Cited by 48
“Govindarajulu et al. (2020) set out to determine the potential effects on LTP induction by the microbiome-dependent metabolite trimethylamine N-oxide (TMAO).”
BackgroundInfluential
The influence of a probiotic supplementation on memory in quail suggests a role of gut microbiota on cognitive abilities in birds
Parois, S. P., Calandreau, L., Kraïmi, N., Gabriel, I., & Leterrier, C. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.022 · Cited by 45
Intermingling of gut microbiota with brain: Exploring the role of probiotics in battle against depressive disorders
Tyagi, P., Tasleem, M., Prakash, S., & Chouhan, G. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109489 · Cited by 42
The gut microbiota‐astrocyte axis: Implications for type 2 diabetic cognitive dysfunction
Li, Z.-H., Jiang, Y., Long, C., Peng, Q., & Yue, R. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14077 · Cited by 41
Infant Gut Microbiota Associated with Fine Motor Skills
Acuña, I., Cerdó, T., Ruiz-Rodriguez, A., Torres-Espínola, F. J., López‐Moreno, A., Aguilera, J., Suárez, A., & Campoy, C. (2021) · Nutrients · doi:10.3390/nu13051673 · Cited by 41
“fermentum improved diabetes-induced impairment of synaptic activity and cognitive function in rats [46].”
Background
Delving the role of nutritional psychiatry to mitigate the COVID-19 pandemic induced stress, anxiety and depression
Shabbir, M. A., Mehak, F., Khan, Z. M., Ahmed, W., Haq, S. M. A. U., Khan, M. R., Bhat, Z. F., & Aadil, R. M. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.12.035 · Cited by 47
Gut microbiota composition of Japanese macaques associates with extent of human encroachment
Lee, W., Hayakawa, T., Kiyono, M., Yamabata, N., & Hanya, G. (2019) · American Journal of Primatology · doi:10.1002/ajp.23072 · Cited by 41
Gut Microbiome and Behavior
Foster, J. A. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.07.005 · Cited by 41
“However, it should be noted that while the probiotic treatment did reduce serum glucose levels compared to nonprobiotic diabetic rat group, these levels remained significantly higher than control rats (Davari et al., 2013).”
BackgroundInfluential
Psychobiotic Effects of Multi-Strain Probiotics Originated from Thai Fermented Foods in a Rat Model
Luang‐In, V., Katisart, T., Konsue, A., Nudmamud‐Thanoi, S., Narbad, A., Saengha, W., Wangkahart, E., Pumriw, S., Samappito, W., & Ling, N. (2020) · Food Science of Animal Resources · doi:10.5851/kosfa.2020.e72 · Cited by 47
Lactobacillus casei-01 Facilitates the Ameliorative Effects of Proanthocyanidins Extracted from Lotus Seedpod on Learning and Memory Impairment in Scopolamine-Induced Amnesia Mice
Xiao, J., Li, S., Sui, Y., Wu, Q., Li, X., Xie, B., Zhang, M., & Sun, Z. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112773 · Cited by 39
Gut Microbiota and Parkinson’s Disease: Implications for Faecal Microbiota Transplantation Therapy
Kang, Y., Kang, X., Zhang, H., Liu, Q., Yang, H., & Fan, W. (2021) · ASN NEURO · doi:10.1177/17590914211016217 · Cited by 38
Adolescent dietary manipulations differentially affect gut microbiota composition and amygdala neuroimmune gene expression in male mice in adulthood
Fülling, C., Lach, G., Bastiaanssen, T. F. S., Fouhy, F., O'Donovan, A. N., Ventura-Silva, A.-P., Stanton, C., Dinan, T. G., & Cryan, J. F. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.02.013 · Cited by 36
Lactic Acid Bacteria in Health and Disease
Xiao, J., Zhang, Y., & Yang, Z. (2014) · Springer eBooks · doi:10.1007/978-94-017-8841-0_5 · Cited by 38
Neurological and Cognitive Significance of Probiotics: A Holy Grail Deciding Individual Personality
Afzal, M., Mazhar, S. F., Sana, S., Naeem, M. A., Rasool, M. H., Saqalein, M., Nisar, M. A., Rasool, M., Bilal, M., Khan, A. A., et al. (2020) · Future Microbiology · doi:10.2217/fmb-2019-0143 · Cited by 34
Microbiome and Metabolome Insights into the Role of the Gastrointestinal–Brain Axis in Parkinson’s and Alzheimer’s Disease: Unveiling Potential Therapeutic Targets
Zacharias, H. U., Kaleta, C., Cossais, F., Schaeffer, E., Berndt, H., Best, L., Dost, T., Glüsing, S., Groussin, M., Poyet, M., et al. (2022) · Metabolites · doi:10.3390/metabo12121222 · Cited by 38
“Concerning probiotics, various animal and few human studies have shown behavioral and neuropsychiatric effects including effects on cognitive function or fatigue [183,184].”
Background
Bacillus licheniformis prevents and reduces anxiety-like and depression-like behaviours
Feng, S., Chen, M., Liu, Y., Yi, Y., Liang, A., Zhang, Y., & Hao, Z. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12580-7 · Cited by 36
Effects of probiotics on GABA/glutamate and oxidative stress in PTZ- induced acute seizure model in rats
ÇİLTAŞ, A. Ç., Toy, C. E., Güneş, H., & Yaprak, M. (2023) · Epilepsy Research · doi:10.1016/j.eplepsyres.2023.107190 · Cited by 36
Saccharomyces boulardii improves the behaviour and emotions of spastic cerebral palsy rats through the gut-brain axis pathway
Tao, D., Zhong, T., Pang, W., & li, X. (2021) · BMC Neuroscience · doi:10.1186/s12868-021-00679-4 · Cited by 33
“The beneficial effects of probiotic consumption on behaviour and brain function are now becoming increasingly appreciated in a variety of inflammatory diseases [66, 67].”
Background
The effects of lactobacilli (L. rhamnosus, L. reuteri, L. Plantarum) on LPS-induced memory impairment and changes in CaMKII-α and TNF-α genes expression in the hippocampus of rat
Zolfaghari, S. I., Khorasgani, M. R., & Noorbakhshnia, M. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113224 · Cited by 32
Effect of pregabalin on contextual memory deficits and inflammatory state-related protein expression in streptozotocin-induced diabetic mice
Sałat, K., Gdula‐Argasińska, J., Malikowska‐Racia, N., Podkowa, A., Lipkowska, A., & Librowski, T. (2016) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-016-1230-x · Cited by 30
“…shown that not only the intracerebral application of STZ leads to memory deficits (Blokland and Jolles 1993; Chen et al. 2013), but the intraperitoneal (ip) administration of this drug can also induce memory impairments (Cai et al. 2011; Davari et al. 2013; Miao et al. 2015; Takizawa et al. 2013).”
Background
Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way?
Zheng, X., Zhang, X., An, K., Ran, C., Wang, G., & Hao, H. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.06.020 · Cited by 29
“…benefits (e.g., Lactobacillus rhamnosus, Bacteroides fragilis), has shown beneficial effects on cognitive impairment associated with diabetes (Davari et al., 2013), behavioral abnormalities in autism spectrum disorder (Hsiao et al., 2013) and stress-induced depression and anxiety in animal…”
A Combination Supplement of Fructo- and Xylo-Oligosaccharides Significantly Abrogates Oxidative Impairments and Neurotoxicity in Maternal/Fetal Milieu Following Gestational Exposure to Acrylamide in Rat
Krishna, G., Divyashri, G., Prapulla, S. G., & ., M. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1687-x · Cited by 29
“These results are consistent with previous reports showing that Bifidobacterium probiotic can augment antioxidant function [61, 62].”
Result
Association Between Consumption of Fermented Food and Food-Derived Prebiotics With Cognitive Performance, Depressive, and Anxiety Symptoms in Psychiatrically Healthy Medical Students Under Psychological Stress: A Prospective Cohort Study
Karbownik, M. S., Mokros, Ł., Dobielska, M., Kowalczyk, M., & Kowalczyk, E. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.850249 · Cited by 33
Bridging the gap: associations between gut microbiota and psychiatric disorders
Ahmed, G. K., Ramadan, H. K., Elbeh, K., & Haridy, N. A. (2024) · Middle East Current Psychiatry · doi:10.1186/s43045-024-00395-9 · Cited by 33
Probiotic actions on diseases: implications for therapeutic treatments
Chiu, Y., Lin, S.-L., Tsai, J., & Lin, M. (2014) · Food & Function · doi:10.1039/c3fo60600g · Cited by 28
Cognitive Impairment and Synaptic Dysfunction in Cardiovascular Disorders: The New Frontiers of the Heart–Brain Axis
Soda, T., Pasqua, T., Sarro, G. D., & Moccia, F. D. (2024) · Biomedicines · doi:10.3390/biomedicines12102387 · Cited by 28
“…l-3-n -Butylphthalide (NBP) [184], the isoquinoline alkaloid berberine [185], the phenolic compound vanillic acid [186], probiotics treatment [187], inhibition of the receptor for advanced glycation end products (RAGE) with the specific blocker FPS-ZM1 [188], physical exercise [189], and…”
Background
The Microbiome and Cancer
Kelly, D. L., Lyon, D., Yoon, S. L., & Horgas, A. L. (2015) · Cancer Nursing · doi:10.1097/ncc.0000000000000286 · Cited by 28
“In fact, probiotics supplementation in diabetic rats recovered the declined basic synaptic transmission and further restored the hippocampal long-term potentiation.(40) With respect to humans, emerging literature in humans suggests an association between the microbiome and cognitive outcomes in individuals with chroni…”
Background
Cross-species examination of single- and multi-strain probiotic treatment effects on neuropsychiatric outcomes
Joseph, J., & Law, C. A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.010 · Cited by 26
The Effects of Probiotic Supplementation on Opioid‐Related Disorder in Patients under Methadone Maintenance Treatment Programs
Molavi, N., Rasouli‐Azad, M., Mirzaei, H., Matini, A. H., Banafshe, H. R., Valiollahzadeh, M., Hassanzadeh, M., Saghazade, A. R., Abbaszadeh‐Mashkani, S., Mamsharifi, P., et al. (2022) · International Journal of Clinical Practice · doi:10.1155/2022/1206914 · Cited by 26
“Probiotics had 6 International Journal of Clinical Practice inhibitory eﬀects on several oxidative stress factors in nervous system disorders in both human [17] and animal models [69–71].”
Microbiota and stress: a loop that impacts memory
Kraïmi, N., Lormant, F., Calandreau, L., Kempf, F., Zemb, O., Lemarchand, J., Constantin, P., Parias, C., Germain, K., Dupont, C., et al. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105594 · Cited by 28
The microbiota-gut- hippocampus axis
Salami, M., & Soheili, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1065995 · Cited by 30
“The probiotic administration enhanced LTP in 6 studies (Davari et al., 2013; Distrutti et al., 2014; Asl et al., 2019; Rezaei Asl et al., 2019; Rezaeiasl et al., 2019; Talani et al., 2020).”
BackgroundSelf-citation
LPS-induced acute neuroinflammation, involving interleukin-1 beta signaling, leads to proteomic, cellular, and network-level changes in the prefrontal cortex of mice
Mittli, D., Tukacs, V., Ravasz, L., Csősz, É., Kozma, T., Kardos, J., Juhász, G. D., & Kékesi, K. A. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2023.100594 · Cited by 24
Recent findings within the microbiota–gut–brain–endocrine metabolic interactome
Obrenovich, M. E., Mana, T. S. C., Rai, H., Shola, D. T. N., Sass, C., McCloskey, B., & Levison, B. S. (2017) · Pathology and Laboratory Medicine International · doi:10.2147/plmi.s121487 · Cited by 24
“Conversely, probiotic treatment has been shown to improve diabetic complications in synaptic activity and cognitive function.(22) Furthermore, there are compounds chemically related to the catecholamines and 5-hydroxytryptamine (5-HT).”
Probiotics improve insulin resistance status in an experimental model of Alzheimer’s disease
Azm, S. A. N., Djazayeri, A., Safa, M., Azami, K., Djalali, M., Sharifzadeh, M. S., & Vafa, M. (2017) · Medical Journal of the Islamic Republic of Iran · doi:10.14196/mjiri.31.103 · Cited by 24
“…the results of our pilot study, water volume was calculated (30 mL) and 2 g of probiotics (probiotics dosage was selected based on a previous study (Davari et al. 2013) and our pilot study) including lactobacillus acidophilus, fermentum, Bifidobacterium lactis, and longum (1010 colony forming…”
Background
L-3-n-butylphthalide attenuates cognitive deficits in db/db diabetic mice
Zhang, S., Ji, S., Bai, X., Yuan, F., Zhang, L., & Li, J. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0356-6 · Cited by 24
Comorbid brain disorders associated with diabetes: therapeutic potentials of prebiotics, probiotics and herbal drugs
Thakur, A. K., Tyagi, S., & Shekhar, N. (2019) · Translational Medicine Communications · doi:10.1186/s41231-019-0043-6 · Cited by 25
A neuroscience perspective of the gut theory of Parkinson's disease
Smith, L. M., & Parr‐Brownlie, L. C. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13869 · Cited by 25
Treatment with gut bifidobacteria improves hippocampal plasticity and cognitive behavior in adult healthy rats
Talani, G., Biggio, F., Mostallino, M. C., Locci, V., Porcedda, C., Boi, L., Saolini, E., Piras, R., Sanna, E., & Biggio, G. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107909 · Cited by 24
Effects of Dioscorea polystachya 'yam gruel' on the cognitive function of diabetic rats with focal cerebral ischemia-reperfusion injury via the gut-brain axis
Pang, S., Luo, Z., Wang, C. C., Hong, X., Zhou, J., Chen, F., Ge, L., Li, X., Dai, Y., Wu, Y., et al. (2020) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2020.02.69 · Cited by 23
“Relevant studies have shown that probiotics, such as Lactobacillus, Clostridium butyricum, and SCFAs have antioxidant effects that reduce oxidative stress, alleviate brain damage and improve cognitive dysfunction (Davari et al., 2013; Kim et al., 2018; Liu et al., 2017; Swidsinski et al., 2012).”
Background
A future perspective on neurodegenerative diseases: nasopharyngeal and gut microbiota
Khan, F., & Oloketuyi, S. F. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13327 · Cited by 22
“Similar reports have claimed that gut flora modulation by probiotics influences gut neuromotor functions reviewed in Verdu (2009), and a study showed that bacterial probiotic supplementation improved impaired memory in diabetic rats (Davari et al. 2013).”
Result
Exploring the promise of psychobiotics: Bridging gut microbiota and mental health for a flourishing society
Kamal, N., Saharan, B. S., Duhan, J. S., Kumar, A., Chaudhary, P., Goyal, C., Kumar, M., Goyat, N., Sindhu, M., & Mudgil, P. (2024) · Medicine in Microecology · doi:10.1016/j.medmic.2024.100118 · Cited by 24
The Brain-gut Axis-where are we now and how can we Modulate these Connections?
Dąbrowski, W., Siwicka-Gieroba, D., Kotfis, K., Zaid, S., Terpiłowska, S., Robba, C., & Siwicki, A. K. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666201119155535 · Cited by 21
“The probiotic supplementation leads to recovery of the basic synaptic transmission in diabetic rats as well as to enhanced activation of superoxide dismutase [66].”
Background
Delaying memory decline: different options and emerging solutions
Schneider, F., Horowitz, A., Lesch, K., & Dandekar, T. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0697-x · Cited by 23
Nausea as a sentinel symptom for cytotoxic chemotherapy effects on the gut-brain axis among women receiving treatment for recurrent ovarian cancer: an exploratory analysis
Donovan, H. S., Thomas, T. H., Campbell, G. B., Boisen, M. M., Rosenblum, L., Edwards, R. P., Bovbjerg, D. H., & Horn, C. C. (2016) · Supportive Care in Cancer · doi:10.1007/s00520-015-3071-4 · Cited by 23
“Accumulating evidence also implicates additional symptoms such as depression and anxiety [6–8], cognitive/memory problems [9, 10], sleep rhythms [11], and fatigue [12, 13].”
Background
Rhizoma Gastrodiae Water Extract Modulates the Gut Microbiota and Pathological Changes of P-TauThr231 to Protect Against Cognitive Impairment in Mice
Zhao, W., Wang, J., Latta, M., Wang, C., Liu, Y., Ma, W., Zhou, Z., Hu, S., Chen, P., & Liu, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.903659 · Cited by 20
The role of the gut microbiota and nutrition on spatial learning and spatial memory: a mini review based on animal studies
Alemohammad, S. M. A., Noori, S. M. R., Samarbafzadeh, E., & Noori, S. M. A. (2022) · Molecular Biology Reports · doi:10.1007/s11033-021-07078-2 · Cited by 18
“Antioxidant and anti-inflammatory characteristics of Bifidobacterium and Lactobacillus have been shown to cause improvement of depression, mood in Pregnant Sprague–Dawley [71], and cognitive function in rats [72] in addition to long-term dietary supplementation with Bifidobacterium and Lactobacillus improving memory i…”
Background
Review of the molecular mechanisms in wound healing: new therapeutic targets?
Palmieri, B., Vadalà, M., & Laurino, C. (2017) · Journal of Wound Care · doi:10.12968/jowc.2017.26.12.765 · Cited by 17
Therapeutic Methods for Gut Microbiota Modification in Lipopolysaccharide-Associated Encephalopathy
Li, S., Guo, H., Xu, X., Hua, R., Zhao, Q., Li, J., Lv, J., & Li, J. (2021) · Shock · doi:10.1097/shk.0000000000001758 · Cited by 18
“Davari (7) found that a cocktail of probiotics, L acidophilus, B lactis, and L fermentum, reversed diabetesinduced cognitive and electrophysiological changes.”
Background
Alterations of the glutamatergic system in diabetes mellitus
Hristov, M., Nankova, A., & Andreeva-Gateva, P. A. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01299-z · Cited by 20
“In addition, probiotic administration was reported to improve synaptic activity and cognitive function in STZ-induced diabetic rats (Davari et al. 2013).”
Modulation of gut microbiota with probiotics as a strategy to counteract endogenous and exogenous neurotoxicity
Skalny, A. V., Aschner, M., Гриценко, В. А., Martins, A. C., Tizabi, Y., Korobeinikova, T. V., Paoliello, M. M. B., & Tinkov, A. A. (2024) · Advances in neurotoxicology · doi:10.1016/bs.ant.2024.02.002 · Cited by 19
Cognitive and Microbiome Impacts of Experimental Ancylostoma ceylanicum Hookworm Infections in Hamsters
Pan, S. C., Ward, D. V., Yin, Y., Hu, Y., Elfawal, M. A., Clark, R. E., & Aroian, R. V. (2019) · Scientific Reports · doi:10.1038/s41598-019-44301-4 · Cited by 18
Application of psychobiotics in clinical treatment of mental disorders: Neurodevelopmental disorders, neurodegenerative diseases, depression and anxiety
Cui, J., Wang, W., Tang, Y., Feng, S., Liu, H., & Hao, Z. (2025) · Interdisciplinary medicine · doi:10.1002/inmd.20240041 · Cited by 21
Acanthopanax senticosus extract alleviates radiation‐induced learning and memory impairment based on neurotransmitter‐gut microbiota communication
Song, C., Yin, Y., Qin, Y., Li, T., Zeng, D., Ju, T., Duan, F., Zhang, Y., & Lu, W. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14134 · Cited by 15
Study on the effects of microencapsulatedLactobacillus delbrueckiion the mouse intestinal flora
Sun, Q., Shi, Y., Wang, F., Han, D., Hong, L., Zhao, Y., & Sun, Q. (2015) · Journal of Microencapsulation · doi:10.3109/02652048.2015.1057249 · Cited by 16
“to improving the cognitive ability (Davari et al., 2013).”
Lactobacillus plantarum CCFM639 can prevent aluminium-induced neural injuries and abnormal behaviour in mice
Yu, L., Zhai, Q., Tian, F., Liu, X., Wang, G., Zhao, J., Zhang, H., Narbad, A., & Chen, W. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2016.12.041 · Cited by 16
A multicenter, randomized controlled comparison of three renutrition strategies for the management of moderate acute malnutrition among children aged from 6 to 24 months (the MALINEA project)
Vray, M., Hedible, K. G. B., Adam, P., Tondeur, L., Manirazika, A., Randremanana, R. V., Maïnassara, H. B., Briend, A., Artaud, C., Platen, C. V., et al. (2018) · Trials · doi:10.1186/s13063-018-3027-3 · Cited by 17
The landscape of microbiota research in Iran; a bibliometric and network analysis
Aazami, H., Dehghanbanadaki, H., Ejtahed, H., Fahimfar, N., Razi, F., Soroush, A., Hasani‐Ranjbar, S., Pasalar, P., Badi, S. A., Siadat, S. D., et al. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00488-2 · Cited by 16
The Reciprocal Causation of the ASK1-JNK1/2 Pathway and Endoplasmic Reticulum Stress in Diabetes-Induced Cognitive Decline
Wu, Y., Yuan, Y., Wu, C., Jiang, T., Wang, B., Xiong, J., Zheng, P., Li, Y., Xu, J., Xu, K., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00602 · Cited by 16
Influence of gut bacteria on type 2 diabetes: Mechanisms and therapeutic strategy
Wen, X., Qi, L., & Zhao, K. (2024) · World Journal of Diabetes · doi:10.4239/wjd.v16.i1.100376 · Cited by 18
Endoneurial immune interplay in peripheral nerve repair: insights and implications for future therapeutic interventions
Sprenger‐Svačina, A., Svačina, M. K. R., Otlu, H. G., Gao, T., Sheikh, K. A., & Zhang, G. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1602112 · Cited by 16
Effect of Tanshinone IIA on Gut Microbiome in Diabetes-Induced Cognitive Impairment
Zheng, Y., Zhou, X., Wang, C., Zhang, J., Chang, D., Liu, W., Zhu, M.-X., Zhuang, S., Shi, H., Wang, X., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.890444 · Cited by 15
Oral Administration of Probiotic Bacteria Alleviates Tau Phosphorylation, Aβ Accumulation, Microglia Activation, and Memory Loss in 5xFAD Mice
Kim, Y. J., Mun, B.-R., Choi, K. Y., & Choi, W. (2024) · Brain Sciences · doi:10.3390/brainsci14030208 · Cited by 16
“Of these strains, lactic acid bacteria (LAB), such as Lactobacillus and Bifidobacterium , are the most widely utilized probiotics [10].”
Background
Reshaping the gut microbiota: Tangliping decoction and its core blood-absorbed component quercetin improve diabetic cognitive impairment
Zhang, W., Yi, C., Song, Z., Yu, B., Jiang, X., Guo, L., Huang, S., Xia, T., Huang, F., Yan, Y., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156560 · Cited by 15
Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats
Rajab, E., Keogh, M. B., Laiva, A. L., Hannan, F. A., Fateel, M., Abdulwahab, F., Madhoob, F. A., AlHamer, B., Ghazzal, S., Dawaishan, A. A., et al. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104757 · Cited by 13
Neuroprotective Effects of Probiotic-Supplemented Diet on Cognitive Behavior of 3xTg-AD Mice
Tan, C., Liu, Y., Zhang, H., Di, C., Xu, D., Liang, C., Zhang, N., Han, B., & Lang, W. (2022) · Journal of Healthcare Engineering · doi:10.1155/2022/4602428 · Cited by 14
“In addition, some animal researches have revealed the necessity of the microbiota-gut-brain axis for the optimal function of brain activities in behavior and electrophysiology [14].”
Background
Retracted
Targeting the gut–microbiota–brain axis in irritable bowel disease to improve cognitive function – recent knowledge and emerging therapeutic opportunities
Tang, H., Chen, X., Huang, S., Gang, Y., Wang, X., & Shen, G.-M. (2023) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0155 · Cited by 14
Interactions between the gut microbiome and the central nervous system and their role in schizophrenia, bipolar disorder and depression
Chrobak, A. A., Nowakowski, J., & Dudek, D. (2016) · Archives of Psychiatry and Psychotherapy · doi:10.12740/app/62962 · Cited by 15
“One study has shown that Lactobacillus helveticus and Bifidobacterium longum also have beneficial psychological effects that are paired with plasma cortisol reduction [16].”
Background
Examining the cognitive benefits of probiotic supplementation in physically active older adults: A randomized clinical trial
Sanborn, V. E., Aljumaah, M. R., Azcárate-Peril, M. A., & Gunstad, J. (2022) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2021-0557 · Cited by 13
The gut microbiota mediates memory impairment under high‐altitude hypoxia via the gut–brain axis in mice
Li, W., Wang, Y., Shi, Y., He, F., Zhao, Z., Liu, J., Gao, Z., Zhang, J., & Shen, X. (2024) · FEBS Journal · doi:10.1111/febs.17365 · Cited by 12
“In mice, even moderate alterations in gut microbiota composition induced by probiotic or fecal microbiota transplantation (FMT), elicit signiﬁcant changes in brain chemistry and function [20,21].”
Intriguing Role of Gut-Brain Axis on Cognition with an Emphasis on Interaction with Papez Circuit
Xavier, J., Anu, M., Fathima, A. S., Ravichandiran, V., & Kumar, N. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220614124145 · Cited by 11
Dietary Fibers and Proteins Modulate Behavior via the Activation of Intestinal Gluconeogenesis
Sinet, F., Soty, M., Zemdegs, J. C. S., Guiard, B. P., Estrada-Meza, J., Malleret, G., Silva, M., Mithieux, G., & Gautier‐Stein, A. (2021) · Neuroendocrinology · doi:10.1159/000514289 · Cited by 11
Neuroprotective Effects of Probiotic Lactobacillus reuteri GMNL-263 in the Hippocampus of Streptozotocin-Induced Diabetic Rats
Lin, J., Tsai, B. C., Kao, H., Chiang, C.-Y., Chen, Y., Chen, W. S., Ho, T., Yao, C., Kuo, W., & Huang, C. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-09982-w · Cited by 10
Serum homocysteine showed potential association with cognition and abnormal gut microbiome in major depressive disorder
Xu, C., Zhao, W.-X., Yu, S., Yun, Y., Ma, T., Fan, N., Song, J., Wang, J., & Zhang, Q. (2025) · World Journal of Psychiatry · doi:10.5498/wjp.v15.i3.102567 · Cited by 10
The metabolic and immunomodulatory functions of Bacteroides fragilis; a next-generation probiotic?
Roustapoor, R., Abdi, E., Khabbaz, A., & Abdi, A. (2025) · Medicine in Microecology · doi:10.1016/j.medmic.2025.100137 · Cited by 11
Altering the Gut Microbiome for Cognitive Benefit?
Huynh, K. A., Schneider, M., & Gareau, M. G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802304-4.00015-3 · Cited by 10
Two gut microbes are necessary and sufficient for normal cognition in Drosophila melanogasterPreprint
DeNieu, M., Mounts, K., & Manier, M. K. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/593723 · Cited by 10
“Moreover, disease models for inflammatory bowel disease [15, 16], diabetes [17], and schizophrenia [18] have associ22 ated the loss of homeostasis of the gut community (dysbiosis) with learning and memory deficits in experimental animals.”
Background
Superior cervical ganglionectomy alters gut microbiota in rats.
Zhang, W., Li, Y., Sun, T., Li, Z., Manyande, A., Xu, W., Feng, M., & Xiang, H. (2022) · PubMed Central · Cited by 9
Probiotic treatment differentially affects the behavioral and electrophysiological aspects in ethanol exposed animals.
زواره, ا. ح. ح., خانی, ر. ح., Pakpour, B., Soheili, M., & Salami, M. (2020) · PubMed Central · doi:10.22038/ijbms.2020.41685.9846 · Cited by 9
“We showed that probiotics restore impaired LTP in an animal model of diabetes (21).”
BackgroundMethodSelf-citation
Dendropanax morbifera Léveille extract ameliorates memory impairments and inflammatory responses in the hippocampus of streptozotocin-induced type 1 diabetic rats
Jung, H. Y., Chung, T., & Hwang, I. K. (2016) · Molecular & Cellular Toxicology · doi:10.1007/s13273-016-0047-5 · Cited by 9
REMOVED: Diabetes exacerbates brain pathology following a focal blast brain injury: New role of a multimodal drug cerebrolysin and nanomedicine
Muresanu, D. F., Sharma, A., Sahib, S., Tian, Z. R., Feng, L., Nozari, A., Lafuente, J. V., Buzoianu, A. D., Sjöquist, P.-O. B., Patnaik, R., et al. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2020.09.004 · Cited by 8
Probiotic Attributes, GABA-Producing Capacity and Cytotoxic Effects of Microbes Isolated from Thai Fermented Foods
Luang‐In, V., Saengha, W., Karirat, T., Deeseenthum, S., Buranrat, B., Nudmamud-Thanoi, S., Ma, N. L., & Narbad, A. (2020) · International Journal of Agriculture and Biology · doi:10.17957/ijab/15.1682 · Cited by 8
Novel ketogenic diet formulation improves sucrose‐induced insulin resistance in canton strain Drosophila melanogaster
Kayode, O. T., Rotimi, D., Okoh, E., Iyobhebhe, M. E., Kayode, A. A. A., & Ojo, O. A. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13907 · Cited by 8
Exercise training and probiotic supplementation effects on skeletal muscle apoptosis prevention in type-Ι diabetic rats
Rezaee, N., Rahmani‐Nia, F., Delfan, M., & Ghahremani, R. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119973 · Cited by 8
Effects of Indigenous Enterococci on the Intestinal Microbiota and the Behavior of Rats on Correction of Experimental Dysbiosis
Ермоленко, Е. И., Abdurasulova, I. N., Котылева, М. П., Svirido, D. A., Matsulevich, A. V., Karaseva, A. B., Тарасова, Е. А., Sizov, V. V., & Suvorov, A. N. (2018) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-018-0591-7 · Cited by 8
Probiotics and Prebiotics
Orsi, C., & Zambrini, A. V. (2017) · doi:10.1002/9781118906460.ch1c · Cited by 8
Experimental Stroke Induces Chronic Gut Dysbiosis and Neuroinflammation in Male MicePreprint
Brichacek, A. L., Nwafor, D. C., Benkovic, S. A., Chakraborty, S., Kenney, S. M., Mace, M. E., Jun, S., Gambill, C. A., Wang, W., Hu, H., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.29.069575 · Cited by 7
“31 probiotic treatment with Lactobacillus plantarum ZDY2013 [84], Clostridium butyricum [85], or probiotic mixtures [86,87] have shown improved outcomes in a number of stroke-related”
Background
ENVOLVIMENTO DA FLORA INTESTINAL NA MODULAÇÃO DE DOENÇAS PSIQUIÁTRICAS
Lach, G., Morais, L. H., Costa, A. P., & Hoeller, A. A. (2017) · VITTALLE - Revista de Ciências da Saúde · doi:10.14295/vittalle.v29i1.6413 · Cited by 12
“Interessantemente, em um modelo animal onde diabete mellitus é induzida em ratos através da administração de estreptozotocina (159,160), ratos diabéticos apresentam déficits de memória e aprendizado devido a prejuízos na potencialização e depressão de longo prazo (LTP e LTD, do inglês long-term potentiation e long-ter…”
Background
Phaseolus lunatus(lima beans) abates Fe2+‐induced hepatic redox imbalance; inhibits intestinal glucose absorption and major carbohydrate catabolic enzymes; and modulates muscle glucose uptake
Erukainure, O. L., Mopuri, R., Chukwuma, C. I., Koorbanally, N. A., & Islam, M. S. (2018) · Journal of Food Biochemistry · doi:10.1111/jfbc.12655 · Cited by 8
Effect of Treadmill Exercise and Probiotic Ingestion on Motor Coordination and Brain Activity in Adolescent Mice
Kim, J.-C., Yoon, B., & Jeon, Y. K. (2020) · Healthcare · doi:10.3390/healthcare9010007 · Cited by 9
“Besides this, probiotic ingestion led to changes in the neurotransmitters involved in exercise and cognitive functions [13,14], and enhanced learning and memory in treated mice [15].”
Background
Effect of Supplementation with Probiotics in Patients with Schizophrenia: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Li, L., Du, F., Liu, X., Song, M., Grosso, G., Battino, M., Boesch, C., Li, H., & Liu, X. (2025) · Foods · doi:10.3390/foods14101773 · Cited by 8
“Animal studies suggest that probiotics can modulate endogenous neuroactive molecules [17], prevent and treat neuronal autoimmune diseases [18], and ameliorate impaired spatial memory in diabetic rats [19].”
Alteration of oral microbiome composition in children living with pesticide-exposed farm workers
Stanaway, I. B., Wallace, J. C., Hong, S., Wilder, C. S., Green, F. H., Tsai, J. M., Knight, M., Workman, T. W., Vigoren, E. M., Smith, M. N., et al. (2022) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2022.114090 · Cited by 6
A Probiotic Mixture Decreases Neuropathy and Oxidative Stress Markers in Diabetic Rats
Shabani, M., Hasanpour, E., Aghighi, F., Mohammadifar, M., Bahmani, F., & Talaei, S. A. (2024) · OBM Neurobiology · doi:10.21926/obm.neurobiol.2403247 · Cited by 7
“A single intraperitoneal dose of Streptozotocin (65 mg/kg) was injected for diabetes induction [30].”
Self-citation
Change in pulmonary function tests and their relation to the serum levels of ceruloplasmin, copper and superoxide dismutase in patients suffering from Type-1 and Type-2 diabetes
Lathiya, N., Aziz, Q., Fawwad, A., Siddiqui, I. A., & Basit, A. (2023) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.39.3.6485 · Cited by 6
Antioxidant properties of swertiamarin, from Enicostemma littorale blume. leaves studied in high fat diet fed and low dose streptozotocin induced diabetic rats
Selvam, R., Koothappan, M., & Subramanian, S. P. (2019) · Asian Journal of Pharmacy and Pharmacology · doi:10.31024/ajpp.2019.5.2.18 · Cited by 6
Probiyotik ve Prebiyotiklerin Bağırsak-Beyin Aksına Etkisi
Özer, M., Özyurt, G., & Harsa, Ş. (2019) · Akademik Gıda · doi:10.24323/akademik-gida.613637 · Cited by 7

Authors: Davari, S., Talaei, S. A., Alaei, H., & salami, M.
Affiliations: Isfahan University of Medical Sciences (IR)
Kashan University of Medical Sciences (IR)
Corresponding author: salami, M.
ORCID: Davari, S.
Talaei, S.A.
Alaei, H.
salami, M.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2013-06
Volume: 240
Pages: 287-296
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2013.02.055
OpenAlex: W2082281485
Cited by: 290
References: 53
Citations by year: 2026: 6 · 2025: 17 · 2024: 19 · 2023: 31 · 2022: 24 · 2021: 25 · 2020: 32 · 2019: 31 · 2018: 18 · 2017: 19 · 2016: 31 · 2015: 17 · 2014: 11 · 2013: 9
FWCI: 33.73
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Deputy of Research, Isfahan University of Medical Sciences (390491)
Deputy of Research, Kashan University of Medical Sciences (9020)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: probiotics, diabetes mellitus, microbiome-gut-brain axis, spatial memory, learning disabilities, hippocampus, synaptic transmission, long-term potentiation, excitatory postsynaptic potentials, Schaffer collaterals, oxidative stress, superoxide dismutase, 8-hydroxy-2'-deoxyguanosine, insulin, streptozotocin-induced diabetes, cognitive function
MeSH terms: 8-Hydroxy-2'-Deoxyguanosine, Analysis of Variance, Animals, Biophysics, Blood Glucose, Brain, Cognition Disorders, Deoxyguanosine, Diabetes Mellitus, Experimental, Disease Models, Animal, Drug Administration Schedule, Electric Stimulation, Hippocampus, Insulin, Male, Streptozocin, Superoxide Dismutase, Rats, Wistar, Long-Term Potentiation, Maze Learning, Probiotics, Rats, Metagenome, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: Behavioral and electrophysiological proofs for microbiome–gut–brain axis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks