The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
White matter astrocytes in health and disease
Open accessAbstract
Myelination by oligodendrocytes is a highly specialized process that relies on intimate interactions between the axon and oligodendrocyte. Astrocytes also have an important part in facilitating myelination in the CNS, however, comparatively less is known about how they affect myelination. This review therefore summarizes the literature and explores lingering questions surrounding differences between white matter and grey matter astrocytes, how astrocytes support myelination, how their dysfunction in pathological states contributes to myelin pathologies and how astrocytes may facilitate remyelination. We propose that astrocytes in the white matter are specialized to facilitate myelination and myelin maintenance by clearance of extracellular ions and neurotransmitters and by secretion of pro-myelinating factors. Aditionally, astrocytes-oligodendrocyte coupling via gapjunctions is crucial for both myelin formation and maintenance, due to K+ buffering and possibly metabolic support for oligodendrocytes via the panglia syncytium. Dysfunctional astrocytes aberrantly affect oligodendrocytes, exemplified by a number of leukodystrophies in which astrocytic pathology is known as the direct cause of myelin pathology. Conversely, in primary demyelinating diseases, such as multiple sclerosis, astrocytes may facilitate remyelination. We suggest that specific manipulation of astrocytes could help prevent myelin pathologies and successfully restore myelin sheaths after demyelination.
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Self-citationAstrocytes: Biology and pathology
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Self-citationAstrocyte reactivity and reactive astrogliosis: costs and benefits
Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934
Myelin in the Central Nervous System: Structure, Function, and Pathology
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Inflammation in Glaucoma: From the back to the front of the eye, and beyond
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Metadata
- Authors
- Lundgaard, I., Osório, M. J., Kress, B. T., Sanggaard, S., & Nedergaard, M.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 276
- Pages
- 161-173
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2069264323
- Cited by
- 290
- References
- 158
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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