The DOI matches its Crossref record; 296 of the 298 references it cites were found in a registry or an index.
Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?
Abstract
The prenatal and postnatal early-life periods are both dynamic and vulnerable windows for brain development. During these important neurodevelopmental phases, essential processes and structures are established. Exposure to adverse events that interfere with this critical sequence of events confers a high risk for the subsequent emergence of mental illness later in life. It is increasingly accepted that the gastrointestinal microbiota contributes substantially to shaping the development of the central nervous system. Conversely, several studies have shown that early-life events can also impact on this gut community. Due to the bidirectional communication between the gut and the brain, it is possible that aberrant situations affecting either organ in early life can impact on the other. Studies have now shown that deviations from the gold standard trajectory of gut microbiota establishment and development in early life can lead not only to disorders of the gastrointestinal tract but also complex metabolic and immune disorders. These are being extended to disorders of the central nervous system and understanding how the gut microbiome shapes brain and behavior during early life is an important new frontier in neuroscience.
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In the citing paper
“Various previous studies have suggested profound microbiome effects on neuroendocrine and immune function, such that dysbiosis could compound ELA-related changes including cortisol dysregulation and chronic inflammation [73–77].”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [74]
In the citing paper
“In this period, neuronal development takes place (73) and it is supported and shaped by maternal microbiota (74–79).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [73]
In the citing paper
“Consistently, certain altered brain developments and behaviors observed in GF mice could be resolved/improved when new born animals were reconstituted with a diverse and intact flora (73, 82, 83).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [73]
Citations
Cites
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Research works printed but not linked: 1
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Cited by
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Van den Bergh, B. R. H., van den Heuvel, M. I., Lahti, M., Braeken, M., de Rooij, S. R., Entringer, S., Hoyer, D., Roseboom, T., Räikkönen, K., King, S., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.003 · Cited by 1,181
The microbiome-gut-brain axis in health and disease
Dinan, T. G., & Cryan, J. F. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.09.007 · Cited by 1,111
Self-citationThe gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration
Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813
Self-citationKynurenine pathway metabolism and the microbiota-gut-brain axis
Kennedy, P. J., Cryan, J. F., Dinan, T. G., & Clarke, G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.002 · Cited by 724
Self-citation
Metadata
- Authors
- O’Mahony, S. M., Clarke, G., Dinan, T. G., & Cryan, J. F.
- Affiliations
- University College Cork (IE)
- Corresponding author
- O’Mahony, S.M.
- Cryan, J.F.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 342
- Pages
- 37-54
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2218048576
- Cited by
- 203
- References
- 298
- Citations by year
- 2026: 13 · 2025: 10 · 2024: 20 · 2023: 17 · 2022: 20 · 2021: 30 · 2020: 20 · 2019: 18 · 2018: 16 · 2017: 18
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- childhood adversity, brain development, gut microbiota, gut-brain axis, prenatal exposure, postnatal development, mental illness risk, central nervous system development, behavior
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological
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