Cited by 204Gut microbiota and healthMaternal Mental Health During Pregnancy and PostpartumChild Abuse and Trauma

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Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

O’Mahony, S.M., Clarke, G., Dinan, T.G., Cryan, J.F.·2017·Neuroscience

DOI 10.1016/j.neuroscience.2015.09.068

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Abstract

The prenatal and postnatal early-life periods are both dynamic and vulnerable windows for brain development. During these important neurodevelopmental phases, essential processes and structures are established. Exposure to adverse events that interfere with this critical sequence of events confers a high risk for the subsequent emergence of mental illness later in life. It is increasingly accepted that the gastrointestinal microbiota contributes substantially to shaping the development of the central nervous system. Conversely, several studies have shown that early-life events can also impact on this gut community. Due to the bidirectional communication between the gut and the brain, it is possible that aberrant situations affecting either organ in early life can impact on the other. Studies have now shown that deviations from the gold standard trajectory of gut microbiota establishment and development in early life can lead not only to disorders of the gastrointestinal tract but also complex metabolic and immune disorders. These are being extended to disorders of the central nervous system and understanding how the gut microbiome shapes brain and behavior during early life is an important new frontier in neuroscience.

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Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228
Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170

Show all 298 references

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Lv, H., Tang, Y., Zhang, H., Li, S., & Fan, Z. (2021) · Animal Science Journal · doi:10.1111/asj.13550 · Cited by 39
Early life stress in mice alters gut microbiota independent of maternal microbiota inheritance
Kemp, K. M., Colson, J. C., Lorenz, R. G., Maynard, C. L., & Pollock, J. S. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00072.2020 · Cited by 39
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(PPR), E. P. O. P. P. P. A. T. R., Ockleford, C., Adriaanse, P., Bennekou, S. H., Berny, P. J., Brock, T. C. M., Duquesne, S., Grilli, S., Hernández, A. F., Klein, M., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5286 · Cited by 34
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Hutchison, S. M., Mâsse, L. C., Pawluski, J. L., & Oberlander, T. F. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2018.02.004 · Cited by 39
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Thomann, A., Thomann, P. A., Wolf, R. C., Hirjak, D., Schmahl, C. G., Ebert, M. P., Szabo, K., Reindl, W., & Griebe, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163202 · Cited by 34
Treating impulsivity with probiotics in adults (PROBIA): study protocol of a multicenter, double-blind, randomized, placebo-controlled trial
Arteaga-Henríquez, G., Rosales-Ortiz, S. K., Vásquez, A. A., Bitter, I., Ginsberg, Y., Ibañez-Jiménez, P., Kilencz, T., Lavebratt, C., Matura, S., Reif, A., et al. (2020) · Trials · doi:10.1186/s13063-019-4040-x · Cited by 38
Prenatal stress effects on offspring brain and behavior: Mediators, alterations and dysregulated epigenetic mechanisms
Haq, S. U., Bhat, U. A., & Kumar, A. (2021) · Journal of Biosciences · doi:10.1007/s12038-021-00153-7 · Cited by 37
Maternal microbiome disturbance induces deficits in the offspring’s behaviors: a systematic review and meta-analysis
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Postoperative pain and the gut microbiome
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Caputi, V., Bastiaanssen, T. F. S., Peterson, V. L., Sajjad, J., Murphy, A., Stanton, C., McNamara, B., Shorten, G., Cryan, J. F., & O’Mahony, S. M. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.06.002 · Cited by 33
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Effect of heat-inactivated Lactobacillus paracasei N1115 on microbiota and gut-brain axis related molecules
Zhang, Y., Pu, F., Cheng, R., Jiawen, G. U. O., Shen, X. P., Wang, S., Zhu, H., Zhang, X., Cheng, G., Li, M., et al. (2020) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2019-025 · Cited by 32
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Li, X., Chen, L.-M., Kumar, G., Zhang, S.-J., Zhong, Q.-H., Zhang, H., Gui, G., Wu, L.-L., Fan, H., & Sheng, J.-W. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.820106 · Cited by 29
Early life gut microbiota: Consequences for health and opportunities for prevention
Wang, S., Cui, J., Jiang, S., Zheng, C., Zhao, J., Zhang, H., & Zhai, Q. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2158451 · Cited by 29
Early-life gut microbiota and neurodevelopment in preterm infants: a narrative review
Beghetti, I., Barone, M., Brigidi, P., Sansavini, A., Corvaglia, L., Aceti, A., & Turroni, S. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1241303 · Cited by 65
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Authors: O’Mahony, S. M., Clarke, G., Dinan, T. G., & Cryan, J. F.
Affiliations: University College Cork (IE)
Corresponding author: O’Mahony, S.M.
Cryan, J.F.
ORCID: O’Mahony, S.M.
Clarke, G.
Dinan, T.G.
Cryan, J.F.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2017-02
Volume: 342
Pages: 37-54
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2015.09.068
OpenAlex: W2218048576
Cited by: 203
References: 298
Citations by year: 2026: 13 · 2025: 10 · 2024: 20 · 2023: 17 · 2022: 20 · 2021: 30 · 2020: 20 · 2019: 18 · 2018: 16 · 2017: 18
FWCI: 1.78
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: childhood adversity, brain development, gut microbiota, gut-brain axis, prenatal exposure, postnatal development, mental illness risk, central nervous system development, behavior
MeSH terms: Gastrointestinal Microbiome, Animals, Brain, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological

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Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

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