The DOI matches its Crossref record; 188 of the 194 references it cites were found in a registry or an index.
Neurobiology of fibromyalgia and chronic widespread pain
Open accessAbstract
Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified. The underlying mechanisms, in both human and animal studies, for the continued pain in individuals with fibromyalgia will be explored in this review. There is a substantial amount of support for alterations of central nervous system nociceptive processing in people with fibromyalgia, and that psychological factors such as stress can enhance the pain experience. Emerging evidence has begun exploring other potential mechanisms including a peripheral nervous system component to the generation of pain and the role of systemic inflammation. We will explore the data and neurobiology related to the role of the CNS in nociceptive processing, followed by a short review of studies examining potential peripheral nervous system changes and cytokine involvement. We will not only explore the data from human subjects with fibromyalgia but will relate this to findings from animal models of fibromyalgia. We conclude that fibromyalgia and related disorders are heterogenous conditions with a complicated pathobiology with patients falling along a continuum with one end a purely peripherally driven painful condition and the other end of the continuum is when pain is purely centrally driven.
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“Although it is not clear how these physiologic alterations are generated, there is a wide agreement that FMS should be considered as a CPSS [9,10,11,32,33,34].”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [34]
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Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
Ji, R.-R., Nackley, A., Huh, Y., Terrando, N., & Maixner, W. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002130 · Cited by 1,630
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Metadata
- Authors
- Sluka, K. A., & Clauw, D. J.
- Affiliations
- University of Iowa (US)
- University of Michigan (US)
- Corresponding author
- Sluka, Kathleen A.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 338
- Pages
- 114-129
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC5083139
- OpenAlex
- W2415752306
- Cited by
- 671
- References
- 194
- Citations by year
- 2026: 49 · 2025: 68 · 2024: 71 · 2023: 70 · 2022: 96 · 2021: 78 · 2020: 89 · 2019: 64 · 2018: 42 · 2017: 39 · 2016: 3
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01DA038261)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (UM1AR063381, R01AR061371)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- fibromyalgia, chronic widespread pain, central sensitization, nociceptive processing, central nervous system, psychological stress, peripheral nervous system, systemic inflammation, cytokines
- MeSH terms
- Animals, Brain, Fibromyalgia, Humans, Spinal Cord, Chronic Pain
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