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Neurobiology of fibromyalgia and chronic widespread pain
Open accessAbstract
Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified. The underlying mechanisms, in both human and animal studies, for the continued pain in individuals with fibromyalgia will be explored in this review. There is a substantial amount of support for alterations of central nervous system nociceptive processing in people with fibromyalgia, and that psychological factors such as stress can enhance the pain experience. Emerging evidence has begun exploring other potential mechanisms including a peripheral nervous system component to the generation of pain and the role of systemic inflammation. We will explore the data and neurobiology related to the role of the CNS in nociceptive processing, followed by a short review of studies examining potential peripheral nervous system changes and cytokine involvement. We will not only explore the data from human subjects with fibromyalgia but will relate this to findings from animal models of fibromyalgia. We conclude that fibromyalgia and related disorders are heterogenous conditions with a complicated pathobiology with patients falling along a continuum with one end a purely peripherally driven painful condition and the other end of the continuum is when pain is purely centrally driven.
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“Although it is not clear how these physiologic alterations are generated, there is a wide agreement that FMS should be considered as a CPSS [9,10,11,32,33,34].”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [34]
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Cites
The american college of rheumatology 1990 criteria for the classification of fibromyalgia
Wolfe, F., Smythe, H. A., Yunus, M. B., Bennett, R. M., Bombardier, C., Goldenberg, D. L., Tugwell, P., Campbell, S. M., Abeles, M., Clark, P., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330203 · Cited by 9,563
Fibromyalgia: A Clinical Review
Clauw, D. J. (2014) · JAMA · doi:10.1001/jama.2014.3266 · Cited by 1,674
Self-citationAn fMRI-Based Neurologic Signature of Physical Pain
Wager, T. D., Atlas, L. Y., Lindquist, M. A., Roy, M., Woo, C.-W., & Kross, E. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1204471 · Cited by 1,597
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia
Gracely, R. H., Petzke, F., Wolf, J. M., & Clauw, D. J. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10225 · Cited by 1,263
Self-citationCommon symptoms in ambulatory care: incidence, evaluation, therapy, and outcome
Kroenke, K., & Mangelsdorff, A. D. (1989) · The American Journal of Medicine · doi:10.1016/0002-9343(89)90293-3 · Cited by 947
Basic and clinical aspects of visceral hyperalgesia
Mayer, E. A., & Gebhart, G. F. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90086-8 · Cited by 920
Primary fibromyalgia (fibrositis): Clinical study of 50 patients with matched normal controls
Yunus, M., Masi, A. T., Calabro, J. J., Miller, K. A., & Feigenbaum, S. L. (1981) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(81)90096-2 · Cited by 910
Pain catastrophizing and neural responses to pain among persons with fibromyalgia
Gracely, R. H. (2004) · Brain · doi:10.1093/brain/awh098 · Cited by 892
Dickenson, A. H., & Sullivan, A. F. (1987) · Neuropharmacology · doi:10.1016/0028-3908(87)90275-9 · Cited by 843
Evidence of augmented central pain processing in idiopathic chronic low back pain
Giesecke, T., Gracely, R. H., Grant, M. A. B., NACHEMSON, A. L., Petzke, F. W., Williams, D. A., & Clauw, D. J. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20063 · Cited by 818
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Research works printed but not linked: 6
- Dawes JM, Andersson DA, Bennett DLH, Bevan S, McMahon SB (2013) Inflammatory mediators and modulators of pain. In: Melzack and wall’s textbook of pain, vol. 6th ed., (McMahon, SB et al., eds), p 48 Philadelphia: Elsevier
- Dina, 2011, Enhanced cytokine-induced mechanical hyperalgesia in skeletal muscle produced by a novel mechanism in rats exposed to unpredictable sound stress, Eur J Pain
- Gregory, 2015, ASIC3 is required for development of fatigue-induced hyperalgesia, Mol Neurobiol, 53, 10
- Petzke, 1999, What do tender points measure?, Arthritis Rheum, 42, S342
- Petzke, 1999, Pain sensitivity in patients with fibromyalgia (FM): expectancy effects on pain measurements, Arthritis Rheum, 42, S342
- Russell, 1996, Characteristics of spinal fluid (CSF) substance p (SP) and calcitonin gene related peptide (CGRP) in fibromyalgia syndrome (FMS), Arthritis Rheum, 39, S275
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Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
Ji, R.-R., Nackley, A., Huh, Y., Terrando, N., & Maixner, W. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002130 · Cited by 1,630
Nociplastic pain: towards an understanding of prevalent pain conditions
Fitzcharles, M.-A., Cohen, S. P., Clauw, D. J., Littlejohn, G., Usui, C., & Häuser, W. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00392-5 · Cited by 1,253
Self-citationFibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update
Siracusa, R., Paola, R. D., Cuzzocrea, S., & Impellizzeri, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083891 · Cited by 768
Iyengar, S., Ossipov, M. H., & Johnson, K. W. (2017) · Pain · doi:10.1097/j.pain.0000000000000831 · Cited by 625
AAPT Diagnostic Criteria for Fibromyalgia
Arnold, L. M., Bennett, R. M., Crofford, L. J., Dean, L. E., Clauw, D. J., Goldenberg, D. L., Fitzcharles, M., Paiva, E. S., Staud, R. M., Sarzi‐Puttini, P., et al. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.10.008 · Cited by 474
Self-citationThe neurobiology of central sensitization
Harte, S. E., Harris, R. E., & Clauw, D. J. (2018) · Journal of Applied Biobehavioral Research · doi:10.1111/jabr.12137 · Cited by 404
Self-citationPersistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis
Buch, M. H., Eyre, S., & McGonagle, D. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-00541-7 · Cited by 329
Exercise-induced pain and analgesia? Underlying mechanisms and clinical translation
Sluka, K. A., Frey‐Law, L., & Bement, M. H. (2018) · Pain · doi:10.1097/j.pain.0000000000001235 · Cited by 336
Self-citationPassive transfer of fibromyalgia symptoms from patients to mice
Goebel, A., Krock, E., Gentry, C., Israel, M. R., Jurczak, A., Urbina, C. M., Sandor, K., Vastani, N., Maurer, M., Cuhadar, U., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144201 · Cited by 278
Teodoro, T., Edwards, M. J., & Isaacs, J. D. (2018) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-317823 · Cited by 241
Potential Mechanisms Underlying Centralized Pain and Emerging Therapeutic Interventions
Eller-Smith, O. C., Nicol, A. L., & Christianson, J. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00035 · Cited by 227
Altered microbiome composition in individuals with fibromyalgia
Minerbi, A., Gonzalez, E., Brereton, N. J. B., Anjarkouchian, A., Dewar, K., Fitzcharles, M.-A., Chevalier, S., & Shir, Y. (2019) · Pain · doi:10.1097/j.pain.0000000000001640 · Cited by 220
Andersen, M. L., Araujo, P., Frange, C., & Tufik, S. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.07.019 · Cited by 218
D’Agnelli, S., Arendt‐Nielsen, L., Gerra, M. C., Zatorri, K., Boggiani, L., Baciarello, M., & Bignami, E. G. (2018) · Molecular Pain · doi:10.1177/1744806918819944 · Cited by 209
Kleykamp, B. A., Ferguson, M. C., McNicol, E., Bixho, I., Arnold, L. M., Edwards, R. R., Fillingim, R., Grol-Prokopczyk, H., Turk, D. C., & Dworkin, R. H. (2021) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2020.10.006 · Cited by 202
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Blyth, F., & Noguchi, N. (2017) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2017.10.004 · Cited by 199
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Kremer, M., Becker, L. J., Barrot, M., & Yalçın, İ. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14686 · Cited by 176
Soni, A., Wanigasekera, V., Mezue, M., Cooper, C. C., Javaid, M. K., Price, A. J., & Tracey, I. (2018) · Arthritis & Rheumatology · doi:10.1002/art.40749 · Cited by 173
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Littlejohn, G. O., & Guymer, E. K. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0672-2 · Cited by 167
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Özsoy-Ünübol, T., & Yagci, E. A. (2020) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.14043 · Cited by 159
Kenny, G., McCann, K., O’Brien, C., Savinelli, S., Tinago, W., Yousif, O., Lambert, J. S., O’Broin, C., Feeney, E. R., de Barra, E., et al. (2022) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofac060 · Cited by 152
Role of inflammation in the pathogenesis and treatment of fibromyalgia
Benlidayı, İ. C. (2019) · Rheumatology International · doi:10.1007/s00296-019-04251-6 · Cited by 144
Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia
Pinto, A. M., Geenen, R., Wager, T. D., Lumley, M. A., Häuser, W., Kosek, E., Ablin, J. N., Amris, K., Branco, J., Buskila, D., et al. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00873-6 · Cited by 161
Creed, F. (2020) · Pain · doi:10.1097/j.pain.0000000000001819 · Cited by 135
Dailey, D. L., Vance, C. G. T., Rakel, B. A., Zimmerman, M. B., Embree, J. L., Merriwether, E. N., Geasland, K. M., Chimenti, R. L., Williams, J. M., Golchha, M., et al. (2019) · Arthritis & Rheumatology · doi:10.1002/art.41170 · Cited by 143
Self-citationIs fibromyalgia associated with a unique cytokine profile? A systematic review and meta-analysis
O’Mahony, L. F., Srivastava, A., Mehta, P., & Ciurtin, C. (2021) · Lara D. Veeken · doi:10.1093/rheumatology/keab146 · Cited by 133
Mease, P. J. (2017) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000388 · Cited by 136
Sluka, K. A., Wager, T. D., Sutherland, S. P., Labosky, P. A., Balach, T., Bayman, E. O., Berardi, G., Brummett, C. M., Burns, J. W., Buvanendran, A., et al. (2023) · Pain · doi:10.1097/j.pain.0000000000002938 · Cited by 127
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Navratilova, E., Ji, G., Phelps, C. E., Qu, C., Hein, M., Yakhnitsa, V., Neugebauer, V., & Porreca, F. (2018) · Pain · doi:10.1097/j.pain.0000000000001458 · Cited by 101
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Nation, K. M., De Felice, M., Hernandez, P. I., Dodick, D. W., Neugebauer, V., Navratilova, E., & Porreca, F. (2018) · Pain · doi:10.1097/j.pain.0000000000001167 · Cited by 96
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Ernberg, M. M., Christidis, N., Ghafouri, B., Bilevičiūtė-Ljungar, I., Löfgren, M., Bjersing, J. L., Palstam, A., Larsson, A., Mannerkorpi, K., Gerdle, B. U. C., et al. (2018) · Mediators of Inflammation · doi:10.1155/2018/3985154 · Cited by 91
Andrade, A., Steffens, R. D. A. K., Sieczkowska, S. M., Peyré‐Tartaruga, L. A., & Vilarino, G. T. (2018) · Revista Brasileira de Reumatologia · doi:10.1186/s42358-018-0033-9 · Cited by 94
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Self-citationCorrea‐Rodríguez, M., Mansouri-Yachou, J. E., Barragán, A. C., Molina, F., Rueda‐Medina, B., & Aguilar‐Ferrándiz, M. E. (2019) · Nutrients · doi:10.3390/nu11051193 · Cited by 77
Kwiatek, R. (2017) · Australian Prescriber · doi:10.18773/austprescr.2017.056 · Cited by 81
de Brito, R. G., Rasmussen, L. A., & Sluka, K. A. (2017) · PAIN Reports · doi:10.1097/pr9.0000000000000618 · Cited by 76
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Su, N., Lobbezoo, F., van Wijk, A. J., van der Heijden, G. J. M. G., & Visscher, C. M. (2016) · Journal of Oral Rehabilitation · doi:10.1111/joor.12479 · Cited by 74
Central sensitivity and fibromyalgia
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Bidari, A., Zadeh, E. M., Ghavidel‐Parsa, B., Rahmani, S., Hosseini, S., & Hassankhani, A. (2019) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-019-00257-4 · Cited by 68
Hung, C.-H., Lee, C.-H., Tsai, M.-H., Chen, C.-H., Lin, H.-F., Hsu, C.-Y., Lai, C.-L., & Chen, C.-C. (2020) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2020-218329 · Cited by 65
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Grandhi, R., Tavakoli, S., Ortega, C., & Simmonds, M. J. (2017) · Brain Sciences · doi:10.3390/brainsci7120160 · Cited by 64
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Agger, J. L., Schröder, A., Gormsen, L. K., Jensen, J. S., Jensen, T. S., & Fink, P. K. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30126-8 · Cited by 52
Lima, L. V., DeSantana, J. M., Rasmussen, L. A., & Sluka, K. A. (2017) · Pain · doi:10.1097/j.pain.0000000000000967 · Cited by 52
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Metadata
- Authors
- Sluka, K. A., & Clauw, D. J.
- Affiliations
- University of Iowa (US)
- University of Michigan (US)
- Corresponding author
- Sluka, Kathleen A.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 338
- Pages
- 114-129
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC5083139
- OpenAlex
- W2415752306
- Cited by
- 671
- References
- 194
- Citations by year
- 2026: 49 · 2025: 68 · 2024: 71 · 2023: 70 · 2022: 96 · 2021: 78 · 2020: 89 · 2019: 64 · 2018: 42 · 2017: 39 · 2016: 3
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01DA038261)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (UM1AR063381, R01AR061371)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- fibromyalgia, chronic widespread pain, central sensitization, nociceptive processing, central nervous system, psychological stress, peripheral nervous system, systemic inflammation, cytokines
- MeSH terms
- Animals, Brain, Fibromyalgia, Humans, Spinal Cord, Chronic Pain
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