Cited by 671Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Mechanisms and TreatmentsPain Management and Treatment

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Neurobiology of fibromyalgia and chronic widespread pain

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Sluka, Kathleen A., Clauw, Daniel J.·2016·Neuroscience

DOI 10.1016/j.neuroscience.2016.06.006PMC PMC5083139

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Abstract

Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified. The underlying mechanisms, in both human and animal studies, for the continued pain in individuals with fibromyalgia will be explored in this review. There is a substantial amount of support for alterations of central nervous system nociceptive processing in people with fibromyalgia, and that psychological factors such as stress can enhance the pain experience. Emerging evidence has begun exploring other potential mechanisms including a peripheral nervous system component to the generation of pain and the role of systemic inflammation. We will explore the data and neurobiology related to the role of the CNS in nociceptive processing, followed by a short review of studies examining potential peripheral nervous system changes and cytokine involvement. We will not only explore the data from human subjects with fibromyalgia but will relate this to findings from animal models of fibromyalgia. We conclude that fibromyalgia and related disorders are heterogenous conditions with a complicated pathobiology with patients falling along a continuum with one end a purely peripherally driven painful condition and the other end of the continuum is when pain is purely centrally driven.

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Resting state connectivity correlates with drug and placebo response in fibromyalgia patients
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Relationship of substance P, 5-hydroxyindole acetic acid and tryptophan in serum of fibromyalgia patients
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Low-Intensity Exercise Reverses Chronic Muscle Pain in the Rat in a Naloxone-Dependent Manner
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Pregabalin in acute and chronic pain
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Measurement of pain threshold in patients with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and healthy controls
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Brief Report: Excitatory and Inhibitory Brain Metabolites as Targets of Motor Cortex Transcranial Direct Current Stimulation Therapy and Predictors of Its Efficacy in Fibromyalgia
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Cerebrospinal Fluid Corticotropin-Releasing Factor Concentration is Associated with Pain but not Fatigue Symptoms in Patients with Fibromyalgia
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Cutaneous C-fiber pain abnormalities of fibromyalgia patients are specifically related to temporal summation
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Persistent deep mechanical hyperalgesia induced by repeated cold stress in rats
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Chapter 20 Electrophysiological evidence for the activation of descending inhibitory controls by nociceptive afferent pathways
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Fibromyalgia: Anti-Inflammatory and Stress Responses after Acute Moderate Exercise
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Repeated swim stress increases pain-induced expression of c-Fos in the rat lumbar cord
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Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress
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Altered visceral sensation in response to somatic pain in the rat☆
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Amperometric Measurement of Glutamate Release Modulation by Gabapentin and Pregabalin in Rat Neocortical Slices: Role of Voltage-Sensitive Ca2+ α2δ-1 Subunit
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Dolorimetry performed at 3 paired tender points highly predicts overall tenderness.
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Selective targeting of ASIC3 using artificial miRNAs inhibits primary and secondary hyperalgesia after muscle inflammation
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ASIC3 Is Required for Development of Fatigue-Induced Hyperalgesia
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Effects of sleep restriction and exercise deprivation on somatic symptoms and mood in healthy adults.
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A community-based survey of fibromyalgia-like pain complaints following the World Trade Center terrorist attacks
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Aerobic Exercise Alters Analgesia and Neurotrophin-3 Synthesis in an Animal Model of Chronic Widespread Pain
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Muscle Fatigue Increases the Probability of Developing Hyperalgesia in Mice
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Excitatory amino acid concentrations increase in the spinal cord dorsal horn after repeated intramuscular injection of acidic saline
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Functional Connectivity of the Default Mode Network and Its Association With Pain Networks in Irritable Bowel Patients Assessed via Lidocaine Treatment
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Obesity increases nociceptive activation of the trigeminal system
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Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
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Authors: Sluka, K. A., & Clauw, D. J.
Affiliations: University of Iowa (US)
University of Michigan (US)
Corresponding author: Sluka, Kathleen A.
ORCID: Sluka, Kathleen A.
Clauw, Daniel J.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2016-12
Volume: 338
Pages: 114-129
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2016.06.006
PMC: PMC5083139
OpenAlex: W2415752306
Cited by: 671
References: 194
Citations by year: 2026: 49 · 2025: 68 · 2024: 71 · 2023: 70 · 2022: 96 · 2021: 78 · 2020: 89 · 2019: 64 · 2018: 42 · 2017: 39 · 2016: 3
FWCI: 7.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (R01DA038261)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (UM1AR063381, R01AR061371)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: fibromyalgia, chronic widespread pain, central sensitization, nociceptive processing, central nervous system, psychological stress, peripheral nervous system, systemic inflammation, cytokines
MeSH terms: Animals, Brain, Fibromyalgia, Humans, Spinal Cord, Chronic Pain

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Neurobiology of fibromyalgia and chronic widespread pain

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