CoChat
Sign Up
Cited by 82

Chronic intermittent ethanol exposure leads to alterations in brain-derived neurotrophic factor within the frontal cortex and impaired behavioral flexibility in both adolescent and adult rats

Fernandez, Gina M., Lew, Brandon J., Vedder, Lindsey C., Savage, Lisa M.·2017·Neuroscience
DOI 10.1016/j.neuroscience.2017.02.045PMC PMC5458357
Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.neuroscience.2017.02.045

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • During acute withdrawal (24 h after last alcohol exposure), early-adolescent exposure leads to decreases in FC BDNF but adult exposure produces increases in FC BDNF.

    “Conversely, during acute withdrawal (24 h after last alcohol exposure), developmental differences arise in FC BDNF, with early-adolescent exposure leading to decreases in FC BDNF but adult exposure producing increases in FC BDNF (Fernandez et al. 2017).”

    From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Fernandez et al. 2017

  • Reductions in FC BDNF may be a consequence of adolescent alcohol exposure, but the duration of this effect is inconsistent.

    “Moreover, recent findings also suggest that reductions in FC brain derived neurotrophic factor (BDNF) may also be a consequence of adolescent alcohol exposure, however the duration of this effect is inconsistent, with some reporting persistent reductions during abstinence (Fernandez et al. 2016) and others reporting reductions during alcohol exposure and acute withdrawal but not during abstinence”

    From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Fernandez et al. 2017

  • Behavioral flexibility has also been shown to be compromised in adult rodents following chronic exposure to alcohol, suggesting that FC-mediated behavioral deficits induced by alcohol may not be exclusive to the adolescent period.

    “It is important to note, however, that behavioral flexibility has also been shown to be compromised in adult rodents following chronic exposure to alcohol, suggesting that FC-mediated behavioral deficits induced by alcohol may not be exclusive to the adolescent period (Fernandez et al. 2017).”

    From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Fernandez et al. 2017

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 57

  1. Badanich KA Becker HC Woodward JJ 2011 Effects of chronic intermittent ethanol exposure on orbitofrontal and medial prefrontal cortex-dependent behaviors in mice Behav Neurosci 125 879 891 22122149 PMC3229192
  2. Badanich KA Fakih ME Gurina TS Roy EK Hoffman JL Uruena-Agnes AR Kirstein CL 2016 Reversal learning and experimenter-administered chronic intermittent ethanol exposure in male rats Psychopharmacology 233 3615 3626 27518574
  3. Bailey KR Crawley JN 2009 Anxiety-Related Behaviors in Mice Methods of Behavior Analysis in Neuroscience Buccafusco JJ Boca Raton, FL CRC Press
  4. Boschen KE Criss KJ Palamarchouk V Roth TL Klintsova AY 2015 Effects of developmental alcohol exposure vs. intubation stress on BDNF and TrkB expression in the hippocampus and frontal cortex of neonatal rats Int J Dev Neurosci Off J Int Soc Dev Neurosci 43 16 24 PMC4442714 25805052
  5. Boutros N Semenova S Liu W Crews FT Markou A 2015 Adolescent intermittent ethanol exposure is associated with increased risky choice and decreased dopaminergic and cholinergic neuron markers in adult rats Int J Neuropsychopharmacol Off Sci J Coll Int Neuropsychopharmacol CINP 18 PMC4368879 25612895
  6. Briones TL Woods J 2013 Chronic binge-like alcohol consumption in adolescence causes depression-like symptoms possibly mediated by the effects of BDNF on neurogenesis Neuroscience 254 324 334 24076087 PMC3983287
  7. Broadwater MA Liu W Crews FT Spear LP 2014 Persistent loss of hippocampal neurogenesis and increased cell death following adolescent, but not adult, chronic ethanol exposure Dev Neurosci 36 297 305 24993092 PMC4125431
  8. Burke NN Coppinger J Deaver DR Roche M Finn DP Kelly J 2016 Sex differences and similarities in depressive- and anxiety-like behaviour in the Wistar-Kyoto rat Physiol Behav 167 28 34 27591842
  9. Chudasama Y Robbins TW 2003 Dissociable Contributions of the Orbitofrontal and Infralimbic Cortex to Pavlovian Autoshaping and Discrimination Reversal Learning: Further Evidence for the Functional Heterogeneity of the Rodent Frontal Cortex J Neurosci 23 8771 8780 14507977 PMC6740430
  10. Coleman LG He J Lee J Styner M Crews FT 2011 Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice Alcohol Clin Exp Res 35 671 688 21223304 PMC3544413
  11. Crews FT Nixon K 2009 Mechanisms of neurodegeneration and regeneration in alcoholism Alcohol Alcohol Oxf Oxfs 44 115 127 PMC2948812 18940959
  12. Crews F He J Hodge C 2007 Adolescent cortical development: a critical period of vulnerability for addiction Pharmacol Biochem Behav 86 189 199 17222895 PMC11646682
  13. Crews FT Braun CJ Hoplight B Switzer RC Knapp DJ 2000 Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats Alcohol Clin Exp Res 24 1712 1723 11104119
  14. Crews FT Sarkar DK Qin L Zou J Boyadjieva N Vetreno RP 2015 Neuroimmune Function and the Consequences of Alcohol Exposure Alcohol Res Curr Rev 37 331 351 PMC4590627 26695754
  15. Crews FT Vetreno RP Broadwater MA Robinson DL 2016 Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior Pharmacol Rev 68 1074 1109 27677720 PMC5050442
  16. Davis MI 2008 Ethanol-BDNF interactions: still more questions than answers Pharmacol Ther 118 36 57 18394710 PMC2553254
  17. Fernandez GM Stewart WN Savage LM 2016 Chronic Drinking During Adolescence Predisposes the Adult Rat for Continued Heavy Drinking: Neurotrophin and Behavioral Adaptation after Long-Term, Continuous Ethanol Exposure PloS One 11 e0149987 26930631 PMC4773001
  18. Floresco SB Block AE Tse MTL 2008 Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure Behav Brain Res 190 85 96 18359099
  19. Ghods-Sharifi S Haluk DM Floresco SB 2008 Differential effects of inactivation of the orbitofrontal cortex on strategy set-shifting and reversal learning Neurobiol Learn Mem 89 567 573 18054257
  20. Hamilton DA Brigman JL 2015 Behavioral flexibility in rats and mice: contributions of distinct frontocortical regions Genes Brain Behav 14 4 21 25561028 PMC4482359
  21. Huang MC Chen CH Liu HC Chen CC Ho CC Leu SJ 2011 Differential patterns of serum brain-derived neurotrophic factor levels in alcoholic patients with and without delirium tremens during acute withdrawal Alcohol Clin Exp Res 35 126 131 21039634
  22. Jansen JM van Holst RJ van den Brink W Veltman DJ Caan MWA Goudriaan AE 2015 Brain function during cognitive flexibility and white matter integrity in alcohol-dependent patients, problematic drinkers and healthy controls Addict Biol 20 979 989 25477246
  23. Koss WA Sadowski RN Sherrill LK Gulley JM Juraska JM 2012 Effects of ethanol during adolescence on the number of neurons and glia in the medial prefrontal cortex and basolateral amygdala of adult male and female rats Brain Res 1466 24 32 22627163 PMC3389213
  24. Kuzmin A Liljequist S Meis J Chefer V Shippenberg T Bakalkin G 2012 Repeated moderate-dose ethanol bouts impair cognitive function in Wistar rats Addict Biol 17 132 140 22026443 PMC3711111
  25. Livy DJ Parnell SE West JR 2003 Blood ethanol concentration profiles: a comparison between rats and mice Alcohol 29 165 171 12798972
  26. Logrip ML Barak S Warnault V Ron D 2015 Corticostriatal BDNF and alcohol addiction Brain Res 1628 Part A 60 67 25801118 PMC4577309
  27. Lyvers M Tobias-Webb J 2010 Effects of acute alcohol consumption on executive cognitive functioning in naturalistic settings Addict Behav 35 1021 1028 20655148
  28. Lyvers M Mathieson N Edwards MS 2015 Blood alcohol concentration is negatively associated with gambling money won on the Iowa gambling task in naturalistic settings after controlling for trait impulsivity and alcohol tolerance Addict Behav 41 129 135 25452056
  29. McClain JA Morris SA Marshall SA Nixon K 2014 Ectopic hippocampal neurogenesis in adolescent male rats following alcohol dependence Addict Biol 19 687 699 23844726 PMC3844012
  30. Mejia-Toiber J Boutros N Markou A Semenova S 2014 Impulsive choice and anxiety-like behavior in adult rats exposed to chronic intermittent ethanol during adolescence and adulthood Behav Brain Res 266C 19 28 PMC4005391 24566059
  31. Miller R King MA Heaton MB Walker DW 2002 The effects of chronic ethanol consumption on neurotrophins and their receptors in the rat hippocampus and basal forebrain Brain Res 950 137 147 12231238
  32. Mooney SM Miller MW 2011 Role of Neurotrophins on Postnatal Neurogenesis in the Thalamus: Prenatal Exposure to Ethanol Neuroscience 179 256 266 21277941 PMC3059403
  33. Moore EM Linsenbardt DN Melón LC Boehm SL 2011 Ontogenetic differences in adolescent and adult C57BL/6J and DBA/2J mice: Anxiety-like, locomotor, and consummatory behaviors Dev Psychobiol 53 141 156 20886536 PMC3375063
  34. Nixon K McClain JA 2010 Adolescence as a critical window for developing an alcohol use disorder: current findings in neuroscience Curr Opin Psychiatry 23 227 232 20224404 PMC3149806
  35. Obernier JA White AM Swartzwelder HS Crews FT 2002 Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats Pharmacol Biochem Behav 72 521 532 12175448
  36. Pandey SC Zhang H Roy A Misra K 2006 Central and medial amygdaloid brain-derived neurotrophic factor signaling plays a critical role in alcohol-drinking and anxiety-like behaviors J Neurosci Off J Soc Neurosci 26 8320 8331 PMC6673799 16899727
  37. Pihl RO Paylan SS Gentes-Hawn A Hoaken PNS 2003 Alcohol affects executive cognitive functioning differentially on the ascending versus descending limb of the blood alcohol concentration curve Alcohol Clin Exp Res 27 773 779 12766621
  38. Quertemont E Green HL Grant KA 2003 Brain ethanol concentrations and ethanol discrimination in rats: effects of dose and time Psychopharmacology 168 262 270 12684735
  39. Raivio N Tiraboschi E Saarikoski ST Castrén E Kiianmaa K 2012 Brain-derived neurotrophic factor expression after acute administration of ethanol Eur J Pharmacol 687 9 13 22546227
  40. Risher ML Fleming RL Boutros N Semenova S Wilson WA Levin ED Markou A Swartzwelder HS Acheson SK 2013 Long-term effects of chronic intermittent ethanol exposure in adolescent and adult rats: radial-arm maze performance and operant food reinforced responding PloS One 8 e62940 23675442 PMC3652810
  41. Savage LM 2012 Sustaining high acetylcholine levels in the frontal cortex, but not retrosplenial cortex, recovers spatial memory performance in a rodent model of diencephalic amnesia Behav Neurosci 126 226 236 22448856 PMC3315061
  42. Van Skike CE Novier A Diaz-Granados JL Matthews DB 2012 The effect of chronic intermittent ethanol exposure on spatial memory in adolescent rats: the dissociation of metabolic and cognitive tolerances Brain Res 1453 34 39 22464184
  43. Slawecki CJ 2006 Two-choice reaction time performance in Sprague-Dawley rats exposed to alcohol during adolescence or adulthood Behav Pharmacol 17 605 614 17021393
  44. Spear LP 2015 Adolescent alcohol exposure: Are there separable vulnerable periods within adolescence? Physiol Behav 148 122 130 25624108 PMC4484315
  45. Spear LP Swartzwelder HS 2014 Adolescent alcohol exposure and persistence of adolescent-typical phenotypes into adulthood: a mini-review Neurosci Biobehav Rev 45 1 8 24813805 PMC4134704
  46. Swartzwelder HS Hogan A Risher ML Swartzwelder RA Wilson WA Acheson SK 2014 Effect of sub-chronic intermittent ethanol exposure on spatial learning and ethanol sensitivity in adolescent and adult rats Alcohol Fayettev N 48 353 360 PMC4084686 24795209
  47. Tait DS Brown VJ 2008 Lesions of the basal forebrain impair reversal learning but not shifting of attentional set in rats Behav Brain Res 187 100 108 17920704
  48. Vedder LC Hall JM Jabrouin KR Savage LM 2015 Interactions Between Chronic Ethanol Consumption and Thiamine Deficiency on Neural Plasticity, Spatial Memory, and Cognitive Flexibility Alcohol Clin Exp Res 39 2143 2153 26419807 PMC4624484
  49. Verdejo-García A Bechara A Recknor EC Pérez-García M 2006 Executive dysfunction in substance dependent individuals during drug use and abstinence: an examination of the behavioral, cognitive and emotional correlates of addiction J Int Neuropsychol Soc JINS 12 405 415 16903133
  50. Vetreno RP Crews FT 2014 Chapter 27 - Current hypotheses on the mechanisms of alcoholism Handbook of Clinical Neurology EVS Pfefferbaum A 477 497 Cambridge, MA Elsevier PMC5898448 25307591
  51. Vetreno RP Crews FT 2015 Binge ethanol exposure during adolescence leads to a persistent loss of neurogenesis in the dorsal and ventral hippocampus that is associated with impaired adult cognitive functioning Front Neurosci 9 35 25729346 PMC4325907
  52. Vetreno RP Qin L Crews FT 2013 Increased receptor for advanced glycation end product expression in the human alcoholic prefrontal cortex is linked to adolescent drinking Neurobiol Dis 59 52 62 23867237 PMC3775891
  53. Vetreno RP Broadwater M Liu W Spear LP Crews FT 2014 Adolescent, but not adult, binge ethanol exposure leads to persistent global reductions of choline acetyltransferase expressing neurons in brain PloS One 9 e113421 25405505 PMC4236188
  54. Walf AA Frye CA 2007 The use of the elevated plus maze as an assay of anxiety-related behavior in rodents Nat Protoc 2 322 328 17406592 PMC3623971
  55. Wang H Peng RY 2016 Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity Mil Med Res 3 26 27583167 PMC5006437
  56. Winstanley CA Olausson P Taylor JR Jentsch JD 2010 Insight into the relationship between impulsivity and substance abuse from studies using animal models Alcohol Clin Exp Res 34 1306 1318 20491734 PMC3380443
  57. Xue G Xue F Droutman V Lu ZL Bechara A Read S 2013 Common Neural Mechanisms Underlying Reversal Learning by Reward and Punishment PLoS ONE 8 PMC3859585 24349211

Cited by

Sorted by citations

Authors
Fernandez, G. M., Lew, B. J., Vedder, L. C., & Savage, L. M.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2017-04
Volume
348
Pages
324-334
ISSN
0306-4522
DOI
10.1016/j.neuroscience.2017.02.045
PMC
PMC5458357
Cited by
82
References
7
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review