Attention, impulsivity, and cognitive flexibility in adult male rats exposed to ethanol binge during adolescence as measured in the five-choice serial reaction time task: the effects of task and ethanol challenges
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Rationale Alcohol abuse is prevalent in adolescent humans, but the long-term behavioral consequences of binge alcohol drinking are unknown. Objectives This study investigated the long-term effects of adolescent intermittent ethanol (AIE) exposure on attention and impulsivity. Methods Adolescent male rats were exposed to 5 g/kg of 25% (v/w) ethanol every 8 h for 4 days. During adulthood, rats were tested in the five-choice serial reaction time task (5-CSRTT) assessing attention, impulsivity and cognitive flexibility. Results There was no metabolic tolerance to ethanol in adolescent rats during AIE exposure. In the 5-CSRTT under baseline conditions, there were no differences between AIE-exposed and control rats in accuracy, omissions, or premature responses, although AIE-exposed rats tended to make more timeout responses than control rats. The short-duration stimulus challenge decreased accuracy and increased omissions and timeout responses in both AIE-exposed and control rats. The long intertrial interval challenge increased premature responses in all rats. An ethanol challenge decreased correct responses, and increased omissions in control, but not in AIE-exposed, rats. Control, but not AIE-exposed, rats exhibited decreased premature and timeout responses after ethanol administration. Response latencies were not affected in AIE-exposed or control rats indicating no sedative effects of ethanol challenge. Conclusions The results indicate that ethanol binge exposure during adolescence has long-lasting neurobehavioral consequences, which persist into adulthood and can be revealed after re-exposure to ethanol. AIE-induced diminished responses to the disruptive effects of ethanol on attention, impulsivity and cognitive flexibility may lead to increased alcohol drinking and other maladaptive behaviors in adulthood.
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Adolescent alcohol exposure enhanced long-term attentional capabilities in one study but produced no change in another.
“For example, adolescent alcohol exposure enhanced long-term attentional capabilities in one study (Boutros et al. 2017) but produced no change in another (Semenova 2012).”
From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Semenova 2012
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Consumo de alcohol y funciones ejecutivas en adolescentes: una revisión sistemática
Villegas-Pantoja, M. Á., Castillo, M. M. A., Benavides-Torres, R. A., & Facundo, F. R. G. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 4 · see citing works
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Diferencias individuales en la impulsividad y la flexibilidad cognitiva en adultos jóvenes sanos
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Engagement for alcohol escalates in the 5-choice serial reaction time task after intermittent access
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Adolescent alcohol binge-drinking induces delayed appearance of behavioral defects in micePreprint
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- Authors
- Semenova, S.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Semenova, Svetlana
- Venue
- Psychopharmacology
- Published
- 2011-09-01
- Volume
- 219
- Issue
- 2
- Pages
- 433-442
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC4018242
- OpenAlex
- W1977773866
- Cited by
- 46
- References
- 69
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 6 · 2013: 4 · 2012: 1
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (U01AA019970)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- adolescent intermittent ethanol exposure, binge drinking, attention, impulsivity, cognitive flexibility, 5-choice serial reaction time task, ethanol challenge, ethanol tolerance, adult male rats, premature responses, response latency
- MeSH terms
- Ethanol, Animals, Attention, Choice Behavior, Cognition, Drug Administration Schedule, Impulsive Behavior, Male, Reaction Time, Serial Learning, Time Factors, Rats, Wistar, Rats
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