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Acute and Chronic Pain Processing in the Thalamocortical System of Humans and Animal Models

Groh, Alexander, Krieger, Patrik, Mease, Rebecca A., Henderson, Luke·2018·Neuroscience

DOI 10.1016/j.neuroscience.2017.09.042

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Abstract

The transmission of noxious stimuli from peripheral receptors to the cortex involves multiple central ascending pathways. While projections to areas in the brainstem and diencephalon are likely involved in mediating the immediate behavioral responses to pain, the assessment of the sensory and emotional/motivational components of pain are likely processed in parallel ascending pathways that relay in the thalamus on their way to the cerebral cortex. In this review we discuss experimental animal and human findings that support the view that a lateral thalamocortical pathway is involved in coding the sensory discriminative aspects of pain, while a medial thalamocortical pathway codes the emotional qualities of pain. In addition, we outline experimental animal and human evidence of functional, anatomical and biochemical alterations in thalamocortical circuits that may be responsible for altered thalamocortical rhythms and the persistent presence of pain following nervous system damage. Finally, we discuss advances in clinical and preclinical development of chronic pain treatments aimed at altering neural and glial function.

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Authors: Groh, A., Krieger, P., Mease, R. A., & Henderson, L.
Affiliations: TUM Klinikum (DE)
Ruhr University Bochum (DE)
The University of Sydney (AU)
Corresponding author: Groh, Alexander
ORCID: Groh, Alexander
Krieger, Patrik
Mease, Rebecca A.
Henderson, Luke
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2018-09
Volume: 387
Pages: 58-71
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2017.09.042
OpenAlex: W2757556887
Cited by: 101
References: 153
Citations by year: 2026: 14 · 2025: 14 · 2024: 16 · 2023: 12 · 2022: 12 · 2021: 12 · 2020: 12 · 2019: 8 · 2018: 1
FWCI: 0.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council of Australia
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords: thalamocortical system, pain processing, acute pain, chronic pain, sensory-discriminative pain, affective pain, ascending pain pathways, glial function, chronic pain management
MeSH terms: Animals, Cerebral Cortex, Disease Models, Animal, Humans, Pain, Thalamus, Chronic Pain, Pain Management

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Acute and Chronic Pain Processing in the Thalamocortical System of Humans and Animal Models

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