Conditioned pain modulation (the diffuse noxious inhibitory control-like effect): its relevance for acute and chronic pain states

Sex, gender, and pain: a review of recent clinical and experimental findings

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Prediction of chronic post-operative pain: Pre-operative DNIC testing identifies patients at risk

Yarnitsky, D., Crispel, Y., Eisenberg, E., Granovsky, Y., Ben-Nun, A., Sprecher, E., Best, L.-A., & Granot, M. (2008) · Pain · doi:10.1016/j.pain.2007.10.033 · Cited by 750 · see citing works

Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition

Julien, N., Goffaux, P., Arsenault, P., & Marchand, S. (2005) · Pain · doi:10.1016/j.pain.2004.12.032 · Cited by 634 · see citing works

Possible Deficiencies of Pain Modulation in Fibromyalgia

Lautenbacher, S., & Rollman, G. B. (1997) · Clinical Journal of Pain · doi:10.1097/00002508-199709000-00003 · Cited by 546 · see citing works

Recommendations on terminology and practice of psychophysical DNIC testing

Yarnitsky, D., Arendt‐Nielsen, L., Bouhassira, D., Edwards, R. R., Fillingim, R. B., Granot, M., Hansson, P. T., Lautenbacher, S., Marchand, S., & Wilder‐Smith, O. H. G. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.02.004 · Cited by 535 · see citing works

Characteristics and prediction of early pain after laparoscopic cholecystectomy

Bisgaard, T., Klarskov, B., Rosenberg, J., & Kehlet, H. (2001) · Pain · doi:10.1016/s0304-3959(00)00406-1 · Cited by 486 · see citing works

Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief

Kosek, E., & Ordeberg, G. (2000) · Pain · doi:10.1016/s0304-3959(00)00310-9 · Cited by 476 · see citing works

The methodology of experimentally induced diffuse noxious inhibitory control (DNIC)-like effect in humans

Pud, D., Granovsky, Y., & Yarnitsky, D. (2009) · Pain · doi:10.1016/j.pain.2009.02.015 · Cited by 465 · see citing works

Diffuse noxious inhibitory controls (DNIC) attenuate temporal summation of second pain in normal males but not in normal females or fibromyalgia patients

Staud, R. M., Robinson, M. E., Vierck, C. J., & Price, D. D. (2002) · Pain · doi:10.1016/s0304-3959(02)00325-1 · Cited by 383 · see citing works

Determinants of endogenous analgesia magnitude in a diffuse noxious inhibitory control (DNIC) paradigm: Do conditioning stimulus painfulness, gender and personality variables matter?

Granot, M., Weissman-Fogel, I., Crispel, Y., Pud, D., Granovsky, Y., Sprecher, E., & Yarnitsky, D. (2008) · Pain · doi:10.1016/j.pain.2007.06.029 · Cited by 371 · see citing works

Impairment of pain inhibition in chronic tension-type headache

Pielsticker, A., Haag, G., Zaudig, M., & Lautenbacher, S. (2005) · Pain · doi:10.1016/j.pain.2005.08.019 · Cited by 315 · see citing works

Deficiency in endogenous modulation of prolonged heat pain in patients with Irritable Bowel Syndrome and Temporomandibular Disorder

King, C. D., Wong, F., Currie, T., Mauderli, A. P., Fillingim, R. B., & Riley, J. L. (2009) · Pain · doi:10.1016/j.pain.2008.12.027 · Cited by 284 · see citing works

Individual differences in endogenous pain modulation as a risk factor for chronic pain

Edwards, R. R. (2005) · Neurology · doi:10.1212/01.wnl.0000171862.17301.84 · Cited by 283 · see citing works

Multifactorial Preoperative Predictors for Postcesarean Section Pain and Analgesic Requirement

Pan, P. H., Coghill, R. C., Houle, T. T., Seid, M. H., Lindel, W. M., Parker, R. L., Washburn, S. A., Harris, L. C., & Eisenach, J. C. (2006) · Anesthesiology · doi:10.1097/00000542-200603000-00007 · Cited by 264 · see citing works

Postcesarean Section Pain Prediction by Preoperative Experimental Pain Assessment

Granot, M., Löwenstein, L., Yarnitsky, D., Tamir, A., & Zimmer, E. Z. (2003) · Anesthesiology · doi:10.1097/00000542-200306000-00018 · Cited by 248 · see citing works

Somatosensory perception and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from rheumatoid arthritis

Leffler, A., Kosek, E., Lerndal, T., Nordmark, B., & Hansson, P. T. (2002) · European Journal of Pain · doi:10.1053/eujp.2001.0313 · Cited by 195 · see citing works

Prediction of Postoperative Pain by Preoperative Nociceptive Responses to Heat Stimulation

Werner, M. U., Duun, P., & Kehlet, H. (2003) · Anesthesiology · doi:10.1097/00000542-200401000-00020 · Cited by 194 · see citing works

Cortical effects of anticipation and endogenous modulation of visceral pain assessed by functional brain MRI in irritable bowel syndrome patients and healthy controls

Song, G. H., Venkatraman, V., Ho, K. Y., Chee, M. W. L., Yeoh, K. G., & Wilder‐Smith, C. H. (2006) · Pain · doi:10.1016/j.pain.2006.06.017 · Cited by 175 · see citing works

Predicting Postoperative Pain by Preoperative Pressure Pain Assessment

Hsu, Y.-W., Somma, J., Hung, Y.-C., Tsai, P.-S., Yang, C.-H., & Chen, C.-C. (2005) · Anesthesiology · doi:10.1097/00000542-200509000-00026 · Cited by 164 · see citing works

Sleep continuity and architecture: Associations with pain‐inhibitory processes in patients with temporomandibular joint disorder

Edwards, R. R., Grace, E., Peterson, S., Klick, B., Haythornthwaite, J. A., & Smith, M. T. (2009) · European Journal of Pain · doi:10.1016/j.ejpain.2008.12.007 · Cited by 158 · see citing works

Pain sensitivity and descending inhibition of pain in Parkinson's disease

Mylius, V., Engau, I., Teepker, M., Stiasny-Kolster, K., Schepelmann, K., Oertel, W. H., Lautenbacher, S., & Möller, J. C. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.145995 · Cited by 152 · see citing works

Oral opioid use alters DNIC but not cold pain perception in patients with chronic pain – New perspective of opioid-induced hyperalgesia

Ram, K. C., Eisenberg, E., Haddad, M., & Pud, D. (2008) · Pain · doi:10.1016/j.pain.2008.05.015 · Cited by 146 · see citing works

Diffuse noxious inhibitory control is delayed in chronic fatigue syndrome: An experimental study

Meeus, M., Nijs, J., de Wauwer, N. V., Toeback, L., & Truijen, S. (2008) · Pain · doi:10.1016/j.pain.2008.05.018 · Cited by 142 · see citing works

Excitatory and inhibitory pain mechanisms during the menstrual cycle in healthy women

Tousignant‐Laflamme, Y., & Marchand, S. (2009) · Pain · doi:10.1016/j.pain.2009.06.018 · Cited by 132 · see citing works

The Deficit of Pain Inhibition in Fibromyalgia Is More Pronounced in Patients With Comorbid Depressive Symptoms

de Souza, J. B., Potvin, S., Goffaux, P., Charest, J., & Marchand, S. (2009) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e318183cfa4 · Cited by 129 · see citing works

Somatosensory perception in a remote pain‐free area and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from long‐term trapezius myalgia

Leffler, A., Hansson, P. T., & Kosek, E. (2002) · European Journal of Pain · doi:10.1053/eujp.2001.0312 · Cited by 120 · see citing works

Widespread hypersensitivity is related to altered pain inhibition processes in irritable bowel syndrome

Piché, M., Arsenault, M., Poitras, P., Rainville, P., & Bouin, M. (2009) · Pain · doi:10.1016/j.pain.2009.10.005 · Cited by 120 · see citing works

Quantitative Sensory Testing and Human Surgery

Wilder‐Smith, O. H. G., TASSONYI, E., Crul, B. J. P., & Arendt‐Nielsen, L. (2003) · Anesthesiology · doi:10.1097/00000542-200305000-00025 · Cited by 109 · see citing works

Noxious Inhibition of Temporal Summation is Impaired in Chronic Tension‐Type Headache

Cathcart, S., Winefield, A. H., Lushington, K., & Rolan, P. E. (2009) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2009.01545.x · Cited by 102 · see citing works

DRD3 Ser9Gly Polymorphism Is Related to Thermal Pain Perception and Modulation in Chronic Widespread Pain Patients and Healthy Controls

Potvin, S., Larouche, A., Normand, E., de Souza, J. B., Gaumond, I., Grignon, S., & Marchand, S. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.03.013 · Cited by 99 · see citing works

Prediction of post‐operative pain by an electrical pain stimulus

Nielsen, P. R., Nørgaard, L. N., Rasmussen, L. S., & Kehlet, H. (2007) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2007.01271.x · Cited by 99 · see citing works

Evidence of descending inhibition deficits in atypical but not classical trigeminal neuralgia

Léonard, G., Goffaux, P., Mathieu, D., Blanchard, J., Kenny, B. G., & Marchand, S. (2009) · Pain · doi:10.1016/j.pain.2009.09.009 · Cited by 89 · see citing works

Pain perception in schizophrenia: no changes in diffuse noxious inhibitory controls (DNIC) but a lack of pain sensitization.

Potvin, S., Stip, E., Tempier, A., Pampoulova, T., Bentaleb, L., Lalonde, P., Lipp, O., Goffaux, P., & Marchand, S. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.11.001 · Cited by 86 · see citing works

Central Processing of Noxious Somatic Stimuli in Patients With Irritable Bowel Syndrome Compared With Healthy Controls

Heymen, S., Maixner, W., Whitehead, W. E., Klatzkin, R. R., Mechlin, B., & Light, K. C. (2010) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181bff800 · Cited by 82 · see citing works

Abnormal pain processing in chronic tension-type headache: a high-density EEG brain mapping study

Buchgreitz, L., Egsgaard, L. L., Jensen, R., Arendt‐Nielsen, L., & Bendtsen, L. (2008) · Brain · doi:10.1093/brain/awn199 · Cited by 77 · see citing works

Pain relief through expectation supersedes descending inhibitory deficits in fibromyalgia patients

Goffaux, P., de Souza, J. B., Potvin, S., & Marchand, S. (2009) · Pain · doi:10.1016/j.pain.2009.02.008 · Cited by 67 · see citing works

Influence of heterotopic noxious conditioning stimulation on spontaneous pain and dynamic mechanical allodynia in central post-stroke pain patients

Tuveson, B., Leffler, A., & Hansson, P. T. (2009) · Pain · doi:10.1016/j.pain.2009.02.002 · Cited by 42 · see citing works

Can Preoperative Electrical Nociceptive Stimulation Predict Acute Pain After Groin Herniotomy?

Aasvang, E. K., Hansen, J. B., & Kehlet, H. (2008) · Journal of Pain · doi:10.1016/j.jpain.2008.05.015 · Cited by 35 · see citing works

The association of sleep and pain: an update and a path forward

Finan, P. H., Goodin, B. R., & Smith, M. T. (2013) · The Journal of Pain · doi:10.1016/j.jpain.2013.08.007 · Cited by 1,620 · see citing works

Evaluating psychosocial contributions to chronic pain outcomes

Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719 · see citing works

Neurobiology of fibromyalgia and chronic widespread pain

Sluka, K. A., & Clauw, D. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.006 · Cited by 671 · see citing works

Chronic postsurgical pain in Europe: An observational study

Fletcher, D., Stamer, U. M., Pogatzki-Zahn, E., Zaslansky, R., Tanase, N. V., Perruchoud, C., Kranke, P., Komann, M., Lehman, T., & Meissner, W. (2015) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000000319 · Cited by 599 · see citing works

Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus

Backonja, M. “., Attal, N., Baron, R., Bouhassira, D., Drangholt, M., Dyck, P. J. B., Edwards, R. R., Freeman, R. L., Gracely, R. H., Haanpää, M., et al. (2013) · Pain · doi:10.1016/j.pain.2013.05.047 · Cited by 582 · see citing works

Chronic nociplastic pain affecting the musculoskeletal system: clinical criteria and grading system

Kosek, E., Clauw, D. J., Nijs, J., Baron, R., Gilron, I., Harris, R. E., Micó, J. A., Rice, A. S. C., & Sterling, M. M. (2021) · Pain · doi:10.1097/j.pain.0000000000002324 · Cited by 598 · see citing works

Conditioned Pain Modulation in Populations With Chronic Pain: A Systematic Review and Meta-Analysis

Lewis, G. N., Rice, D. A., & McNair, P. J. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.07.005 · Cited by 564 · see citing works

Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy

Yarnitsky, D., Granot, M., Nahman‐Averbuch, H., Khamaisi, M., & Granovsky, Y. (2012) · Pain · doi:10.1016/j.pain.2012.02.021 · Cited by 561 · see citing works

Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities

Davis, K. D., Aghaeepour, N., Ahn, A. H., Angst, M. S., Borsook, D., Brenton, A., Burczynski, M. E., Crean, C. S., Edwards, R. R., Gaudilliere, B. L., et al. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0362-2 · Cited by 499 · see citing works

Unraveling the mechanisms of manual therapy: modeling an approach

Bialosky, J. E., Beneciuk, J. M., Bishop, M. D., Coronado, R. A., Penza, C. W., Simon, C. B., & George, S. Z. (2018) · Journal of Orthopaedic & Sports Physical Therapy · doi:10.2519/jospt.2018.7476 · Cited by 482 · see citing works

CGRP and the Trigeminal System in Migraine

Iyengar, S., Johnson, K. W., Ossipov, M. H., & Aurora, S. K. (2019) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13529 · Cited by 491 · see citing works

Discordance between pain and radiographic severity in knee osteoarthritis: Findings from quantitative sensory testing of central sensitization

Finan, P. H., Buenaver, L. F., Bounds, S. C., Hussain, S., Park, R. J., Haque, U. J., Campbell, C. M., Haythornthwaite, J. A., Edwards, R. R., & Smith, M. T. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34646 · Cited by 473 · see citing works

Pain sensitization in people with knee osteoarthritis: a systematic review and meta-analysis

Fingleton, C., Smart, K. M., Moloney, N. A., Fullen, B. M., & Doody, C. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.02.163 · Cited by 446 · see citing works

The transition of acute postoperative pain to chronic pain: an integrative overview of research on mechanisms

Chapman, C. R., & Vierck, C. J. (2017) · The Journal of Pain · doi:10.1016/j.jpain.2016.11.004 · Cited by 423 · see citing works

Nociplastic pain criteria or recognition of central sensitization? Pain phenotyping in the past, present and future

Nijs, J., Lahousse, A., Kapreli, E., Bilika, P., Saraçoğlu, İ., Malfliet, A., Coppieters, I., De Baets, L., Leysen, L., Roose, E., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153203 · Cited by 430 · see citing works

Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations

Edwards, R. R., Dworkin, R. H., Turk, D. C., Angst, M. S., Dionne, R., Freeman, R., Hansson, P., Haroutounian, S., Arendt-Nielsen, L., Attal, N., et al. (2016) · Pain · doi:10.1097/j.pain.0000000000000602 · Cited by 403 · see citing works

Pain vulnerability: a neurobiological perspective

Denk, F., McMahon, S. B., & Tracey, I. (2014) · Nature Neuroscience · doi:10.1038/nn.3628 · Cited by 363 · see citing works

Physiologic Effects of Dry Needling

Cagnie, B. J., Dewitte, V., Barbe, T., Timmermans, F., Delrue, N., & Meeus, M. (2013) · Current Pain and Headache Reports · doi:10.1007/s11916-013-0348-5 · Cited by 340 · see citing works

Low Back Pain: Guidelines for the Clinical Classification of Predominant Neuropathic, Nociceptive, or Central Sensitization Pain

Nijs, J. (2015) · Pain Physician · doi:10.36076/ppj.2015/18/e333 · Cited by 314 · see citing works

Peripheral input and its importance for central sensitization

Baron, R., Hans, G. H., & Dickenson, A. H. (2013) · Annals of Neurology · doi:10.1002/ana.24017 · Cited by 280 · see citing works

The diverse therapeutic actions of pregabalin: is a single mechanism responsible for several pharmacological activities?

Stahl, S. M., Porreca, F., Taylor, C. P., Cheung, R. Y., Thorpe, A. J., & Clair, A. G. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.04.001 · Cited by 277 · see citing works

Measurement Properties of the Central Sensitization Inventory: A Systematic Review

Scerbo, T., Colasurdo, J., Dunn, S., Unger, J., Nijs, J., & Cook, C. E. (2017) · Pain Practice · doi:10.1111/papr.12636 · Cited by 268 · see citing works

Chronic cough as a neuropathic disorder

Chung, K. F., McGarvey, L. P., & Mazzone, S. B. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70043-2 · Cited by 259 · see citing works

Pain after knee arthroplasty: an unresolved issue

Grosu, I., Lavand'homme, P. M., & Thienpont, E. (2013) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-013-2750-2 · Cited by 253 · see citing works

Similarities between exercise-induced hypoalgesia and conditioned pain modulation in humans

Vægter, H. B., Handberg, G., & Graven‐Nielsen, T. (2013) · Pain · doi:10.1016/j.pain.2013.09.023 · Cited by 253 · see citing works

Human Experimental Pain Models for Assessing the Therapeutic Efficacy of Analgesic Drugs

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Extracorporeal shock wave therapy mechanisms in musculoskeletal regenerative medicine

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Treatment of central sensitization in patients with chronic pain: time for change?

Nijs, J., Leysen, L., Vanlauwe, J., Logghe, T., Ickmans, K., Polli, A., Malfliet, A., Coppieters, I., & Huysmans, E. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1647166 · Cited by 225 · see citing works

Assessment of musculoskeletal pain sensitivity and temporal summation by cuff pressure algometry

Graven‐Nielsen, T., Vægter, H. B., Finocchietti, S., Handberg, G., & Arendt‐Nielsen, L. (2015) · Pain · doi:10.1097/j.pain.0000000000000294 · Cited by 214 · see citing works

Exercise-induced hypoalgesia after acute and regular exercise: experimental and clinical manifestations and possible mechanisms in individuals with and without pain

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Is neuroplasticity in the central nervous system the missing link to our understanding of chronic musculoskeletal disorders?

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Treatment of central sensitization in patients with ‘unexplained’chronic pain: An update

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The plasticity of descending controls in pain: translational probing

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Psychological Factors and Conditioned Pain Modulation

Nahman‐Averbuch, H., Nir, R., Sprecher, E., & Yarnitsky, D. (2015) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000296 · Cited by 184 · see citing works

Joint disease in haemophilia: Pathophysiology, pain and imaging

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Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?

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The progression from acute to chronic pain

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The role of central sensitization in shoulder pain: A systematic literature review

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Validation of the Pain Sensitivity Questionnaire in chronic pain patients

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Diffuse noxious inhibitory controls and nerve injury

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Chronic exposure to insufficient sleep alters processes of pain habituation and sensitization

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Psychosocial, Physical, and Neurophysiological Risk Factors for Chronic Neck Pain: A Prospective Inception Cohort Study

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The Role of Descending Inhibitory Pathways on Chronic Pain Modulation and Clinical Implications

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Alteration in pain modulation in women with persistent pain after lumpectomy: influence of catastrophizing

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Brainstem Pain-Control Circuitry Connectivity in Chronic Neuropathic Pain

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Distraction Analgesia in Chronic Pain Patients

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What do monoamines do in pain modulation?

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Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients?

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Pain Modulation: From Conditioned Pain Modulation to Placebo and Nocebo Effects in Experimental and Clinical Pain

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The predictive value of quantitative sensory testing: a systematic review on chronic postoperative pain and the analgesic effect of pharmacological therapies in patients with chronic pain

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Methods and strategies of tDCS for the treatment of pain: current status and future directions

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Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information

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Non-inflammatory Causes of Pain in Patients with Rheumatoid Arthritis

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Comparing test–retest reliability and magnitude of conditioned pain modulation using different combinations of test and conditioning stimuli

Imai, Y., Petersen, K. K., Mørch, C. D., & Arendt Nielsen, L. (2016) · Somatosensory & Motor Research · doi:10.1080/08990220.2016.1229178 · Cited by 127 · see citing works

Neuropathic Pain and Spinal Cord Injury: Phenotypes and Pharmacological Management

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The Role of Quantitative Sensory Testing in the Evaluation of Musculoskeletal Pain Conditions

Pavlaković, G., & Petzke, F. W. (2010) · Current Rheumatology Reports · doi:10.1007/s11926-010-0131-0 · Cited by 124 · see citing works

Effects of intensity of electroacupuncture on chronic pain in patients with knee osteoarthritis: a randomized controlled trial

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Current and Emerging Pharmacotherapy for Fibromyalgia

Tzadok, R., & Ablin, J. N. (2020) · Pain Research and Management · doi:10.1155/2020/6541798 · Cited by 122 · see citing works

Hypoalgesia After Exercise and the Cold Pressor Test is Reduced in Chronic Musculoskeletal Pain Patients With High Pain Sensitivity

Vægter, H. B., Handberg, G., & Graven‐Nielsen, T. (2015) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000223 · Cited by 121 · see citing works

Cognitive-Behavioral Therapy for Comorbid Insomnia and Chronic Pain

Finan, P. H., Buenaver, L. F., Runko, V. T., & Smith, M. T. (2014) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2014.02.007 · Cited by 117 · see citing works

Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial

Zanette, S. D. A., Vercelino, R., Laste, G., Rozisky, J. R., Schwertner, A., Machado, C. B., Xavier, F., de Souza, I. C. C., Deitos, A., Torres, I. L. D. S., et al. (2014) · BMC Pharmacology and Toxicology · doi:10.1186/2050-6511-15-40 · Cited by 117 · see citing works

Pain inhibits pain; human brainstem mechanisms

Youssef, A. M., Macefield, V. G., & Henderson, L. A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.08.060 · Cited by 113 · see citing works

Reticular Formation and Pain: The Past and the Future

Martins, I., & Tavares, I. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00051 · Cited by 114 · see citing works

Alloknesis and hyperknesis—mechanisms, assessment methodology, and clinical implications of itch sensitization

Andersen, H. H., Akiyama, T., Nattkemper, L. A., van Laarhoven, A. I. M., Elberling, J., Yosipovitch, G., & Arendt‐Nielsen, L. (2018) · Pain · doi:10.1097/j.pain.0000000000001220 · Cited by 113 · see citing works

Effects of Motor Cortex Modulation and Descending Inhibitory Systems on Pain Thresholds in Healthy Subjects

Reidler, J. S., de Mendonça, M. E., Santana, M. B., Wang, X., Lenkinski, R. E., Motta, A. F., Marchand, S., Latif, L. A., & Fregni, F. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.01.005 · Cited by 113 · see citing works

Does exercise induce hypoalgesia through conditioned pain modulation?

Ellingson, L. D., Koltyn, K. F., Kim, J., & Cook, D. B. (2013) · Psychophysiology · doi:10.1111/psyp.12168 · Cited by 110 · see citing works

Exercise-induced Hypoalgesia in People With Knee Osteoarthritis With Normal and Abnormal Conditioned Pain Modulation

Fingleton, C., Smart, K. M., & Doody, C. (2016) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000418 · Cited by 111 · see citing works

Conditioned pain modulation as a biomarker of chronic pain: a systematic review of its concurrent validity

Fernandes, C., Pidal-Miranda, M., Samartin-Veiga, N., & Carrillo‐de‐la‐Peña, M. T. (2019) · Pain · doi:10.1097/j.pain.0000000000001664 · Cited by 111 · see citing works

The Role of Descending Modulation in Manual Therapy and Its Analgesic Implications: A Narrative Review

Vigotsky, A. D., & Bruhns, R. P. (2015) · Pain Research and Treatment · doi:10.1155/2015/292805 · Cited by 114 · see citing works

The transition from acute to chronic post surgical pain

Shipton, E. A. (2011) · Anaesthesia and Intensive Care · doi:10.1177/0310057x1103900506 · Cited by 108 · see citing works

Cohort description: The Danish study of Functional Disorders

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Conditioned pain modulation in patients with nonspecific chronic back pain with chronic local pain, chronic widespread pain, and fibromyalgia

Gerhardt, A., Eich, W., Treede, R., & Tesarz, J. (2016) · Pain · doi:10.1097/j.pain.0000000000000777 · Cited by 103 · see citing works

Why sickness hurts: A central mechanism for pain induced by peripheral inflammation.

Karshikoff, B., Jensen, K., Kosek, E., Kalpouzos, G., Soop, A., Ingvar, M., Höglund, C. O., Lekander, M., & Axelsson, J. (2016) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2016.04.001 · Cited by 93 · see citing works

Parabrachial complex links pain transmission to descending pain modulation

Roeder, Z., Chen, Q., Davis, S., Carlson, J. D., Tupone, D., & Heinricher, M. M. (2016) · Pain · doi:10.1097/j.pain.0000000000000688 · Cited by 105 · see citing works

Optimizing and Accelerating the Development of Precision Pain Treatments for Chronic Pain: IMMPACT Review and Recommendations

Edwards, R. R., Schreiber, K. L., Dworkin, R. H., Turk, D. C., Baron, R., Freeman, R. L., Jensen, T. S., Latrémolière, A., Markman, J. D., Rice, A. S. C., et al. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.08.010 · Cited by 103 · see citing works

Acute and Chronic Pain Processing in the Thalamocortical System of Humans and Animal Models

Groh, A., Krieger, P., Mease, R. A., & Henderson, L. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.042 · Cited by 101 · see citing works

Gain control mechanisms in the nociceptive system

Treede, R. (2016) · Pain · doi:10.1097/j.pain.0000000000000499 · Cited by 102 · see citing works

Recognition and Treatment of Central Sensitization in Chronic Pain Patients: Not Limited to Specialized Care

Nijs, J., Goubert, D., & Ickmans, K. (2016) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2016.0612 · Cited by 98 · see citing works

Lateralized kappa opioid receptor signaling from the amygdala central nucleus promotes stress-induced functional pain

Nation, K. M., De Felice, M., Hernandez, P. I., Dodick, D. W., Neugebauer, V., Navratilova, E., & Porreca, F. (2018) · Pain · doi:10.1097/j.pain.0000000000001167 · Cited by 96 · see citing works

Modality and sex differences in pain sensitivity during human endotoxemia

Karshikoff, B., Lekander, M., Soop, A., Lindstedt, F., Ingvar, M., Kosek, E., Höglund, C. O., & Axelsson, J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.11.014 · Cited by 95 · see citing works

Cortical influences on brainstem circuitry responsible for conditioned pain modulation in humans

Youssef, A. M., Macefield, V. G., & Henderson, L. A. (2016) · Human Brain Mapping · doi:10.1002/hbm.23199 · Cited by 95 · see citing works

Optimism and the Experience of Pain: Benefits of Seeing the Glass as Half Full

Goodin, B. R., & Bulls, H. W. (2013) · Current Pain and Headache Reports · doi:10.1007/s11916-013-0329-8 · Cited by 95 · see citing works

Acute psychosocial stress reduces pain modulation capabilities in healthy men

Geva, N., Pruessner, J. C., & Defrin, R. (2014) · Pain · doi:10.1016/j.pain.2014.09.023 · Cited by 94 · see citing works

Nociplastic pain and central sensitization in patients with chronic pain conditions: a terminology update for clinicians

Nijs, J., Malfliet, A., & Nishigami, T. (2023) · Brazilian Journal of Physical Therapy · doi:10.1016/j.bjpt.2023.100518 · Cited by 93 · see citing works

Sex Differences in the Stability of Conditioned Pain Modulation (CPM) among Patients with Chronic Pain

Martel, M. O., Wasan, A. D., & Edwards, R. R. (2013) · Pain Medicine · doi:10.1111/pme.12220 · Cited by 92 · see citing works

Neurostimulation methods in the treatment of chronic pain

Moisset, X., Lantéri‐Minet, M., & Fontaine, D. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02092-y · Cited by 91 · see citing works

Sex differences in experimental measures of pain sensitivity and endogenous pain inhibition

Goodin, B. R., Bulls, H. W., Freeman, E. L., Robbins, M. T., Anderson, A., & Ness, T. J. (2015) · Journal of Pain Research · doi:10.2147/jpr.s84607 · Cited by 90 · see citing works

Changes in Pain Sensitivity and Pain Modulation During Oral Opioid Treatment: The Impact of Negative Affect

Edwards, R. R., Dolman, A. J., Michna, E., Katz, J. N., Nedeljković, S. S., Janfaza, D. R., Isaac, Z., Martel, M. O., Jamison, R. N., & Wasan, A. D. (2016) · Pain Medicine · doi:10.1093/pm/pnw010 · Cited by 87 · see citing works

The ACTTION–APS–AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions

Kent, M. L., Tighe, P. J., Belfer, I., Brennan, T. J., Bruehl, S. P., Brummett, C. M., Buckenmaier, C. C., Buvanendran, A., Cohen, R. I., Desjardins, P. J., et al. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.02.421 · Cited by 88 · see citing works

Central pain processing is altered in people with Achilles tendinopathy

Tompra, N., van Dieën, J. H., & Coppieters, M. W. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-095476 · Cited by 87 · see citing works

Is the Conditioned Pain Modulation Paradigm Reliable? A Test-Retest Assessment Using the Nociceptive Withdrawal Reflex

Manresa, J. A. B., Fritsche, R., Vuilleumier, P. H., Oehler, C., Mørch, C. D., Arendt‐Nielsen, L., Andersen, O. K., & Curatolo, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100241 · Cited by 84 · see citing works

Neuropathic Pain: Is Quantitative Sensory Testing Helpful?

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Sex differences and hormonal modulation of deep tissue pain

Traub, R. J., & Ji, Y. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.07.002 · Cited by 83 · see citing works

Neuropathic Pain and Spinal Cord Injury: Management, Phenotypes, and Biomarkers

Widerström-Noga, E. G. (2023) · Drugs · doi:10.1007/s40265-023-01903-7 · Cited by 86 · see citing works

Can quantitative sensory testing predict responses to analgesic treatment?

Grosen, K., Fischer, I. W. D., Olesen, A. E., & Drewes, A. M. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2013.00330.x · Cited by 81 · see citing works

Discovery of endogenous opioid systems: what it has meant for the clinician's understanding of pain and its treatment

Ballantyne, J. C., & Sullivan, M. D. (2017) · Pain · doi:10.1097/j.pain.0000000000001043 · Cited by 79 · see citing works

The neurobiology of acute pain

Bell, A. M. (2018) · The Veterinary Journal · doi:10.1016/j.tvjl.2018.05.004 · Cited by 80 · see citing works

Prolonged Perioperative Use of Pregabalin and Ketamine to Prevent Persistent Pain after Cardiac Surgery

Anwar, S., Cooper, J. A., Rahman, J., Sharma, C., & Langford, R. M. (2019) · Anesthesiology · doi:10.1097/aln.0000000000002751 · Cited by 79 · see citing works

Cardiovascular influences on conditioned pain modulation

Chalaye, P., Devoize, L., Lafrenaye, S., Dallel, R., & Marchand, S. (2013) · Pain · doi:10.1016/j.pain.2013.04.027 · Cited by 78 · see citing works

The effects of elevated pain inhibition on endurance exercise performance

Flood, A. P., Waddington, G. S., Keegan, R. J., Thompson, K., & Cathcart, S. (2017) · PeerJ · doi:10.7717/peerj.3028 · Cited by 77 · see citing works

Pain inhibits pain: Conditioned pain modulation (CPM)

Yi, T. A. N. G., Hu, L., DanDan, T. A. N. G., & Peng, W. (2015) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972015-00872 · Cited by 7 · see citing works

Effect of Pain Induction or Pain Reduction on Conditioned Pain Modulation in Adults: A Systematic Review

Goubert, D., Danneels, L. A., Cagnie, B. J., Oosterwijck, J. V., Kolba, K., Noyez, H., & Meeus, M. (2014) · Pain Practice · doi:10.1111/papr.12241 · Cited by 50 · see citing works

Assessment of conditioned pain modulation in healthy participants and patients with chronic pain: manifestations and implications for pain progression

Petersen, K. K., McPhee, M. E., Hoegh, M., & Graven‐Nielsen, T. (2019) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000419 · Cited by 47 · see citing works

Conditioned pain modulation—A comprehensive review

Ramaswamy, S., & Wodehouse, T. (2020) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2020.11.002 · Cited by 221 · see citing works

Conditioned Pain Modulation: A Predictor for Development and Treatment of Neuropathic Pain

Granovsky, Y. (2013) · Current Pain and Headache Reports · doi:10.1007/s11916-013-0361-8 · Cited by 75 · see citing works