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Serum Exosomal miR-223 Serves as a Potential Diagnostic and Prognostic Biomarker for Dementia
Abstract
The aims of this study were to examine the levels of serum and exosomal miR-137, miR-155 and miR-223, three neuroinflammation-related miRNAs, in dementia patients and to explore the value of these miRNAs for the diagnosis and prognostic evaluation of dementia. Thirty-two patients with dementia were enrolled, and sixteen volunteers without dementia served as controls. Serum exosomes were isolated by precipitation with ExoQuick and characterized by western blotting, nanoparticle-tracking analysis and immunofluorescence microscopy. The levels of both total serum miRNAs and serum exosomal miRNAs were determined by real-time quantitative PCR. Total serum miRNAs and serum exosomal miRNAs were both detected to be down-regulated. The median level of serum exosomal miR-223 was significantly decreased in dementia patients (p < 0.01). The level of miR-223 was significantly correlated with Mini-Mental State Examination (MMSE) scores, Clinical Dementia Rating (CDR) scores, magnetic resonance spectroscopy (MRS) spectral ratios and serum concentrations of IL-1β, IL-6, TNF-α, and CRP. The diagnostic utility of exosomal miR-233 was evaluated by the area under the receiver operating characteristic (ROC) curve, and the area under the curve (AUC) was 0.875. This study suggests that serum exosomal miR-223 is a promising biomarker for diagnosing dementia and evaluating the progression of disease.
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“In another study, Wei et al. identified a subset of potential diagnostic miRNA biomarkers that correlated with some of the clinical scales used for AD diagnosis [59].”
From miR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal Dementia (2025) · cites this paper as [59]
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Cited by
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Regulation of exosome production and cargo sorting
Wei, H., Chen, Q., Lin, L., Sha, C., Li, T., Liu, Y., Yin, X., Xu, Y., Chen, L., Gao, W., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.53671 · Cited by 385
Self-citationXu, X., Iqbal, Z., Xu, L., Wen, C., Duan, L., Xia, J., Yang, N., Zhang, Y., & Liang, Y. (2024) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13610 · Cited by 68
Monteiro-Reis, S., Carvalho-Maia, C., Bart, G., Vainio, S. J., Pedro, J., Silva, E. R., Sales, G., Henrique, R., & Jerónimo, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063267 · Cited by 21
Manzini, V., Cappelletti, P., Orefice, N. S., Brentari, I., Rigby, M. J., Lo Giudice, M., Feligioni, M., Rivabene, R., Crestini, A., Manfredi, F., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-024-04386-z · Cited by 16
Metadata
- Authors
- Wei, H., Xu, Y., Xu, W., Zhou, Q., Chen, Q., Yang, M., Feng, F., Liu, Y., Zhu, X., Yu, M., & Li, Y.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 379
- Pages
- 167-176
- ISSN
- 0306-4522
- Cited by
- 84
- References
- 4
- Language
- en
- Funders
- Natural Science Foundation of China (81402165/81672913)
- Six talent peaks project in Jiangsu Province (2016-WSW-125)
- “333 Project” research projects in Jiangsu Province (BRA2016141)
- Natural Science Foundation of Jiangsu Province (BK20141288/BK20171311)
- Jiangsu Provincial Medical Youth Talent (QNRC2016460/FRC201788)
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