Brain‐derived extracellular vesicles: Potential diagnostic biomarkers for central nervous system diseases

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

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Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

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Optimized exosome isolation protocol for cell culture supernatant and human plasma

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Engineering exosomes for targeted drug delivery

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Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

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Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

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Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study

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Isolation of exosomes from whole blood by integrating acoustics and microfluidics

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The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling

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Exosomes are released by cultured cortical neurones

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Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

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Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

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A Comparative Study of Serum Exosome Isolation Using Differential Ultracentrifugation and Three Commercial Reagents

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Nanoscale lateral displacement arrays for the separation of exosomes and colloids down to 20 nm

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High‐speed centrifugation induces aggregation of extracellular vesicles

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Current methods for the isolation of extracellular vesicles

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Oligodendrocytes secrete exosomes containing major myelin and stress‐protective proteins: Trophic support for axons?

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Integrated Magneto–Electrochemical Sensor for Exosome Analysis

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Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

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Parkinson’s Disease

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Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

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Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers

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Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment

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Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1

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Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease

Goetzl, E. J., Kapogiannis, D., Schwartz, J. B., Lobach, I. V., Goetzl, L., Abner, E. L., Jicha, G. A., Karydas, A. M., Boxer, A., & Miller, B. L. (2016) · The FASEB Journal · doi:10.1096/fj.201600816r · Cited by 398 · see citing works

Exosome isolation: a microfluidic road-map

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Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile

Winston, C. N., Goetzl, E. J., Akers, J. C., Carter, B. S., Rockenstein, E. M., Galasko, D. R., Masliah, E., & Rissman, R. A. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.04.001 · Cited by 379 · see citing works

Concordance between the assessment of Aβ42, T‐tau, and P‐T181‐tau in peripheral blood neuronal‐derived exosomes and cerebrospinal fluid

Jia, L., Qiu, Q., Zhang, H., Chu, L., Du, Y., Zhang, J., Zhou, C., Liang, F., Shi, S., Wang, S., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.05.002 · Cited by 376 · see citing works

Exosome secretion is a key pathway for clearance of pathological TDP-43

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Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles

Wang, Z., Wu, H., Fine, D., Schmulen, J., Hu, Y., Godin, B., Zhang, J. X. J., & Liu, X. (2013) · Lab on a Chip · doi:10.1039/c3lc41343h · Cited by 358 · see citing works

Dopamine in Parkinson's disease

Latif, S., Jahangeer, M., Razia, D. E. M., Ashiq, M., Ghaffar, A., Akram, M., Allam, A. E., Bouyahya, A., Garipova, L., Shariati, M. A., et al. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.08.009 · Cited by 348 · see citing works

Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural‐derived blood exosomes of preclinical Alzheimer's disease

Kapogiannis, D., Boxer, A. L., Schwartz, J. B., Abner, E. L., Biragyn, A., Masharani, U. B., Frassetto, L. A., Petersen, R. C., Miller, B. L., & Goetzl, E. J. (2014) · The FASEB Journal · doi:10.1096/fj.14-262048 · Cited by 345 · see citing works

Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations

Prada, I., Gabrielli, M., Turola, E., Iorio, A., D’Arrigo, G., Parolisi, R., De Luca, M., Pacifici, M., Bastoni, M., Lombardi, M., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-017-1803-x · Cited by 312 · see citing works

Serum GFAP as a biomarker for disease severity in multiple sclerosis

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Serum neuronal exosomes predict and differentiate Parkinson’s disease from atypical parkinsonism

Jiang, C., Hopfner, F., Katsikoudi, A., Hein, R., Catli, C., Evetts, S. G., Huang, Y., Wang, H., Ryder, J. W., Kuhlenbäeumer, G., et al. (2020) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-322588 · Cited by 279 · see citing works

Exosomal microRNA signatures in multiple sclerosis reflect disease status

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Blood neuro‐exosomal synaptic proteins predict Alzheimer's disease at the asymptomatic stage

Jia, L., Zhu, M., Kong, C., Pang, Y., Zhang, H., Qiu, Q., Wei, C., Tang, Y., Wang, Q., Li, Y., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12166 · Cited by 251 · see citing works

Regulation of Postsynaptic Retrograde Signaling by Presynaptic Exosome Release

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Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

Kapogiannis, D., Mustapic, M., Shardell, M. D., Berkowitz, S. T., Diehl, T. C., Spangler, R. D., Tran, J., Lazaropoulos, M. P., Chawla, S., Gulyani, S., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.2462 · Cited by 241 · see citing works

Exosome-mediated delivery of gene vectors for gene therapy

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The Serum Exosome Derived MicroRNA-135a, -193b, and -384 Were Potential Alzheimer's Disease Biomarkers.

Yang, T., Liu, C. G., Gao, S. C., Zhang, Y., & Wang, P. C. (2018) · PubMed · doi:10.3967/bes2018.011 · Cited by 230 · see citing works

Exosome separation using microfluidic systems: size‐based, immunoaffinity‐based and dynamic methodologies

Yang, F., Liao, X., Tian, Y. Y., & Li, G. (2017) · Biotechnology Journal · doi:10.1002/biot.201600699 · Cited by 226 · see citing works

MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer’s disease

Liu, C., Song, J., Zhang, Y., & Wang, P. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2484 · Cited by 221 · see citing works

Increased Brain-Specific MiR-9 and MiR-124 in the Serum Exosomes of Acute Ischemic Stroke Patients

Ji, Q., Ji, Y.-H., Peng, J.-W., Zhou, X., Chen, X., Zhao, H., Xu, T., Chen, L., & Xu, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163645 · Cited by 221 · see citing works

Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis

Kimura, K., Hohjoh, H., Fukuoka, M., Sato, W., Oki, S., Tomi, C., Yamaguchi, H., Kondo, T., Takahashi, R., & Yamamura, T. (2017) · Nature Communications · doi:10.1038/s41467-017-02406-2 · Cited by 221 · see citing works

Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease

Goetzl, E. J., Abner, E. L., Jicha, G. A., Kapogiannis, D., & Schwartz, J. B. (2018) · The FASEB Journal · doi:10.1096/fj.201700731r · Cited by 219 · see citing works

Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment

Liang, Y., Xu, X., Xu, L., Iqbal, Z., Ouyang, K., Zhang, H., Wen, C., Duan, L., & Xia, J. (2022) · Theranostics · doi:10.7150/thno.69368 · Cited by 217 · see citing works

MicroRNA biomarkers of Parkinson’s disease in serum exosome-like microvesicles

Cao, X., Lu, J., Zhao, Z., Li, M.-C., Lu, T., An, X., & Xue, L. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.02.045 · Cited by 207 · see citing works

Increased Circulating Exosomal miRNA-223 Is Associated with Acute Ischemic Stroke

Chen, Y., Song, Y., Huang, J., Qu, M., Zhang, Y., Geng, J., Zhang, Z., Liu, J., & Yang, G.-Y. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00057 · Cited by 207 · see citing works

CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease

Shi, M., Kovac, A., Korff, A., Cook, T. J., Ginghina, C., Bullock, K. M., Yang, L., Stewart, T., Zheng, D., Aro, P., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.04.003 · Cited by 206 · see citing works

miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer’s Patients

Cha, D. J., Mengel, D., Mustapić, M., Liu, W., Selkoe, D. J., Kapogiannis, D., Galasko, D. R., Rissman, R. A., Bennett, D. A., & Walsh, D. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01208 · Cited by 201 · see citing works

Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification

Liu, Q., Li, D., Pan, X., & Liang, Y. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02081-0 · Cited by 201 · see citing works

Ser(P)‐1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease

Fraser, K. B., Rawlins, A. B., Clark, R. G., Alcalay, R. N., Standaert, D. G., Liu, N., & West, A. B. (2016) · Movement Disorders · doi:10.1002/mds.26686 · Cited by 197 · see citing works

Edible exosome-like nanoparticles from portulaca oleracea L mitigate DSS-induced colitis via facilitating double-positive CD4+CD8+T cells expansion

Zhu, M., Xu, H., Liang, Y.-J., Xu, J., Yue, N.-N., Zhang, Y., Tian, C., Yao, J., Wang, L., Nie, Y., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02065-0 · Cited by 196 · see citing works

A longitudinal study on α‐synuclein in plasma neuronal exosomes as a biomarker for Parkinson’s disease development and progression

Niu, M., Li, Y., Li, G., Zhou, L., Luo, N., Yao, M., Kang, W., & Liu, J. (2020) · European Journal of Neurology · doi:10.1111/ene.14208 · Cited by 178 · see citing works

Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies

Gámez‐Valero, A., Campdelacreu, J., Vilas, D., Ispierto, L., Reñé, R., Álvarez, R., Armengol, M. P., Borràs, F. E., & Beyer, K. (2019) · Translational Neurodegeneration · doi:10.1186/s40035-019-0169-5 · Cited by 175 · see citing works

Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis

Selmaj, I., Cichalewska, M., Namiecińska, M., Gałązka, G., Horzelski, W., Selmaj, K. W., & Mycko, M. P. (2017) · Annals of Neurology · doi:10.1002/ana.24931 · Cited by 168 · see citing works

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease

Cicognola, C., Brinkmalm, G., Wahlgren, J., Portelius, E., Gobom, J., Cullen, N. C., Hansson, O., Parnetti, L., Constantinescu, R., Wildsmith, K., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-018-1948-2 · Cited by 168 · see citing works

α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy

Dutta, S., Hornung, S., Kruayatidee, A., Maina, K. N., Rosario, I. D., Paul, K. C., Wong, D. Y., Folle, A. D., Markovic, D., Palma, J., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02324-0 · Cited by 163 · see citing works

Cell-derived nanovesicle-mediated drug delivery to the brain: Principles and strategies for vesicle engineering

Liang, Y., Iqbal, Z., Lu, J., Wang, J., Zhang, H., Chen, X., Duan, L., & Xia, J. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2022.10.008 · Cited by 162 · see citing works

Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy

Fussi, N., Höllerhage, M., Chakroun, T., Nykänen, N.-P., Rösler, T. W., Koeglsperger, T., Wurst, W., Behrends, C., & Höglinger, G. U. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0816-2 · Cited by 161 · cited 1× · see citing works

Identification of a circulating miRNA signature in extracellular vesicles collected from amyotrophic lateral sclerosis patients

Saucier, D., Wajnberg, G., Roy, J. W., Beauregard, A., Chacko, S. M., Crapoulet, N., Fournier, S., Ghosh, A., Lewis, S. M., Marrero, A., et al. (2018) · Brain Research · doi:10.1016/j.brainres.2018.12.016 · Cited by 135 · see citing works

Isolation of extracellular vesicle from blood plasma using electrophoretic migration through porous membrane

Cho, S., Jo, W., Heo, Y., Kang, J. Y., Kwak, R., & Park, J. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.04.091 · Cited by 131 · see citing works

CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke

Liu, Y., Li, Y., Zhang, T., Zhang, T., Li, Y., Tan, Z., Ma, D., Zhang, Y., Wang, S., Zhang, Y., et al. (2022) · Circulation Research · doi:10.1161/circresaha.121.319412 · Cited by 131 · see citing works

SNAP-25 in Serum Is Carried by Exosomes of Neuronal Origin and Is a Potential Biomarker of Alzheimer’s Disease

Agliardi, C., Guerini, F. R., Zanzottera, M., Bianchi, A., Nemni, R., & Clerici, M. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1501-x · Cited by 130 · see citing works

Serum secreted miR-137-containing exosomes affects oxidative stress of neurons by regulating OXR1 in Parkinson’s disease

Jiang, Y., Liu, J., Chen, L., Jin, Y., Zhang, G., Lin, Z., Du, S., Fu, Z., Chen, T., Qin, Y., et al. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146331 · Cited by 117 · see citing works

Diagnosis of Hyperacute and Acute Ischaemic Stroke: The Potential Utility of Exosomal MicroRNA-21-5p and MicroRNA-30a-5p

Wang, W., Li, D.-B., Li, R.-Y., Zhou, X., Yu, D.-J., Lan, X.-Y., Li, J.-P., & Liu, J.-L. (2018) · Cerebrovascular Diseases · doi:10.1159/000488365 · Cited by 113 · see citing works

Circulating exosomal miRNAs as diagnostic biomarkers in Parkinson's disease.

Yf, Y., Mw, Q., Gc, L., Fb, Z., & Hc, R. (2018) · PubMed · doi:10.26355/eurrev_201808_15727 · Cited by 111 · see citing works

Increased serum exosomal miR-134 expression in the acute ischemic stroke patients

Zhou, J., Chen, L., Chen, B., Huang, S., Zeng, C., Wu, H., Chen, C., & Long, F. (2018) · BMC Neurology · doi:10.1186/s12883-018-1196-z · Cited by 110 · see citing works

Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction

Yu, Z., Shi, M. Y., Stewart, T., Fernagut, P., Huang, Y. X. R., Tian, C., Dehay, B., Atik, A., Yang, D., Giorgi, F. D., et al. (2020) · Brain · doi:10.1093/brain/awaa110 · Cited by 108 · see citing works

Release of heat shock proteins (Hsps) and the effects of extracellular Hsps on neural cells and tissues

Tytell, M. (2005) · International Journal of Hyperthermia · doi:10.1080/02656730500041921 · Cited by 106 · see citing works

Multiple sclerosis: Serum-derived exosomes express myelin proteins

Gałązka, G., Mycko, M. P., Selmaj, I., Raine, C. S., & Selmaj, K. W. (2017) · Multiple Sclerosis Journal · doi:10.1177/1352458517696597 · Cited by 103 · see citing works

Programming assembly of biomimetic exosomes: An emerging theranostic nanomedicine platform

Xu, X., Xu, L., Wen, C., Xia, J., Zhang, Y., & Liang, Y. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100760 · Cited by 101 · see citing works

MicroRNA expression profiles of neuron-derived extracellular vesicles in plasma from patients with amyotrophic lateral sclerosis

Katsu, M., Hama, Y., Utsumi, J., Takashina, K., Yasumatsu, H., Mori, F., Wakabayashi, K., Shoji, M., & Sasaki, H. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.03.048 · Cited by 99 · see citing works

Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer’s Disease Progression

Nam, E., Lee, Y., Moon, C., & Chang, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145007 · Cited by 97 · see citing works

Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles

Cheng, L., Vella, L. J., Barnham, K. J., McLean, C., Masters, C. L., & Hill, A. F. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1766822 · Cited by 95 · see citing works

Serum Exosomal miR-223 Serves as a Potential Diagnostic and Prognostic Biomarker for Dementia

Wei, H., Xu, Y., Xu, W., Zhou, Q., Chen, Q., Yang, M., Feng, F., Liu, Y., Zhu, X., Yu, M., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.03.016 · Cited by 92 · see citing works

Differential Expression of Plasma Exo-miRNA in Neurodegenerative Diseases by Next-Generation Sequencing

Nie, C., Sun, Y., Zhen, H., Guo, M. L., Ye, J., Liu, Z., Yang, Y. X., & Zhang, X. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00438 · Cited by 89 · see citing works

Neuronal exosomes in saliva of Parkinson's disease patients: A pilot study

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Comparison of the extraction and determination of serum exosome and miRNA in serum and the detection of miR-27a-3p in serum exosome of ALS patients

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Nanomedicines for the Treatment of CNS Diseases

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Circulating Exosomal circRNAs Contribute to Potential Diagnostic Value of Large Artery Atherosclerotic Stroke

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Decreased Serum Exosomal miR-152-3p Contributes to the Progression of Acute Ischemic Stroke

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Exosomal HSP70 for Monitoring of Frontotemporal Dementia and Alzheimer’s Disease: Clinical and FDG-PET Correlation

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Circulating exosomal lncRNAs as predictors of risk and unfavorable prognosis for large artery atherosclerotic stroke

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Profile and Functional Prediction of Plasma Exosome-Derived CircRNAs From Acute Ischemic Stroke Patients

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Can dementia become the most prevalent disease at the time of death in Germany? Projections up to the year 2060 for the five most important diseases at the time of death

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Analysis of α-Synuclein in Exosomes

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Bone Targeting Nanoparticles for the Treatment of Osteoporosis

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Exosomes as Biomarkers and Therapeutic Agents in Neurodegenerative Diseases: Current Insights and Future Directions

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CNS cell-derived exosome signatures as blood-based biomarkers of neurodegenerative diseases

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Most L1CAM Is not Associated with Extracellular Vesicles in Human Biofluids and iPSC–Derived Neurons

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Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System Pathologies

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Transmission of reduced levels of miR-34/449 from sperm to preimplantation embryos is a key step in the transgenerational epigenetic inheritance of the effects of paternal chronic social instability stress

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Central Nervous System-Derived Extracellular Vesicles as Biomarkers in Alzheimer’s Disease

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Extracellular vesicles: Function, resilience, biomarker, bioengineering, and clinical implications

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Exosomes as new generation vehicles for drug delivery systems

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Neural Stem Cell-Derived Small Extracellular Vesicles: key Players in Ischemic Stroke Therapy – A Comprehensive Literature Review

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MicroRNAs as Regulators, Biomarkers, and Therapeutic Targets in Autism Spectrum Disorder

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Engineering bacterial membrane vesicles: A new paradigm in biomedical innovation

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Current progression in application of extracellular vesicles in central nervous system diseases

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Brain-Derived Exosomal CircRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke

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Extracellular vesicles as nanomaterial carriers: Endowing superior targeting capability and biosafety

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Engineered exosome-based drug delivery system for synergistic cancer therapy via autophagy inhibition and chemotherapy

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Present and future use of exosomes containing proteins and RNAs in neurodegenerative diseases for synaptic function regulation: A comprehensive review

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Round window membrane extracellular vesicles facilitate inner ear drug delivery

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Induction of Neuroinflammation and Brain Oxidative Stress by Brain-Derived Extracellular Vesicles from Hypertensive Rats

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Extracellular vesicles as biomarkers in traumatic brain injury: a systematic review of animal and clinical studies

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Brain-Derived Exosomes in Neurodevelopmental and Neuropsychiatric Disorders: Molecular Insights, Therapeutic Potential, and Translational Challenges

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The researcher's guide to selecting biomarkers in mental health studies

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Comparison of the protein composition of isolated extracellular vesicles from mouse brain and dissociated brain cell culture medium

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Astrocyte-derived exosomes regulate sperm miR-34c levels to mediate the transgenerational effects of paternal chronic social instability stress

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Molecularly Imprinted Membranes for Selective Biomarker Recognition: Recent Advances and Emerging Strategies

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Recent advances in biomimetic nanodelivery systems for the treatment of osteoporosis

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Most L1CAM is not associated with extracellular vesicles in human biofluids and iPSC–derived neuronsPreprint

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Whispers in the Brain: Extracellular Vesicles in Neuropathology and the Diagnostic Alchemy of Neurological Diseases

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Phage Display Screening of Anchor Peptides for Red Blood Cell-Derived Extracellular Vesicles

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From bench to bedside: The evolution of extracellular vesicle diagnostics through microfluidic and paper-based technologies

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Nanotechnology-driven strategies for gene therapy of arthritis

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Tissue-derived extracellular vesicles: comparing Ts-EVs and Te-EVs in extraction, characteristics and research trends

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Extracellular vesicles as minimally invasive biomarkers and therapeutic platforms in rare neurological diseases

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A Pilot Study of Saliva MicroRNA Signatures in Children with Moderate-to-Severe Traumatic Brain Injury

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Exosomes as a window of opportunity in hepatocellular carcinoma: Insights from diagnostic to targeted drug delivery

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The roles of extracellular vesicles in mental disorders: information carriers, biomarkers, therapeutic agents

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Alzheimer’s Disease-Associated Molecular Abnormalities in White Matter Glia and Related Pathologies Detected in Unfractionated and O4-Selected Serum Exosomes Using a Liquid Biopsy Approach

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Microglia modulate concussion biomarkers and cognitive recovery in male mice

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Incretin-Related Pathology and Serum Exosome Detection in Experimental Alcohol-Related Brain Damage

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Apoptotic vesicles: from biological characteristics to clinical translational prospects

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Extracellular vesicles derived from cerebrospinal fluid of patients with multiple sclerosis contain inflammatory cytokines: a possible biomarker potential

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Extracellular vesicle-mediated bidirectional communication between the brain and peripheral organs in Alzheimer’s disease: evidence, mechanisms, and translational perspectives

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The nano-neuro nexus: smart sensors at the frontier of detecting neurodegeneration

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Specific Extracellular Vesicles, Generated and Operating at Synapses, Contribute to Neuronal Effects and Signaling

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Toxoplasma gondii infection of neurons alters the production and content of extracellular vesicles altering astrocyte phenotype and contributing to the loss of GLT-1 in the infected brainPreprint

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Differential microRNA expression profiling of peripheral blood L1CAM neural-enriched and bulk extracellular vesicles in individuals with bipolar disorderPreprint

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Novel mouse models for tracing brain-derived extracellular vesicles

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GABAergic MicroRNA-34a in the Dorsal Raphe Nuclei Contributes to Circulating MicroRNA-34a Levels

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Brain Synapses: Neurons, Astrocytes, and Extracellular Vesicles in Health and Diseases

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Targeted isolation of astrocyte-derived extracellular vesicles using peptide-imprinted nanocomposites for neurological diagnostics

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Diagnostic application of extracellular vesicles as biomarkers in neurological disorders

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Brain-Derived Extracellular Vesicle Subpopulations: from Bulk Measurements to Single-Entity Assays

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Fine element integrated label aware neural network with parrot optimizer for the diagnosis of Alzheimer’s disease in MRI images

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Circulating miRNAs for glioblastoma monitoring: from biofluid to clinical decision

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Exosome research and neuroimaging techniques: Visualization analysis of development trends and research hotspots

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A Multivariable Plasma Extracellular Vesicle Surface Profile Associated with Post-COVID-19 SyndromePreprint

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Markers and Enrichment Strategies for Brain-Derived Extracellular Vesicles: Current Evidence, Limitations and Future Directions

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Glial-derived extracellular vesicles as therapeutic drug carriers for targeted drug delivery in neurodegenerative diseases

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L1CAM-Enriched Extracellular Vesicle MicroRNAs in Mild Cognitive Impairment and Alzheimer’s Disease: An Exploratory Study

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Smart Nanoscale Extracellular Vesicles in the Brain: Unveiling their Biology, Diagnostic Potential, and Therapeutic Applications

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Brain-Derived Extracellular Vesicles in Health and Disease: A Methodological Perspective

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