H3K9 acetylation of Tph2 involved in depression-like behavior in Male, but not female, juvenile offspring rat induced by prenatal stress
Abstract
Increasing evidence has shown that prenatal stress (PS) could cause depression-like behavior in the offspring, which is sex-specific. However, the underlying mechanisms remain to be elucidated. This study is to investigate the involvement of tryptophan hydroxylase 2 (Tph2) H3K9 acetylation (H3K9ac) modification on PS-induced depression-like behavior in juvenile offspring rats (JOR). PS models were established, with or without trichostatin A (TSA) treatment. Animal behavior was assessed by the sucrose preference test (SPT) and forced swimming test (FST). The mRNA and protein expression levels of TPH2 in the dorsal raphenucleus (DRN), hippocampus, and prefrontal cortex were detected with quantitative real-time PCR and Western blot analysis, respectively. The Tph2 H3K9ac levels in the hippocampus were also analyzed. SPT and FST showed significantly reduced sucrose preference and significantly prolonged immobility in PS-induced male juvenile offspring rats (MJOR). Moreover, the mRNA and protein expression levels of TPH2 in the DRN and hippocampus were significantly declined, while the hippocampal Tph2 H3K9ac levels were significantly declined in the PS-induced MJOR. Furthermore, the PS-induced effects in MJOR could be reversed by the microinjection of TSA. However, no significant effects were observed for the female juvenile offspring rats (FJORs). In conclusion, our results showed that the Tph2 H3K9ac modification is only involved in PS-induced depression-like behavior in MJOR, in a sex-specific manner. These findings might contribute to the understanding of the disease pathogenesis and clinical treatment in future.
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Prenatal stress-induced HPA hyperreactivity coexists with alterations in HDAC/DNMT activity.
“Animal studies demonstrate that prenatal stress-induced HPA hyperreactivity coexists with alterations in HDAC/DNMT activity”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Dang et al., 2018
Cites
Depression: a new animal model sensitive to antidepressant treatments
PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451 · see citing works
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889 · see citing works
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · see citing works
Histones and histone modifications
Peterson, C. L., & Laniel, M.-A. (2004) · Current Biology · doi:10.1016/j.cub.2004.07.007 · Cited by 1,313 · see citing works
Cellular Memory and the Histone Code
Turner, B. M. (2002) · Cell · doi:10.1016/s0092-8674(02)01080-2 · Cited by 1,142 · see citing works
The long-term behavioural consequences of prenatal stress
Weinstock, M. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.002 · Cited by 1,045 · see citing works
Kilgore, M., Miller, C. A., Fass, D. M., Hennig, K. M., Haggarty, S. J., Sweatt, J. D., & Rumbaugh, G. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.197 · Cited by 727 · see citing works
Acetylation of non-histone proteins modulates cellular signalling at multiple levels
Spange, S., Wagner, T., Heinzel, T., & Krämer, O. H. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.08.027 · Cited by 661 · see citing works
DNA methylation and chromatin modification
Ng, H.-H., & Adrian, B. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80024-0 · Cited by 648 · see citing works
Antidepressant Actions of Histone Deacetylase Inhibitors
Covington, H. E., Maze, I., LaPlant, Q. C., Vialou, V. F., Ohnishi, Y. N., Berton, O., Fass, D. M., Renthal, W., Rush, A. J., Wu, E. Y., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1758-09.2009 · Cited by 624 · see citing works
Serotonin and brain development: role in human developmental diseases
Whitaker-Azmitia, P. M. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00615-3 · Cited by 506 · see citing works
Côté, F., Thévenot, E., Fligny, C., Fromes, Y., Darmon, M. C., Ripoche, M., Bayard, E., Hanoun, N., Saurini, F., Lechat, P. P., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233056100 · Cited by 483 · see citing works
Epigenetics of the depressed brain: role of histone acetylation and methylation
Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413 · see citing works
Pothion, S., Bizot, J., Trovero, F., & Belzung, C. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.04.008 · Cited by 400 · see citing works
Chronic mild stress impact: Are females more vulnerable?
Dalla, C., Antoniou, K., Drossopoulou, G., Xagoraris, M., Kokras, N., Sfikakis, A., & Papadopoulou‐Daifoti, Z. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.068 · Cited by 336 · see citing works
Grønli, J., Murison, R. C. C., Fiske, E., Bjorvatn, B., Sørensen, E., Portas, C. M., & URSIN, R. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.02.007 · Cited by 292 · see citing works
Prenatal stressors in rodents: Effects on behavior
Weinstock, M. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.004 · Cited by 264 · see citing works
Role of Prefrontal Cortex Glucocorticoid Receptors in Stress and Emotion
McKlveen, J. M., Myers, B., Flak, J. N., Bundzikova, J., Solomon, M. B., Seroogy, K. B., & Herman, J. P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.024 · Cited by 237 · see citing works
Donner, N. C., & Handa, R. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.06.046 · Cited by 197 · see citing works
Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition
Covington, H. E., Vialou, V. F., LaPlant, Q., Ohnishi, Y. N., & Nestler, E. J. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.02.022 · Cited by 178 · see citing works
Rayen, I., van den Hove, D., Prickaerts, J., Steinbusch, H. W. M., & Pawluski, J. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024003 · Cited by 175 · see citing works
More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides
Boldrini, M., Underwood, M. D., Mann, J. J., & Arango, V. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.083 · Cited by 174 · see citing works
Owen, D., & Matthews, S. G. (2003) · Endocrinology · doi:10.1210/en.2002-0145 · Cited by 156 · see citing works
Espallergues, J., Teegarden, S. L., Veerakumar, A., Boulden, J., Challis, C., Jochems, J., Chan, M., Petersen, T. L., Deneris, E. S., Matthias, P., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5634-11.2012 · Cited by 147 · see citing works
How age, sex and genotype shape the stress response
Novais, A., Monteiro, S., Roque, S., Correia‐Neves, M., & Sousa, N. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.11.004 · Cited by 140 · see citing works
Vetencourt, J. F. M., Tiraboschi, E., Spolidoro, M., Castrén, E., & Maffei, L. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07488.x · Cited by 138 · see citing works
Effects of maternal stress during pregnancy on forced swimming test behavior of the offspring
Alonso, S. J., Arévalo, R., Afonso, D., & Rodrı́guez, M. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90538-y · Cited by 135 · see citing works
Frye, C. A., & Wawrzycki, J. M. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(03)00159-4 · Cited by 130 · see citing works
Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice
Stork, O., Welzl, H., Wotjak, C. T., Hoyer, D., Delling, M., Cremer, H., & Schachner, M. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19990905)40:3 · Cited by 127 · see citing works
Prenatal stress causes gender‐dependent neuronal loss and oxidative stress in rat hippocampus
Zhu, Z., Li, X., Chen, W., Zhao, Y., Li, H., Qing, C., Jia, N., Bai, Z., & Liu, J. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20338 · Cited by 122 · see citing works
Garcia, L. S. B., Comim, C. M., Valvassori, S. S., Réus, G. Z., Andreazza, A. C., Stertz, L., Fries, G. R., Gavioli, E. C., Kapczinski, F. P., & Quevedo, J. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2008.00210.x · Cited by 122 · see citing works
van den Hove, D., Kenis, G., Brass, A., Opstelten, R., Rutten, B. P. F., Bruschettini, M., Blanco, C. E., Lesch, K., Steinbusch, H. W. M., & Prickaerts, J. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.09.011 · Cited by 114 · see citing works
The potential use of histone deacetylase inhibitors in the treatment of depression
Fuchikami, M., Yamamoto, S., Morinobu, S., Okada, S., Yamawaki, Y., & Yamawaki, S. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.03.010 · Cited by 111 · see citing works
Szymańska, M., Budziszewska, B., Jaworska-Feil, L., Basta‐Kaim, A., Kubera, M., Leśkiewicz, M., Regulska, M., & Lasoń, W. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.12.012 · Cited by 110 · see citing works
Benoit, J. D., RAKIC, P. T., & Frick, K. M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.12.001 · Cited by 109 · see citing works
Keshet, G., & Weinstock, M. (1995) · Pharmacology, Biochemistry and Behavior · doi:10.1016/0091-3057(94)00289-u · Cited by 104 · see citing works
van den Hove, D., Leibold, N. K., Strackx, E., Martínez-Claros, M., Lesch, K., Steinbusch, H. W. M., Schruers, K. R. J., & Prickaerts, J. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.09.006 · Cited by 93 · see citing works
Sex, stress, and epigenetics: regulation of behavior in animal models of mood disorders
Hodes, G. E. (2013) · Biology of Sex Differences · doi:10.1186/2042-6410-4-1 · Cited by 82 · see citing works
Miyagawa, K., Tsuji, M., Fujimori, K., Saito, Y., & Takeda, H. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.02.002 · Cited by 81 · see citing works
Morris, M. J., & Monteggia, L. M. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.02.005 · Cited by 75 · see citing works
Tryptophan Hydroxylase as Novel Target for the Treatment of Depressive Disorders
Matthes, S., Mosienko, V., Bashammakh, S., Alenina, N. V., & Bäder, M. (2010) · Pharmacology · doi:10.1159/000279322 · Cited by 74 · see citing works
Bogoch, Y., Biala, Y. N., Linial, M., & Weinstock, M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04402.x · Cited by 74 · see citing works
Individual differences in the effects of prenatal stress exposure in rodents
Boersma, G. J., & Tamashiro, K. L. (2014) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.006 · Cited by 71 · see citing works
The involvement of ERK/CREB/Bcl-2 in depression-like behavior in prenatally stressed offspring rats
Guan, L., Jia, N., Zhao, X., Zhang, X., Tang, G., Yang, L., Sun, H., Wang, D., Su, Q., Song, Q., et al. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.08.003 · Cited by 62 · see citing works
Involvement of pGluR1, EAAT2 and EAAT3 in offspring depression induced by prenatal stress
Zhang, X., Jia, N., Zhao, X. Y., Tang, G. K., Guan, L. X., Wang, D., Sun, H., Li, H., & Zhu, Z. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.031 · Cited by 60 · see citing works
Scopinho, A. A., Scopinho, M., Lisboa, S. F. D. S., Corrêa, F. M. D. A., Guimarães, F. S., & Joca, S. R. L. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.06.018 · Cited by 59 · see citing works
Epigenetic Mechanisms of Serotonin Signaling
Holloway, T. D., & González‐Maeso, J. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00033 · Cited by 59 · see citing works
Trans-generational Effects of Early Life Stress: The Role of Maternal Behavior
Schmauss, C., Lee-McDermott, Z., & Ramos-Medina, L. (2014) · Scientific Reports · doi:10.1038/srep04873 · Cited by 52 · see citing works
Liu, D., Qiu, H.-M., Fei, H.-Z., Hu, X.-Y., Xia, H.-J., Wang, L.-J., Qin, L.-J., Jiang, X.-H., & Zhou, Q.-X. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370213513987 · Cited by 49 · see citing works
Df, A., Alekseenko, O. V., Bakshtanovskaia, I. V., Koriakina, L. A., Lipina, T. V., Tenditnik, M. V., Bondar, N. P., Kovalenko, I. L., & Nn, K. (2004) · PubMed · Cited by 41 · see citing works
Anderson, L., Gomes, M. R., daSilva, L. F., Pereira, A. D. S. A., Mourão, M. D. M., Romier, C., Pierce, R. J., & Verjovski‐Almeida, S. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005539 · Cited by 31 · see citing works
Charoenphandhu, N., Nuntapornsak, A., Wongdee, K., Krishnamra, N., & Charoenphandhu, J. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1527-0 · Cited by 21 · see citing works
Qiu, H., Yang, J., Jiang, X., Hu, X.-Y., Liu, D., & Zhou, Q. (2015) · Neuroreport · doi:10.1097/wnr.0000000000000482 · Cited by 21 · see citing works
Tsuji, M., Miyagawa, K., & Takeda, H. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.14r07cp · Cited by 19 · see citing works
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Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link
Hanswijk, S. I., Spoelder, M., Shan, L., Verheij, M. M. M., Muilwijk, O. G., Li, W., Liu, C., Kolk, S. M., & Homberg, J. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165850 · Cited by 86 · see citing works
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Perry, C. J., Campbell, E. J., Drummond, K. D., Lum, J. S., & Kim, J. H. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15208 · Cited by 58 · see citing works
Jiao, H., Yan, Z., Ma, Q., Li, X., Jiang, Y.-M., Liu, Y., & Chen, J. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s185295 · Cited by 50 · see citing works
Singh, G., Singh, V., & Schneider, J. S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.10.016 · Cited by 35 · see citing works
Haq, S. U., Bhat, U. A., & Kumar, A. (2021) · Journal of Biosciences · doi:10.1007/s12038-021-00153-7 · Cited by 34 · see citing works
Cheng, S., Zhu, Z., Li, H., Wang, W., Jiang, Z., Pan, F., Liu, D., Ho, R., & Ho, C. S. H. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.02.086 · Cited by 30 · see citing works
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Rainville, J. R., Lipuma, T., & Hodes, G. E. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.02.003 · Cited by 25 · see citing works
Zhu, X., Tao, Q., Sun‐Waterhouse, D., Li, W., Liu, S., & Cui, C. (2019) · Food & Function · doi:10.1039/c9fo01467e · Cited by 24 · see citing works
Possamai-Della, T., Cararo, J. H., Aguiar-Geraldo, J. M., Peper-Nascimento, J., Zugno, A. I., Fries, G. R., Quevedo, J., & Valvassori, S. S. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03348-1 · Cited by 16 · see citing works
Lu, Y., Jiang, J., Si, J., Wu, Q., Tian, F., Jiao, K., Mu, Y., Dong, P., & Zhu, Z. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104629 · Cited by 14 · see citing works
Fang, Y., Li, Y., Wang, S., Deng, J., Liang, J., Li, S., Yang, D., & Yan, B. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149780 · Cited by 11 · see citing works
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Huang, L., Yao, W., Wang, T., Li, J., He, Q., & Huang, F. (2020) · Metabolites · doi:10.3390/metabo10040146 · Cited by 8 · see citing works
Dong, Y., Weng, J., Zhu, Y., Sun, D., He, W., Chen, Q., Cheng, J., Zhu, Y., & Jiang, Y. (2023) · BMC Genomics · doi:10.1186/s12864-023-09186-8 · Cited by 8 · see citing works
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Li, L., Zhang, W., Sun, C., Chai, Z., Wang, K., Zhou, Q., & Wang, X. (2024) · Developmental Neuroscience · doi:10.1159/000543152 · Cited by 5 · see citing works
Lv, Y., Chen, P., Kuang, L., Han, Z., Solanki, B., Zhou, W., Tao, F., Chen, R., & Yao, Y. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147029 · Cited by 5 · see citing works
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Silva-Costa, L. C., & Smith, B. J. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-05460-0_10 · Cited by 4 · see citing works
Santos, L., Possa, L., Fröhlich, N., Behrens, L. M. P., Barbosa, C., Tiefensee-Ribeiro, C., Gelain, D., Almeida, R. F., & Moreira, J. C. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04455-2 · Cited by 4 · see citing works
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Tao, L., Li, X., Tu, X., Liu, R., Xu, J., Lv, Y., & Yao, Y. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115139 · Cited by 4 · see citing works
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Dong, Y., Weng, J., Zhu, Y., Sun, D., He, W., Chen, Q., Cheng, J., Zhu, Y., & Jiang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26571244
Dong, Y., Weng, J., Zhu, Y., Sun, D., He, W., Chen, Q., Cheng, J., Zhu, Y., & Jiang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26571259
Dong, Y., Weng, J., Zhu, Y., Sun, D., He, W., Chen, Q., Cheng, J., Zhu, Y., & Jiang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26571262
Dong, Y., Weng, J., Zhu, Y., Sun, D., He, W., Chen, Q., Cheng, J., Zhu, Y., & Jiang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26571274
Dong, Y., Weng, J., Zhu, Y., Sun, D., He, W., Chen, Q., Cheng, J., Zhu, Y., & Jiang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26571253
Dong, Y., Weng, J., Zhu, Y., Sun, D., He, W., Chen, Q., Cheng, J., Zhu, Y., & Jiang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26571256
Dong, Y., Weng, J., Zhu, Y., Sun, D., He, W., Chen, Q., Cheng, J., Zhu, Y., & Jiang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26571247
Dong, Y., Weng, J., Zhu, Y., Sun, D., He, W., Chen, Q., Cheng, J., Zhu, Y., & Jiang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26571268
Dong, Y., Weng, J., Zhu, Y., Sun, D., He, W., Chen, Q., Cheng, J., Zhu, Y., & Jiang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26571265
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- Authors
- Dang, S., Lu, Y., Su, Q., Lin, T., Zhang, X., Zhang, H., Zhang, J., Zhang, L., Zhu, Z., & Li, H.
- Affiliations
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
- Northwest University (CN)
- Corresponding author
- Zhu, Zhongliang
- Li, Hui
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 381
- Pages
- 138-148
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2795837827
- Cited by
- 30
- References
- 55
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 8 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 2
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81671342, 30970952, 18110059, 81271497)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- prenatal stress, depression-like behavior, tryptophan hydroxylase 2, H3K9 acetylation, histone modifications, sex differences, trichostatin A, dorsal raphe nucleus, hippocampus, prefrontal cortex, epigenetic regulation
- MeSH terms
- Acetylation, Animals, Behavior, Animal, Brain, Depression, Female, Histones, Male, Pregnancy, Prenatal Exposure Delayed Effects, Sex Characteristics, Stress, Psychological, Tryptophan Hydroxylase, Rats, Sprague-Dawley, Gene Expression Regulation, Developmental, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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