Plasma nitrite response and arterial reactivity differentiate vascular health and performance
Open accessAbstract
NO is crucial for endothelial function and vascular health. Plasma nitrite (NO(2)(-)) is the main oxidation product of NO and has been shown to reflect changes in eNOS activity. We hypothesized that plasma NO(2)(-) response to physical exercise stress along with physiological endothelial function would be reduced with increasing severity of vascular disease. Subject groups were: (a) risk factors but no vascular disease (RF); (b) Type 2 diabetes with no vascular disease (DM); (c) diagnosed peripheral arterial disease (PAD); and (d) DM+PAD. Venous blood was drawn at rest and 10min following maximal exercise. Plasma samples were analyzed by reductive chemiluminescence. Brachial diameters were imaged prior to, during and following 5min of forearm occlusion (BAFMD). There were no differences in resting plasma NO(2)(-) or BA diameters between groups. The PAD groups had lower age adjusted BAFMD responses (p0.05). Within group analysis revealed an increase in NO(2)(-) in the RF group (+39.3%), no change in the DM (-15.51%), and a decrease in the PAD (-44.20%) and PAD+DM (-39.95%). This was maintained after adjusting for age and VO(2peak) (p0.05). DeltaNO(2)(-) and BAFMD were the strongest independent predictors of VO(2peak) in multivariate linear regression. These findings suggest DeltaNO(2)(-) discriminates severity of cardiovascular disease risk, is related to endothelial function and predicts exercise capacity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Induction of plasma nitrite levels during supervised exercise therapy is significantly blunted in diabetic patients with PAD versus non-diabetic PAD patients or diabetics alone.
“induction of plasma nitrite levels during supervised exercise therapy were significantly blunted in diabetic patients with PAD versus non-diabetic PAD patients or diabetics alone [173].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [173]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064 · see citing works
Corretti, M. C., Anderson, T. J., Benjamin, E. J., Celermajer, D. S., Charbonneau, F., Creager, M. A., Deanfield, J. E., Drexler, H., Gerhard‐Herman, M. D., Herrington, D. M., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01746-6 · Cited by 4,606 · see citing works
The clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · cited 1× · see citing works
“Several studies have established its value as a predictor of cardiovascular events in “at risk” populations[26–29].”
BackgroundHofstra, L., Tordoir, J. H. M., Kitslaar, P. J. E. H. M., Hoeks, A. P. G., & Daemen, M. J. A. P. (1996) · PubMed · doi:10.1161/01.cir.94.6.1283 · Cited by 1,603 · see citing works
Celermajer, D. S., Sørensen, K. E., Georgakopoulos, D., Bull, C., Thomas, O., Robinson, J. T. C., & Deanfield, J. E. (1993) · Circulation · doi:10.1161/01.cir.88.5.2149 · Cited by 1,532 · see citing works
Celermajer, D. S., Sørensen, K. E., Spiegelhalter, D. J., Georgakopoulos, D., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90305-0 · Cited by 1,334 · see citing works
Nowy rok, stare problemy, ale i nowe możliwości
Czupryniak, L. (2014) · Via Medica Journals · Cited by 1,192 · see citing works
Prognostic Significance of Endothelial Dysfunction in Hypertensive Patients
Perticone, F., Ceravolo, R., Pujia, A., Ventura, G., Iacopino, S., Scozzafava, A., Ferraro, A., Chello, M., Mastroroberto, P., Verdecchia, P., et al. (2001) · Circulation · doi:10.1161/01.cir.104.2.191 · Cited by 1,059 · see citing works
Blood Flow Regulation by <i>S</i> -Nitrosohemoglobin in the Physiological Oxygen Gradient
Stamler, J. S., Jia, L., Eu, J. P., McMahon, T. J., Demchenko, I. T., Bonaventura, J., Gernert, K., & Piantadosi, C. A. (1997) · Science · doi:10.1126/science.276.5321.2034 · Cited by 1,050 · see citing works
Peripheral Arterial Disease in Diabetic and Nondiabetic Patients
Jude, E. B., Oyibo, S. O., Chalmers, N., & Boulton, A. J. M. (2001) · Diabetes Care · doi:10.2337/diacare.24.8.1433 · Cited by 809 · see citing works
Gokce, N., Keaney, J. F., Hunter, L. M., Watkins, M. T., Menzoı́an, J. O., & Vita, J. A. (2002) · Circulation · doi:10.1161/01.cir.0000012543.55874.47 · Cited by 782 · see citing works
Gokce, N., Keaney, J. F., Hunter, L. M., Watkins, M. T., Nedeljkovic, Z. S., Menzoı́an, J. O., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00333-4 · Cited by 776 · see citing works
Aging and Endothelial Function in Normotensive Subjects and Patients With Essential Hypertension
Taddei, S., Virdis, A., Mattei, P., Ghiadoni, L., Gennari, A., Fasolo, C. B., Sudano, I., & Salvetti, A. (1995) · Circulation · doi:10.1161/01.cir.91.7.1981 · Cited by 710 · see citing works
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674 · cited 1× · see citing works
“Recent studies suggest nitrite protects against ischemia–reperfusion injury [39,40] and may regulate gene expression [41].”
BackgroundNitric oxide metabolism and breakdown
Kelm, M. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00020-1 · Cited by 673 · see citing works
Inorganic nitrate is a possible source for systemic generation of nitric oxide
Lundberg, J. O., & Govoni, M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.027 · Cited by 657 · see citing works
Effects of dietary nitrate on oxygen cost during exercise
Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01713.x · Cited by 637 · see citing works
Standards of Medical Care for Patients With Diabetes Mellitus
American Diabetes Association (2003) · Diabetes Care · doi:10.2337/diacare.26.2007.s33 · Cited by 610 · see citing works
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals
Kleinbongard, P., Dejam, A., Lauer, T., Rassaf, T., Schindler, A., Picker, O., Scheeren, T., Gödecke, A., Schrader, J., Schulz, R., et al. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00406-4 · Cited by 586 · see citing works
Lauer, T., Preik, M., Rassaf, T., Strauer, B. E., Deussen, A., Feelisch, M., & Kelm, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221381098 · Cited by 585 · see citing works
Peripheral arterial disease in patients with diabetes.
Marso, S., & Hiatt, W. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.09.065 · Cited by 571 · see citing works
Endothelial Function Testing as a Biomarker of Vascular Disease
Verma, S., Buchanan, M. R., & Anderson, T. J. (2003) · Circulation · doi:10.1161/01.cir.0000089191.72957.ed · Cited by 565 · see citing works
Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555 · see citing works
Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain
Neunteufl, T., Heher, S., Katzenschlager, R., Wölfl, G., Kostner, K., Maurer, G., & Weidinger, F. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)00857-2 · Cited by 553 · see citing works
Critical Issues in Peripheral Arterial Disease Detection and Management A Call to Action
Belch, J. J. F. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.8.884 · Cited by 551 · see citing works
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
Bryan, N. S., Fernandez, B. O., Bauer, S. M., Garcia-Saura, M. F., Milsom, A. B., Rassaf, T., Maloney, R. E., Bharti, A., Rodriguez, J., & Feelisch, M. (2005) · Nature Chemical Biology · doi:10.1038/nchembio734 · Cited by 518 · see citing works
Endothelial Dysfunction and Cardiovascular Risk Prediction in Peripheral Arterial Disease
Brevetti, G., Silvestro, A., Schiano, V., & Massimo Chiariello, A. (2003) · Circulation · doi:10.1161/01.cir.0000095273.92468.d9 · Cited by 482 · see citing works
Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans
Kleinbongard, P., Dejam, A., Lauer, T., Jax, T., Kerber, S., Gharini, P., Balzer, J., Zotz, R. B., Scharf, R. E., Willers, R., et al. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.025 · Cited by 388 · see citing works
Standards of medical care for patients with diabetes mellitus
(1989) · The Journal of the American Osteopathic Association · doi:10.1515/jom-1989-890715 · Cited by 361 · see citing works
Nitrite‐derived nitric oxide: a possible mediator of ‘acidic–metabolic’ vasodilation
Modin, A., Björne, H., Herulf, M., Alving, K., Weitzberg, E., & Lundberg, J. O. N. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00771.x · Cited by 346 · see citing works
NO Generation From Nitrite and Its Role in Vascular Control
Lundberg, J. O., & Weitzberg, E. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000161048.72004.c2 · Cited by 341 · see citing works
Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.
Doyle, M. P., Pickering, R. A., DeWeert, T. M., Hoekstra, J. W., & Pater, D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43285-1 · Cited by 334 · see citing works
Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation.
Gilligan, D. M., Panza, J. A., Kilcoyne, C. M., Waclawiw, M. A., Casino, P. R., & Quyyumi, A. A. (1994) · Circulation · doi:10.1161/01.cir.90.6.2853 · Cited by 293 · see citing works
DISFUNCTION OF VASCULAR ENDOTHELIUM IN DIABETES MELLITUS
Cohen, R. A. (1993) · Cited by 254 · see citing works
Direct measurement of nitric oxide in human beings
Vallance, P. J., Bhagat, K., MacAllister, R. J., Patton, S. R., Maliñski, T., Radomski, M. W., & Moncada, S. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91211-8 · Cited by 169 · see citing works
Kelm, M. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00259-4 · Cited by 141 · see citing works
Nitric oxide synthase-derived plasma nitrite predicts exercise capacity
Rassaf, T., Lauer, T., Heiss, C., Balzer, J., Mangold, S., Leyendecker, T., Rottler, J., Drexhage, C., Meyer, C., & Kelm, M. (2007) · British Journal of Sports Medicine · doi:10.1136/bjsm.2007.035758 · Cited by 122 · see citing works
Role of nitric oxide in skeletal muscle blood flow at rest and during dynamic exercise in humans
Hickner, R. C., Fisher, J. S., Ehsani, A. A., & Kohrt, W. M. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.1.h405 · Cited by 105 · see citing works
Plasma nitrite reserve and endothelial function in the human forearm circulation
Rassaf, T., Heiss, C., Hendgen-Cotta, U., Balzer, J., Matern, S., Kleinbongard, P., Lee, A., Lauer, T., & Kelm, M. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.006 · Cited by 86 · see citing works
Stability and reproducibility of brachial artery flow-mediated dilation
Welsch, M. A., Allen, J. D., & Geaghan, J. P. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200206000-00009 · Cited by 80 · see citing works
(2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01808-9 · Cited by 71 · see citing works
The prognosis of non-critical limb ischaemia: a systematic review of population-based evidence.
Hooi, J. D., Stoffers, J., Knottnerus, J. A., & van Ree, J. W. (1999) · Europe PMC (PubMed Central) · Cited by 65 · see citing works
Predicting which patients will develop chronic critical leg ischemia.
Dormandy, J., Heeck, L., & Vig, S. (1999) · PubMed · Cited by 60 · see citing works
Regional and whole-body markers of nitric oxide production following hyperemic stimuli
Allen, J. D., Cobb, F. R., & Gow, A. J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.12.018 · Cited by 53 · see citing works
SoRelle, R. (2000) · PubMed · Cited by 53 · see citing works
Nitrate and Nitrite: Origin in Humans
Tannenbaum, S. R. (1979) · Science · doi:10.1126/science.472751 · Cited by 48 · see citing works
Allen, J. D., Cobb, F. R., Kraus, W. E., & Gow, A. J. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.016 · Cited by 31 · see citing works
Response : Nitrate and Nitrite: Origin in Humans
Witter, J. P., Gatley, S. J., & Balish, E. (1979) · Science · doi:10.1126/science.205.4413.1335 · Cited by 28 · see citing works
Robbins, A. (1979) · Science · doi:10.1126/science.472750 · Cited by 22 · see citing works
SoRelle, R. (2003) · Circulation · doi:10.1161/01.cir.0000104140.79111.22 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [32]Allen J Plasma Nitrite Response and Arterial Reactivity Differentiate Cardiovascular Health Status and Performance Submitted to FRBM 2007 PMC2676216 19371597
Cited by
Sorted by citations
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease
Kenjale, A. A., Ham, K. L., Stabler, T., Robbins, J. L., Johnson, J. L., VanBruggen, M., Privette, G., Yim, E., Kraus, W. E., & Allen, J. D. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00071.2011 · Cited by 316 · see citing works
Self-citationTherapeutic angiogenesis for critical limb ischaemia
Annex, B. H. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.70 · Cited by 300 · see citing works
Gilchrist, M., Winyard, P. G., & Benjamin, N. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.10.005 · Cited by 157 · see citing works
Burleigh, M. C., Liddle, L., Monaghan, C., Muggeridge, D. J., Sculthorpe, N., Butcher, J. P., Henriquez, F. L., Allen, J. D., & Easton, C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.03.023 · Cited by 127 · see citing works
Self-citationInorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113 · see citing works
Therapeutic Angiogenesis for Peripheral Artery Disease
Iyer, S. R., & Annex, B. H. (2017) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2017.07.012 · Cited by 104 · see citing works
Allen, J. D., Stabler, T., Kenjale, A., Ham, K. L., Robbins, J. L., Duscha, B. D., Dobrosielski, D. A., & Annex, B. H. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.06.033 · Cited by 101 · see citing works
Self-citationNitric oxide scavenging by red cell microparticles
Liu, C., Zhao, W., Christ, G. J., Gladwin, M. T., & Kim‐Shapiro, D. B. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.002 · Cited by 95 · see citing works
Achneck, H. E., Jamiolkowski, R. M., Jantzen, A. E., Haseltine, J., Lane, W. O., Huang, J. K., Galinat, L. J., Serpe, M. J., Lin, F., Li, M., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.073 · Cited by 85 · see citing works
Castiglione, N., Rinaldo, S., Giardina, G., Stelitano, V., & Cutruzzolà, F. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4196 · Cited by 79 · see citing works
The potential role of the red blood cell in nitrite-dependent regulation of blood flow
Patel, R. P., Hogg, N., & Kim-Shapiro, D. B. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq323 · Cited by 70 · see citing works
Nitrite and nitric oxide metabolism in peripheral artery disease
Allen, J. D., Giordano, T., & Kevil, C. G. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.03.003 · Cited by 69 · see citing works
Richards, J. C., Racine, M. L., Hearon, C. M., Kunkel, M. J., Luckasen, G. J., Larson, D. G., Allen, J. D., & Dinenno, F. A. (2018) · Physiological Reports · doi:10.14814/phy2.13572 · Cited by 58 · see citing works
Walking Exercise Therapy Effects on Lower Extremity Skeletal Muscle in Peripheral Artery Disease
McDermott, M. M., Dayanidhi, S., Kosmac, K., Saini, S. K., Slysz, J. T., Leeuwenburgh, C., Hartnell, L. M., Sufit, R. L., & Ferrucci, L. (2021) · Circulation Research · doi:10.1161/circresaha.121.318242 · Cited by 57 · see citing works
Totzeck, M., Hendgen-Cotta, U. B., Rammos, C., Frommke, L.-M., Knackstedt, C., Predel, H.-G., Kelm, M., & Rassaf, T. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.05.003 · Cited by 56 · see citing works
Bir, S. C., Pattillo, C. B., Pardue, S., Kolluru, G. K., Shen, X., Giordano, T., & Kevil, C. G. (2013) · Diabetes · doi:10.2337/db13-0890 · Cited by 51 · see citing works
Dietary nitrate supplementation in cardiovascular health: an ergogenic aid or exercise therapeutic?
Woessner, M. N., McIlvenna, L. C., Ortiz de Zevallos, J., Neil, C. J., & Allen, J. D. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00414.2017 · Cited by 50 · see citing works
Lane, W. O., Jantzen, A. E., Carlon, T. A., Jamiolkowski, R. M., Grenet, J. E., Ley, M. M., Haseltine, J., Galinat, L. J., Lin, F., Allen, J. D., et al. (2012) · Journal of Visualized Experiments · doi:10.3791/3349 · Cited by 51 · see citing works
Woessner, M. N., VanBruggen, M., Pieper, C. F., Sloane, R. J., Kraus, W. E., Gow, A. J., & Allen, J. D. (2018) · Circulation Research · doi:10.1161/circresaha.118.313131 · Cited by 52 · see citing works
Park, S., Pekas, E. J., Anderson, C. P., Kambis, T. N., Mishra, P. K., Schieber, M. N., Wooden, T. K., Thompson, J. R., Kim, K., & Pipinos, I. I. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00690.2021 · Cited by 46 · see citing works
Dufour, S. P., Patel, R. P., Brandon, A., Teng, X., Pearson, J., Barker, H., Ali, L., Yuen, A. H. Y., Smolenski, R. T., & González-Alonso, J. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00389.2010 · Cited by 45 · see citing works
Mohler, E. R., Hiatt, W. R., Gornik, H. L., Kevil, C. G., Quyyumi, A. A., Haynes, W. G., & Annex, B. H. (2013) · Vascular Medicine · doi:10.1177/1358863x13515043 · Cited by 43 · see citing works
Exercise intolerance in Type 2 diabetes: is there a cardiovascular contribution?
Poitras, V. J., HUDSON, R. W., & Tschakovsky, M. E. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00070.2017 · Cited by 45 · see citing works
Single-Dose Pharmacokinetics of Different Oral Sodium Nitrite Formulations in Diabetes Patients
Greenway, F. L., Predmore, B. L., Flanagan, D. R., Giordano, T., Qiu, Y., Brandon, A., Lefer, D. J., Patel, R. P., & Kevil, C. G. (2012) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2011.0291 · Cited by 43 · see citing works
Allen, J. D., Stäbler, T., Kenjale, A. A., Ham, K. L., Robbins, J. L., Duscha, B. D., Kraus, W. E., & Annex, B. H. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.08.002 · Cited by 42 · see citing works
Pattillo, C. B., Bir, S. C., Rajaram, V., & Kevil, C. G. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq297 · Cited by 43 · see citing works
Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Remodeling
Yuan, S. S., & Kevil, C. G. (2015) · Microcirculation · doi:10.1111/micc.12248 · Cited by 37 · see citing works
Macías, D., Moore, S., Crosby, A., Southwood, M. R., Du, X., Tan, H., Xie, S., Vassallo, A. M., Wood, A. J. T., Wallace, E. M., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.02061-2019 · Cited by 35 · see citing works
Pekas, E. J., Wooden, T. K., Yadav, S. K., & Park, S. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00121.2021 · Cited by 33 · see citing works
Effects of a novel hydrogen sulfide prodrug in a porcine model of acute limb ischemia
Rushing, A. M., Donnarumma, E., Polhemus, D. J., Au, K., Victoria, S. E., Schumacher, J., Li, Z., Jenkins, J. S., Lefer, D. J., & Goodchild, T. T. (2019) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2018.08.172 · Cited by 31 · see citing works
Bock, J. M., Treichler, D. P., Norton, S. L., Ueda, K., Hughes, W. E., & Casey, D. P. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.08.007 · Cited by 30 · see citing works
Chevalier, J. M., Yin, H. R., Arpino, J., O’Neil, C. H., Nong, Z., Gilmore, K. J., Lee, J. J., Prescott, E., Hewak, M., Rice, C. L., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101251 · Cited by 30 · see citing works
Djordjevic, D. Z., Cubrilo, D. G., Barudzic, N. S., Vuletic, M. S., Zivkovic, V. I., Nešić, M., Radovanović, D. S., Djuric, D. M., & Jakovljevic, V. L. (2012) · General Physiology and Biophysics · doi:10.4149/gpb_2012_025 · Cited by 30 · see citing works
Hybrid Nitric Oxide Donor and its Carrier for the Treatment of Peripheral Arterial Diseases
Le, D., Kuriakose, A. E., Nguyen, D. X., Nguyen, K. T., & Acharya, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-08441-9 · Cited by 25 · see citing works
Ojalvo, A. G., Acosta, J. B., Figueroa‐Martínez, A., Béquet‐Romero, M., Mendoza‐Marí, Y., Fernández‐Mayola, M., Fabelo‐Martínez, A., & Guillén, G. E. (2019) · International Wound Journal · doi:10.1111/iwj.13189 · Cited by 23 · see citing works
Nitrite, NO and hypoxic vasodilation
Allen, J. D., & Gow, A. J. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00447.x · Cited by 23 · see citing works
Portella, R. D. L., Bickta, J., & Shiva, S. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6260 · Cited by 21 · see citing works
Isolation of Functional Human Endothelial Cells from Small Volumes of Umbilical Cord Blood
Kang, S. D., Carlon, T. A., Jantzen, A. E., Lin, F., Ley, M. M., Allen, J. D., Stäbler, T., Haley, N. R., Truskey, G. A., & Achneck, H. E. (2013) · Annals of Biomedical Engineering · doi:10.1007/s10439-013-0807-5 · Cited by 20 · see citing works
Monaghan, C., McIlvenna, L. C., Liddle, L., Burleigh, M. C., Weller, R., Fernandez, B. O., Feelisch, M., Muggeridge, D. J., & Easton, C. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-3835-x · Cited by 19 · see citing works
Potential mechanisms for reduced delivery of nitric oxide to peripheral tissues in diabetes mellitus
Stäbler, T., Kenjale, A. A., Ham, K., Jelesoff, N. E., & Allen, J. D. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05599.x · Cited by 19 · see citing works
Nitric oxide donors for peripheral artery disease
Falconer, D., Παπαγεωργίου, Ν., Salem, K. M., Lim, W. Y., Katsargyris, Α., Avgerinos, E. D., & Tousoulis, D. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.02.009 · Cited by 19 · see citing works
Djordjevic, D. Z., Jakovljevic, V. L., Cubrilo, D. G., Zlatkovic, M., Zivkovic, V. I., & Djuric, D. M. (2010) · The Open Biochemistry Journal · doi:10.2174/1874091x01004010100 · Cited by 17 · see citing works
Thurston, T. S., Weavil, J. C., Hureau, T. J., Gifford, J. R., Georgescu, V. P., Wan, H.-Y., La Salle, D. T., Richardson, R. S., & Amann, M. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00400.2021 · Cited by 16 · see citing works
Regenerated Microvascular Networks in Ischemic Skeletal Muscle
Yin, H. R., Arpino, J., Lee, J. J., & Pickering, J. G. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.662073 · Cited by 16 · see citing works
Lane, W. O., Jantzen, A. E., Carlon, T. A., Jamiolkowski, R. M., Grenet, J. E., Ley, M. M., Haseltine, J., Galinat, L. J., Lin, F., Allen, J. D., et al. (2012) · Journal of Visualized Experiments · doi:10.3791/3349-v · Cited by 15 · see citing works
Boeno, F. P., Ramis, T. R., Farinha, J. B., de Lemos, L. S., Medeiros, N. D. S., & Ribeiro, J. L. (2018) · Jornal Vascular Brasileiro · doi:10.1590/1677-5449.011017 · Cited by 14 · see citing works
Pettit, A. P., Kipen, H. M., Laumbach, R. J., Ohman‐Strickland, P., Kelly-McNeill, K., Cepeda, C., Fan, Z. T., Amorosa, L. F., Lubitz, S. E., Schneider, S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144250 · Cited by 13 · see citing works
Plasma nitrite is an indicator of acute changes in ambient air pollutant concentrations
Gandhi, S. K., Rich, D. Q., Ohman‐Strickland, P., Kipen, H. M., & Gow, A. J. (2014) · Inhalation Toxicology · doi:10.3109/08958378.2014.913216 · Cited by 11 · see citing works
Fernández, C. E., Obi-onuoha, I. C., Wallace, C. S., Satterwhite, L. L., Truskey, G. A., & Reichert, W. M. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.10.004 · Cited by 10 · see citing works
Silva, B. M., Neves, F. J., Rocha, N. G., Sales, A. R. K., Medeiros, R. F., Barbosa, T. C., Pereira, F. S., Cardoso, F. T., & da Nóbrega, A. C. L. (2012) · Translational research · doi:10.1016/j.trsl.2012.05.004 · Cited by 10 · see citing works
The Microbiome and Endothelial Function
Leslie, J. L., & Annex, B. H. (2018) · Circulation Research · doi:10.1161/circresaha.118.313813 · Cited by 10 · see citing works
Pekas, E. J., Anderson, C. P., & Park, S. (2022) · Microvascular Research · doi:10.1016/j.mvr.2022.104469 · Cited by 9 · see citing works
Increased Yield of Endothelial Cells from Peripheral Blood for Cell Therapies and Tissue Engineering
Jamiolkowski, R. M., Kang, S. D., Rodriguez, A. K., Haseltine, J., Galinat, L. J., Jantzen, A. E., Carlon, T. A., Darrabie, M. D., Arciniegas, A. J. L., Mantilla, J. G., et al. (2015) · Regenerative Medicine · doi:10.2217/rme.15.2 · Cited by 8 · see citing works
Jantzen, A. E., Achneck, H. E., & Truskey, G. A. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34613 · Cited by 8 · see citing works
Wallis, T., Minnion, M., Freeman, A. T., Bates, A. S., Otto, J. M., Wootton, S. A., Fletcher, S., Grocott, M. P. W., Feelisch, M., Jones, M. G., et al. (2023) · Antioxidants · doi:10.3390/antiox12081645 · Cited by 6 · see citing works
Tan, R., Baranauskas, M. N., Karl, S. T., de Zevallos, J. O., Shei, R., Paris, H. L. R., Wiggins, C. C., & Bailey, S. J. (2023) · Nitric Oxide · doi:10.1016/j.niox.2023.05.003 · Cited by 7 · see citing works
Sultan, S., Kavanagh, E. P., & Hynes, N. (2018) · Vascular · doi:10.1177/1708538117753213 · Cited by 5 · see citing works
Plasma nitrite response in older women to a physical function test
Dobrosielski, D. A., Presley, T. D., Perlegas, A. S., Marsh, A. P., Kim‐Shapiro, D. B., & Rejeski, W. J. (2010) · Aging Clinical and Experimental Research · doi:10.1007/bf03337734 · Cited by 3 · see citing works
Stoner, L. R., Hanson, E. D., Gram, M., Allen, J. D., & Malin, S. K. (2018) · Circulation Journal · doi:10.1253/circj.cj-18-0283 · Cited by 3 · see citing works
Praliciguat and Soluble Guanylate Cyclase Stimulators for Peripheral Artery Disease
Kosmac, K., Ismaeel, A., Kim‐Shapiro, D. B., & McDermott, M. M. (2023) · Circulation Research · doi:10.1161/circresaha.122.322298 · Cited by 3 · see citing works
Nitrite and Nitrate in Ischemia–Reperfusion Injury
Lefer, D. J., Bryan, N. S., & Organ, C. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_16 · Cited by 2 · see citing works
Tan, R., Baranauskas, M. N., Karl, S. T., de Zevallos, J. O., Shei, R., Paris, H. L. R., Wiggins, C. C., & Bailey, S. J. (2023) · Nitric Oxide · doi:10.1016/j.niox.2023.06.004 · Cited by 2 · see citing works
Nitrite and Nitrate in Ischemia-Reperfusion Injury
Lavu, M., Gundewar, S., & Lefer, D. J. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-616-0_14 · Cited by 2 · see citing works
Lj., V., Cubrilo, D. G., Zivkovic, V. I., Djordjevic, D. Z., & Djuric, D. M. (2012) · InTech eBooks · doi:10.5772/32546 · Cited by 1 · see citing works
Bryan, N. S., & Loscalzo, J. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-616-0_17 · Cited by 1 · see citing works
Thornhill, L. (2016) · ORCA Online Research @Cardiff (Cardiff University)
Andrade-Lima, A. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.39.2018.tde-24042018-095503
PERFORMANCE EFFECTS OF CITRULLINE MALATE AND BEETROOT JUICE SUPPLEMENTATION
Trexler, E. T. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/e6z2-3p03
Woessner, M. N. (2019) · Victoria University Research Repository (Victoria University)
Bryan, N. S., & Loscalzo, J. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_22
Exercise interventions in women with Polycystic Ovary Syndrome
Moreno‐Asso, A., Patten, R. K., & McIlvenna, L. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89843-0.00020-9 · Cited by 1 · see citing works
Exercise Therapy for Peripheral Artery Disease: Mechanisms, Outcomes, and Optimal Methods
McDermott, M. M. (2025) · Springer eBooks · doi:10.1007/978-3-032-02460-2_12
Wang, Q., Qian, N., Liu, Y., & Zhou, M. (2026) · Endocrine · doi:10.1007/s12020-026-04836-9
Investigating the role of nitric oxide clones in cardiovascular conditions
Arif, S. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
- Authors
- Allen, J. D., Miller, E. M., Schwark, E., Robbins, J. L., Duscha, B. D., & Annex, B. H.
- Affiliations
- Duke University (US)
- Duke Medical Center (US)
- University of Virginia (US)
- Corresponding author
- Allen, Jason D.
- Venue
- Nitric Oxide
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 20
- Issue
- 4
- Pages
- 231-237
- ISSN
- 1089-8603 (ISSN-L)
- PMC
- PMC2676216
- OpenAlex
- W2034538856
- Cited by
- 76
- References
- 51
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 12 · 2017: 5 · 2016: 1 · 2015: 4 · 2014: 2 · 2013: 8 · 2012: 9
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nitric Oxide (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL075752)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- plasma nitrite, endothelial function, peripheral arterial disease, type 2 diabetes, exercise capacity, peak oxygen uptake, brachial artery flow-mediated dilation, forearm occlusion, cardiovascular risk factors
- MeSH terms
- Aged, Blood Flow Velocity, Brachial Artery, Endothelium, Vascular, Forearm, Humans, Middle Aged, Nitric Oxide, Nitrites, Vasodilation, Peripheral Vascular Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
