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Plasma nitrite flux predicts exercise performance in peripheral arterial disease after 3 months of exercise training
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Plasma nitrite is a major oxidation product of nitric oxide. It has also recently been suggested to perform an endocrine-like function as a nitric oxide donor in hypoxic tissues, allowing vasodilation. Exercise performance is limited in peripheral arterial disease because of an inadequate blood supply to working tissues. We hypothesized that exercise training in peripheral arterial disease subjects will improve "plasma nitrite flux" and endothelial function, to accompany increased exercise performance. Peripheral arterial disease subjects were tested at baseline and after 3 months supervised or home exercise training. Venous blood (arm) was drawn at rest and 10 min after a maximal graded treadmill test. Samples were added to heparin and centrifuged and plasma was snap-frozen for analysis by reductive chemiluminescence. Brachial artery endothelial function was measured in response to a hyperemic stimulus (flow-mediated dilation). At 3 months the peripheral arterial disease-supervised exercise group showed increases in claudication onset pain time (+138 s, p< or =0.05), peak walking time (+260 s, p< or =0.01), VO(2peak) (1.3 ml/kg/min, p< or =0.05), brachial artery flow-mediated dilation (+2%, p< or =0.05), and plasma nitrite flux (+33% p< or =0.05). There were no changes in the peripheral arterial disease-home exercise group. The change in plasma nitrite flux predicted the change in claudication onset pain (r(2)=0.59, p< or =0.01). These findings suggest that changes in plasma nitrite are related to endothelial function and predict exercise performance in peripheral arterial disease.
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Plasma nitrite concentration is positively associated with exercise capacity in humans.
“Indeed, several studies have reported that plasma [nitrite] is positively associated with exercise capacity in humans [26–29].”
From Dietary Nitrate Supplementation and Exercise Performance (2014) · cites this paper as [26]
Plasma nitrite flux predicts the time to claudication onset pain reflecting exercise performance ability.
“the authors found that plasma nitrite flux predicted the time to claudication onset pain reflecting exercise performance ability [174].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [174]
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Metadata
- Authors
- Allen, J. D., Stabler, T., Kenjale, A., Ham, K. L., Robbins, J. L., Duscha, B. D., Dobrosielski, D. A., & Annex, B. H.
- Affiliations
- Duke Medical Center (US)
- Duke University (US)
- Johns Hopkins University (US)
- University of Virginia (US)
- Corresponding author
- Allen, Jason D.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 49
- Issue
- 6
- Pages
- 1138-1144
- ISSN
- 0891-5849 (ISSN-L)
- PMC
- PMC2922965
- OpenAlex
- W2086928620
- Cited by
- 101
- References
- 39
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 9 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 10 · 2017: 6 · 2016: 7 · 2015: 11 · 2014: 7 · 2013: 8 · 2012: 6
- FWCI
- 17.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01 HL755752, R01HL075752)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- peripheral arterial disease, exercise training, exercise performance, endothelial function, flow-mediated dilation, nitric oxide, walking distance, home-based exercise, supervised exercise, peak oxygen uptake
- MeSH terms
- Brachial Artery, Electrocardiography, Endothelium, Vascular, Exercise Test, Exercise Therapy, Female, Humans, Intermittent Claudication, Luminescent Measurements, Male, Middle Aged, Nitrites, Prognosis, Vasodilation, Walking, Athletic Performance, Peripheral Arterial Disease
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