Effect of chronic sodium nitrite therapy on monocrotaline-induced pulmonary hypertension

Pankey, Edward A.; Badejo, Adeleke M.; Casey, David B.; Lasker, George F.; Riehl, Russel A.; Murthy, Subramanyam N.; Nossaman, Bobby D.; Kadowitz, Philip J.

doi:10.1016/j.niox.2012.02.004

Cited by 35Pulmonary Hypertension Research and TreatmentsNitric Oxide and Endothelin EffectsVascular Anomalies and Treatments

Effect of chronic sodium nitrite therapy on monocrotaline-induced pulmonary hypertension

Open access

Pankey, Edward A., Badejo, Adeleke M., Casey, David B., Lasker, George F., Riehl, Russel A., Murthy, Subramanyam N., Nossaman, Bobby D., Kadowitz, Philip J.·2012·Nitric Oxide

DOI 10.1016/j.niox.2012.02.004PMC PMC3366021

Open this paper in CoChat — free account

Abstract

Pulmonary hypertension (PH) is a rare disorder that without treatment is progressive and often fatal within 3 years. The treatment of PH involves the use of a diverse group of drugs and lung transplantation. Although nitrite was once thought to be an inactive metabolite of endothelial-derived nitric oxide (NO), there is increasing evidence that nitrite may be useful in the treatment of PH, but the mechanism by which nitrite exerts its beneficial effect remains uncertain. The purpose of this study was to investigate the effect of chronic sodium nitrite treatment in a PH model in the rat. Following induction of PH with a single injection of monocrotaline, 60 mg; daily ip injections of sodium nitrite (3mg/kg) starting on day 14 and continuing for 21 days, resulted in a significantly lower pulmonary arterial pressure on day 35 when compared to values in untreated animals with monocrotaline-induced PH. In monocrotaline-treated rats, daily treatment with ip nitrite injections for 21 days decreased right ventricular mass and pathologic changes in small pulmonary arteries. Nitrite therapy did not change systemic arterial pressure or cardiac output when values were measured on day 35. The decreases in pulmonary arterial pressure in response to iv injections of sodium nitroprusside, sodium nitrite, and BAY 41-8543 were not different in rats with monocrotaline-induced pulmonary hypertension and rats with chronic nitrite therapy when compared to responses in animals in which pulmonary arterial pressure was increased with U46619. These findings are consistent with the hypothesis that the mechanisms that convert nitrite to vasoactive NO, activate soluble guanylyl cyclase and mediate the vasodilator response to NO or an NO derivative are not impaired. The present data are consistent with the results of a previous study in monocrotaline-induced PH in which systemic arterial pressure and cardiac output were not evaluated and are consistent with the hypothesis that nitrite is effective in the treatment of monocrotaline-induced PH in the rodent.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.niox.2012.02.004

Cites

82 of 82 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Delivered via intravenous, inhaled, or oral routes, nitrite reduces pulmonary and right heart pressures and prevents or reverses characteristic vascular remodeling and right ventricular hypertrophy (RVH) in several animal models of PAH.
“Delivered via intravenous, inhaled, or oral routes, nitrite reduces pulmonary and right heart pressures and prevents or reverses characteristic vascular remodeling and right ventricular hypertrophy (RVH) in several animal models of PAH[15,117,143,146–149].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [147]
Oral administration of nitrate and nitrite provides reversal of vascular and ventricular remodeling in several models of PAH.
“reversal of vascular and ventricular remodeling in several models of PAH[147,150].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [147]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · cited 1× · see citing works
“Nitrite therapy has been shown to have a beneficial effect in a wide variety of cardiovascular disorders in experimental animals [32,55,56,64].”
Clinical classification of pulmonary hypertension
Simonneau, G., Galiè, N., Rubin, L. J., Langleben, D., Seeger, W., Domenighetti, G. M., Gibbs, S., Lebrec, D., Speich, R., Beghetti, M., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.02.037 · Cited by 1,895 · see citing works
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807 · see citing works
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates
Ignarro, L. J., Lippton, H., Edwards, J. C., Baricos, W. H., Hyman, A. L., Kadowitz, P. J., & Gruetter, C. A. (1981) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32738-2 · Cited by 1,633 · see citing works
Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations
Arnold, W. P., Mittal, C. K., Katsuki, S., & Murad, F. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3203 · Cited by 1,459 · see citing works
Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension
Giaid, A., & Saleh, D. M. (1995) · New England Journal of Medicine · doi:10.1056/nejm199507273330403 · Cited by 1,366 · see citing works
Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.
Ignarro, L. J., Byrns, R. E., Buga, G. M., & Wood, K. S. (1987) · Circulation Research · doi:10.1161/01.res.61.6.866 · Cited by 1,164 · see citing works
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
Garthwaite, J., Southam, E., Boulton, C. L., Nielsen, E. B., Schmidt, K., & Mayer, B. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10233-2 · Cited by 1,101 · see citing works
Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome
Dellinger, R. P., Zimmerman, J. L., Taylor, R. W., Straube, R., Hauser, D. L., Criner, G. J., DAVIS, K. E., Hyers, T. M., & Papadakos, P. J. (1998) · Critical Care Medicine · doi:10.1097/00003246-199801000-00011 · Cited by 769 · see citing works
Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine.
Katsuki, S., Arnold, W. P., Mittal, C. K., & Murad, F. (1977) · PubMed · Cited by 701 · see citing works
Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs
Furchgott, R. F., & Bhadrakom, S. (1953) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)05163-8 · Cited by 655 · see citing works
Nitric oxide as a unique signaling molecule in the vascular system: a historical overview.
Ignarro, L. J. (2002) · PubMed · Cited by 623 · see citing works
Deoxymyoglobin Is a Nitrite Reductase That Generates Nitric Oxide and Regulates Mitochondrial Respiration
Shiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research · doi:10.1161/01.res.0000260171.52224.6b · Cited by 599 · see citing works
Low-Dose Inhaled Nitric Oxide in Patients With Acute Lung Injury A Randomized Controlled Trial
Taylor, R. W. (2004) · JAMA · doi:10.1001/jama.291.13.1603 · Cited by 549 · see citing works
Identification of the enzymatic mechanism of nitroglycerin bioactivation
Chen, Z., Zhang, J., & Stamler, J. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122225199 · Cited by 541 · see citing works
Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.
Gruetter, C. A., Gruetter, D. Y., Lyon, J., Kadowitz, P. J., & Ignarro, L. J. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32778-3 · Cited by 533 · see citing works
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
Huang, Z. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24650 · Cited by 520 · see citing works
Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions
Millar, T. M., Stevens, C. R., Benjamin, N., Eisenthal, R., Harrison, R., & Blake, D. R. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00430-x · Cited by 491 · see citing works
ON THE USE OF NITRITE OF AMYL IN ANGINA PECTORIS.
Brunton, T. L. (1867) · The Lancet · doi:10.1016/s0140-6736(02)51392-1 · Cited by 410 · see citing works
Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans
Kleinbongard, P., Dejam, A., Lauer, T., Jax, T., Kerber, S., Gharini, P., Balzer, J., Zotz, R. B., Scharf, R. E., Willers, R., et al. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.025 · Cited by 388 · see citing works
A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis
Jansson, E. Å., Huang, L., Malkey, R., Govoni, M., Nihlén, C., Olsson, A., Stensdotter, M., Petersson, J., Holm, L., Weitzberg, E., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.92 · Cited by 356 · see citing works
Active Nitric Oxide Produced in the Red Cell under Hypoxic Conditions by Deoxyhemoglobin-mediated Nitrite Reduction
Nagababu, E., Ramasamy, S., Abernethy, D. R., & Rifkind, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307572200 · Cited by 349 · see citing works
Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.
Doyle, M. P., Pickering, R. A., DeWeert, T. M., Hoekstra, J. W., & Pater, D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43285-1 · Cited by 334 · see citing works
Nitrite Infusion in Humans and Nonhuman Primates: Endocrine Effects, Pharmacokinetics, and Tolerance Formation
Dejam, A., Hunter, C. J., Tremonti, C., Pluta, R. M., Hon, Y. Y., Grimes, G., Partovi, K., Pelletier, M. M., Oldfield, E. H., Cannon, R. O., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.712133 · Cited by 334 · see citing works
Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite possible involvement of S-nitrosothiols
Ignarro, L. J., & Gruetter, C. S. (1980) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(80)90297-4 · Cited by 317 · see citing works
Nitric Oxide: A Unique Endogenous Signaling Molecule in Vascular Biology
Ignarro, L. J. (1999) · Bioscience Reports · doi:10.1023/a:1020150124721 · Cited by 305 · see citing works
Treatment and survival in children with pulmonary arterial hypertension: the UK Pulmonary Hypertension Service for Children 2001–2006
Haworth, S. G., & Hislop, A. A. (2008) · Heart · doi:10.1136/hrt.2008.150086 · Cited by 305 · see citing works
NITRO-GLYCERINE AS A REMEDY FOR ANGINA PECTORIS.
Murrell, W. (1879) · The Lancet · doi:10.1016/s0140-6736(02)46032-1 · Cited by 293 · see citing works
Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase
Boulton, C. L., Southam, E., & Garthwaite, J. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00349-n · Cited by 282 · see citing works
Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator
Hunter, C. J., Dejam, A., Blood, A. B., Shields, H., Kim-Shapiro, D. B., Machado, R. F., Tarekegn, S., Mulla, N., Hopper, A. O., Schechter, A. N., et al. (2004) · Nature Medicine · doi:10.1038/nm1109 · Cited by 281 · see citing works
The Reaction between Nitrite and Deoxyhemoglobin
Huang, K. T., Keszler, A., Patel, N., Patel, R. P., Gladwin, M. T., Kim-Shapiro, D. B., & Hogg, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501496200 · Cited by 253 · see citing works
An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation
Chen, Z., Foster, M. W., Zhang, J., Mao, L., Rockman, H. A., Kawamoto, T., Kitagawa, K., Nakayama, K. I., Hess, D. T., & Stamler, J. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503723102 · Cited by 232 · see citing works
Regulation of Vascular Homeostasis by Nitric Oxide
Radomski, M. W., & Moncada, S. (1993) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646156 · Cited by 232 · see citing works
Inhaled Nitric Oxide
Rich, G. F., Murphy, G. D., Roos, C. M., & Johns, R. A. (1993) · Anesthesiology · doi:10.1097/00000542-199306000-00004 · Cited by 217 · see citing works
Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues.
Katsuki, S., Arnold, W. P., & Murad, F. (1977) · PubMed · Cited by 206 · see citing works
Mechanisms Underlying Erythrocyte and Endothelial Nitrite Reduction to Nitric Oxide in Hypoxia: Role for Xanthine Oxidoreductase and Endothelial Nitric Oxide Synthase
Webb, A. J., Milsom, A. B., Rathod, K. S., Chu, W. L., Qureshi, S., Lovell, M. J., Lecomte, F. M. J., Perrett, D., Raimondo, C., Khoshbin, E., et al. (2008) · Circulation Research · doi:10.1161/circresaha.108.175810 · Cited by 203 · see citing works
Nitrite Potently Inhibits Hypoxic and Inflammatory Pulmonary Arterial Hypertension and Smooth Muscle Proliferation via Xanthine Oxidoreductase–Dependent Nitric Oxide Generation
Zuckerbraun, B. S., Shiva, S., Ifedigbo, E., Mathier, M. A., Mollen, K. P., Rao, J., Bauer, P. M., Choi, J. J. W., Curtis, E., Choi, A. M. K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.891077 · Cited by 192 · see citing works
Pulmonary arterial hypertension in children
Widlitz, A. C., & Barst, R. J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00088302 · Cited by 183 · see citing works
Nitric oxide NO - biogeneration regulation and relevence to human diseases
Bian, K. (2003) · Frontiers in bioscience · doi:10.2741/997 · Cited by 164 · see citing works
Biotransformation of organic nitrates to nitric oxide by vascular smooth muscle and endothelial cells
Feelisch, M., & Kelm, M. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81290-2 · Cited by 162 · see citing works
Does Nitric Oxide Mediate the Vasodilator Activity of Nitroglycerin?
Kleschyov, A. L., Oelze, M. W., Daiber, A., Huang, Y., Mollnau, H., Schulz, E., Sydow, K., Fichtlscherer, B., Mülsch, A., & Münzel, T. F. (2003) · Circulation Research · doi:10.1161/01.res.0000100067.62876.50 · Cited by 161 · see citing works
Evaluation and Management of the Patient with Pulmonary Arterial Hypertension
Rubin, L. J., & Badesch, D. B. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-143-4-200508160-00009 · Cited by 149 · see citing works
CANCER, CHOLESTEROL, CAROTENE, AND TOCOPHEROL
Peto, R. (1981) · The Lancet · doi:10.1016/s0140-6736(81)90453-0 · Cited by 133 · see citing works
The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles
Mayer, B., & Beretta, M. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.263 · Cited by 123 · see citing works
Plasma Nitroso Compounds Are Decreased in Patients With Endothelial Dysfunction
Heiß, C., Lauer, T., Dejam, A., Kleinbongard, P., Hamada, S., Rassaf, T., Matern, S., Feelisch, M., & Kelm, M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.06.089 · Cited by 115 · see citing works
Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities
Dalsgaard, T., Simonsen, U., & Fago, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01298.2006 · Cited by 110 · see citing works
Long-Term Outcome of Lung and Heart-Lung Transplantation for Idiopathic Pulmonary Arterial Hypertension
Toyoda, Y., Thacker, J., dos Santos, R. S., Nguyen, D., Bhama, J. K., Bermudez, C. A., Kormos, R. L., Johnson, B. A., Crespo, M. M., Pilewski, J. M., et al. (2008) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2008.05.049 · Cited by 97 · see citing works
Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling
Zuckerbraun, B. S., George, M. P., & Gladwin, M. T. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq370 · Cited by 97 · see citing works
Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice
Champion, H. C., Bivalacqua, T. J., Greenberg, S. S., Giles, T. D., Hyman, A. L., & Kadowitz, P. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182225899 · Cited by 95 · see citing works
Pulmonary Arterial Hypertension
Rubin, L. J. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200510-112jh · Cited by 91 · see citing works
Effects of thiols, sugars, and proteins on nitric oxide activation of guanylate cyclase.
Braughler, J. M., Mittal, C. K., & Murad, F. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86335-4 · Cited by 90 · see citing works
Pulmonary vasodilator activity of prostacyclin (PGI2) in the cat.
Hyman, A. L., & Kadowitz, P. J. (1979) · Circulation Research · doi:10.1161/01.res.45.3.404 · Cited by 87 · see citing works
Discrepancies Between Nitroglycerin and NO-Releasing Drugs on Mitochondrial Oxygen Consumption, Vasoactivity, and the Release of NO
Núñez, C., Víctor, V. M., Tur, R., Alvarez, A. M., Moncada, S., Esplugues, J. V., & D’Ocón, P. (2005) · Circulation Research · doi:10.1161/01.res.0000190588.84680.34 · Cited by 85 · see citing works
Nitric oxide inhalation attenuates pulmonary hypertension and improves gas exchange in endotoxin shock
Weitzberg, E., Rudehill, A., & Lundberg, J. M. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90352-i · Cited by 84 · see citing works
Hemoglobin oxygen fractional saturation regulates nitrite-dependent vasodilation of aortic ring bioassays
Isbell, T. S., Gladwin, M. T., & Patel, R. P. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00759.2007 · Cited by 82 · see citing works
Pulmonary arterial hypertension
Raiesdana, A., & Loscalzo, J. (2006) · Annals of Medicine · doi:10.1080/07853890600622143 · Cited by 79 · see citing works
Bioactivation of Nitroglycerin by Purified Mitochondrial and Cytosolic Aldehyde Dehydrogenases
Beretta, M., Gruber, K. F., Kollau, A., Russwurm, M., Koesling, D., Goessler, W., Keung, W. M., Schmidt, K., & Mayer, B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801182200 · Cited by 72 · see citing works
Clinical translation of nitrite therapy for cardiovascular diseases
Calvert, J. W., & Lefer, D. J. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.11.001 · Cited by 72 · see citing works
Nitrite directly vasodilates hypoxic vasculature via nitric oxide‐dependent and ‐independent pathways
Pinder, A. G., Pittaway, E., Morris, K., & James, P. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00340.x · Cited by 66 · see citing works
In Vitro Activation of Soluble Guanylyl Cyclase and Nitric Oxide Release: A Comparison of NO Donors and NO Mimetics
Artz, J. D., Toader, V., Zavorin, S. I., Bennett, B. M., & Thatcher, G. R. J. (2001) · Biochemistry · doi:10.1021/bi002885x · Cited by 66 · see citing works
Relaxation of intrapulmonary artery and vein by nitrogen oxide-containing vasodilators and cyclic GMP.
Edwards, J. C., Ignarro, L. J., Hyman, A. L., & Kadowitz, P. J. (1984) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21579-8 · Cited by 64 · see citing works
Pulmonary vasodilator responses to sodium nitrite are mediated by an allopurinol-sensitive mechanism in the rat
Casey, D. B., Badejo, A. M., Dhaliwal, J. S., Murthy, S. N., Hyman, A. L., Nossaman, B. D., & Kadowitz, P. J. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00543.2008 · Cited by 61 · see citing works
Aerosolized Soluble Nitric Oxide Donor Improves Oxygenation and Pulmonary Hypertension in Acute Lung Injury
Jacobs, B. R., Brilli, R. J., Ballard, E. T., PASSERINI, D. J., & Smith, D. J. B. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.5.9802114 · Cited by 49 · see citing works
Vascular Bioactivation of Nitroglycerin Is Catalyzed by Cytosolic Aldehyde Dehydrogenase-2
Beretta, M., Wölkart, G., Schernthaner, M., Griesberger, M., Neubauer, R., Schmidt, K., Sacherer, M., Heinzel, F. R., Kohlwein, S. D., & Mayer, B. (2011) · Circulation Research · doi:10.1161/circresaha.111.245837 · Cited by 45 · see citing works
Vascular responses to nitrite are mediated by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase in the ratThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research.
Golwala, N. H., Hodenette, C., Murthy, S. N., Nossaman, B. D., & Kadowitz, P. J. (2009) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-101 · Cited by 41 · see citing works
INFLUENCE OF SODIUM NITRITE ON THE CARDIOVASCULAR SYSTEM AND ON RENAL ACTIVITY
Weiss, S. (1933) · Archives of Internal Medicine · doi:10.1001/archinte.1933.00160010112011 · Cited by 39 · see citing works
Inhaled nitrite reverses hemolysis-induced pulmonary vasoconstriction in newborn lambs without blood participation
Blood, A. B., Schroeder, H. J., Terry, M. H., Merrill-Henry, J., Bragg, S. L., Vrancken, K., Liu, T., Herring, J. L., Sowers, L. C., Wilson, S. M., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.001073 · Cited by 36 · cited 2× · see citing works
“In a recent study in the newborn lamb, inhaled nitrite induced pulmonary vasodilation whereas infused nitrite was without effect [53].”
In vitro and in vivo kinetic handling of nitrite in blood: effects of varying hemoglobin oxygen saturation
Blood, A. B., & Power, G. G. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01259.2006 · Cited by 35 · see citing works
Cardioprotective actions of nitrite therapy and dietary considerations
Nathan, S. B. (2009) · Frontiers in bioscience · doi:10.2741/3568 · Cited by 34 · see citing works
Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat
Badejo, A. M., Hodnette, C., Dhaliwal, J. S., Casey, D. B., Pankey, E., Murthy, S. N., Nossaman, B. D., Hyman, A. L., & Kadowitz, P. J. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00959.2009 · Cited by 32 · see citing works
Mitochondrial nitrite reduction coupled to soluble guanylate cyclase activation: Lack of evidence for a role in the bioactivation of nitroglycerin
Kollau, A., Beretta, M., Russwurm, M., Koesling, D., Keung, W. M., Schmidt, K., & Mayer, B. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.09.003 · Cited by 31 · see citing works
Unusual pulmonary vasodilator activity of 13,14-dehydroprostacyclin methyl ester: comparison with endoperoxides and other prostanoids.
Hyman, A. L., Chapnick, B. M., Kadowitz, P. J., Lands, W. E. M., Crawford, C. G., Fried, J., & Barton, J. N. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5711 · Cited by 29 · see citing works
Cardiovascular prevention by dietary nitrate and nitrite
Lundberg, J. O. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00246.2009 · Cited by 29 · see citing works
Emerging role of nitrite in myocardial protection
Lefer, D. J. (2009) · Archives of Pharmacal Research · doi:10.1007/s12272-009-1804-y · Cited by 27 · see citing works
Site-Directed Mutagenesis of Aldehyde Dehydrogenase-2 Suggests Three Distinct Pathways of Nitroglycerin Biotransformation
Wenzl, M. V., Beretta, M., Griesberger, M., Russwurm, M., Koesling, D., Schmidt, K., Mayer, B., & Gorren, A. C. F. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.071704 · Cited by 26 · see citing works
Red blood cells prevent inhibition of hypoxic pulmonary vasoconstriction by nitrite in isolated, perfused rat lungs
Deem, S. A., Min, J.-H., Moulding, J., Eveland, R. L., & Swenson, E. R. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00812.2006 · Cited by 26 · see citing works
Analysis of Pulmonary Vasodilator Responses to SB-772077-B [4-(7-((3-Amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a Novel Aminofurazan-Based Rho Kinase Inhibitor
Dhaliwal, J. S., Badejo, A. M., Casey, D. B., Murthy, S. N., & Kadowitz, P. J. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.151449 · Cited by 25 · see citing works
Acute administration of l-arginine restores nitric oxide-mediated relaxation in isolated pulmonary arteries from pulmonary hypertensive exercise trained rats
Goret, L., Tanguy, S., Guiraud, I., Dauzat, M., & Obert, P. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.037 · Cited by 24 · see citing works
The current status of nitrites in the treatment of coronary artery disease
Weisse, A. B., & Regan, T. J. (1969) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(69)90036-x · Cited by 20 · see citing works
Nitrate-Based Vasodilators Inhibit Multiple Vascular Aldehyde Dehydrogenases
Murphy, T. C., Arntzen, R., & Picklo, M. J. (2005) · Cardiovascular Toxicology · doi:10.1385/ct:5:3:321 · Cited by 15 · see citing works
Inhaled nitric oxide in the treatment of persistent pulmonary hypertension/ hypoxic respiratory failure in neonates: an update.
Cook, L. N., & Stewart, D. L. (2005) · PubMed · Cited by 12 · see citing works
Pulmonary arterial hypertension: therapeutic algorithm.
Galiè, N., & Branzi, A. (2005) · PubMed · Cited by 8 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

[48]Cosby K Partovi KS Crawford JH Patel RP Reiter CD Martyr S Yang BK Waclawiw MA Zalos G Xu X Huang KT Shields H Kim-Shapiro DB Schechter AN Cannon RO 3rd Gladwin MT Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation.[see comment] Nature Med 9 2003 1498 505 14595407

Sorted by citations

The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway
Kapil, V., Khambata, R. S., Jones, D. A., Rathod, K., Primus, C., Massimo, G., Fukuto, J. M., & Ahluwalia, A. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019240 · Cited by 248 · see citing works
Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health
Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works
Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases
Omar, S. A., Webb, A. J., Lundberg, J. O., & Weitzberg, E. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12441 · Cited by 175 · see citing works
Soluble Guanylate Cyclase Stimulators in Pulmonary Hypertension
Stasch, J., & Evgenov, O. V. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-38664-0_12 · Cited by 168 · see citing works
Soluble Guanylate Cyclase: A New Therapeutic Target for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension
Dasgupta, A., Bowman, L., D’Arsigny, C. L., & Archer, S. (2014) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.10 · Cited by 82 · see citing works
Inorganic nitrite supplementation for healthy arterial aging
Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68 · see citing works
Oxidative Stress and Therapeutic Development in Lung Diseases
Villegas, L. R. (2014) · Journal of Pulmonary & Respiratory Medicine · doi:10.4172/2161-105x.1000194 · Cited by 58 · see citing works
A Brief Overview of Nitric Oxide and Reactive Oxygen Species Signaling in Hypoxia-Induced Pulmonary Hypertension
Jaitovich, A., & Jourd’heuil, D. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-63245-2_6 · Cited by 58 · see citing works
Nitrate–Nitrite–Nitric Oxide Pathway in Pulmonary Arterial Hypertension Therapeutics
Sparacino-Watkins, C. E., Lai, Y., & Gladwin, M. T. (2012) · Circulation · doi:10.1161/circulationaha.112.107821 · Cited by 47 · see citing works
New insights into the role of soluble guanylate cyclase in blood pressure regulation
Buys, E. S., & Sips, P. Y. (2014) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000441048.91041.3a · Cited by 43 · see citing works
Safety and pharmacokinetics of sodium nitrite in patients with subarachnoid hemorrhage: a Phase IIA study
Oldfield, E. H., Loomba, J. J., Monteith, S. J., Crowley, R. W., Medel, R., Gress, D. R., Kassell, N. F., Dumont, A. S., & Sherman, C. R. (2013) · Journal of neurosurgery · doi:10.3171/2013.3.jns13266 · Cited by 42 · see citing works
Discovery and development of sGC stimulators for the treatment of pulmonary hypertension and rare diseases
Sandner, P., Becker‐Pelster, E., & Stasch, J. P. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.05.001 · Cited by 38 · see citing works
Analysis of responses to the TRPV4 agonist GSK1016790A in the pulmonary vascular bed of the intact-chest rat
Pankey, E. A., Zsombok, A., Lasker, G. F., & Kadowitz, P. J. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00303.2013 · Cited by 35 · see citing works
Design and synthesis of new coumarin–chalcone/NO hybrids of potential biological activity
El-Sherief, H. A. M., Abuo‐Rahma, G. E. A., Shoman, M. E., Beshr, E. A. M., & El-Baky, R. M. A. (2017) · Medicinal Chemistry Research · doi:10.1007/s00044-017-2004-9 · Cited by 33 · see citing works
Therapy for Pulmonary Arterial Hypertension: Glance on Nitric Oxide Pathway
Tettey, A. T., Jiang, Y., Li, X., & Li, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.767002 · Cited by 34 · see citing works
Nitrite Confers Preconditioning and Cytoprotection After Ischemia/Reperfusion Injury Through the Modulation of Mitochondrial Function
Portella, R. D. L., Bickta, J., & Shiva, S. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6260 · Cited by 21 · see citing works
Intratracheal administration of cyclooxygenase-1-transduced adipose tissue-derived stem cells ameliorates monocrotaline-induced pulmonary hypertension in rats
Somanna, N. K., Wörner, P. M., Murthy, S. N., Pankey, E. A., Schächtele, D. J., Hilaire, R. S., Jansen, D., Chaffin, A. E., Nossaman, B. D., Alt, E., et al. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00589.2013 · Cited by 20 · see citing works
Sodium nitrite augments lungS-nitrosylation and reverses chronic hypoxic pulmonary hypertension in juvenile rats
Jankov, R. P., Daniel, K. L., Iny, S., Kantores, C., Ivanovska, J., Fadel, N. B., & Jain, A. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00184.2018 · Cited by 18 · see citing works
Nutraceuticals in the Treatment of Pulmonary Arterial Hypertension
Sánchez-Gloria, J. L., Osorio‐Alonso, H., Arellano-Buendía, A. S., Carbó, R., Hernández-Díazcouder, A., Guzmán-Martín, C. A., Rubio‐Gayosso, I., & Sánchez‐Muñoz, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144827 · Cited by 16 · see citing works
Nitric Oxide Formation From Inorganic Nitrate
Lundberg, J. O., & Weitzberg, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00012-0 · Cited by 12 · see citing works
Stimulation of nitric oxide-sensitive soluble guanylate cyclase in monocrotaline-induced pulmonary hypertensive rats
Tawa, M., Furukawa, T., Tongu, H., Sugihara, M., Taguwa, S., Yamanaka, M., Yano, Y., Matsumori, H., Kitada, R., Sawano, T., et al. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.04.045 · Cited by 12 · see citing works
Nebivolol has a beneficial effect in monocrotaline-induced pulmonary hypertension
Pankey, E. A., Edward, J. A., Swan, K. W., Bourgeois, C. R. T., Bartow, M. J., Yoo, D., Peak, T. C., Song, B. M., Chan, R. A., Murthy, S. N., et al. (2016) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0431 · Cited by 9 · see citing works
Aldehyde dehydrogenase 2 partly mediates hypotensive effect of nitrite on l -NAME-induced hypertension in normoxic rat
Sonoda, K., Ohtake, K., Kubo, Y., Uchida, H., Uchida, M., Natsume, H., Kobayashi, M., & Kobayashi, J. (2013) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2013.846355 · Cited by 8 · see citing works
Effects of inorganic nitrate in a rat model of monocrotaline‐induced pulmonary arterial hypertension
Malikova, E., Carlström, M., Kmecová, Z., Marušáková, M., Zsigmondova, B., Křenek, P., Klimas, J., & Henrohn, D. (2019) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13309 · Cited by 7 · see citing works
Effects of Beet Juice Supplementation on Monocrotaline-Induced Pulmonary Hypertension in Rats
Tawa, M., Yano, Y., Yamanaka, M., Sawano, T., Iesaki, K., Murata, Y., Tanaka, R., Nakagawa, K., Ohkita, M., & Matsumura, Y. (2018) · American Journal of Hypertension · doi:10.1093/ajh/hpy144 · Cited by 7 · see citing works
Preventive effects of nitrate-rich beetroot juice supplementation on monocrotaline-induced pulmonary hypertension in rats
Tawa, M., Nagata, R., Sumi, Y., Nakagawa, K., Sawano, T., Ohkita, M., & Matsumura, Y. (2021) · PLoS ONE · doi:10.1371/journal.pone.0249816 · Cited by 6 · see citing works
MORPHOMETRIC AND MORPHOLOGICAL FEATURES OF RAT BRONCHUS-ASSOCIATED LYMPHOID TISSUE UNDER THE IMPACT OF THE COMPLEX OF FOOD ADDITIVES
Yeroshenko, G. A., Donets, I., Шевченко, К. В., Vatsenko, А. V., Ulanovska-Tsyba, N. А., Рябушко, О. Б., & Klepets, O. V. (2023) · World of Medicine and Biology · doi:10.26724/2079-8334-2023-3-85-209-215 · Cited by 4 · see citing works
Ameliorative Effects of Beetroot Juice Supplementation on Monocrotaline-Induced Pulmonary Hypertension in Rats
Tawa, M., Nagano, J., Kitama, J., Abe, S., Fujita, A., Nakagawa, K., & Ohkita, M. (2022) · Future Pharmacology · doi:10.3390/futurepharmacol2040033 · Cited by 3 · see citing works
Airway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasia
Gentle, S. J., Freeman, A., Patel, R. P., Ambalavanan, N., & Lal, C. V. (2020) · Respiratory Research · doi:10.1186/s12931-020-01508-8 · Cited by 2 · see citing works
Pulmonary Hypertension in Chronic Neonatal Lung Disease: Mechanisms and Targets
Jankov, R. P., & Tanswell, A. K. (2017) · Springer eBooks · doi:10.1007/978-3-319-67096-6_11
Recent publications by ochsner authors.
(2012) · PubMed Central
Effect of Long Term Exposure to Sodium Nitrite on Gene Responsible for DNA Repair
Mirza, A., & Hiti, S. M. A. A. (2014) · Iraqi National Journal of Nursing Specialties · doi:10.58897/injns.v27i2.203
THE CURRENT ISSUES ON THE IMPACT OF MONOSODIUM GLUTAMATE FOOD ADDITIVE ON THE VISUAL ORGAN AND THE HUMAN BODY
Synenko, V. A., Yeroshenko, G. А., Шевченко, К. В., Klepets, O. V., Григоренко, А. С., Соколенко, В. М., & Шарлай, Н. М. (2024) · World of Medicine and Biology · doi:10.26724/2079-8334-2024-3-89-258-262
Predictive vascular growth and remodeling in pulmonary hypertension: simulating intervention effects from captured evolutionPreprint
Jahani, F., Cardenas, B., Manning, E., & Szafron, J. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.07.743318
Investigating the role of nitric oxide clones in cardiovascular conditions
Arif, S. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)

Continuous low-dose NO inhalation does not prevent monocrotaline-induced pulmonary hypertension in rats
Maruyama, J., Maruyama, K., Mitani, Y., Kitabatake, M., Yamauchi, T., & Miyasaka, K. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.272.1.h517 · Cited by 31 · see citing works
Effect and mechanism of nitrendipine on pulmonary hypertension induced by monocrotaline
Li, Z. (1997) · Zhongguo yaolixue tongbao
Role of inhibition of nitric oxide production in monocrotaline-induced pulmonary hypertension
Mathew, R., Gloster, E. S., Sundararajan, T., Thompson, C. I., Zeballos, G. A., & Gewitz, M. H. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.5.1493 · Cited by 43 · see citing works
Nitric oxide improves pulmonary vascular impedance, transpulmonary efficiency, and left ventricular filling in chronic pulmonary hypertension
Chen, E. P., Bittner, H. B., Tull, F., Craig, D. M., Davis, R. D., & Trigt, P. V. (1997) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(97)70257-5 · Cited by 13 · see citing works
[PP.22.02] EFFECTS OF NITRATE THERAPY IN MONOCROTALINE-INDUCED PULMONARY HYPERTENSION IN RATS
Kmecová, Z., Malíková, E., Křenek, P., & Klimas, J. (2017) · Journal of Hypertension · doi:10.1097/01.hjh.0000523808.44295.71 · Cited by 1 · see citing works

Authors: Pankey, E. A., Badejo, A. M., Casey, D. B., Lasker, G. F., Riehl, R. A., Murthy, S. N., Nossaman, B. D., & Kadowitz, P. J.
Affiliations: Tulane University (US)
Corresponding author: Kadowitz, Philip J.
ORCID: Pankey, Edward A.
Lasker, George F.
Murthy, Subramanyam N.
Nossaman, Bobby D.
Venue: Nitric Oxide
Publisher: Elsevier BV
Published: 2012-06
Volume: 27
Issue: 1
Pages: 1-8
ISSN: 1089-8603 (ISSN-L)
DOI: 10.1016/j.niox.2012.02.004
PMC: PMC3366021
OpenAlex: W1980023169
Cited by: 35
References: 82
Citations by year: 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 2
FWCI: 3.87
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Nitric Oxide (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (HL 62000, HL 77421)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Genetics › Vascular Anomalies and Treatments
Keywords: sodium nitrite, pulmonary hypertension, monocrotaline, nitrite therapy, soluble guanylate cyclase, pulmonary artery pressure, right ventricular hypertrophy, pulmonary vasodilation, sodium nitroprusside, U46619, systemic blood pressure, cardiac output
MeSH terms: Animals, Blood Pressure, Cardiac Output, Dose-Response Relationship, Drug, Hemodynamics, Hypertension, Pulmonary, Lung, Morpholines, Nitric Oxide, Nitroprusside, Pyrimidines, Sodium Nitrite, Monocrotaline, Rats, Sprague-Dawley, Hypertrophy, Right Ventricular, Tunica Media, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effect of chronic sodium nitrite therapy on monocrotaline-induced pulmonary hypertension

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks