The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance
Open accessAbstract
Insulin regulates glucose uptake and storage in peripheral tissues, and has been shown to act within the hypothalamus to acutely regulate food intake and metabolism. The machinery for transduction of insulin signaling is also present in other brain areas, particularly in the hippocampus, but a physiological role for brain insulin outside the hypothalamus has not been established. Recent studies suggest that insulin may be able to modulate cognitive functions including memory. Here we report that local delivery of insulin to the rat hippocampus enhances spatial memory, in a PI-3-kinase dependent manner, and that intrahippocampal insulin also increases local glycolytic metabolism. Selective blockade of endogenous intrahippocampal insulin signaling impairs memory performance. Further, a rodent model of type 2 diabetes mellitus produced by a high-fat diet impairs basal cognitive function and attenuates both cognitive and metabolic responses to hippocampal insulin administration. Our data demonstrate that insulin is required for optimal hippocampal memory processing. Insulin resistance within the telencephalon may underlie the cognitive deficits commonly reported to accompany type 2 diabetes.
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Insulin and neurodegenerative disease: shared and specific mechanisms
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Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease
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Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study
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Hypothalamic KATP channels control hepatic glucose production
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Memory improvement following induced hyperinsulinemia in Alzheimer’s disease
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Self-citationSupport for a Bimodal Role for Type II Adrenal Steroid Receptors in Spatial Memory
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Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitus
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“…extends to impairment of insulin signaling within the hippocampus, consistent with mRNA measurements in the temporal lobe of high-fatfed mice (Moroz et al., 2008); a recent study (Clegg et al., 2005) has shown that a similar impairment of central insulin signaling in DIO animals exists…”
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Cited by
Craft, S. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.233 · Cited by 1,253
Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity
Kanoski, S. E., & Davidson, T. L. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.12.003 · Cited by 676
Agrawal, M., Saraf, S., Saraf, S., Antimisiaris, S. G., Chougule, M. B., Shoyele, S. A., & Alexander, A. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.05.011 · Cited by 630
Glucose transporters in brain in health and disease
Koepsell, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02441-x · Cited by 558
Hippocampal insulin resistance and cognitive dysfunction
Biessels, G. J., & Reagan, L. P. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4019 · Cited by 537
Metadata
- Authors
- McNay, E. C., Ong, C. T., McCrimmon, R. J., Cresswell, J., Bogan, J. S., & Sherwin, R. S.
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 93
- Issue
- 4
- Pages
- 546-553
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W2067902437
- Cited by
- 397
- References
- 10
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- green
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