Cited by 199Memory and Neural MechanismsStress Responses and CortisolAdrenal Hormones and Disorders

Support for a Bimodal Role for Type II Adrenal Steroid Receptors in Spatial Memory

Conrad, Cheryl D., Lupien, Sonia J., McEwen, Bruce S.·1999·Neurobiology of Learning and Memory

Abstract

We investigated the effects of acute adrenal steroid treatment on spatial memory using the Y-maze and employing adrenal steroid receptor antagonists and agonists. For receptor activation, adrenalectomized rats were injected 2 h prior to their first Y-maze trial with sesame oil (adrenalectomy or SHAM), stress levels of corticosterone, a Type I receptor agonist (aldosterone), or a Type II receptor agonist (RU362). For receptor inactivation, unoperated rats were injected with a Type I receptor antagonist (RU318), a Type II receptor antagonist (RU555), sesame oil, or not injected at all. The findings indicated that spatial memory was impaired when the Type II receptors were blocked (RU555) or highly occupied (corticosterone or RU362) and normal for the other treatment conditions. These data suggest that the Type II receptors may be responsible for the inverted U-shaped relationship between spatial memory and corticosterone levels reported by others.

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Crossref · 10.1006/nlme.1998.3898

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Authors
Conrad, C. D., Lupien, S. J., & McEwen, B. S.
Affiliations
  • Arizona State University (US)
  • Douglas Mental Health University Institute (CA)
  • Rockefeller University (US)
Venue
Neurobiology of Learning and Memory
Publisher
Elsevier BV
Published
1999-07
Volume
72
Issue
1
Pages
39-46
ISSN
1074-7427 (ISSN-L)
OpenAlex
W2026986199
Cited by
199
References
21
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 6 · 2014: 11 · 2013: 9 · 2012: 5
FWCI
4.62
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Learning and Memory (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5f32mh010804-02)
  • National Institute of Mental Health (MH-41256, MH10804)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
spatial memory, corticosterone, aldosterone, adrenalectomy, Y-maze, inverted U-shaped relationship, glucocorticoid receptor antagonist
MeSH terms
Adrenalectomy, Aldosterone, Mineralocorticoid Receptor Antagonists, Analysis of Variance, Androstanols, Animals, Corticosterone, Hippocampus, Male, Memory, Receptors, Glucocorticoid, Rats, Sprague-Dawley, Receptors, Mineralocorticoid, Maze Learning, Rats

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