Support for a Bimodal Role for Type II Adrenal Steroid Receptors in Spatial Memory
Abstract
We investigated the effects of acute adrenal steroid treatment on spatial memory using the Y-maze and employing adrenal steroid receptor antagonists and agonists. For receptor activation, adrenalectomized rats were injected 2 h prior to their first Y-maze trial with sesame oil (adrenalectomy or SHAM), stress levels of corticosterone, a Type I receptor agonist (aldosterone), or a Type II receptor agonist (RU362). For receptor inactivation, unoperated rats were injected with a Type I receptor antagonist (RU318), a Type II receptor antagonist (RU555), sesame oil, or not injected at all. The findings indicated that spatial memory was impaired when the Type II receptors were blocked (RU555) or highly occupied (corticosterone or RU362) and normal for the other treatment conditions. These data suggest that the Type II receptors may be responsible for the inverted U-shaped relationship between spatial memory and corticosterone levels reported by others.
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Acute stress or corticosterone can impair hippocampus-specific memory processing in rats and people.
“and can impair hippocampus-specific memory processing in rats (de Quervain et al. [157]; Conrad et al. [158]; Roozendaal et al. [159]) and people (Kirschbaum et al. [160]; de Quervain et al. [161]; Wolf et al. [162]; Payne et al. [163]; Buss et al. [164]; Wolf et al. [165]; Elzinga et al. [76]; Kuhlmann et al. [166]; Kuhlmann et al. [167]; Payne et al. [168]; Buchanan”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Conrad et al. [158]
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- Authors
- Conrad, C. D., Lupien, S. J., & McEwen, B. S.
- Affiliations
- Arizona State University (US)
- Douglas Mental Health University Institute (CA)
- Rockefeller University (US)
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 72
- Issue
- 1
- Pages
- 39-46
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W2026986199
- Cited by
- 199
- References
- 21
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 6 · 2014: 11 · 2013: 9 · 2012: 5
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f32mh010804-02)
- National Institute of Mental Health (MH-41256, MH10804)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- spatial memory, corticosterone, aldosterone, adrenalectomy, Y-maze, inverted U-shaped relationship, glucocorticoid receptor antagonist
- MeSH terms
- Adrenalectomy, Aldosterone, Mineralocorticoid Receptor Antagonists, Analysis of Variance, Androstanols, Animals, Corticosterone, Hippocampus, Male, Memory, Receptors, Glucocorticoid, Rats, Sprague-Dawley, Receptors, Mineralocorticoid, Maze Learning, Rats
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