Cited by 700Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsDiabetes, Cardiovascular Risks, and Lipoproteins

Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study

Leibson, C. L, Rocca, W. A., Hanson, V. A., Cha, R., Kokmen, E., O'Brien, P. C., Palumbo, P. J.·1997·American Journal of Epidemiology

Abstract

It is unclear whether persons with diabetes are at increased risk for dementia, including Alzheimer's disease. Existing studies are limited by small sample size, selection bias, and case-control designs. This population-based historical cohort study provides estimates of the risk of dementia and Alzheimer's disease associated with adult onset diabetes mellitus (AODM). The sample included all persons with AODM residing in Rochester, Minnesota, on January 1, 1970, plus all persons diagnosed in Rochester or who moved to Rochester with the diagnosis between January 1, 1970, and December 31, 1984. Individuals were followed through review of their complete medical records from AODM diagnosis until dementia onset, emigration, death, or January 1, 1985. Standardized morbidity ratios for dementia and Alzheimer's disease were calculated, using an expected incidence based on age- and sex-specific rates for the Rochester population. Poisson regression was used to estimate risks for persons with AODM relative to those without. Of the 1,455 cases of AODM followed for 9,981 person-years, 101 developed dementia, including 77 who met criteria for Alzheimer's disease. Persons with AODM exhibited significantly increased risk of all dementia (Poisson regression relative risk (RR) = 1.66, 95% confidence interval (CI) 1.34-2.05). Risk of Alzheimer's disease was also elevated (for men, R = 2.27, 95% CI 1.55-3.31; for women, RR = 1.37, 95% CI 0.94-2.01). These findings emphasize the importance of AODM prevention and prompt additional investigation of the relation between AODM and dementia.

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Crossref · 10.1093/oxfordjournals.aje.a009106

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Authors
Leibson, C. L., Rocca, W. A., Hanson, V. A., Cha, R., Kokmen, E., O'Brien, P. C., & Palumbo, P. J.
Affiliations
Mayo Clinic (US)
Corresponding author
Leibson, C. L
Venue
American Journal of Epidemiology
Published
1997-02-15
Volume
145
Issue
4
Pages
301-308
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
OpenAlex
W1984044273
Cited by
700
References
31
Citations by year
2026: 8 · 2025: 8 · 2024: 15 · 2023: 18 · 2022: 16 · 2021: 30 · 2020: 25 · 2019: 26 · 2018: 30 · 2017: 32 · 2016: 31 · 2015: 21 · 2014: 31 · 2013: 31 · 2012: 36
FWCI
14.17
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Diabetes Association
  • National Institutes of Health (5r29ag008729-05)
  • National Institute on Aging (AG-08031, P30AG008031, AG-08729)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
diabetes mellitus, dementia, Alzheimer's disease, type 2 diabetes, dementia risk, sex differences, Rochester, Minnesota
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Dementia, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Minnesota, Population Surveillance, Regression Analysis, Risk, Risk Factors, Urban Health, Cohort Studies, Incidence, Age Distribution

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