Antibiotic resistance propagation through probiotics

Daniali, Marzieh; Nikfar, Shekoufeh; Abdollahi, Mohammad

doi:10.1080/17425255.2020.1825682

Cited by 90Antibiotic Resistance in BacteriaProbiotics and Fermented FoodsPharmaceutical and Antibiotic Environmental Impacts

Antibiotic resistance propagation through probiotics

Daniali, Marzieh, Nikfar, Shekoufeh, Abdollahi, Mohammad·2020·Expert Opinion on Drug Metabolism & Toxicology

DOI 10.1080/17425255.2020.1825682

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Abstract

INTRODUCTION: The widespread use of probiotics globally has established an argument against their safety profile. Recent studies investigated the gastrointestinal tract (GIT) as a reservoir for antibiotic resistance genes and horizontal gene transfer (HGT) amongst opportunistic pathogens, probiotics, and the normal microbiota which might cause severe clinical implications. AREAS COVERED: In this review, we aimed to discuss the potential role of probiotics in spreading antibiotic resistance. All relevant data were found through online/updated databases such as PubMed, Google Scholar, and Clinicaltrials.gov. This review is based on the studies undertaken over the past two decades (2000-2020). EXPERT OPINION: Microorganisms are capable of transferring resistance genes to survive against antimicrobial medications. Transference of resistance genes among pathogens, probiotics, and gut microbiota in the GIT through HGT endow probiotics as a possible source for antimicrobial resistance genes, which is responsible for the development of the antibiotic resistance crisis. According to the expression of genes in mechanisms of antibiotics resistance and probiotics HGT, the hypothesis of the role of these microorganisms in personalized medicine and gene therapy could also be considered.

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The presence of such ARGs and VFs may have clinical relevance, particularly in immunocompromised individuals or those with disrupted gut barriers, where opportunities for opportunistic infection or horizontal gene transfer may be increased.
“The presence of such ARGs and VFs may have clinical relevance, particularly in immunocompromised individuals or those with disrupted gut barriers, where opportunities for opportunistic infection or horizontal gene transfer may be increased.22,29-35”
From Safety and efficacy concerns in Indian probiotics: Insights from whole-genome sequencing and in vitro assessment (2026) · cites this paper as [29]

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Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes
Fu, Y., Dou, Q., Smalla, K., Wang, Y., Johnson, T. A., Brandt, K. K., Mei, Z., Liao, M., Hashsham, S. A., Schäffer, A., et al. (2023) · mLife · doi:10.1002/mlf2.12101 · Cited by 65 · see citing works
In-depth genomic identification and safety evaluation of Lactobacillus Acidophilus LA85
Qi, Y., Dong, Y., Gu, J., Cai, Y., Zhang, Y., Gai, Z., & Han, M. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106604 · Cited by 9 · see citing works
Safety and efficacy concerns in Indian probiotics: Insights from whole-genome sequencing and in vitro assessment
Madhumathi, I., Ramesh, V., Rathakrishnan, B., Abirami, B., Gunasekaran, K., Kumar, T. S., Jeyasankar, P., Raja, G., Selvam, K., Rajendran, S., et al. (2026) · Gut microbes reports · doi:10.1080/29933935.2026.2668863
“29-35 Genomic studies of the composite genome of Bacillus from the probiotic Enterogermina ® formulation have similarly reported a mobilome enriched with transposons and other mobile genetic elements, along with a novel plasmid sequence.”

Authors: Daniali, M., Nikfar, S., & Abdollahi, M.
Affiliations: Pharmaceutical Sciences Research Center (IR)
Pharmaceutical Management and Economics Research Center (IR)
Personalized Medicine Research Center (IR)
Corresponding author: Abdollahi, Mohammad
ORCID: Daniali, Marzieh
Nikfar, Shekoufeh
Abdollahi, Mohammad
Venue: Expert Opinion on Drug Metabolism & Toxicology
Publisher: Informa UK Limited
Published: 2020-09-27
Volume: 16
Issue: 12
Pages: 1207-1215
ISSN: 1742-5255 (ISSN-L)
1744-7607
DOI: 10.1080/17425255.2020.1825682
OpenAlex: W3087000429
Cited by: 90
References: 84
Citations by year: 2026: 16 · 2025: 24 · 2024: 10 · 2023: 18 · 2022: 15 · 2021: 7
FWCI: 0.71
Type: journal article
Language: en
Open access: closed
Locations: Expert Opinion on Drug Metabolism & Toxicology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
Keywords: probiotics, antibiotic resistance genes, horizontal gene transfer, gut microbiota, gastrointestinal tract, antimicrobial resistance, opportunistic pathogens, probiotic safety, personalized medicine, gene therapy
MeSH terms: Gastrointestinal Microbiome, Animals, Anti-Infective Agents, Drug Resistance, Microbial, Humans, Genetic Therapy, Probiotics, Gene Transfer, Horizontal, Gastrointestinal Tract, Precision Medicine

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Antibiotic resistance propagation through probiotics

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