Cited by 190Neuroendocrine regulation and behaviorOlfactory and Sensory Function StudiesNeuropeptides and Animal Physiology

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Oxytocin plasma concentrations after single intranasal oxytocin administration–a study in healthy men

Gossen, A., Hahn, A., Westphal, L., Prinz, S., Schultz, R.T., Gründer, G., Spreckelmeyer, K.N.·2012·Neuropeptides

DOI 10.1016/j.npep.2012.07.001

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Abstract

The neuropeptide oxytocin has become a subject of great interest in studies investigating human social cognition. Single intranasal administration of the hormone has been reported to have positive behavioral effects, such as increasing trust or facilitating social approach, 45-80 min after administration. However, little is still known about the long-term pharmacokinetics of oxytocin nasal spray application in humans. This study addressed the question how long oxytocin plasma levels remain elevated following nasal spray administration. Another goal was to examine the influence of oxytocin administration on endogenous steroid hormones since such alterations might modulate social behavior via an indirect way. Eight healthy Caucasian men were challenged with a single intranasal application of 26 international units of oxytocin. Changes in oxytocin blood plasma levels, as well as steroid hormone levels of progesterone, testosterone and estradiol were assessed at 5 consecutive time points over a period of 3.5 h (-5, +30, +90, +150, +210 min relative to oxytocin administration). Results gave evidence for a substantial rise of oxytocin plasma levels 30 min after intranasal administration, observed in 7 of 8 participants. Group mean oxytocin plasma level was found to have returned to baseline already 90 min post administration, though in some individuals the plasma levels was still elevated relative to sampling at post 150 min. Steroid hormone analyses yielded a slight augmentation of endogenous testosterone levels 210 min after oxytocin administration. Our data confirms previous findings that oxytocin administered as a nasal spray enters the blood circulation, elevating oxytocin plasma levels for a limited time. Our findings suggest that this time window differs between individuals, but that, for the used dose, it does not extend beyond 150 min post administration. The data further provides preliminary evidence that intranasal oxytocin has an enhancing effect on testosterone in healthy men.

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Викторовна, К. Е., & Бикбов, И. З. (2025) · Russian Biomedical Research · doi:10.56871/rbr.2025.67.63.006
Additional file 1 of Oxytocin-induced increase in N,N-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms
Kato, Y., Kuwabara, H., Okada, T., Munesue, T., Benner, S., Kuroda, M., Kojima, M., Yassin, W., Eriguchi, Y., Kameno, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14100733
Additional file 2 of Oxytocin-induced increase in N,N-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms
Kato, Y., Kuwabara, H., Okada, T., Munesue, T., Benner, S., Kuroda, M., Kojima, M., Yassin, W., Eriguchi, Y., Kameno, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14100736
Effects of intranasal oxytocin combined with resistance training on testosterone, cortisol, fatigue, and skin temperature in paralympic powerlifting athletes
Mendonça, T. P., Aidar, F. J., Bădicu, G., Santos, L. D. R., Paz, Â. D. A., Marçal, A. C., Orangi, B. M., Ulusoy, A., de Souza, R. F., & Brito, C. J. (2026) · European Journal of Applied Physiology · doi:10.1007/s00421-026-06163-3
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Variation in DNA methylation of the oxytocin gene is associated with prosocial, reward-related, decision-making
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Influence of the activities imposed by the human being on equine emotional responses
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Effects of intranasal oxytocin on fear, pain and aversive memory
Silva, J. U., & Brito, I. (2026) · Neuropeptides · doi:10.1016/j.npep.2026.102618
Raman Imaging-based Analysis of Drug Powder Dissolution on Calu-3 Cell Monolayers as a Mechanistic Predictor of Nasal Absorption
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BindingDB Entry 50002504: LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism.
BindingDB (2020) · UC San Diego · doi:10.7270/q24j0hrf

Authors: Gossen, A., Hahn, A., Westphal, L., Prinz, S., Schultz, R. T., Gründer, G., & Spreckelmeyer, K. N.
Affiliations: Jülich Aachen Research Alliance (DE)
RWTH Aachen University (DE)
University of Pennsylvania (US)
Corresponding author: Spreckelmeyer, K.N.
ORCID: Schultz, R.T.
Gründer, G.
Venue: Neuropeptides
Publisher: Elsevier BV
Published: 2012-10
Volume: 46
Issue: 5
Pages: 211-215
ISSN: 0143-4179 (ISSN-L)
DOI: 10.1016/j.npep.2012.07.001
OpenAlex: W2136974459
Cited by: 189
References: 21
Citations by year: 2026: 9 · 2025: 8 · 2024: 7 · 2023: 9 · 2022: 14 · 2021: 16 · 2020: 18 · 2019: 11 · 2018: 22 · 2017: 13 · 2016: 16 · 2015: 17 · 2014: 12 · 2013: 15 · 2012: 1
FWCI: 21.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropeptides (publishedVersion)
PubMed (publishedVersion)
RWTH Publications (RWTH Aachen) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, intranasal administration, plasma oxytocin, pharmacokinetics, testosterone, steroid hormones, progesterone, estradiol, social behavior, healthy men
MeSH terms: Administration, Intranasal, Adult, Estradiol, Humans, Male, Oxytocin, Progesterone, Testosterone

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Oxytocin plasma concentrations after single intranasal oxytocin administration–a study in healthy men

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